CN115671201A - Traditional Chinese medicine plaster for treating premature beat - Google Patents
Traditional Chinese medicine plaster for treating premature beat Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine application for treating premature beat, which comprises a spunlace non-woven fabric blank patch and an extract coated in the middle of the spunlace non-woven fabric blank patch, wherein the extract comprises a traditional Chinese medicine composition and a dressing, and the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 120-240 parts of codonopsis pilosula, 120-240 parts of fried bighead atractylodes rhizome, 40-80 parts of honey-fried licorice root, 40-80 parts of rhizoma acori graminei, 60-120 parts of schisandra chinensis, 60-120 parts of platycladi seed, 120-240 parts of poria cocos, 120-240 parts of astragalus membranaceus, 60-120 parts of salvia miltiorrhiza, 40-80 parts of mangnolia officinalis, 60-120 parts of angelica sinensis, 40-80 parts of prepared polygala tenuifolia, 100-200 parts of nardostachys chinensis, 40-80 parts of cinnamon, 60-120 parts of fried spina date seed, 60-120 parts of radix ophiopogonis, 40-80 parts of menthol and 20-40 parts of borneol. The medicines in the Chinese medicinal application paste are compatible, complement each other, play a role of strengthening body resistance and banking up root together, benefit qi and nourish blood, activate blood and dissolve stasis, and calm heart and tranquilize mind, have the advantages of obvious effect, exact medicinal effect and quick response, and are worthy of clinical popularization and application.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine plaster for treating premature beat.
Background
Cardiovascular diseases have become the main cause of premature death of Chinese at present. Arrhythmia, a common cardiovascular disease, can be one of the accompanying symptoms of other diseases as well as the early or only clinical manifestations of heart abnormalities. In recent 30 years, the average annual incidence rate of sudden cardiac death events in China was 0.04%, and about 50% -70% of sudden cardiac death was associated with ventricular tachyarrhythmia.
At present, for the western medicine treatment of ventricular premature contraction, the '2020 ventricular arrhythmia Chinese specialist consensus' indicates that for a patient suspected of ventricular premature contraction induced cardiomyopathy, the ventricular premature is to be treated actively. For premature ventricular patients without organic heart disease, application of too aggressive a therapeutic strategy is not recommended. Although beta blockers or non-dihydropyridine calcium channel blockers may be used as appropriate, there is no evidence of their effectiveness for a while, and calcium channel blockers themselves may cause significant symptoms such as palpitations, headache, and fatigue. While the systems for catheter ablation therapy are well established, their invasive procedures, strict indications and their high cost are still prohibitive to some patients.
Disclosure of Invention
In view of the above disadvantages in the prior art, according to the embodiments of the present invention, it is desirable to provide a Chinese medicine patch for treating premature beat, which aims to solve the problems of poor treatment effect and high price when the existing medicine is used for treating premature beat.
According to the embodiment, the traditional Chinese medicine application for treating premature beat comprises a spunlace non-woven fabric blank patch and an extract coated in the middle of the spunlace non-woven fabric blank patch, wherein the extract comprises a traditional Chinese medicine composition and a dressing, and the traditional Chinese medicine application is characterized in that the traditional Chinese medicine composition comprises the following raw medicines in parts by weight: 120-240 parts of codonopsis pilosula, 120-240 parts of fried bighead atractylodes rhizome, 40-80 parts of honey-fried licorice root, 40-80 parts of rhizoma acori graminei, 60-120 parts of schisandra chinensis, 60-120 parts of platycladi seed, 120-240 parts of poria cocos, 120-240 parts of astragalus membranaceus, 60-120 parts of salvia miltiorrhiza, 40-80 parts of mangnolia officinalis, 60-120 parts of angelica sinensis, 40-80 parts of prepared polygala tenuifolia, 100-200 parts of nardostachys chinensis, 40-80 parts of cinnamon, 60-120 parts of fried spina date seed, 60-120 parts of radix ophiopogonis, 40-80 parts of menthol and 20-40 parts of borneol.
According to one embodiment, in the traditional Chinese medicine application for treating premature beat, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 180 parts of codonopsis pilosula, 180 parts of fried bighead atractylodes rhizome, 60 parts of honey-fried licorice root, 60 parts of grassleaf sweelflag rhizome, 90 parts of Chinese magnoliavine fruit, 90 parts of platycladi seed, 150 parts of poria cocos, 180 parts of astragalus membranaceus, 90 parts of salvia miltiorrhiza, 60 parts of magnolia officinalis, 90 parts of Chinese angelica, 60 parts of prepared polygala root, 150 parts of nardostachys root, 60 parts of cinnamon, 90 parts of fried spina date seed, 90 parts of dwarf lilyturf tuber, 60 parts of menthol and 30 parts of borneol.
