CN115671201B - Traditional Chinese medicine application for treating premature beat - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine application for treating premature beat, which comprises a spun-laced non-woven fabric blank paste and an extract coated in the middle of the spun-laced non-woven fabric blank paste, wherein the extract comprises a traditional Chinese medicine composition and a dressing, and the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 120-240 parts of radix codonopsis pilosulae, 120-240 parts of stir-fried bighead atractylodes rhizome, 40-80 parts of honey-fried licorice root, 40-80 parts of grassleaf sweelflag rhizome, 60-120 parts of Chinese magnoliavine fruit, 60-120 parts of platycladi seed, 120-240 parts of Indian buead, 120-240 parts of astragalus root, 60-120 parts of red sage root, 40-80 parts of officinal magnolia bark, 60-120 parts of Chinese angelica, 40-80 parts of prepared polygala root, 100-200 parts of nardostachyos root, 40-80 parts of cassia bark, 60-120 parts of stir-fried spina date seed, 60-120 parts of dwarf lilyturf tuber, 40-80 parts of menthol and 20-40 parts of borneol. The traditional Chinese medicine plaster has the advantages of good effects of relieving mental stress, taking effect quickly, having obvious effect, definite medicinal effect and taking effect quickly, and being worthy of clinical popularization and application.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine application for treating premature beat.
Background
Cardiovascular disease has become the main cause of premature death in Chinese. Arrhythmia is a common cardiovascular disease, and can be used not only as early or only clinical manifestation of heart abnormality, but also as one of the accompanying symptoms of other diseases.
Currently, for western medicine treatment of ventricular premature beat, the "2020 national expert consensus on ventricular arrhythmias" indicates that for patients suspected of ventricular premature beat-induced cardiomyopathy, ventricular premature should be positively treated. For premature ventricular patients without organic heart disease, it is not recommended to apply too aggressive a therapeutic strategy. Although beta blockers or non-dihydropyridine calcium channel blockers may be used as appropriate, there is no evidence of evidence-based medical evidence of their effectiveness, and the calcium channel blockers themselves may cause significant symptoms such as palpitations, headache, weakness, etc. The architecture of catheter ablation therapy, while very complete, is prohibitively expensive for some patients due to the invasive procedure, the rigorous indications, and the high cost of the procedure.
Disclosure of Invention
In order to overcome the above-mentioned shortcomings of the prior art, according to the embodiments of the present invention, it is desirable to provide a traditional Chinese medicine application for treating premature beat, which aims to solve the problems of poor treatment effect and high price when the existing medicine is used for treating premature beat.
According to the embodiment, the traditional Chinese medicine application for treating premature beat provided by the invention comprises a spun-laced non-woven fabric blank paste and an extract coated in the middle of the spun-laced non-woven fabric blank paste, wherein the extract comprises a traditional Chinese medicine composition and a dressing, and is characterized in that the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 120-240 parts of radix codonopsis pilosulae, 120-240 parts of stir-fried bighead atractylodes rhizome, 40-80 parts of honey-fried licorice root, 40-80 parts of grassleaf sweelflag rhizome, 60-120 parts of Chinese magnoliavine fruit, 60-120 parts of platycladi seed, 120-240 parts of Indian buead, 120-240 parts of astragalus root, 60-120 parts of red sage root, 40-80 parts of officinal magnolia bark, 60-120 parts of Chinese angelica, 40-80 parts of prepared polygala root, 100-200 parts of nardostachyos root, 40-80 parts of cassia bark, 60-120 parts of stir-fried spina date seed, 60-120 parts of dwarf lilyturf tuber, 40-80 parts of menthol and 20-40 parts of borneol.
According to one embodiment, in the traditional Chinese medicine application for treating premature beat, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 180 parts of codonopsis pilosula, 180 parts of stir-fried bighead atractylodes rhizome, 60 parts of honey-fried licorice root, 60 parts of grassleaf sweelflag rhizome, 90 parts of shizandra berry, 90 parts of platycladi seed, 150 parts of Indian buead, 180 parts of membranous milkvetch root, 90 parts of danshen root, 60 parts of officinal magnolia bark, 90 parts of Chinese angelica, 60 parts of prepared thinleaf milkwort root-bark, 150 parts of nardostachyos root, 60 parts of cassia bark, 90 parts of stir-fried spina date seed, 90 parts of dwarf lilyturf tuber, 60 parts of menthol and 30 parts of borneol.
