CN115671164A

CN115671164A - Composition for treating impotence

Info

Publication number: CN115671164A
Application number: CN202211509755.5A
Authority: CN
Inventors: 王威
Original assignee: Nanchong Traditional Chinese Medicine Hospital
Current assignee: Nanchong Traditional Chinese Medicine Hospital
Priority date: 2022-11-29
Filing date: 2022-11-29
Publication date: 2023-02-03

Abstract

The invention discloses a composition for improving impotence, which is prepared from the following raw materials in parts by weight: 40 to 60 portions of cynomorium songaricum, 40 to 60 portions of clove, 20 to 40 portions of gecko, 7 to 13 portions of moxa and 7 to 13 portions of ephedra down. The traditional Chinese medicine composition has the effects of strengthening the foundation and cultivating primordial qi, and has a remarkable effect on treating impotence with spleen-kidney deficiency syndrome.

Description

Composition for treating impotence

Technical Field

The invention particularly relates to a composition for treating impotence.

Background

Impotence is a common sexual disorder disease, which refers to a condition that the male cannot have a sexual desire but the penis cannot erect or is not hard or hard but not durable, and cannot give up normal sexual intercourse after more than 3 months. The causes of impotence are complex and the majority of functional causes. According to traditional Chinese medicine, impotence is caused by the relaxation of tendons due to emotional distress, stagnation of liver-qi, kidney-qi deficiency, decline of vital gate fire, dampness-brewing and heat-generation, stagnation of liver-qi and gallbladder. The Ming dynasty Zhang Jingyue in its Jing Yue book named impotence and discussed comprehensively and insightfully the etiology and pathogenesis of this disease. Impotence in men is usually caused by decline of the fire of the gate of life, deficiency and cold of essence, or qi … … which is caused by overstrain of seven emotions and impairment of yang-producing qi, and flaccidity due to excessive damp-heat. "modern medicine" considers that the human body receives various related stimuli (such as the stimulation of opposite sex or the stimulation of visual receptor or the local stimulation from weak stem), firstly transmits the sexual stimulation to the sexual central well of cerebral cortex to excite the sexual stimulation, then the sexual stimulation is transmitted to the erection central well of spinal cord (the local stimulation from penis can be directly transmitted to the erection central well), the impulse is transmitted to the penis through paragenic nerve to make the blood sinus of the penis regret congestion and swell, and then the penis erects. Impotence can result from any cause, as long as any one of the above-mentioned mechanisms of sexual excitement transmission is affected.

Impotence not only causes pain and annoyance to patients, but also can lead to family rupture and become a social problem for serious patients. Therefore, the treatment of impotence is currently an important medical research topic. In recent years, the traditional Chinese medicine accumulates abundant treatment experiences in the aspect of treating impotence and obtains better clinical curative effect. The traditional Chinese medicine treatment mainly comprises oral administration, acupuncture and moxibustion, massage and external application. Patent CN202010322873.X discloses a navel traditional Chinese medicine patch for treating impotence and premature ejaculation, which has the curative effect of treating impotence, but has more traditional Chinese medicine symptoms causing impotence, such as insufficiency of kidney-yang, liver depression and qi stagnation, deficiency of both heart and spleen, damp-heat in liver and gallbladder, and the like, and has no dialectical formula according to the basic theory of traditional Chinese medicine, no pertinence, so that patients cannot accurately take the medicine, and the patch has more medicinal taste and high cost, and is not beneficial to popularization and application.

Disclosure of Invention

In order to solve the problems, the invention provides a composition for treating impotence, which is prepared from the following raw material medicines in parts by weight: 40 to 60 portions of cynomorium songaricum, 40 to 60 portions of clove, 20 to 40 portions of gecko, 7 to 13 portions of moxa and 7 to 13 portions of ephedra down.

Further, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight:

50 parts of cynomorium songaricum, 50 parts of clove, 30 parts of gecko, 10 parts of moxa and 10 parts of ephedra down.

Furthermore, the traditional Chinese medicine composition is a preparation prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.

Furthermore, the preparation is externally applied to the Shenque acupoint.

Furthermore, the external preparation is a solution, a paste, an emulsion, a film agent, a pill, a powder and a paste.

The invention also provides a preparation method of the composition, which comprises the following steps:

(1) Weighing the raw materials according to the proportion;

(2) Grinding herba Cynomorii, flos Caryophylli, and Gecko into powder, adding vegetable oil, decocting until the decoction is golden and brown, filtering, adding folium Artemisiae Argyi and herba Ephedrae down, mixing, and kneading into ellipsoid.

The invention finally provides the use of the composition in the preparation of a medicament for treating impotence.

Further, the medicine is a medicine for treating impotence caused by deficiency of both spleen and kidney.

Further, the drug is a drug for improving male erectile hardness.

Further, the medicine has the function of consolidating basis and cultivating vigor.

In the composition, gecko is a monarch drug and has the effects of tonifying lung and kidney, supporting yang and replenishing vital essence; the cynomorium songaricum kidney-yang tonifies yin-blood deficiency fire, the yang is enriched to arrest spontaneous emission, the yin is strengthened and the marrow is benefited, the clove warms the kidney, increases the osmosis of the medicine, is ministerial medicine, the ephedra down is pungent in property of warming and running, the effect of strengthening the yang of the whole formula is promoted, the folium artemisiae argyi is messenger medicine, the medicine is guided to gather in the lower qi sea, the medicine is gradually released, the penis is stimulated to be hyperemic, and therefore the purposes of strengthening the body resistance and reinforcing the primordial qi, improving the erection hardness and improving the impotence are achieved.

Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.

The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Detailed Description

Example 1 preparation of the drug of the invention, navel soothing oil

The formula is as follows: 50g of cynomorium songaricum, 50g of clove, 30g of gecko, 10g of moxa and 10g of ephedra down.

