CN113893290A

CN113893290A - Externally applied medicine for reducing male penis sensitivity and preparation method thereof

Info

Publication number: CN113893290A
Application number: CN202111155146.XA
Authority: CN
Inventors: 严晨华
Original assignee: Xining Weishui Biotechnology Co ltd
Current assignee: Xining Weishui Biotechnology Co ltd
Priority date: 2021-09-29
Filing date: 2021-09-29
Publication date: 2022-01-07

Abstract

The invention discloses an external medicine for reducing male penis sensitivity and a preparation method thereof, wherein the external medicine comprises the following raw materials in parts by weight: 10 parts of vinegar schisandra chinensis, 15 parts of cortex lycii radicis, 10 parts of fructus cnidii, 12-15 parts of pomegranate bark, 15 parts of spina gleditsiae, 10-15 parts of mangnolia officinalis, 15 parts of asarum, 20 parts of gallnut and 10-15 parts of longspur epimedium. The external medicine adopts the compatibility of all components, and aims to 'purge fire and reduce allergy to treat diarrhea', the external medicine takes 10 days as 1 course of treatment, the premature ejaculation symptom of a patient is obviously improved after the external medicine is used for 2 courses of treatment, the external medicine can completely get rid of the medicine after the external medicine is continuously used for 3 courses of treatment, and the self-confidence is recovered; the external medicine of the invention is all Chinese medicinal components, no chemicals are added, the patient can not produce psychological tolerance, and the psychological distress of the patient caused by premature ejaculation for a long time is solved.

Description

Externally applied medicine for reducing male penis sensitivity and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine composition, in particular to an external medicine for reducing male penis sensitivity and a preparation method thereof.

Background

Premature ejaculation, which is considered to be the most common disease in ejaculation disorder, is characterized by erection of penis during sexual intercourse but loss of control of ejaculation, and the penis before or just after insertion into vagina is ejaculated, with the incidence rate accounting for 35% -50% of adult men. Premature ejaculation is often caused by oversensitivity of penile sensation or overexcitation of penile sensory nerves, and therapies such as psychotherapy, manual training, drug therapy and the like have appeared in recent years.

1. Sexual sensation centralized training method

The concentrated sexual sensation training method is a treatment means on the premise of gradually increasing the ability of distinguishing the penile sensation, and is suitable for premature ejaculation caused by psychological reasons such as guilt, uneasiness, and loss of confidence of sexual life. The method is used for experiencing and enjoying pleasure through means of tactile stimulation such as hugging, stroking, massaging and the like.

2. Behavior therapy

(1) And (3) squeezing and kneading: the method is a behavior therapy for sequential training. The method comprises stimulating penis to achieve inseminating sensation, immediately stopping stimulation, placing thumb on frenulum of penis, placing index finger and middle finger on dorsal side of penis just above and below coronary sulcus, pressing for 4 s, and suddenly relaxing. The strength of the pressure used for squeezing is in direct proportion to the erection degree, people with hard erection squeeze the penis, people with soft penis squeeze the penis with moderate strength, and the sense of urgency of ejaculation can be delayed by repeated training.

(2) Batch process: this method is also a form of behavioral therapy, aiming to increase the stimulation threshold required for ejaculation by training. The method comprises stimulating penis to the extent of ejaculation, stopping stimulation, stimulating penis to reduce climax, and stimulating penis repeatedly until male can tolerate a large amount of stimulation without ejaculation.

(3) Pulling the scrotum: traction of the scrotum and testis during sexual intercourse reduces sexual excitability and delays ejaculation.

3. Oral drug therapy

(1) The clomipramine is a tricyclic antipsychotic, and has the action principle of blocking the excitation of norepinephrine on cerebral cortex and strengthening the inhibition of 5-hydroxytryptamine on the cerebral, thereby reducing the sexual excitability and controlling premature ejaculation. But large doses may cause anejaculation. 25mg each time, 3 times daily.