According to one embodiment, in the traditional Chinese medicine application for treating premature beat, the extract is a big honeyed pill, the dressing is honey, eighteen raw material medicines of the traditional Chinese medicine composition are crushed into fine powder, sieved, mixed uniformly, and added with a proper amount of honey to prepare the big honeyed pill.
In the traditional Chinese medicine application paste, the codonopsis pilosula is sweet in taste and neutral in nature, enters lung and spleen channels, and has the effects of tonifying middle-jiao and Qi, invigorating spleen and nourishing blood to promote the production of body fluid; astragalus root, radix astragali, sweet in flavor and slightly warm in nature, enters lung and spleen channels, and can tonify qi, raise yang, induce diuresis to alleviate edema, and is the essential drug for tonifying qi; the fried bighead atractylodes rhizome is sweet and bitter in taste and warm in nature, enters spleen and stomach channels, strengthens spleen and tonifies qi, eliminates dampness and promotes diuresis; poria has sweet and light taste and neutral nature, and has effects in invigorating spleen, tranquilizing mind, promoting diuresis and eliminating dampness; prepared licorice root, radix Glycyrrhizae Praeparata, sweet in taste, neutral in nature, enters heart, lung, spleen and stomach channels, and has the effects of tonifying heart qi, restoring heart pulse, benefiting spleen qi, promoting transportation and transformation, nourishing yin and blood, restoring pulse and stopping palpitation. "the book of changes" cloud: to impair the heart, nourish the heart. The treatment should be done exclusively for true blood, which is abundant, so it is not enough to be treated with assistance by heart. The traditional Chinese medicine composition is a monarch drug, can tonify qi and spleen, the spleen is a source for generating and transforming qi and blood, the spleen and the stomach are strong and strong due to the splenic qi, once the transportation and transformation functions of the spleen and the stomach are recovered, the qi and the blood can be naturally generated and continuously generated, and the heart and the blood are sufficient, so that the spirit can be calmed. The angelica is sweet and pungent in flavor and warm in nature, belongs to liver, heart and spleen channels, can tonify blood and activate blood circulation, is a key blood-enriching medicine, is compatible with the astragalus root, can tonify qi and produce blood by combining the two medicines, and can nourish and transform the qi, so as to tonify qi, consolidate blood and promote qi and blood circulation. The fried spina date seed is sweet and sour in taste and neutral in nature, enters heart, liver and gallbladder channels, calms heart, soothes nerves, nourishes heart and promotes the production of body fluid; the polygala root prepared is bitter and pungent in taste and slightly warm in nature, enters heart, kidney and lung channels, soothes nerves, benefits intelligence and communicates heart and kidney, and is recorded in famous medical records: "Heart-nourishing and tranquilizing", heart-nourishing and blood-relieving, convulsion-relieving, heart-calming, phlegm-dispersing and saliva-dispersing "is also emphasized in Dian nan materia Medica" for "heart-nourishing and tranquilizing", because it can calm heart qi, stop palpitation, replenish vital essence, dispel heart-qi and heat in the skin, face and eye. Treating epilepsy, opisthotonus, convulsion, expectoration, shaking hands and feet, constipation, urination, reddish and whitish turbidity, stranguria with chyluria, and spermatorrhea. The schisandra chinensis has the functions of invigorating qi, promoting the production of body fluid, tonifying kidney, calming heart and tranquilizing mind; baizi ren is sweet in flavor and neutral in nature, and enters heart, kidney and large intestine meridians, and has the actions of nourishing heart and tranquilizing mind. The medicines enter heart meridian, enrich blood and nourish heart, and calm heart and tranquilize mind. Radix aucklandiae has the effects of regulating qi and activating spleen, so that the tonifying effect is realized without stagnation. The dwarf lilyturf tuber is sweet and slightly bitter in taste and slightly cold in nature, belongs to heart, lung and stomach channels, clears heart, relieves restlessness, nourishes yin and promotes the production of body fluid; magnolia bark, cortex magnoliae officinalis, radix seu folium magnoliae officinalis is warm in nature, enters spleen, stomach, lung, large intestine channels, eliminates dampness and phlegm, and dispels the depressed liver and binds, and is mentioned in Shen nong's herbal Jing: it is used to treat apoplexy, typhoid, headache, cold and heat, palpitation, qi and blood stagnation, muscle death and three pests. Rhizoma acori graminei enters heart and stomach channels, phlegm is eliminated, resuscitation is brought to mind, and the palpitation, the insomnia and the amnesia caused by malnutrition of heart and mind are treated; the salvia miltiorrhiza is bitter in taste and slightly warm, enters heart and liver channels, can cool blood, clear heart and relieve restlessness, has the functions of nourishing heart and soothing nerves, and has the effect of invigorating blood circulation and removing blood stasis in ancient people, namely Yun Yiwei salvia miltiorrhiza powder which is similar to the four-ingredient decoction. The whole formula has proper compatibility, so that the traditional Chinese medicine can tonify without stagnation, and can promote blood circulation without damaging healthy energy.
