CN117599122A - Five-wonderful incense and preparation method and application thereof - Google Patents
Five-wonderful incense and preparation method and application thereof Download PDFInfo
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- CN117599122A CN117599122A CN202311712564.3A CN202311712564A CN117599122A CN 117599122 A CN117599122 A CN 117599122A CN 202311712564 A CN202311712564 A CN 202311712564A CN 117599122 A CN117599122 A CN 117599122A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 201000001881 impotence Diseases 0.000 claims abstract description 33
- 239000003814 drug Substances 0.000 claims abstract description 31
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 239000000341 volatile oil Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 210000004185 liver Anatomy 0.000 claims abstract description 11
- 241000402754 Erythranthe moschata Species 0.000 claims abstract description 10
- 241000758794 Asarum Species 0.000 claims abstract description 9
- 241000804384 Cynomorium songaricum Species 0.000 claims abstract description 9
- 241000173529 Aconitum napellus Species 0.000 claims abstract description 8
- 229940023019 aconite Drugs 0.000 claims abstract description 8
- 239000008280 blood Substances 0.000 claims abstract description 8
- 210000004369 blood Anatomy 0.000 claims abstract description 8
- 240000007436 Cananga odorata Species 0.000 claims abstract description 7
- 235000002566 Capsicum Nutrition 0.000 claims abstract description 6
- 239000006002 Pepper Substances 0.000 claims abstract description 6
- 235000016761 Piper aduncum Nutrition 0.000 claims abstract description 6
- 235000017804 Piper guineense Nutrition 0.000 claims abstract description 6
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 5
- 241000722363 Piper Species 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 2
- 241000233855 Orchidaceae Species 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000009098 adjuvant therapy Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000009986 erectile function Effects 0.000 abstract description 10
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- 230000006870 function Effects 0.000 abstract description 3
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- 244000203593 Piper nigrum Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000005728 strengthening Methods 0.000 description 4
- 238000010792 warming Methods 0.000 description 3
- 235000007650 Aralia spinosa Nutrition 0.000 description 2
- 208000010228 Erectile Dysfunction Diseases 0.000 description 2
- 241000949456 Zanthoxylum Species 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
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- 230000001225 therapeutic effect Effects 0.000 description 2
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- 206010000060 Abdominal distension Diseases 0.000 description 1
- 241000227129 Aconitum Species 0.000 description 1
- 241001081440 Annonaceae Species 0.000 description 1
- 235000007571 Cananga odorata Nutrition 0.000 description 1
- 241000222511 Coprinus Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
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- 238000000692 Student's t-test Methods 0.000 description 1
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- 244000089698 Zanthoxylum simulans Species 0.000 description 1
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- 235000019634 flavors Nutrition 0.000 description 1
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- 238000012353 t test Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The invention discloses a composition for assisting in treating impotence, which is prepared from the following raw materials in parts by weight: 0.1 to 1 part by weight of musk, 20 to 40 parts by weight of cynomorium songaricum, 10 to 30 parts by weight of ambergris, 5 to 15 parts by weight of asarum, 5 to 15 parts by weight of aconite, 5 to 15 parts by weight of pepper and 10 to 30 parts by volume of ylang-ylang essential oil. The invention can obviously improve the erectile function of the impotence patient, in particular to the erection function of liver depression blood stasis type impotence through specific medicines and dosage. Because the preparation is inhaled, the preparation does not pass through the gastrointestinal tract, avoids liver and intestine circulation, has high safety and has practical popularization and application values.
Description
Technical Field
The invention particularly relates to a wonderful incense and a preparation method and application thereof.
Background
Impotence refers to a condition of male penile erectile dysfunction. Impotence is a common disease of middle-aged and elderly men, and has high incidence rate. The impotence, a disease, is known in the book of internal menstruation as "impotence", "flaccidity of tendons", "disuse of yin organs", etc. The word "impotence" can be explained as "impotence and weak yang" especially under the guidance of the theory of yang deficiency and impotence in traditional Chinese medicine, so that the doctor always treats impotence from warming kidney and strengthening yang, and the patient has preference for kidney-warming yang-tonifying drugs. However, yang-strengthening herbs are often used in clinic to cause impotence.
The impotence not only causes pain and trouble to the patient, but also can cause family rupture to become a social problem. Thus, the treatment of impotence is currently an important medical research topic. In recent years, traditional Chinese medicine has accumulated a lot of therapeutic experience in treating impotence. Patent CN202010322873.X discloses a navel Chinese medicinal patch for treating impotence and premature ejaculation, which has the curative effect of treating the impotence, but the traditional Chinese medicinal patch is not specific because of the formula differentiation according to the basic theory of the traditional Chinese medicine, so that patients cannot accurately take medicines, the impotence is easy to occur due to yang strengthening, and the traditional Chinese medicinal patch has more medicinal flavors and high cost and is not beneficial to popularization and application.