(2) Methyldopa, a commonly used medicine for treating hypertension, is mixed with dopamine to form a pseudo-transmitter, participates in the release of catecholamine transmitters in the central nervous system and the peripheral nervous system, influences the excitability of the nervous system, causes the reduction of sexual excitability, and about 50 percent of men show ejaculation delay. The product can not be taken for a long time to prevent sexual hypofunction. 0.5g for each time, 2-3 times daily, and is orally administered.

(3) Guanethidine is a nerve ending anti-adrenergic medicine and can block sympathetic nerve ending from releasing norepinephrine, and 50-60% of men show delayed ejaculation or no ejaculation. 25mg each time, 1-2 times daily, and is orally administered.

(4) The phenoxybenzamine can reduce the excitability of sympathetic nerves, thereby reducing the excitability of ejaculation reflex, and has better treatment effect, 20-30 mg per day and oral administration.

(5) Bi Li jin (dapoxetine hydrochloride) was successfully developed and marketed in China in 12 months of 2013, so far Bi Li jin is the only drug approved by European countries and China CFDA for treating premature ejaculation, and is orally taken once a day at 30 mg.

(6) Other medicines, phenobarbital 30mg, promethazine 12.5mg, or diazepam 2.5mg, are orally taken 1 hour before sexual life, have sedative effect on nervous system, and relatively reduce excitability of ejaculation center.

4. Topical application of drugs

The glans penis is the most sensitive area in the male sexual excitation organ, and the glans penis can be coated with 1% -2% of cocaine liquid or 1% of dyclonine cold cream 5-10 minutes before sexual life, so that the sensitivity of the head of the penis can be reduced, and the excitability of the ejaculation center is reduced to delay the ejaculation reflex.

5. Surgical treatment

Penis dorsal nerve blocking operation: part of sensory nerves are cut off through the operation, the sensitivity of the glans penis is reduced, and the afferent nerve impulses are reduced, so that the time for the ejaculation nerves to reach the excitation threshold is prolonged, and the aim of treating the premature ejaculation can be achieved.

Psychological therapies, manual training, oral medications, external sprays, topical medications, and surgical treatments have been widely used over the years. However, psychological treatment and manipulation training are of little effect, and most oral drugs are commonly used in psychoses or hypertension to achieve the effect of reducing excitability or the effect of reducing excitement conduction of sympathetic nerves and parasympathetic nerves to ejaculation center, and are prescription drugs, which are not favorable for long-term administration. Topical sprays and topical medications can cause damage to the penis with prolonged use and can induce a variety of related diseases. The curative effect of surgical treatment is very uncertain, the technology is not perfect, and the surgical treatment can not be applied to clinical popularization absolutely as research and discussion after the will of patients is fully considered at most.

Disclosure of Invention

In order to solve the problem that the side effect of the existing medicament for treating the male penis sensitivity is obvious or the penis is damaged, the invention aims to provide an external medicament for reducing the male penis sensitivity; in addition, the invention also provides a preparation method of the externally applied medicine for reducing the penis sensitivity of men.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides an external medicine for reducing male penis sensitivity, which comprises the following raw materials in parts by weight:

10 parts of vinegar schisandra chinensis, 15 parts of cortex lycii radicis, 10 parts of fructus cnidii, 12-15 parts of pomegranate bark, 15 parts of spina gleditsiae, 10-15 parts of mangnolia officinalis, 15 parts of asarum, 20 parts of gallnut and 10-15 parts of longspur epimedium.

Preferably, 8-10 parts by weight of clove and 10-12 parts by weight of dark plum are also included.

In the formula, vinegar-processed schisandra chinensis has the effects of relieving exterior syndrome and dispelling cold, dispelling wind and relieving pain, and dredging orifices, epimedium has the effects of tonifying kidney yang, strengthening muscles and bones, and dispelling wind-damp, clove has warm property, pungent taste, sweet and pungent taste, and strong heat; the magnolia officinalis eliminates dampness and phlegm, and purges qi to eliminate fullness; cortex Lycii has effects of cooling blood, removing heat, clearing lung-heat and lowering fire. For tidal fever due to yin deficiency; pomegranate rind and Chinese honeylocust spine have the functions of detumescence, toxin expelling, pus discharge and disinsection, and are used for treating initial carbuncle and deep-rooted carbuncle or no festation due to pus formation; externally treating scabies, tinea and leprosy; the gallnut has the effects of astringing lung and reducing fire, relieving diarrhea with astringents, arresting sweating, stopping bleeding, astringing dampness and healing sore;

