WO2023116222A1 - Atomization base solution, cigarette liquid and electronic atomization apparatus - Google Patents

Abstract

Provided are an atomization base solution, a smoking liquid, and an electronic atomization apparatus. The atomization base solution comprises the following components counted in parts by weight: 50-70 parts of 1,3-butanediol, 1-5 parts of sugar alcohol and 15-40 parts of water; the atomization base solution does not comprise propylene glycol or glycerol. 1,3-butanediol and water serve as the main atomization components, at the same time, sugar alcohol dissolved in water serves as an auxiliary atomization component of the electronic cigarette liquid. Compared to a traditional electronic cigarette atomization base solution, with the use of sugar alcohol dissolved in water as an auxiliary atomization improvement component, the water content in the atomization base solution is increased, the content of harmful substances in the atomization process is reduced, and the safety of the electronic cigarette is improved.

Description

An atomization base liquid, smoke liquid and electronic atomization device

cross reference

This application claims the priority of the Chinese patent application submitted to the State Intellectual Property Office of China on December 23, 2021, with the application number 202111591028.3, and the title of the invention is "An Atomized Base Liquid, E-liquid, and Electronic Atomization Device". The entire contents are incorporated by reference in this application.

technical field

The present application relates to the technical field of electronic cigarettes, in particular to an atomized base liquid, liquid smoke and an electronic atomization device.

Background technique

Electronic vaping products have achieved rapid development in recent years, and tobacco giants have gradually applied their expertise in vaping to health care. E-cigarette liquid is one of the important components of electronic cigarettes. At present, the mainstream e-cigarette liquid is mainly composed of flavors and fragrances, nicotine, propylene glycol, glycerin, etc. in a certain proportion, so as to simulate the aroma of traditional cigarettes to the greatest extent. , aroma and taste purposes.

Since the e-cigarette liquid contains propylene glycol and glycerin, propylene glycol and glycerin will release a certain amount of harmful substances such as aldehydes and ketones during the atomization heating process, and the release of harmful substances will be aggravated when the e-cigarette is dry-burned.

Therefore, it is an urgent technical problem to do a good job in reducing the harm of electronic cigarettes, reducing the release of harmful substances in electronic cigarettes, and improving the safety of electronic cigarettes.

Contents of the invention

Therefore, the technical problem to be solved in the present application is to overcome the defects in the smoking safety of electronic cigarettes in the prior art, so as to provide an atomized base liquid, e-liquid and an electronic atomization device.

In order to solve the above technical problems, the application adopts the following technical solutions:

A kind of atomized base liquid, comprises the following components in parts by weight:

50-70 parts of 1,3-butanediol, 1-5 parts of sugar alcohol and 15-40 parts of water.

Optionally, the atomized base liquid includes the following components in parts by weight:

60-70 parts of 1,3-butanediol, 1-5 parts of sugar alcohol and 15-25 parts of water.

Optionally, the atomized base liquid does not include propylene glycol and glycerin.

Optionally, the sugar alcohol is selected from at least one of erythritol, sorbitol, xylitol or mannitol.

Optionally, the sugar alcohol is a mixture of erythritol and sorbitol, and the mass ratio of erythritol and sorbitol is

Optionally, the sugar alcohol is a mixture of erythritol and xylitol, and the mass ratio of the erythritol and xylitol is

Optionally, the sugar alcohol is a mixture of erythritol and mannitol, and the mass ratio of the erythritol and mannitol is

Optionally, the water content is greater than 10% by weight. This content can be obtained by dividing the weight of water by the total weight of the atomized base fluid.

An e-liquid, including the above-mentioned atomized base liquid.

Optionally, the e-liquid includes the following components in parts by weight:

50-70 parts of 1,3-butanediol, 1-5 parts of sugar alcohol, 15-40 parts of water, 5-10 parts of Chinese herbal medicine extract and 3-5 parts of fragrance base raw material.

