CN115697321A - 用于向肝星状细胞递送治疗剂的脂质纳米颗粒的阳离子脂质 - Google Patents

用于向肝星状细胞递送治疗剂的脂质纳米颗粒的阳离子脂质 Download PDF

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CN115697321A
CN115697321A CN202180022603.XA CN202180022603A CN115697321A CN 115697321 A CN115697321 A CN 115697321A CN 202180022603 A CN202180022603 A CN 202180022603A CN 115697321 A CN115697321 A CN 115697321A
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compound
mol
lipid
alkyl
divalent
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詹姆斯·海斯
林荞梦
理查德·J·霍兰德
张文轩
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Gainawan Science Co ltd
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Gainawan Science Co ltd
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    • C07F7/02—Silicon compounds
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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CN202180022603.XA 2020-02-11 2021-02-11 用于向肝星状细胞递送治疗剂的脂质纳米颗粒的阳离子脂质 Pending CN115697321A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062975116P 2020-02-11 2020-02-11
US62/975,116 2020-02-11
PCT/US2021/017676 WO2021163339A1 (en) 2020-02-11 2021-02-11 Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells

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CN115697321A true CN115697321A (zh) 2023-02-03

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CN202180022603.XA Pending CN115697321A (zh) 2020-02-11 2021-02-11 用于向肝星状细胞递送治疗剂的脂质纳米颗粒的阳离子脂质

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US (1) US20230139594A1 (https=)
EP (1) EP4103172A4 (https=)
JP (1) JP7843707B2 (https=)
KR (1) KR20220140531A (https=)
CN (1) CN115697321A (https=)
AU (1) AU2021218409A1 (https=)
BR (1) BR112022015803A2 (https=)
CA (1) CA3170547A1 (https=)
IL (1) IL295441A (https=)
MX (1) MX2022009861A (https=)
WO (1) WO2021163339A1 (https=)

Cited By (1)

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CN117045791A (zh) * 2023-03-22 2023-11-14 中国药科大学 肝星状细胞neu1的靶向过表达剂在制备治疗肝纤维化的药物中的应用

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JP2025168864A (ja) * 2024-04-30 2025-11-12 信越化学工業株式会社 含窒素多官能オルガノキシシラン化合物の製造方法
WO2026003582A2 (en) 2024-06-27 2026-01-02 Axelyf ehf. Lipids and lipid nanoparticles
WO2026022656A2 (en) 2024-07-22 2026-01-29 Genevant Sciences Gmbh Lipid particle formulations with permanently charged cationic lipids
WO2026022677A1 (en) 2024-07-22 2026-01-29 Genevant Sciences Gmbh Permanently charged cationic lipids
WO2026030375A2 (en) 2024-07-30 2026-02-05 Genzyme Corporation Lipid nanoparticles and methods of manufacture and use thereof

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CN117045791A (zh) * 2023-03-22 2023-11-14 中国药科大学 肝星状细胞neu1的靶向过表达剂在制备治疗肝纤维化的药物中的应用
CN117045791B (zh) * 2023-03-22 2025-10-03 中国药科大学 肝星状细胞neu1的靶向过表达剂在制备治疗肝纤维化的药物中的应用

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JP2023513698A (ja) 2023-04-03
NZ791587A (en) 2025-06-27
CA3170547A1 (en) 2021-08-19
EP4103172A1 (en) 2022-12-21
WO2021163339A1 (en) 2021-08-19
EP4103172A4 (en) 2024-05-01
JP7843707B2 (ja) 2026-04-10
IL295441A (en) 2022-10-01
US20230139594A1 (en) 2023-05-04
MX2022009861A (es) 2022-11-07
BR112022015803A2 (pt) 2022-10-11
AU2021218409A1 (en) 2022-09-22
KR20220140531A (ko) 2022-10-18

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