in a second aspect of the present invention, there is provided a method for preparing an external preparation for decreasing male penis sensitivity, comprising the steps of:

s1, weighing the materials;

s2, grouping, namely taking cortex lycii radicis, spina gleditsiae and gallnut as a first group, cortex magnoliae officinalis and longspur epimedium as a second group, asarum and pomegranate rind as a third group, and fructus cnidii and vinegar schisandra chinensis as a fourth group, and respectively soaking the fourth group in water to obtain a first group of mixture, a second group of mixture, a third group of mixture and a fourth group of mixture;

s3, decocting the first group of mixture, adding the second group of mixture after decocting, and decocting;

s4, decocting the third group of mixture, and adding the decocted decoction into S3;

s5, adding the fourth group of mixture into S4, and decocting to obtain decoction, which is the externally applied medicine for reducing male penis sensitivity.

Wherein, each group of materials in the S2 is respectively placed in a medicine decocting machine with a filtering device or a cloth bag for soaking for not less than 15 min.

Wherein the weight ratio of water to solid materials in the first group of mixed materials, the second group of mixed materials, the third group of mixed materials and the fourth group of mixed materials is 3.5-7.

Wherein the decocting method comprises boiling with strong fire, and decocting with slow fire for 30-60 min.

Wherein, also include step S6: taking out the solid materials, soaking in water, repeating S3-S5 for the second time, and mixing the decoction obtained by the second time and the decoction obtained by the first time.

In a third aspect of the present invention, there is provided a method for preparing an external preparation for decreasing male penis sensitivity, comprising the steps of:

s1, weighing the materials;

s2, grouping, namely taking cortex lycii radicis, spina gleditsiae, dark plum fruit and gallnut as a first group, cortex magnoliae officinalis, clove and longspur epimedium as a second group, asarum and pomegranate rind as a third group, fructus cnidii and vinegar schisandra chinensis as a fourth group, and respectively soaking each group in water to obtain a first group of mixture, a second group of mixture, a third group of mixture and a fourth group of mixture;

s5, adding the fourth group of mixture into S4, and decocting to obtain decoction.

Compared with the prior art, the invention has the following beneficial effects: the external medicine adopts the compatibility of all components, aims at 'reducing allergy and treating diarrhea', takes 10 days as a treatment course, obviously improves the premature ejaculation symptom after 2 treatment courses of use, can completely get rid of the medicine after 3 treatment courses of continuous use, and recovers the self-confidence; the external medicine of the invention is all Chinese medicinal components, no chemicals are added, the patient can not produce psychological tolerance, and the psychological distress of the patient caused by premature ejaculation for a long time is solved.

Detailed Description

The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.

The symptoms of premature ejaculation are mostly considered to be caused by 'kidney deficiency' in traditional Chinese medicine, and are mostly treated by using a prescription consisting of yin-nourishing and yang-strengthening medicines. The experience of the inventor for clinical diagnosis and treatment of premature ejaculation in more than ten years shows that most of the syndrome differentiation and medication methods are inconsistent with the reality. Particularly, the living standard of people is greatly improved, premature ejaculation caused by malnutrition is less common, and the syndrome of damp-heat accumulation in interior or damp-heat in lower jiao is more common. Therefore, formulating this recipe is intended to "purging fire and reducing allergy to treat diarrhea".

An external medicine for reducing male penis sensitivity comprises the following raw materials in parts by weight:

10 parts of vinegar schisandra chinensis, 15 parts of cortex lycii radicis, 10 parts of fructus cnidii, 12-15 parts of pomegranate bark, 15 parts of spina gleditsiae, 10-15 parts of mangnolia officinalis, 15 parts of asarum, 10-15 parts of longspur epimedium and 20 parts of gallnut.

The externally applied medicine for reducing the sensitivity of the male penis is prepared by the method of decocting firstly, then adding, decocting additionally and wrapping and decocting.