Optionally, the fragrance base raw material includes the following components in parts by weight:

5-20 parts of nicotine, 2-12 parts of macrostigmatrienone, 3-8 parts of β-ionone, and 2-12 parts of turkenone.

Optionally, the fragrance base raw material further includes 1,3-butanediol, and the content of 1,3-butanediol complements the sum of the components of the fragrance base raw material to 100 parts.

Optionally, the Chinese herbal medicine extract is selected from at least one of ebony extract, perilla leaf extract, kudzu root extract or peppermint extract, and can be ebony extract, perilla leaf extract, kudzu root extract A combination of four kinds of extracts and peppermint extracts, further optionally, the mass ratio of the ebony extract, perilla leaf extract, kudzu root extract, and peppermint extract is 1-4:1-4:1-4: 1~2.

According to the raw material characteristics of the Chinese herbal medicine extract, it can be extracted by different extraction methods. The ebony extract can be obtained by ethanol extraction, the mint raw material can be extracted by supercritical carbon dioxide to obtain the mint extract, and the kudzu root and perilla leaves can be soaked. , boiled to obtain the extract, and select the best extraction method for each raw material, so that the extraction of each raw material can achieve the best effect.

An electronic atomization device, including the above-mentioned atomization base liquid or e-liquid. The electronic atomization device includes the above-mentioned atomization base liquid or e-liquid, which has the same or similar effects.

Beneficial effect:

This application uses 1,3-butanediol and water as the main atomization components, and at the same time uses sugar alcohol dissolved in water as the auxiliary atomization component of e-cigarette liquid. Water is used as an auxiliary smoke-enhancing component, which increases the water content in the atomization base liquid, reduces the content of harmful substances in the atomization process, and increases the safety of electronic cigarettes.

Optionally, the atomized base liquid does not include glycerin and propylene glycol. Propylene glycol and glycerin will release a certain amount of harmful substances such as aldehydes and ketones during the atomization heating process, and the release of harmful substances will be aggravated when the electronic cigarette is dry-burned. This application excludes the addition of glycerin and propylene glycol, which can improve the safety of electronic cigarettes. In addition, it can also alleviate adverse effects such as sweetness and dry mouth caused by the presence of glycerin.

Optionally, the atomized base liquid includes, in parts by weight: 60-70 parts of 1,3-butanediol, 1-5 parts of sugar alcohol and 15-25 parts of water, and the atomized base liquid does not include Propylene Glycol and Glycerin. This optional solution significantly increases the water content in the e-liquid and improves safety. Moreover, compared with the traditional atomized base liquid, the amount of atomized smoke obtained is not weaker than the atomized base liquid containing glycerin and propylene glycol. In addition, traditional e-cigarette liquid contains glycerin, and glycerin will cause adverse effects such as sweetness and dry mouth during the process of atomization and smoking. The optional scheme of the present application improves the moistness of the oral cavity and improves mouthfeel comfort. Moreover, there is no glycerin sweetness and dry mouth, and the mouthfeel is significantly improved.

In an optional technical solution of the present application, the sugar alcohol is at least one selected from erythritol, sorbitol, xylitol or mannitol. Erythritol, sorbitol, xylitol, and mannitol are all safe functional sweeteners, which can cover the slightly bitter almond taste of 1,3-butanediol. It can promote the secretion of saliva in the mouth, increase the moisture of the mouth, and relieve the symptoms of dry mouth after drinking.

In an optional technical solution of the present application, the content of the water is greater than 10% by weight. When the moisture content is >10%, the atomized smoke volume of the electronic cigarette will be significantly reduced, so the moisture content in the traditional electronic cigarette base liquid will not exceed 10%. However, when the water content is greater than 10%, the dilution effect of water on the atomizer can reduce the content of harmful substances such as aldehydes and ketones formed by the cracking of the atomizer in electronic cigarettes, and improve the safety of electronic cigarettes. This application uses 1,3-butanediol and water as the main atomization components, and uses sugar alcohol dissolved in water as the auxiliary atomization component of e-cigarette liquid, so as to achieve a high amount of atomized smoke and the safety of e-cigarettes .

