CN115698318B - 用于邻近检测测定的对照 - Google Patents
用于邻近检测测定的对照Info
- Publication number
- CN115698318B CN115698318B CN202180036813.4A CN202180036813A CN115698318B CN 115698318 B CN115698318 B CN 115698318B CN 202180036813 A CN202180036813 A CN 202180036813A CN 115698318 B CN115698318 B CN 115698318B
- Authority
- CN
- China
- Prior art keywords
- probe
- nucleic acid
- sequence
- hybridization
- pair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/162—Helper probe
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202610430195.6A CN122279021A (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
| CN202511409661.4A CN121109552A (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2004469.9 | 2020-03-27 | ||
| GBGB2004469.9A GB202004469D0 (en) | 2020-03-27 | 2020-03-27 | Controls for proximity detection assays |
| PCT/EP2021/058025 WO2021191450A1 (en) | 2020-03-27 | 2021-03-26 | Controls for proximity detection assays |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202610430195.6A Division CN122279021A (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
| CN202511409661.4A Division CN121109552A (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115698318A CN115698318A (zh) | 2023-02-03 |
| CN115698318B true CN115698318B (zh) | 2026-03-24 |
Family
ID=70553456
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180036813.4A Active CN115698318B (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
| CN202610430195.6A Pending CN122279021A (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
| CN202511409661.4A Pending CN121109552A (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202610430195.6A Pending CN122279021A (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
| CN202511409661.4A Pending CN121109552A (zh) | 2020-03-27 | 2021-03-26 | 用于邻近检测测定的对照 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US20230107654A1 (enExample) |
| EP (3) | EP4745246A2 (enExample) |
| JP (3) | JP7365513B2 (enExample) |
| CN (3) | CN115698318B (enExample) |
| CA (1) | CA3201060A1 (enExample) |
| DE (1) | DE202021004362U1 (enExample) |
| GB (1) | GB202004469D0 (enExample) |
| WO (1) | WO2021191450A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202004469D0 (en) * | 2020-03-27 | 2020-05-13 | Olink Proteomics Ab | Controls for proximity detection assays |
| US12704508B2 (en) | 2021-06-02 | 2026-08-11 | Alamar Biosciences, Inc. | Nucleic acid linked immune-sandwich assay (NULISA) |
| GB202213956D0 (en) * | 2022-09-23 | 2022-11-09 | Xu Bo | Molecular interaction detection and profiling |
| EP4615996A1 (en) * | 2022-11-11 | 2025-09-17 | Olink Proteomics AB | Library of proximity probes and method of use |
| EP4743220A1 (en) | 2023-07-11 | 2026-05-20 | Olink Proteomics AB | DRIED REAGENTS |
| EP4744052A1 (en) | 2023-07-12 | 2026-05-20 | Olink Proteomics AB | METHOD, COMPONENTS AND SOFTWARE FOR DETECTING A SYSTEMATIC ERROR IN A PROTEIN DETECTION SYSTEM |
| WO2025031642A1 (en) | 2023-08-07 | 2025-02-13 | Olink Proteomics Ab | A method for determining run errors for an analysis-method for quantifying a plurality of analytes in a plurality of biological samples |
| WO2025111398A1 (en) * | 2023-11-20 | 2025-05-30 | Alamar Biosciences, Inc. | Reduction of non-cognate signal in multiplex proximity ligation assays |
| WO2025199005A1 (en) | 2024-03-20 | 2025-09-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Biomarkers for identifying cancer patients at high risk for chemotherapy-induced cardiotoxicity |
| WO2025252658A1 (en) * | 2024-06-03 | 2025-12-11 | Olink Proteomics Ab | New product and method |
| WO2025262178A1 (en) | 2024-06-18 | 2025-12-26 | Olink Proteomics Ab | System and method for detecting analytes in a sample |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106995838A (zh) * | 2011-05-11 | 2017-08-01 | 欧凌科公司 | 解折叠邻近探针及其使用方法 |
| CN108368538A (zh) * | 2015-10-21 | 2018-08-03 | 欧凌科蛋白质公司 | 用于生成邻近探针的方法 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE504798C2 (sv) | 1995-06-16 | 1997-04-28 | Ulf Landegren | Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten |
| SE9601676D0 (sv) | 1996-04-30 | 1996-04-30 | Ulf Landegren | Improved probing of specific mucleic acids |