According to one embodiment, in the traditional Chinese medicine application for treating premature beat, the extract is big honeyed pills, the dressing is honey, eighteen raw material medicines of the traditional Chinese medicine composition are crushed into fine powder, sieved, mixed uniformly, and a proper amount of honey is added to prepare the big honeyed pills.
In the traditional Chinese medicine application, the codonopsis pilosula is sweet in taste and flat in nature, and has the effects of invigorating the spleen and replenishing qi, strengthening the spleen, nourishing blood and promoting the production of body fluid; astragalus root is sweet in taste and slightly warm in nature, enters lung and spleen meridians, can tonify qi and raise yang, induce diuresis and alleviate edema, and is a key herb for tonifying qi; the stir-baked atractylodes macrocephala koidz is sweet and bitter in taste, warm in nature, and enters spleen and stomach channels, and has the effects of strengthening spleen and replenishing qi, and drying dampness and promoting diuresis; poria is sweet and light in taste, flat in nature, and enters heart, lung, spleen and kidney meridians, and has the effects of strengthening spleen and soothing nerves, promoting diuresis and removing dampness; the honey-fried licorice root is sweet in taste and flat in nature, and can tonify heart qi, restore heart pulse, tonify spleen qi, promote transportation and transformation, nourish yin and blood, restore pulse and stop palpitation after entering heart, lung, spleen and stomach meridians. Cloud of "book of changes: the heart is damaged, and nourished. The recipe is to supplement true blood, if true blood is rich, the heart is supplemented with assistance, and no cure is required. "it is used as principal drug, and it is used to supplement qi and invigorate spleen, spleen is the source of qi and blood, spleen qi is sufficient to invigorate qi and blood, spleen and stomach are strong, and once the transportation and transformation functions of spleen and stomach are restored, qi and blood are naturally and continuously biochemically changed, and heart blood is sufficient to make it calm. Dang Gui is sweet and pungent in flavor and warm in nature, and is classified as liver, heart and spleen meridians, tonifying blood and promoting blood circulation, assisting in producing blood, and is a key herb for tonifying blood, combined with Huang Qi, both herbs are used together to tonify qi and produce blood so as to nourish the source of the biochemistry and make qi and consolidate blood full. The stir-fried wild jujube has sweet and sour taste, is neutral in nature, and can restore heart, liver and gall meridians, calm heart and calm mind, nourish heart and promote the production of body fluid; the processed polygala tenuifolia is bitter and pungent in taste and slightly warm in nature, enters heart, kidney and lung meridians, calms the nerves and benefits intelligence, and transmits heart and kidney, and polygala tenuifolia is recorded in Ming Yi Bie Ji: "centering qi, stopping palpitation, replenishing vital essence, removing diaphragmatic qi of heart and heat in skin, yellow face" and "Dian nan Ben Cao" also emphasize the actions of nourishing heart and tranquillizing, "nourishing heart blood, relieving convulsion, calming heart, and dispersing phlegm and saliva". Treating epilepsy, such as opisthotoma, convulsion, vomiting, phlegm and saliva, hand and foot operations, etc. "Schisandra chinensis enters heart, kidney and lung channels, supplements qi and produces fluid, tonifies kidney and calms heart and calms mind; bai Zi ren is sweet in flavor and neutral in nature, enters heart, kidney and large intestine meridians, and mainly nourishes heart and calms mind. The above medicinal materials are added into heart meridian, and have effects of replenishing blood, nourishing heart, and tranquilizing mind. The costustoot is added for regulating qi and activating spleen, so that the costustoot can be supplemented without stagnation. Radix Ophiopogonis has sweet and slightly bitter taste and slightly cold property, and is responsible for heart, lung and stomach channels, clearing heart and relieving restlessness, nourishing yin and promoting fluid production; the magnolia officinalis is warm, enters spleen, stomach, lung and large intestine meridians, and has the functions of drying dampness and resolving phlegm, and resolving stagnation and resolving masses, and the Shennong herbal meridian is mentioned in the following description: "mainly used for treating apoplexy and typhoid fever, headache, cold and heat, palpitation, qi and blood arthralgia, and removing three worms. "rhizoma Acori Graminei is effective in restoring heart and stomach meridian, eliminating phlegm, inducing resuscitation and refreshing mind, and can be used for treating palpitation, insomnia and amnesia due to malnutrition of heart and mind; danshen is bitter in flavor, slightly warm, enters heart and liver meridian, can cool blood and relieve restlessness, has the effect of nourishing heart and soothing nerves, and in addition, ancient people have clouds of 'Yiwei Danshen san' and 'Gongwu decoction', emphasizes the effect of activating blood and removing stasis. The whole formula is properly combined, so that the Chinese medicinal composition can tonify without stagnancy and promote blood circulation without hurting the healthy energy.