In the optional technical solution of the present application, the Chinese herbal medicine extract is a combination of four kinds of ebony extract, perilla leaf extract, kudzu root extract and peppermint extract. At the same time, the four medicinal materials of ebony, perilla leaf, kudzu root, and mint are used in combination, and their extracts are added to the e-cigarette liquid to make it relieve the headache and dry mouth after drinking, and at the same time add a characteristic aroma to further enhance the richness of the taste Spend. In addition, kudzu root promotes body fluids to quench thirst and detoxify alcohol, which is the key medicine for detoxification of alcohol, ebony plum promotes body fluids to quench thirst and astringe lungs, perilla leaf promotes qi and harmonizes stomach, mint dispels wind-heat, clears the head, and the four are used together to relieve hangover Brain, clearing away heat, restlessness and peace of mind, benefiting the stomach, promoting body fluid and quenching thirst, can effectively relieve symptoms such as thirst, dry throat, fullness in the chest, dizziness and other symptoms after drinking, adding it to the e-cigarette liquid, making the e-cigarette liquid It can relieve the symptoms of drunk head and dry mouth. In addition, the characteristic aroma of ume alcohol and sweet and sour can reduce irritation and improve the aftertaste; mint has a refreshing mint aroma, which can bring a lasting cool feeling and make the smoke clear and bright. Chinese herbal medicine extracts not only have a variety of anti-alcoholic ingredients to relieve headaches and dry mouth after drinking, but also have characteristic aromas, which further enhance the richness of aromas and the comfort of dry mouth.

Description of drawings

In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the following will briefly introduce the accompanying drawings that need to be used in the description of the specific embodiments or prior art. Obviously, the accompanying drawings in the following description The figures show some implementations of the present application, and those skilled in the art can obtain other figures based on these figures without any creative effort.

Fig. 1 is a diagram of dry mouth-saliva osmotic pressure changes in the examples and comparative examples of the present application, wherein the implementation cases are examples.

Detailed ways

In this application, the preparation method of Chinese herbal medicine extract comprises:

(1) Take 4 to 12 parts of ebony raw materials and grind them to 30 mesh, add 3 to 5 times of 95% ethanol to leaching at 70°C for 10 hours after taking the crushed ebony raw materials, vacuum filter, and concentrate with a rotary evaporator until the density is 1.1g/mL, The stock solution was prepared, and the stock solution was filtered and sterilized by a 0.2mm microporous sterilizing membrane to obtain the ebony extract, which was stored at 4°C for future use.

(2) Take 1 to 5 parts of mint raw materials and crush them to 80 to 120 meshes, and carry out supercritical carbon dioxide extraction on the pulverized mint raw materials for primary separation. Critical carbon dioxide extraction, ie, peppermint extract.

(3) Grind 2-10 parts of kudzu root and 2-10 parts of perilla leaves to 50-80 mesh, add 6-9 times of water for the first extraction and soak for 2 hours, boil for 3 hours at 85°C, and add water for 6 hours for the second extraction After ~9 times of boiling, warm soak at 85°C for 2 hours, combine the two extracts, filter, concentrate the filtrate to a density of 1.1g/mL, add 3 times the volume of 95% ethanol for alcohol precipitation, and concentrate the supernatant to a clear paste after filtration , to obtain kudzu root and perilla leaf extracts.

(4) Add peppermint extract and ebony extract to the obtained concentrated clear cream and mix evenly to obtain the Chinese herbal medicine extract.