| SE516272C2 (sv) | 2000-02-18 | 2001-12-10 | Ulf Landegren | Metoder och kit för analytdetektion mha proximitets-probning |
| US7306904B2 (en) * | 2000-02-18 | 2007-12-11 | Olink Ab | Methods and kits for proximity probing |
| AU2001293336A1 (en) | 2000-04-11 | 2001-10-23 | Ulf Landegren | Nucleic acid detection medium |
| WO2001092579A2 (en) | 2000-05-30 | 2001-12-06 | Pe Corporation (Ny) | Methods for detecting target nucleic acids using coupled ligation and amplification |
| US6511809B2 (en) | 2000-06-13 | 2003-01-28 | E. I. Du Pont De Nemours And Company | Method for the detection of an analyte by means of a nucleic acid reporter |
| GB2382137A (en) | 2001-11-20 | 2003-05-21 | Mats Gullberg | Nucleic acid enrichment |
| US8013134B2 (en) | 2001-11-23 | 2011-09-06 | Olink Ab | Kit for proximity probing with multivalent proximity probes |
| TWI375796B (en) | 2003-04-18 | 2012-11-01 | Becton Dickinson Co | Immuno-amplification |
| EP2789383B1 (en) | 2004-01-07 | 2023-05-03 | Illumina Cambridge Limited | Molecular arrays |
| SE0401270D0 (sv) | 2004-05-18 | 2004-05-18 | Fredrik Dahl | Method for amplifying specific nucleic acids in parallel |
| WO2005123963A2 (en) | 2004-06-14 | 2005-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in analyte detection using proximity probes |
| CN101137758B (zh) | 2004-11-03 | 2012-10-10 | 意力速分子诊断股份有限公司 | 均相分析物检测 |
| US7883848B2 (en) | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
| GB0605584D0 (en) | 2006-03-20 | 2006-04-26 | Olink Ab | Method for analyte detection using proximity probes |
| EP2049688B1 (en) | 2006-08-01 | 2018-01-24 | Applied Biosystems, LLC | Detection of analytes and nucleic acids |
| WO2008033442A2 (en) | 2006-09-12 | 2008-03-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for performing low background multiplex nucleic acid amplification reactions |
| WO2008153492A1 (en) | 2007-06-11 | 2008-12-18 | Henrik Johansson | Method for introducing common and/or individual sequence elements in a target nucleic acid molecule |
| US8633139B2 (en) * | 2007-12-21 | 2014-01-21 | Abbvie Biotherapeutics Inc. | Methods of screening complex protein libraries to identify altered properties |
| GB201004292D0 (en) | 2010-03-15 | 2010-04-28 | Olink Ab | Assay for localised detection of analytes |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US9255291B2 (en) * | 2010-05-06 | 2016-02-09 | Bioo Scientific Corporation | Oligonucleotide ligation methods for improving data quality and throughput using massively parallel sequencing |
| GB201011971D0 (en) | 2010-07-15 | 2010-09-01 | Olink Ab | Methods and product |
| WO2012049316A1 (en) | 2010-10-15 | 2012-04-19 | Olink Ab | Dynamic range methods |
| EP2633081B1 (en) | 2010-10-29 | 2017-01-11 | Olink Bioscience AB | Proximity ligation technology for western blot applications |
| US20120196294A1 (en) | 2011-01-17 | 2012-08-02 | Life Technologies Corporation | Workflow for detection of ligands using nucleic acids |
| GB201101621D0 (en) | 2011-01-31 | 2011-03-16 | Olink Ab | Method and product |
| US10597701B2 (en) | 2011-05-11 | 2020-03-24 | Navinci Diagnostics Ab | Unfolding proximity probes and methods for the use thereof |
| GB201108678D0 (en) | 2011-05-24 | 2011-07-06 | Olink Ab | Multiplexed proximity ligation assay |
| GB201201547D0 (en) | 2012-01-30 | 2012-03-14 | Olink Ab | Method and product |
| WO2013142389A1 (en) | 2012-03-20 | 2013-09-26 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| GB201218909D0 (en) | 2012-10-22 | 2012-12-05 | Univ Singapore | Assay for the parallel detection of biological material based on PCR |
| US20160369321A1 (en) | 2012-11-14 | 2016-12-22 | Olink Ab | RCA Reporter Probes and Their Use in Detecting Nucleic Acid Molecules |
| US10174366B2 (en) | 2012-11-14 | 2019-01-08 | Olink Bioscience Ab | Localised RCA-based amplification method |
| US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| ES2875998T3 (es) | 2013-09-30 | 2021-11-11 | Vesicode Ab | Procedimientos de perfilado de complejos moleculares mediante el uso de códigos de barras dependientes de la proximidad |
| GB201320145D0 (en) | 2013-11-14 | 2014-01-01 | Olink Ab | Localised RCA-based amplification method using a padlock-probe |