Modern pharmacology suggests that: the astragalus has the functions of strengthening heart, promoting urination and improving heart blood discharge, and the main component of astragalus saponin-mediated protection mechanism may be related to improving heart function and reducing myocardial oxidative damage through MDA reduction, SOD maintenance and free radical-induced myocardial cell damage. In addition, eAM by preventing Ca 2+ Blocking cell death and opening mitochondrial K ATP Channels to enhance viability of cardiomyocytes to reduce apoptosis; the codonopsis pilosula has a great inhibition effect on acute myocardial ischemia, particularly caused by posterior pituitrin; the red sage root and the angelica have the effect of dilating coronary artery and have a certain degree of prevention effect on arrhythmia of patients suffering from myocardial ischemia reperfusion; semen Ziziphi Spinosae can reduceThe occurrence probability of arrhythmia event caused by the medicine, especially the medicine such as chloroform, aconitine, barium chloride and the like; the rhizoma Acori Graminei oil can resist various atrial and ventricular arrhythmias of experimental animals; the dwarf lilyturf tuber has the positive inotropic effect and has obvious antiarrhythmic effect.
As a special component in the external medicine, borneol is pungent in taste and cool in nature, and enters heart, spleen and lung meridians without going left; peppermint is pungent and cool in nature, enters lung and liver meridians, and as a pair of medicaments for promoting permeation, the mint is not only has the efficacy of inducing resuscitation and refreshing, but also can bring cool feeling to skin when being used topically. It has been demonstrated that topical application of menthol increases blood flow in the skin microvasculature and that the effect is dose dependent. This increase in local blood flow is mediated by sensory nerves and EDHF. In addition, the borneol serving as a permeability enhancer also has quite satisfactory performance, and the borneol has relatively low toxicity on skin cells, and the borneol with proper concentration does not generate obvious skin irritation, so that a good foundation is laid for local external application of acupoint application.
In the traditional Chinese medicine application, the components are reasonably matched, the medicine formula is strict, and the pathogenesis of premature beat is regulated: deficiency of both qi and blood in the heart and spleen. Aiming at the main pathogenesis, the Chinese medicinal composition plays roles of replenishing qi to invigorate the spleen, nourishing the heart, soothing the nerves and stopping palpitation. Clinical data prove that the prescription has definite clinical curative effect and no obvious adverse reaction or toxic or side effect. The traditional Chinese medicine composition can improve the heart function of a premature beat patient, reduce the oxidative damage of myocardial cells and balance the autonomic nerve function by replenishing qi to invigorate the spleen, nourishing the heart to calm the mind and stopping palpitation, thereby alleviating clinical symptoms.
The traditional Chinese medicine plaster can improve the heart function of a premature beat patient, reduce the oxidative damage of myocardial cells and balance the autonomic nerve function. The medicines are combined to complement each other, so that the Chinese medicament has the effects of strengthening body resistance and banking up root, tonifying qi and nourishing blood, activating blood and dissolving stasis, and has the advantages of good and quick effect of calming heart and soothing nerves, obvious effect, exact medicinal effect and quick response, and is worthy of clinical popularization and application.
Detailed Description
The invention will be further illustrated with reference to specific examples. These examples should be construed as merely illustrative of the present invention and not limiting the scope of the present invention. Various changes and modifications to the present invention may be made by one skilled in the art after reading the description herein, and such equivalent changes and modifications are intended to fall within the scope of the present invention as defined in the appended claims.
Examples
180 g of codonopsis pilosula, 180 g of stir-fried bighead atractylodes rhizome, 60 g of honey-fried licorice root, 60 g of grassleaf sweelflag rhizome, 90 g of Chinese magnoliavine fruit, 90 g of platycladi seed, 150 g of poria cocos, 180 g of astragalus root, 90 g of red sage root, 60 g of magnolia officinalis, 90 g of Chinese angelica, 60 g of prepared polygala tenuifolia, 150 g of nardostachyos root, 60 g of cinnamon, 90 g of stir-fried spina date seed, 90 g of dwarf lilyturf tuber, 60 g of menthol and 30 g of borneol are weighed, crushed into fine powder, sieved, uniformly mixed, added with a proper amount of honey to prepare a big honeyed pill with the diameter of 1cm, and the big honeyed pill is coated on the middle part of a water thorn non-woven fabric blank paste to prepare a traditional Chinese medicine application (hereinafter called heart calming paste) for standby.