Preparation of e-cigarette liquid fragrance base raw materials: 5-20 parts of nicotine, 2-12 parts of macrostigmatrienone, 3-8 parts of β-ionone and 2-12 parts of turkenone, with 1,3-butan The diol is supplemented to 100 parts by weight, and the mixture is evenly stirred to obtain the flavor base raw material of the e-cigarette liquid.

Add 1,3-butanediol, sugar alcohol and water to the Chinese herbal medicine extract and the fragrance base raw material of the e-cigarette liquid, stir and mix evenly to obtain the e-cigarette liquid, wherein the e-cigarette liquid includes by weight parts: 50-70 parts of 1,3-butanediol, 5-10 parts of sugar alcohol, 15-40 parts of water, 5-10 parts of Chinese herbal medicine extract, 5 parts of fragrance base raw material.

Example 1

This embodiment provides an electronic cigarette liquid, the specific preparation steps are as follows:

Preparation of herbal extracts:

(1) Take 1 kg of ebony raw material and pulverize it through a 30-mesh sieve, add 5 times of 95% ethanol to leaching at 70°C for 10 hours after taking the pulverized ebony raw material, vacuum filter, concentrate to a density of 1.1g/mL with a rotary evaporator, and make a stock solution, The stock solution was filtered and sterilized by a 0.2mm microporous sterilizing membrane to obtain the ebony extract, which was stored at 4°C for future use.

(2) Take 1 kg of mint raw material and crush it to 80-120 meshes, and perform supercritical carbon dioxide extraction on the pulverized mint raw material, one-stage separation, separation pressure 6MPa, separation temperature 50°C, extraction time: 90min, and supercritical carbon dioxide extraction of mint is obtained. , namely, peppermint extract.

(3) Crush 1 kg of kudzu root and 1 kg of perilla leaves to 50-80 meshes, add 9 times of water for the first extraction and soak for 2 hours, boil for 3 hours at 85°C, and add water for the second extraction for 6 times and then soak for 2 hours at 85°C , combined two extracts, filtered, the filtrate was concentrated to a density of 1.1g/ML, added 3 times the volume of 95% ethanol for alcohol precipitation, filtered and the supernatant was concentrated to a clear paste to obtain Pueraria lobata and perilla leaf extracts, press The mass ratio of ebony extract, perilla leaf extract, kudzu root extract and peppermint extract is 1:1:1:1, adding peppermint extract and ebony extract respectively, and mixing evenly to obtain Chinese herbal medicine extract.

Preparation of e-cigarette liquid fragrance base raw materials:

10g of nicotine, 8g of macrostigmatrienone, 4g of β-ionone, and 8g of turkelenone were added to 100g with 1,3-butanediol, and stirred evenly to obtain the flavor base raw material for electronic cigarette liquid.

mix:

Add 70g of 1,3-butanediol, 4g of erythritol, 1g of mannitol, and 15g of deionized water to the above 5g of Chinese herbal medicine extract and 5g of e-cigarette liquid fragrance base raw materials, and dissolve the sugar alcohol in water in advance. Stir the mixture at room temperature and mix evenly to obtain e-cigarette liquid.

Example 2

This embodiment provides an electronic cigarette liquid, the specific preparation steps are as follows:

Preparation of herbal extracts:

(1) Take 1 kg of ebony raw material and pulverize it through a 30-mesh sieve, add 5 times of 95% ethanol to leaching at 70°C for 10 hours after taking the pulverized ebony raw material, vacuum filter, concentrate to a density of 1.1g/mL with a rotary evaporator, and make a stock solution, The stock solution was filtered and sterilized by a 0.2mm microporous sterilizing membrane to obtain the ebony extract, which was stored at 4°C for future use.

(2) Take 1 kg of mint raw material and crush it to 80-120 meshes, and perform supercritical carbon dioxide extraction on the pulverized mint raw material, one-stage separation, separation pressure 6MPa, separation temperature 50°C, extraction time: 90min, and obtain supercritical carbon dioxide extraction of mint , namely, peppermint extract.