Decocting firstly: cortex Lycii, spina Gleditsiae, Galla chinensis, and mume fructus;

the following steps: cortex Magnolia officinalis, flos Caryophylli, herba Epimedii;

decocting additionally: asarum, pomegranate rind;

wrapping and frying: fructus Cnidii, vinegar fructus Schisandrae chinensis.

Specifically, the materials are divided into a first group, cortex lycii radicis, spina gleditsiae and gallnut are taken as a first group, cortex magnoliae officinalis and herba epimedii are taken as a second group, asarum and pomegranate rind are taken as a third group, fructus cnidii and vinegar schisandra chinensis are taken as a fourth group, and each group is respectively soaked in water to obtain a first group of mixture, a second group of mixture, a third group of mixture and a fourth group of mixture;

decocting firstly: boiling the first mixture for 10-15 min;

the following steps: decocting the first group of mixture, adding the second group of mixture, and decocting for 5-10 min;

decocting additionally: decocting the third group of mixture for 10-15min, and adding the medicinal liquid into the first and second groups;

wrapping and frying: and taking the fourth group of mixture, adding the mixture into the mixed system of the first group, the second group and the third group, decocting for 10-15 minutes, and obtaining the decoction which is the externally applied medicine for reducing the sensitivity of the male penis.

In order to facilitate the separation of the solid materials from the decoction, the solid materials are respectively placed in a decocting machine or a cloth bag with a filter device for soaking for not less than 15 min. Generally, the soaking time is not less than 30min, the number of flowers and leaves can be reduced to 15min, the soaking time of stones, mesogens, carapace, roots and fruits is prolonged, and solid materials cannot be washed by water.

The amount of water and decoction is controlled during decoction, and the decoction is not added with water and/or discarded at will, and if the decoction is too much, the decoction can be properly concentrated.

Usually, two times of decoction are adopted, and the decoction obtained after the two times of decoction are evenly mixed and then packaged. The water amount is added during the first decoction, the decoction is preferably 2-5cm higher than the medicine surface when the decoction is started, or 5 times of the solid material, and water should be added for the patients with longer decoction time. The mass ratio of the added water to the solid material is 3.5-7; the water amount is added during the second decoction, and the water amount is 1cm higher than the medicine surface or about 2 times of the solid material mass.

The decoction is carried out by boiling with strong fire, and slowly decocting with slow fire for 30-40 min; the heat-clearing and aromatic medicines should not be decocted for a long time, and decocted for 30-45min after boiling; the second decoction is carried out for a slightly shorter time than the first decoction.

In order to facilitate decoction, a decocting machine is preferably selected, most decocting machines have the functions of automatic extrusion and automatic stirring, and the automatic extrusion or stirring is carried out for more than 2 times at intervals after the liquid medicine is boiled; or decocting in common container, placing solid material in cloth bag, boiling, and manually squeezing the cloth bag for more than 2 times.

When the method is adopted to prepare the externally applied medicine for reducing the penis sensitivity of the male, each dose of the medicine for the adult is generally decocted to 550-600 mL.

The application method of the external medicine comprises the following steps: the external preparation is heated to 40-50 deg.C, dipped in medicinal liquid with a clean cotton towel to scrub glans penis and penis for 10min, then dipped in finger to scrub glans penis for 5min, and wiped with towel to dry, and no clean water is needed within several hours, once a day, and preferably for different rooms during treatment.

The externally applied medicine has a treatment course of 10 days, has obvious effect after being used for 2 treatment courses, can completely get rid of the medicine after being continuously used for 3 treatment courses, and recovers the self-confidence.

In addition, the external medicine is matched with self behavior therapy to further improve the treatment effect, because the self behavior therapy is used to deepen the sensitivity of a sensitivity source while the drug effect plays a role in reducing the sensitivity, thereby achieving the effect of reducing the sensitivity.

Example 1

An external medicine for reducing male penis sensitivity comprises the following raw materials:

15g of spina gleditsiae, 15g of asarum, 20g of gallnut, 15g of cortex lycii radicis, 10g of vinegar-processed schisandra chinensis, 15g of longspur epimedium, 15g of mangnolia officinalis, 12g of pomegranate rind, 10g of fructus cnidii, 10g of dark plum and 10g of clove.