Modern pharmacology indicates that: astragalus has the functions of strengthening heart, promoting urination and increasing cardiac output, and the mechanism of the protective effect mediated by astragaloside as the main component of astragalus probably relates to improving the function of heart and reducing the oxidative damage of myocardium by reducing MDA, maintaining SOD and reducing the damage of myocardial cells induced by free radicals. In addition, eAM works by blocking Ca 2+ Blocking cell death and opening mitochondrial K ATP Channels to enhance the viability of cardiomyocytes to reduce apoptosis; the codonopsis pilosula has a great inhibition effect on acute myocardial ischemia, particularly caused by pituitrin; the salvia miltiorrhiza and the angelica have the effect of dilating coronary arteries and have a certain degree of prevention effect on arrhythmia of patients suffering from myocardial ischemia reperfusion; the spina date seed can reduce the occurrence probability of arrhythmia events caused by medicaments, particularly chloroform, aconitine, barium chloride and other medicaments; the calamus oil in the grassleaf sweelflag rhizome can resist various atrial and ventricular arrhythmias of experimental animals; the ophiopogon root has positive inotropic effect and obvious arrhythmia resisting effect.
As a specific component in the external medicine, the borneol is pungent in taste and cool in nature, and has the effect of entering heart, spleen and lung channels without being held; the mint is pungent in flavor and cool in nature, enters lung and liver meridians, and has the effects of inducing resuscitation and refreshing mind as a pair of permeation-promoting medicines, and can bring cool feeling to skin when being locally externally used. It has been demonstrated that topical application of menthol increases blood flow in the skin microvasculature and that the effect is dose dependent. This increase in local blood flow is mediated by the sensory nerves and EDHF. In addition, the borneol is used as a permeability enhancer, so that quite satisfactory performance is presented, the borneol has relatively low toxicity on skin cells, and obvious skin irritation is not generated by the borneol with proper concentration, so that a good foundation is laid for local external application of acupoint application.
In the traditional Chinese medicine application paste, the components are reasonably matched, the medicine formula is strict, and the pathogenesis of the premature beat is determined as follows: deficiency of both qi and blood of the heart and spleen. Has the functions of replenishing qi to invigorate the spleen, nourishing the heart, soothing the nerves and stabilizing palpitation aiming at main pathogenesis. Clinical data prove that the formula has definite clinical curative effect and no obvious adverse reaction and toxic or side effect. The traditional Chinese medicine composition can improve the cardiac function of a patient with premature beat, reduce the oxidative damage of myocardial cells and balance the autonomic nerve function by replenishing qi to invigorate the spleen, nourishing the heart to calm the nerves and stabilizing palpitation, thereby relieving clinical symptoms.
The Chinese medicinal patch can improve the cardiac function of a patient with premature beat, reduce the oxidative damage of myocardial cells and balance the function of autonomic nerve. The Chinese medicinal herbs are compatible and complement each other, so that the Chinese medicinal herbs have the effects of strengthening body resistance and banking up root together, tonifying qi and nourishing blood, activating blood and dissolving stasis, and calming heart and soothing nerves, have the advantages of good and quick response, are obvious in effect, exact in medicinal effect and quick in response, and are worthy of clinical popularization and application.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. These examples are to be construed as merely illustrative and not limitative of the remainder of the disclosure in any way whatsoever. After reading the description of the invention, one skilled in the art can make various changes and modifications to the invention, and such equivalent changes and modifications also fall into the scope of the invention defined by the claims.
Examples
Weighing 180 g of codonopsis pilosula, 180 g of fried bighead atractylodes rhizome, 60 g of honey-fried licorice root, 60 g of grassleaf sweelflag rhizome, 90 g of Chinese magnoliavine fruit, 90 g of platycladi seed, 150 g of poria cocos, 180 g of astragalus membranaceus, 90 g of salvia miltiorrhiza, 60 g of mangnolia officinalis, 90 g of Chinese angelica, 60 g of prepared polygala tenuifolia, 150 g of nardostachys root, 60 g of cinnamon, 90 g of fried spina date seed, 90 g of radix ophiopogonis, 60 g of menthol and 30 g of borneol, crushing the raw materials into fine powder, sieving the fine powder, uniformly mixing the fine powder, adding a proper amount of honey to prepare a large honeyed pill with the diameter of 1cm, coating the large honeyed pill in the middle of a spunlace non-woven fabric blank patch to prepare a traditional Chinese medicine patch (hereinafter called a Ningxin patch) for later use.