(3) Grind 1 kg of kudzu root and 1 kg of perilla leaves to 50-80 meshes, add 6 times of water for the first extraction and soak for 2 hours, boil for 3 hours at 85°C, and add water for the second extraction for 9 times and then soak for 2 hours at 85°C , combined two extracts, filtered, concentrated the filtrate to a density of 1.1g/mL, added 3 times the volume of 95% ethanol to precipitate, filtered the supernatant and concentrated to a clear paste, and obtained Pueraria lobata and perilla leaf extracts, according to The mass ratio of ebony extract, perilla leaf extract, kudzu root extract, and peppermint extract is 4:4:4:1, and peppermint extract and ebony extract are added respectively, and the Chinese herbal medicine extract is obtained after uniformity.

Preparation of e-cigarette liquid fragrance base raw materials:

10g of nicotine, 8g of macrostigmatrienone, 4g of β-ionone, and 8g of turkelenone were added to 100g with 1,3-butanediol, and stirred evenly to obtain the flavor base raw material for electronic cigarette liquid.

mix:

Add 60g of 1,3-butanediol, 3g of erythritol, 2g of sorbitol, and 25g of deionized water to 5g of Chinese herbal medicine extract and 5g of e-cigarette liquid fragrance base raw material. The sugar alcohol is dissolved in water in advance. Stir the mixture at room temperature and mix evenly to obtain e-cigarette liquid.

Example 3

This embodiment provides an electronic cigarette liquid, the specific preparation steps are as follows:

Add 50 g of 1,3-butanediol, 2 g of erythritol, 3 g of xylitol, and 35 g of deionized water to 5 g of the Chinese herbal medicine extract obtained in Example 1 and 5 g of the e-cigarette liquid fragrance base raw material, and the sugar alcohol Dissolve in water, stir and mix the above mixture at room temperature to obtain the e-cigarette liquid.

Example 4

This embodiment provides an electronic cigarette liquid, the specific preparation steps are as follows:

Add 5g of Chinese herbal medicine extract and 5g of e-cigarette liquid fragrance base in Example 2, add 70g of 1,3-butanediol, 4g of erythritol, 1g of xylitol and 15g of deionized water, and dissolve the sugar alcohol in the water in advance , the above mixture is stirred and mixed evenly at room temperature to obtain the e-cigarette liquid for alleviating head and mouth dryness after drinking.

Example 5

This embodiment provides an electronic cigarette liquid, the specific preparation steps are as follows:

Add 60g of 1,3-butanediol, 4g of erythritol, 1g of mannitol and 25g of deionized water to 5g of Chinese herbal medicine extract and 5g of e-cigarette liquid fragrance base raw material in Example 2, and dissolve the sugar alcohol in the In water, the above mixture was stirred and mixed uniformly at room temperature to obtain the e-cigarette liquid.

Example 6

This embodiment provides an electronic cigarette liquid, the specific preparation steps are as follows:

Add 5g of Chinese herbal medicine extract and 5g of e-cigarette liquid fragrance base material in Example 2, add 50g of 1,3-butanediol, 2g of erythritol, 3g of sorbitol and 35g of deionized water, and dissolve the sugar alcohol in advance In water, the above mixture was stirred and mixed uniformly at room temperature to obtain the e-cigarette liquid.

Comparative example 1

This comparative example provides an electronic cigarette liquid, and the specific preparation steps are as follows:

Add 40 g of propylene glycol and 50 g of glycerin to 5 g of the Chinese herbal medicine extract and 5 g of e-cigarette liquid aroma base in Example 1, and stir and mix the mixture at room temperature to obtain e-cigarette liquid comparative example 1.

Comparative example 2

This comparative example provides an electronic cigarette liquid, and the specific preparation steps are as follows:

Add 5g of Chinese herbal medicine extract and 5g of e-cigarette liquid aroma base material in Example 2, add 40g of propylene glycol and 50g of glycerin, stir and mix evenly at room temperature, and obtain e-cigarette liquid comparative example 2.