The preparation method comprises the following steps:

1. taking cortex lycii radicis, spina gleditsiae, dark plum fruit and Chinese gall as a first group, cortex magnoliae officinalis, clove and longspur epimedium as a second group, asarum and pomegranate rind as a third group, and fructus cnidii and vinegar schisandra chinensis as a fourth group, and mixing the following raw materials in parts by weight: the mass ratio of the solid materials is 4:1, and each group of the solid materials is soaked in water respectively to obtain a first group of mixed materials, a second group of mixed materials, a third group of mixed materials and a fourth group of mixed materials;

2. decocting the first group of mixture for 10-15min, adding the second group of mixture, and decocting for 5-10 min;

3. decocting the third group of mixture for 5-10min, and adding the decoction in step 2;

4. and (4) adding the fourth group of mixture into the step (3) and decocting the mixture for 5-10min to obtain the externally applied medicine for reducing the sensitivity of the male penis.

Example 2

15g of spina gleditsiae, 15g of asarum, 20g of gallnut, 15g of cortex lycii radicis, 10g of vinegar-processed schisandra chinensis, 10g of longspur epimedium, 10g of mangnolia officinalis, 15g of pomegranate rind and 10g of fructus cnidii.

The preparation method is the same as example 1.

Example 3

15g of spina gleditsiae, 15g of asarum, 20g of gallnut, 15g of cortex lycii radicis, 10g of vinegar-processed schisandra chinensis, 10g of longspur epimedium, 12g of mangnolia officinalis, 13g of pomegranate rind and 10g of fructus cnidii.

The preparation method is the same as example 1.

Example 4

15g of spina gleditsiae, 15g of asarum, 20g of gallnut, 15g of cortex lycii radicis, 10g of vinegar-processed schisandra chinensis, 10g of longspur epimedium, 12g of mangnolia officinalis, 13g of pomegranate rind, 10g of fructus cnidii, 8g of clove and 12g of dark plum.

The preparation method is the same as example 1.

Example 5

15g of spina gleditsiae, 15g of asarum, 20g of gallnut, 15g of cortex lycii radicis, 10g of vinegar-processed schisandra chinensis, 12g of longspur epimedium, 10g of mangnolia officinalis, 12g of pomegranate bark, 10g of fructus cnidii, 9g of clove and 12g of dark plum.

The preparation method is the same as example 1.

Test example 1

Yang Yi, 37 years old, chief complaints: spermatorrhea and premature ejaculation for more than ten years after marriage. Married postnatal 1 woman, 13 years old. There is a history of frequent masturbation in the last decade before marriage, which starts every day, sometimes even several times a day. The spontaneous ejaculation is too early in the same room every time, the sexual desire is still good, the penis erects normally, but the ejaculation is performed in the same room, which never exceeds 1 minute. Women never have a single climax and even dislike the same room.

After 2 treatment courses of the externally applied medicine of the example 1, the symptoms of the poplar are obviously relieved, the emotion is stable, and the time is prolonged to 5 minutes. After 10 doses of the external medicine of the embodiment 1 are used, drinking is forbidden, and the sexual intercourse duration time is 3-8 minutes. The sexual life is normal after 2 years of follow-up.

Test example 2

The patient premature ejaculation for 3 years is tested to be normal by the examination of prostate and seminal fluid in hospital, the vibration sensation of penis is measured, and the somatosensory evoked potential of the dorsal nerve of penis is measured, which belongs to the premature ejaculation caused by the centripetal conduction function of the dorsal nerve of penis and the excitation of the cranial nerve center. The drug for external use of 10 doses in example 1 was used, and the drug was cured with 20 doses after follow-up, and was not released any more.

Test example 3

Some horse, male, age 29, married 1 year. The penis vibration sensation is measured as organic premature ejaculation through regular blood and urine examination in hospitals. The external medicine of the embodiment 2 is used twice a day, sexual intercourse is prohibited, and after 2 treatment courses, the condition of the disease is greatly improved; the medicine is continuously taken for 10 doses once a day, and then the sexual life is normal after follow-up, and the wife is pregnant and does not release again.