Test example (Chinese medicine application)
(1) First stage (lead-in period: -1-0 week)
The patients at this stage refer to the recommended treatment method of "Chamber arrhythmia Chinese expert consensus" (China medical Congress of cardiac electrophysiology and pacing, china society of physicians and Chinese Association, specialized committee of cardiology, 2016), and give consistent health education and antiarrhythmic drug treatment (oral propafenone hydrochloride tablet).
(2) Second stage (treatment period: 1-4 weeks)
(1) Treatment group (Ningxin patch group) (35 people): orally administering propafenone hydrochloride tablet and external application heart-calming patch;
the administration method comprises the following steps: orally administered propafenone hydrochloride tablet (3 times daily, 100mg each time) +topical heart-calming patch
The dosage of the heart-calming plaster is as follows: large honeyed pill with diameter of 1cm is applied to the interior of the two sides of the acupoint for 6 hr once a day. 4 weeks is a treatment course.
(2) Control group (35 people): orally taken prafenone hydrochloride tablet.
The administration method comprises the following steps: propafenone hydrochloride tablets (100 mg each time, 3 times daily) were orally administered.
The therapeutic effects of the treated and control groups after completion of the treatment are shown in tables 1-4 below.
The Chinese medicine plaster can reduce the premature beat amount and the symptoms caused by the premature beat effectively, and has good curative effect on the premature beat.
TABLE 1 comparison of the early Chamber count before and after treatment for two groups of patients (M (Q25-Q45))
Note that: in comparison with the pre-treatment period, * P<0.05, ** p is less than 0.01; in comparison with the control group, △ P<0.05, △△ P<0.01。
TABLE 2 comparison of ventricular premature efficacy in two groups of patients
Note that: in comparison with the pre-treatment period, * P<0.05, ** p is less than 0.01; in comparison with the control group, △ P<0.05, △△ P<0.01。
TABLE 3 comparison of the integral of the symptoms of the traditional Chinese medical science before and after the treatment of the two patients
Note that: in comparison with the pre-treatment period, * P<0.05, ** p is less than 0.01; in comparison with the control group, △ P<0.05, △△ P<0.01。
TABLE 4 comparison of the efficacy of Chinese medicine for two groups of patients
Note that: in comparison with the pre-treatment period, * P<0.05, ** P<0.01; in comparison with the control group, △ P<0.05, △△ P<0.01。
Claims (2)
1. the traditional Chinese medicine application for treating premature beat comprises a water-jet non-woven fabric blank paste and an extract coated in the middle of the water-jet non-woven fabric blank paste, wherein the extract comprises a traditional Chinese medicine composition and a dressing, and is characterized in that the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 120-240 parts of radix codonopsis pilosulae, 120-240 parts of stir-fried bighead atractylodes rhizome, 40-80 parts of honey-fried licorice root, 40-80 parts of grassleaf sweelflag rhizome, 60-120 parts of Chinese magnoliavine fruit, 60-120 parts of platycladi seed, 120-240 parts of Indian buead, 120-240 parts of astragalus root, 60-120 parts of red sage root, 40-80 parts of officinal magnolia bark, 60-120 parts of Chinese angelica, 40-80 parts of prepared polygala root, 100-200 parts of nardostachyos root, 40-80 parts of cassia bark, 60-120 parts of stir-fried spina date seed, 60-120 parts of dwarf lilyturf tuber, 40-80 parts of menthol and 20-40 parts of borneol; the extract is big honeyed pill, the dressing is honey, eighteen raw materials of the traditional Chinese medicine composition are crushed into fine powder, sieved, mixed evenly, added with a proper amount of honey, and prepared into big honeyed pill.
2. The traditional Chinese medicine application for treating premature beat according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 180 parts of codonopsis pilosula, 180 parts of stir-fried bighead atractylodes rhizome, 60 parts of honey-fried licorice root, 60 parts of grassleaf sweelflag rhizome, 90 parts of shizandra berry, 90 parts of platycladi seed, 150 parts of Indian buead, 180 parts of membranous milkvetch root, 90 parts of danshen root, 60 parts of officinal magnolia bark, 90 parts of Chinese angelica, 60 parts of prepared thinleaf milkwort root-bark, 150 parts of nardostachyos root, 60 parts of cassia bark, 90 parts of stir-fried spina date seed, 90 parts of dwarf lilyturf tuber, 60 parts of menthol and 30 parts of borneol.
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