Comparative example 3

This comparative example provides an electronic cigarette liquid, and the specific preparation steps are as follows:

Add 45 g of propylene glycol and 50 g of glycerin to 5 g of the e-cigarette liquid aroma base material in Example 1, stir and mix evenly at room temperature, and obtain e-cigarette liquid comparative example 3.

Smoke Test Results

Inhale 6 e-liquid samples from the configured examples 1-6 and 2 mL e-liquid samples from comparative examples 1-2 respectively and put them into the e-cigarette appliance with a power of 6.5W, using an e-cigarette smoking machine Suction, suction method: pump for 3S, stop for 27S, the suction volume is 55mL, every 25 puffs is a cycle, a total of 200 puffs are drawn, and the weight change of the pod before and after each 25 puffs is accurately weighed to obtain the average weight of the aerosol per puff. weight. The data of the e-liquids in Examples 1-6 were compared with those in Comparative Examples 1-2 to measure the amount of smoke in each e-liquid sample. The specific data are shown in Table 1 below.

Table 1 Experimental data of smoke volume test

the	Smoke volume (mg/puff)
Example 1	6.62

Example 2	5.17
Example 3	4.43
Example 4	6.55
Example 5	5.97
Example 6	4.99
Comparative example 1	6.70
Comparative example 2	6.54

From the comparison of the amount of smoke in Table 1, it can be seen that the amount of water in this e-liquid should not be too high, otherwise the amount of smoke will be reduced. Optionally, under the conditions of 1,3-butanediol content of 60-70 parts by weight, sugar alcohol content of 1-5 parts by weight, and water content of 15-25 parts by weight in the e-liquid containing no propylene glycol or glycerin, E-liquids without propylene glycol and glycerin can achieve a smoke volume similar to that of traditional e-liquids, and at the same time significantly increase the water content in the e-liquids, improving safety.

taste test

Add the 6 e-liquid samples of Examples 1-6 above and the 2 e-liquid samples of Comparative Examples 1-2 into the e-cigarette device with a power of 6.5W, adopt the scoring method of blind evaluation, and use the large circulation product Inhalation method, the e-cigarette liquid is smoked, and the taste and taste group composed of 5 people conducts sensory evaluation respectively. The taste evaluation criteria are as follows in Table 2, mainly including the following evaluation indicators, aroma concentration, irritation (miscellaneous gas) , smoke volume, sweetness, throat hit, smoke humidity, coordination, satisfaction. The maximum score of each evaluation index is 10 points, and each evaluation index is scored in a unit of 0.5 points. Except for the irritant (miscellaneous gas) which is scored in the reverse direction, the rest of the indicators are scored in the positive direction.

The meaning of the evaluation of the 8 indicators is, aroma concentration: the intensity of the nasal cavity and oral cavity to the overall sense of smoke; irritation: the sensory perception of irritation in the mouth, throat, and nasal cavity of the smoke after atomization of e-cigarette liquid, Such as graininess, acupuncture and miscellaneous gas, etc.; smoke volume: the total amount of aerosol formed after the e-cigarette liquid is atomized, and the volume of smoke that is felt through the mouth and visually after exhalation. Sweetness: the degree of sweetness perceived in the oral cavity and the degree of sweetness felt in the nasal cavity after the e-cigarette liquid is atomized; throat hit: the physical impact of the smoke on the throat after inhaling the aerosol Sensory intensity; smoke humidity: the dryness and wetness of smoke particle droplets perceived by the mouth and nasal cavity; coordination: the mixing uniformity and coordination of the aroma of the e-cigarette liquid atomized. Satisfaction, the feeling of short-term brain excitement reflected by the absorption of nicotine in the lungs under the same number of mouthfuls, can be symptoms such as numbness and dizziness in the head.