The preparation method comprises the following steps: weighing herba Cynomorii, flos Caryophylli, and Gecko at a certain ratio, grinding into powder, adding 10ml vegetable oil, decocting until golden and brown, filtering, adding folium Artemisiae Argyi and herba Ephedrae down, mixing, and kneading into ellipsoid with diameter of 1 cm.

The using method comprises the following steps: the navel oil is taken and put into the navel of a user, and the medicine is left for 24 hours.

Example 2 preparation of the drug of the invention, navel oil

The formula is as follows: 40g of cynomorium songaricum, 40g of clove, 20g of gecko, 7g of moxa and 7g of ephedra down.

The preparation method comprises the following steps: the same as example 1;

the using method comprises the following steps: the same as in example 1.

Example 3 preparation of the drug of the invention, navel oil

The formula is as follows: 60g of cynomorium songaricum, 60g of clove, 40g of gecko, 13g of moxa and 13g of ephedra down.

The preparation method comprises the following steps: the same as example 1;

the using method comprises the following steps: the same as in example 1.

The advantageous effects of the present invention are described below by way of test examples.

Test example 1 clinical test

1 clinical data

1.1 general data

40 cases are impotence patients who are treated in traditional Chinese medicine hospitals in Nanxi city in 1-2022 in 2021, and are divided into 20 cases of traditional Chinese medicine treatment groups and 20 cases of western medicine treatment groups according to the willingness of the patients. 20 cases of the Chinese medicines, 62 years old with the biggest age, 20 years old with the smallest age, 0.5-30 years of course, 20 cases of the western medicines, 59 years old with the biggest age, 25 years old with the smallest age, 0.5-29 years of course, no obvious difference between the two groups of baseline data (P > 0.05)

1.2 inclusion criteria

1) Primary ED;

2) The syndrome differentiation of the traditional Chinese medicine is the syndrome of deficiency of both spleen and kidney;

3) Age 18-70 years;

4) Treatment was informed.

1.3 exclusion criteria

1) Patients with secondary ED;

2) Secondary erectile dysfunction or other sexual dysfunction;

3) Those who have undergone relevant treatment within approximately 2 months;

4) Those with organic genitourinary disorders;

5) Patients with mental disorders;

6) It is allergic to the use of drugs.

2 method

2.1 methods of treatment

The western medicine group is sildenafil (Baiyunshan pharmaceutical general factory, national Standard for medicine H20143255, manufactured by Guangzhou Baiyunshan pharmaceutical group GmbH) 50mg taken 1 time before sleep at night.

The traditional Chinese medicines comprise 50g of cynomorium songaricum, 50g of clove and 30g of gecko, the cynomorium songaricum is ground into powder, the powder is added with rape oil, the mixture is decocted with small fire to be golden and crisp, then the dregs are filtered out, and the liquid is filled into a container. At last, 10g of moxa and 10g of ephedra down are mixed and put into a container, 10ml of liquid is added, the mixture is kneaded into an ellipsoid to obtain 'navel oil', the oil is put into the navel of a patient, and the medicine is left for 24 hours and is continuously used for 6 weeks.

2.2 curative effect standard: the evaluation of the effect is carried out according to the relevant standards in Wang Qi, the main code of Men's science, and the evaluation is divided into obvious effect, effective effect and ineffective effect.

2.3 Observation indexes:

1) IELT patients self-determine Intravaginal Ejaculation Latency (IELT) before and after treatment.

2) PEDT scoring, pre-and post-treatment Premature Ejaculation Diagnostic Tool (PEDT) scoring, including 5 items of control force, frequency, minimal stimulation, distress, and difficulty in interpersonal communication, PEDT,11 is classified as premature ejaculation. 3) And (5) observing adverse drug reactions.

2.4 statistical methods SPSS21.0 software as data processing tool, the counting data rate (%) is expressed, and the measuring data is used

Represent, respectively carry out X ² And (t) testing; p <0.05 is statistically significant.

3, results:

3.1 The curative effect comparison of 2 groups of patients is shown in the table 1:

table 1 comparative efficacy of patients in group 2 [ case (%) ]

Injection compared with western medicine group, # P <0.05

3.2 The IELT, PEDT comparisons before and after treatment for group 2 patients are shown in:

note that Δ P <0.05 compared to pre-treatment; compared with the western medicine group, # P <0.05

The results show that the navel oil has difference compared with the sildenafil tablets, can better improve the impotence symptom of patients, has small side effect, is convenient and simple, and is suitable for long-term use.

Claims

1. A composition for treating impotence, comprising: the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight:

40 to 60 portions of cynomorium songaricum, 40 to 60 portions of clove, 20 to 40 portions of gecko, 7 to 13 portions of moxa and 7 to 13 portions of ephedra down.

2. The composition of claim 1, wherein: the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight:

3. The composition according to claim 1 or 2, characterized in that: the preparation is prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.

4. The composition of claim 3, wherein: the preparation is externally applied to the Shenque acupoint.

5. The composition of claim 4, wherein: the preparation is in the form of solution, paste, emulsion, pellicle, pill, powder, or paste.

6. A process for preparing a composition according to any one of claims 1 to 5, characterized in that: it comprises the following steps:

(1) Weighing the raw material medicines according to the proportion of claim 1;

7. Use of a composition as claimed in any one of claims 1 to 5 in the manufacture of a medicament for the treatment of impotence.

8. Use according to claim 8, characterized in that: the medicine is used for treating impotence with syndrome of deficiency of both spleen and kidney.

9. Use according to claim 8, characterized in that: the medicine is used for improving male erectile hardness.

10. Use according to any one of claims 7 to 9, characterized in that: the medicine has the effects of strengthening body resistance and cultivating vigor.