CN115697373A - 线粒体衍生肽和其类似物作为包括癌症的年龄相关性疾病的治疗的用途 - Google Patents

线粒体衍生肽和其类似物作为包括癌症的年龄相关性疾病的治疗的用途 Download PDF

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Publication number
CN115697373A
CN115697373A CN202180035238.6A CN202180035238A CN115697373A CN 115697373 A CN115697373 A CN 115697373A CN 202180035238 A CN202180035238 A CN 202180035238A CN 115697373 A CN115697373 A CN 115697373A
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artificial sequence
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Chinese (zh)
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平查斯·科恩
凯文·严
金素贞
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University of Southern California USC
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University of Southern California USC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202180035238.6A 2020-05-15 2021-05-14 线粒体衍生肽和其类似物作为包括癌症的年龄相关性疾病的治疗的用途 Pending CN115697373A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063025495P 2020-05-15 2020-05-15
US63/025,495 2020-05-15
PCT/US2021/032641 WO2021231988A2 (en) 2020-05-15 2021-05-14 Mitochondrial-derived peptides and analogs thereof for use as a therapy for age-related diseases including cancer

Publications (1)

Publication Number Publication Date
CN115697373A true CN115697373A (zh) 2023-02-03

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CN202180035238.6A Pending CN115697373A (zh) 2020-05-15 2021-05-14 线粒体衍生肽和其类似物作为包括癌症的年龄相关性疾病的治疗的用途

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US (1) US12577281B2 (https=)
EP (1) EP4149511B1 (https=)
JP (1) JP2023528220A (https=)
KR (1) KR20230019112A (https=)
CN (1) CN115697373A (https=)
CA (1) CA3181427A1 (https=)
MX (1) MX2022014123A (https=)
WO (1) WO2021231988A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115697373A (zh) 2020-05-15 2023-02-03 南加利福尼亚大学 线粒体衍生肽和其类似物作为包括癌症的年龄相关性疾病的治疗的用途
WO2026021591A1 (zh) * 2024-07-26 2026-01-29 南京安吉生物科技有限公司 一种新型调节能量代谢的微肽mp29及其应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9419553D0 (en) * 1994-09-27 1994-11-16 Univ Bristol Polypeptides and their use in the treatment of auto-immune disease
WO2001081581A2 (en) * 2000-04-21 2001-11-01 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
CN101586112A (zh) * 2009-06-19 2009-11-25 中国科学院上海有机化学研究所 诺丝七肽的生物合成基因簇
US20140296139A1 (en) * 2013-03-15 2014-10-02 The Regents Of The University Of California Mitochondrial-derived peptide mots3 regulates metabolism and cell survival
WO2015010094A1 (en) * 2013-07-18 2015-01-22 Eutropics Pharmaceuticals, Inc. Differential bh3 mitochondrial profiling
US20170088852A1 (en) * 2014-05-28 2017-03-30 Evogene Ltd. Isolated polynucleotides, polypeptides and methods of using same for increasing abiotic stress tolerance, biomass and yield of plants
CA3026458A1 (en) * 2016-06-24 2017-12-28 University Of Southern California Mentsh analogs as therapeutics for diabetes, obesity, and their associated diseases and complications
CN110494151A (zh) * 2017-02-14 2019-11-22 耶路撒冷希伯来大学伊森姆研究发展有限公司 Naf-1衍生肽及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115697373A (zh) 2020-05-15 2023-02-03 南加利福尼亚大学 线粒体衍生肽和其类似物作为包括癌症的年龄相关性疾病的治疗的用途

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9419553D0 (en) * 1994-09-27 1994-11-16 Univ Bristol Polypeptides and their use in the treatment of auto-immune disease
WO2001081581A2 (en) * 2000-04-21 2001-11-01 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
CN101586112A (zh) * 2009-06-19 2009-11-25 中国科学院上海有机化学研究所 诺丝七肽的生物合成基因簇
US20140296139A1 (en) * 2013-03-15 2014-10-02 The Regents Of The University Of California Mitochondrial-derived peptide mots3 regulates metabolism and cell survival
WO2015010094A1 (en) * 2013-07-18 2015-01-22 Eutropics Pharmaceuticals, Inc. Differential bh3 mitochondrial profiling
US20170088852A1 (en) * 2014-05-28 2017-03-30 Evogene Ltd. Isolated polynucleotides, polypeptides and methods of using same for increasing abiotic stress tolerance, biomass and yield of plants
CA3026458A1 (en) * 2016-06-24 2017-12-28 University Of Southern California Mentsh analogs as therapeutics for diabetes, obesity, and their associated diseases and complications
CN110494151A (zh) * 2017-02-14 2019-11-22 耶路撒冷希伯来大学伊森姆研究发展有限公司 Naf-1衍生肽及其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIM SU-JEONG等: "Mitochondrially derived peptides as novel regulators of metabolism", 《THE JOURNAL OF PHYSIOLOGY》, vol. 595, no. 21, 18 July 2017 (2017-07-18), pages 6613 - 6621 *
ZUCCATO CAMILA FLORENCIA等: "Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases", 《EXPERT OPINION ON THERAPEUTIC TARGETS》, vol. 23, no. 2, 24 December 2018 (2018-12-24), pages 117 - 126 *

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Publication number Publication date
WO2021231988A3 (en) 2022-02-24
WO2021231988A2 (en) 2021-11-18
KR20230019112A (ko) 2023-02-07
CA3181427A1 (en) 2021-11-18
US12577281B2 (en) 2026-03-17
EP4149511B1 (en) 2026-03-25
MX2022014123A (es) 2022-12-08
JP2023528220A (ja) 2023-07-04
US20230167161A1 (en) 2023-06-01
EP4149511A2 (en) 2023-03-22
EP4149511A4 (en) 2024-05-22

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