Table 2 E-cigarette liquid sensory quality evaluation criteria

Evaluation method: Provide the examples, comparative samples and sensory quality evaluation standard table to the technical experts of evaluation and absorption, and evaluate and absorb each index according to the requirements of the table.

Statistical method: The evaluation results of all tasting group members are valid, calculate the arithmetic mean of the individual evaluation results of each tasting member, and keep the results to one decimal place, and add the arithmetic mean of each individual item to get the total point.

Table 3 Comparison of sample smoking data between implementation cases and comparative examples

The smoking data in Table 3 shows that the e-cigarette liquid flavor content remains unchanged, with 1,3-butanediol, sugar alcohol, and water as the e-cigarette base liquid, the 1,3-butanediol content in the e-cigarette liquid is 60 parts -70 parts, sugar alcohol content 1-5 parts, and water content 15-25 parts, the amount of smoke observed by naked eyes can reach the smoke effect of traditional atomized base liquid, and the addition of it can relieve the symptoms of dandruff and mouth after drinking. Dried Chinese herbal extracts and sugar alcohols increase the humidity and sweetness of the smoke in the mouth. Optionally, erythritol and mannitol are selected as the sugar alcohols, which have the best effect on improving the taste.

Aldehyde and ketone compound detection experiment

The content of aldehydes and ketones in aerosol was determined to characterize the safety of electronic cigarette liquid. The experimental samples were selected from the e-cigarette liquid of Examples 4-6 and the e-cigarette liquid of Comparative Example 1, and two samples were tested for each group of cases.

Test Methods:

CORESTA recommended method CRM81 is used to smoke e-cigarettes. The puff parameters are puff duration 3s, puff interval 30s, puff volume 55mL, and refer to CRM81 and CRM74 to detect aerosol capture capacity (ACM), aldehydes and ketones A total of 1 to 50 smoke aldehydes and ketones were collected.

Aldehydes and ketones test results are as follows:

Table 4 Data of aldehydes and ketones in smoke oil of Experimental Examples 4-6 and Comparative Example 1

Note: ND = not detected, below the detection limit.

From the comparison of the data in Table 4, it can be seen that the aldehydes and ketones in the smoke of the experimental examples 4 to 6 of this application using 1,3-butanediol, sugar alcohol, and water as the base liquid of the electronic cigarette are significantly reduced, and the safety is obviously superior. Comparative example 1 of the traditional atomization base liquid of electronic cigarettes based on propylene glycol and glycerin. Compared with the traditional e-cigarette base fluid, the e-cigarette base fluid that does not contain propylene glycol and glycerin has better safety.

Upper head, dry mouth evaluation and dry mouth - osmotic pressure test results

Screen test subjects (n=3) who are around 30 years old, in good health, and have drinking and smoking habits, and measure their body weight. They are randomly divided into 9 groups. The test participants are deprived of water and food for 2 hours, and have no nicotine intake for at least 12 hours before the test . In this study, 6 samples from implementation cases 1 to 6 and 3 samples from comparative examples 1 to 3 were used. The blank control group drank 100 mL of a certain 53° liquor, and collected saliva with a saliva collection tube at intervals of 30 minutes from before drinking. Saliva osmotic pressure test, the experimental group drank 100mL of a certain 53° liquor, then smoked the e-cigarette samples of each implementation case, took 10 puffs of cigarettes within 3 minutes, and then collected saliva with a saliva collection tube. The saliva was collected at intervals of 30 minutes and tested for saliva osmolality, a total of 6 times, and the saliva osmolality/body weight (mOsm/kg) value was calculated for each test. After drinking for 3 hours, provide the test participants with an evaluation form for head and mouth dryness after drinking, and investigate various indicators according to the requirements of the form. The standards of the evaluation form are as follows in Table 5.