| JP6484636B2 (ja) * | 2014-01-16 | 2019-03-13 | イラミーナ インコーポレーテッド | 固相担体におけるアンプリコン調製および配列決定 |
| GB201401885D0 (en) | 2014-02-04 | 2014-03-19 | Olink Ab | Proximity assay with detection based on hybridisation chain reaction (HCR) |
| GB201413718D0 (en) | 2014-08-01 | 2014-09-17 | Olink Ab | Method for selecting a target nucleic acid sequence |
| GB201413717D0 (en) | 2014-08-01 | 2014-09-17 | Olink Ab | Method for selecting a target nucleic acid sequence |
| AU2017257624B2 (en) | 2016-04-25 | 2023-05-25 | President And Fellows Of Harvard College | Hybridization chain reaction methods for in situ molecular detection |
| GB201614023D0 (en) | 2016-08-16 | 2016-09-28 | Olink Bioscience Ab | Double-stranded circle probes |
| WO2018052464A1 (en) | 2016-09-16 | 2018-03-22 | Plexbio Co., Ltd. | Methods and systems for multiplex assays |
| JP2020514746A (ja) | 2016-12-01 | 2020-05-21 | ノーティラス バイオテクノロジー インコーポレイテッド | タンパク質をアッセイする方法 |
| WO2018108328A1 (en) * | 2016-12-16 | 2018-06-21 | F. Hoffmann-La Roche Ag | Method for increasing throughput of single molecule sequencing by concatenating short dna fragments |
| JP2020515267A (ja) | 2017-03-30 | 2020-05-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 多重アイソタイプ特異的抗体の検出 |
| JP7536450B2 (ja) | 2017-06-05 | 2024-08-20 | ベクトン・ディキンソン・アンド・カンパニー | 単一細胞用のサンプルインデックス付加 |
| WO2019238944A1 (en) | 2018-06-15 | 2019-12-19 | Olink Proteomics Ab | Biomarker panel for ovarian cancer |
| JP7727628B2 (ja) | 2019-12-03 | 2025-08-21 | アラマー バイオサイエンシーズ， インク． | 核酸結合免疫サンドイッチアッセイ（ｎｕｌｉｓａ） |
| GB202004469D0 (en) * | 2020-03-27 | 2020-05-13 | Olink Proteomics Ab | Controls for proximity detection assays |
-
2020
- 2020-03-27 GB GBGB2004469.9A patent/GB202004469D0/en not_active Ceased
-
2021
- 2021-03-26 EP EP26168195.1A patent/EP4745246A2/en active Pending
- 2021-03-26 CN CN202180036813.4A patent/CN115698318B/zh active Active
- 2021-03-26 WO PCT/EP2021/058025 patent/WO2021191450A1/en not_active Ceased
- 2021-03-26 JP JP2022558355A patent/JP7365513B2/ja active Active
- 2021-03-26 EP EP21713709.0A patent/EP4127217B1/en active Active
- 2021-03-26 CN CN202610430195.6A patent/CN122279021A/zh active Pending
- 2021-03-26 DE DE202021004362.4U patent/DE202021004362U1/de active Active
- 2021-03-26 CN CN202511409661.4A patent/CN121109552A/zh active Pending
- 2021-03-26 US US17/907,138 patent/US20230107654A1/en not_active Abandoned
- 2021-03-26 EP EP23182913.6A patent/EP4269608A1/en active Pending
- 2021-03-26 CA CA3201060A patent/CA3201060A1/en active Pending
-
2023
- 2023-06-16 US US18/336,450 patent/US20230323424A1/en not_active Abandoned
- 2023-09-06 JP JP2023144527A patent/JP7747700B2/ja active Active
-
2025
- 2025-04-08 US US19/172,702 patent/US12534751B1/en active Active
- 2025-04-08 US US19/172,703 patent/US12540355B1/en active Active
- 2025-09-18 JP JP2025155392A patent/JP2025176187A/ja active Pending
-
2026
- 2026-01-08 US US19/443,203 patent/US20260132439A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106995838A (zh) * | 2011-05-11 | 2017-08-01 | 欧凌科公司 | 解折叠邻近探针及其使用方法 |
| CN108368538A (zh) * | 2015-10-21 | 2018-08-03 | 欧凌科蛋白质公司 | 用于生成邻近探针的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN121109552A (zh) | 2025-12-12 |
| EP4127217A1 (en) | 2023-02-08 |
| JP7747700B2 (ja) | 2025-10-01 |
| US20230107654A1 (en) | 2023-04-06 |
| EP4269608A1 (en) | 2023-11-01 |
| GB202004469D0 (en) | 2020-05-13 |
| US20230323424A1 (en) | 2023-10-12 |
| JP7365513B2 (ja) | 2023-10-19 |
| US12534751B1 (en) | 2026-01-27 |
| WO2021191450A1 (en) | 2021-09-30 |
| JP2023519366A (ja) | 2023-05-10 |
| EP4127217B1 (en) | 2026-04-15 |
| US20260132439A1 (en) | 2026-05-14 |
| EP4745246A2 (en) | 2026-05-20 |
| CN122279021A (zh) | 2026-06-26 |
| JP2025176187A (ja) | 2025-12-03 |
| JP2023171748A (ja) | 2023-12-05 |
| US12540355B1 (en) | 2026-02-03 |
| DE202021004362U1 (de) | 2024-01-11 |
| CA3201060A1 (en) | 2021-09-30 |
| CN115698318A (zh) | 2023-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: J. Broberry Inventor after: M. Lundberg Inventor after: Wick Lukas Inventor before: J. Broberry |
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| GR01 | Patent grant | ||
| GR01 | Patent grant |