Test example 4

Some marginalia, male, 23 years old, and early marriage. Premature ejaculation appeared during marriage, the room was not met all the time, the face was ruddy, the body was strong, the tongue was red, the tongue fur was thin, the pulse was wiry and tense, the spirit was not declined, and the feeling was impatient. Has been treated in various hospitals, and the effect is not good. The external medicine of the embodiment 4 is decocted for 20 doses, one dose is taken every day, and the medicine is used for treating without premature ejaculation symptoms, so the effect is ideal.

Test example 5

When a certain piece is in age 28 and married for more than 1 year, sexual life is abnormal, premature ejaculation occurs without obvious inducement, intermittent onset begins, and then frequent onset occurs, so that sexual life cannot be passed. After being taken, the herbs such as jin Kui Shen Qi Wan and Suo Yang are indicated for poor curative effect accompanied by lassitude, hypodynamia, vexation, insomnia, spontaneous perspiration, palpitation and self-confidence deficiency. After 15 doses of the external medicine of example 5 are adopted, the compound diagnosis has normal sleep, the vexation is relieved, and the spirit is better.

Three diagnoses: the sexual intercourse time is prolonged by 5 minutes, and ejaculation can be controlled at will.

Test example 6

602 male patients with medical history of 30-60 years are randomly selected, and the course of the disease is 6 months to several years.

Diagnostic criteria: failure to achieve or maintain adequate penile erection to complete a satisfactory sexual life, penile erectile dysfunction or erectile weakness and failure to complete a normal sexual intercourse.

The treatment method comprises the following steps: the external medicine prepared in the embodiment 3 is adopted, before the medicine is used, the external medicine is heated to 40-50 ℃, the glans and the penis are lightly scrubbed for 10 minutes by dipping the medicine liquid in a clean cotton towel, then the glans is dipped and scrubbed for 5 minutes by fingers and is wiped dry by a towel, the glans does not need to be washed by clear water within a few hours, the medicine is taken once a day, 10 days are a treatment course, 3 treatment courses are totally treated, and the treatment period cannot be in the same room.

Evaluation of therapeutic Effect

And (3) curing: achieving or maintaining enough penile erection to complete satisfactory sexual life and controlling ejaculation time;

improvement: enough penis erection can be achieved, but the control time is short;

and (4) invalidation: there is no way to achieve a sufficient penile erection to complete sexual life, and even if it is, ejaculation is out of control.

The treatment effect is as follows:

12 cases are cured, accounting for 2.1 percent, 589 cases are improved, accounting for 97.7 percent, 1 case is invalid, accounting for 0.2 percent, and the effective rate is 99.8 percent.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims

1. The externally applied medicine for reducing the penis sensitivity is characterized by comprising the following raw materials in parts by weight:

2. The topical pharmaceutical composition for reducing male penile sensitivity as claimed in claim 1, further comprising 8-10 parts by weight of clove and 10-12 parts by weight of dark plum.

3. A method for preparing the externally applied agent for decreasing male penis sensitivity according to claim 1, comprising the steps of:

s1, weighing the materials;

4. The method of claim 3, wherein the groups of materials in S2 are soaked in the decoction machine or cloth bag with filter for not less than 15 min.

5. The method of claim 3, wherein the weight ratio of water to solid material in the first, second, third and fourth sets of mixes is 3.5-7.

6. The method for preparing the externally applied medicine for decreasing male penis sensitivity as claimed in claim 3, wherein the decoction method is boiling with strong fire and then slowly decocting with slow fire for 30-60 min.

7. The method of claim 3, further comprising a step S6: taking out the solid materials, soaking in water, repeating S3-S5 for the second time, and mixing the decoction obtained by the second time and the decoction obtained by the first time.

8. A method for preparing the externally applied agent for decreasing male penis sensitivity according to claim 2, comprising the steps of:

s1, weighing the materials;

9. The method of claim 8, wherein the groups of materials in S2 are soaked in the decoction machine or cloth bag with filter for not less than 15 min.

10. The method of claim 8, wherein the weight ratio of water to solid material in the first, second, third and fourth sets of mixes is 3.5-7.