Table 5 Evaluation questionnaire for headache and dry mouth after drinking

Table 6 The evaluation of smoking liquids on the head and dry mouth after drinking each implementation case and comparative example

According to the data in Table 6 of the top and dry mouth evaluation and the dry mouth-osmotic pressure change data in Figure 1, it can be seen that the content of 1,3-butanediol in the e-liquid is 50-70 parts by weight, and the content of erythritol and mannitol is 1%- 5%, water content of 15 to 40 parts by weight, optionally, the greater the mass fraction of ebony extract, pueraria lobata root and perilla leaf extract in the Chinese herbal medicine extract, it can relieve dizziness/dizziness after drinking, shaking headache, The effect of dry mouth symptoms is more obvious, and the osmotic pressure of saliva in the oral cavity decreases significantly.

Apparently, the above-mentioned embodiments are only examples for clear description, rather than limiting the implementation. For those of ordinary skill in the art, other changes or changes in different forms can be made on the basis of the above description. It is not necessary and impossible to exhaustively list all the implementation manners here. However, the obvious changes or changes derived therefrom are still within the protection scope of the invention of the present application.

Claims (14)

1. An atomized base liquid is characterized in that it comprises the following components in parts by weight:

   50-70 parts of 1,3-butanediol, 1-5 parts of sugar alcohol and 15-40 parts of water.
2. Atomized base liquid as claimed in claim 1, is characterized in that, described atomized base liquid comprises the following components in parts by weight:

   60-70 parts of 1,3-butanediol, 1-5 parts of sugar alcohol and 15-25 parts of water.
3. The atomized base fluid according to claim 1 or 2, wherein the atomized base fluid does not include propylene glycol and glycerin.
4. The atomized base liquid according to claim 1 or 2, wherein the sugar alcohol is selected from at least one of erythritol, sorbitol, xylitol or mannitol.
5. atomized base liquid as claimed in claim 1 or 2, is characterized in that, described sugar alcohol is the mixture of erythritol and sorbitol, and the mass ratio of described erythritol and sorbitol is

   

   
6. Atomized base liquid as claimed in claim 1 or 2, is characterized in that, described sugar alcohol is the mixture of erythritol and xylitol, and the mass ratio of described erythritol and xylitol is

   
7. Atomized base liquid as claimed in claim 1 or 2, is characterized in that, described sugar alcohol is the mixture of erythritol and mannitol, and the mass ratio of described erythritol and mannitol is

   
8. The atomized base liquid according to claim 1 or 2, characterized in that the content of the water is greater than 10% by weight.
9. An e-liquid, characterized by comprising the atomized base liquid according to any one of claims 1-8.
10. The e-liquid according to claim 9, wherein the e-liquid comprises the following components in parts by weight:

    50-70 parts of 1,3-butanediol, 1-5 parts of sugar alcohol, 15-40 parts of water, 5-10 parts of Chinese herbal medicine extract and 3-5 parts of fragrance base raw material.
11. The e-liquid according to claim 10, wherein the fragrance-based material comprises the following components in parts by weight:

    5-20 parts of nicotine, 2-12 parts of macrostigmatrienone, 3-8 parts of β-ionone, and 2-12 parts of turkenone.
12. The e-liquid according to claim 11, characterized in that, the aroma base material also includes 1,3-butanediol, and the content of 1,3-butanediol complements the sum of the components of the aroma base material to 100 parts .
13. The e-liquid according to claim 10, wherein the Chinese herbal medicine extract is selected from at least one of ebony extract, perilla leaf extract, kudzu root extract or peppermint extract, and may be ebony extract , Perilla leaf extract, Pueraria root extract and Peppermint extract, further optionally, the mass ratio of the ebony extract, Perilla leaf extract, Pueraria root extract, and Peppermint extract is 1 to 4 : 1~4: 1~4: 1~2.
14. An electronic atomization device, comprising the atomization base liquid according to any one of claims 1-8 or the e-liquid according to any one of claims 9-13.

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