Experimental example (Chinese medicine application)
(1) First stage (lead-in period: -1-0 week)
Patients in this stage are treated with consistent health education and anti-arrhythmic drug therapy (oral propafenone hydrochloride tablets) according to the treatment method recommended by the national experts consensus on ventricular arrhythmia (the society for medical science of China, the division of electrocardio-physiology and pacing, the committee of the institute of cardiac rhythm professional, 2016).
(2) Second stage (treatment period: 1-4 weeks)
(1) Treatment group (ningxin plaster group) (35 persons): oral propafenone hydrochloride tablets and external use mind-calming patches;
the medication method comprises the following steps: oral propafenone hydrochloride tablet (3 times daily, 100mg each time) + external use heart calming plaster
The usage and dosage of the heart calming plaster are as follows: big honeyed pill with diameter of 1cm is applied to Neiguan acupoint on both sides once a day for 6 hr each time. 4 weeks is a course of treatment.
(2) Control group (35 persons): the propafenone hydrochloride tablet is taken orally.
The medication method comprises the following steps: propafenone hydrochloride tablets (3 times daily, 100mg each time) were taken orally.
The therapeutic effects of the treatment groups and the control group after completion of the treatment are shown in the following tables 1 to 4.
As can be seen from the table, the application of the Chinese medicine patch can effectively reduce the number of premature beats and various symptoms caused by the premature beats, and has good treatment effect on the premature beats.
TABLE 1 comparison of the total number of ventricular premature beats before and after treatment in two groups of patients (M (Q25-Q45))
Note: compared with the treatment before the treatment, * P＜0.05， ** p is less than 0.01; compared with the control group, the compound of the formula, △ P＜0.05， △△ P＜0.01。
TABLE 2 Compare the ventricular premature response of the two groups of patients
Note: compared with the treatment before the treatment, * P＜0.05， ** p is less than 0.01; compared with the control group, the compound of the formula, △ P＜0.05， △△ P＜0.01。
TABLE 3 comparison of the Chinese medical syndrome integral before and after treatment of two groups of patients
Note: compared with the treatment before the treatment, * P＜0.05， ** p is less than 0.01; compared with the control group, the compound of the formula, △ P＜0.05， △△ P＜0.01。
TABLE 4 comparison of the therapeutic effects of the two groups of patients
Note: compared with the treatment before the treatment, * P＜0.05， ** p is less than 0.01; compared with the control group, the compound of the formula, △ P＜0.05， △△ P＜0.01。
Claims (3)
1. a traditional Chinese medicine application for treating premature beat comprises a spunlace non-woven fabric blank patch and an extract coated in the middle of the spunlace non-woven fabric blank patch, wherein the extract comprises a traditional Chinese medicine composition and a dressing, and is characterized in that the traditional Chinese medicine composition is composed of the following raw medicines in parts by weight: 120-240 parts of codonopsis pilosula, 120-240 parts of fried bighead atractylodes rhizome, 40-80 parts of honey-fried licorice root, 40-80 parts of rhizoma acori graminei, 60-120 parts of schisandra chinensis, 60-120 parts of platycladi seed, 120-240 parts of poria cocos, 120-240 parts of astragalus membranaceus, 60-120 parts of salvia miltiorrhiza, 40-80 parts of mangnolia officinalis, 60-120 parts of angelica sinensis, 40-80 parts of prepared polygala tenuifolia, 100-200 parts of nardostachys chinensis, 40-80 parts of cinnamon, 60-120 parts of fried spina date seed, 60-120 parts of radix ophiopogonis, 40-80 parts of menthol and 20-40 parts of borneol.
2. The traditional Chinese medicine plaster for treating premature beat according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 180 parts of codonopsis pilosula, 180 parts of fried bighead atractylodes rhizome, 60 parts of honey-fried licorice root, 60 parts of grassleaf sweelflag rhizome, 90 parts of Chinese magnoliavine fruit, 90 parts of platycladi seed, 150 parts of poria cocos, 180 parts of astragalus membranaceus, 90 parts of salvia miltiorrhiza, 60 parts of magnolia officinalis, 90 parts of Chinese angelica, 60 parts of prepared polygala root, 150 parts of nardostachys root, 60 parts of cinnamon, 90 parts of fried spina date seed, 90 parts of dwarf lilyturf tuber, 60 parts of menthol and 30 parts of borneol.
3. The traditional Chinese medicine plaster for treating premature beat according to claim 1 or 2, wherein the extract is a big honeyed pill, the dressing is honey, eighteen raw material medicines of the traditional Chinese medicine composition are crushed into fine powder, sieved, mixed evenly, added with a proper amount of honey and prepared into a big honeyed pill.
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