The traditional Chinese medicine considers that the impotence is closely related to liver depression, and a traditional Chinese medicine composition mainly used for soothing liver and relieving depression for treating the impotence in a targeted manner is necessary to be developed.
Disclosure of Invention
In order to solve the problems, the invention provides a composition for assisting in treating impotence, which is prepared from the following raw materials in parts by weight:
0.1 to 1 part by weight of musk, 20 to 40 parts by weight of cynomorium songaricum, 10 to 30 parts by weight of ambergris, 5 to 15 parts by weight of asarum, 5 to 15 parts by weight of aconite, 5 to 15 parts by weight of pepper and 10 to 30 parts by volume of ylang-ylang essential oil.
Further, the material is prepared from the following raw materials in parts by weight:
0.5 part of musk, 30 parts of cynomorium songaricum, 20 parts of ambergris, 10 parts of asarum, 10 parts of aconite, 10 parts of pepper, and 20 parts of orchid essential oil.
Further, it is a preparation prepared by taking powder of raw materials or water or organic solvent extract of raw materials as an active ingredient and adding pharmaceutically acceptable auxiliary materials.
Further, the preparation is an external preparation; the external preparation is an inhalation preparation; the inhalation formulation comprises a liquid or solid incense.
The invention also provides a preparation method of the composition, which comprises the following steps:
1) Weighing the raw materials according to the proportion;
2) Pulverizing Moschus, herba Cynomorii, ambergris, herba asari, radix Aconiti and fructus Zanthoxyli, adding essential oil of flos ylanicae to obtain incense stick, and drying.
Further, the length of the joss sticks is 5-15 cm, and the diameter is 0.1-1 cm.
The invention also provides application of the composition in preparing a medicament for assisting in treating impotence.
Further, the mass ratio of the composition to the wanbi is 8-9 g:50mg.
The invention finally provides an application of the composition in combination with the wanai in preparing a medicine for treating impotence.
Further, the medicine is a medicine for assisting in treating liver depression and blood stasis type impotence.
Still further, the medicament is a medicament that improves erectile function.
The ratio of the weight parts to the volume parts is g/ml.
The ylang flower essential oil is flowers of ylang (Cananga odorta (lam.) Hook.f. & Thomson) of the Annonaceae ylang genus, and is extracted by a distillation method.
The musk is used as a monarch, estrus activity is promoted, the mind is active, the burst enthusiasm is promoted, the cynomorium songaricum is used for strengthening yang and thickening, ambergris powder is used for aromatizing qi, the ylang flowers are warm and pleasant, the qi and blood are promoted to gather in external genitalia, the musk is persistent and not scattered, the asarum and the aconitum are used for warming spleen and kidney Yang Huo, the sexual desire is promoted, the Chinese prickly ash is used for guiding medicine downwards, and the effects of promoting emotion and thickening yin are achieved by the whole formula.
The solid incense agent prepared by the composition, namely the five wonderful incense, can obviously improve the erectile function of the impotence patient, in particular the erection function of liver depression and blood stasis type impotence through specific medicines and dosage. Because the preparation is inhaled, the preparation does not pass through the gastrointestinal tract, avoids liver and intestine circulation, has high safety and has practical popularization and application values.
It should be apparent that, in light of the foregoing, various modifications, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
The above-described aspects of the present invention will be described in further detail below with reference to specific embodiments in the form of examples. It should not be understood that the scope of the above subject matter of the present invention is limited to the following examples only. All techniques implemented based on the above description of the invention are within the scope of the invention.
Detailed Description
The materials used in the embodiments of the present invention are all commercially available.
Example 1 preparation of the drug of the invention, wumiaoxiang
The formula comprises the following components: musk 0.5g, cynomorium songaricum 30g, ambergris powder 20g, asarum herb 10g, aconite 10g, pricklyash peel 10g and ylang-ylang flower essential oil 20ml.
The preparation method comprises the following steps:
1) Weighing the raw materials according to the proportion;
2) Pulverizing Moschus, herba Cynomorii, ambergris, herba asari, radix Aconiti and fructus Zanthoxyli into powder, adding ylang flower essential oil, rubbing into 10cm long, 0.4cm diameter line incense, and drying in shade to obtain 10 pieces of five wonderful incense (each weight is 8-9 g);
the using method comprises the following steps: when needed, the five wonderful incense is burnt and inhaled.
EXAMPLE 2 preparation of the drug of the invention-Wumiaoxiang
The formula comprises the following components: 1g of musk, 40g of cynomorium songaricum, 30g of ambergris powder, 15g of asarum, 15g of aconite, 15g of pepper and 30ml of ylang-ylang essential oil.
The preparation method comprises the following steps: pulverizing Moschus, herba Cynomorii, ambergris, herba asari, radix Aconiti and fructus Zanthoxyli into powder, adding ylang flower essential oil, rubbing into 10cm long, 0.4cm diameter line incense, and drying in shade.
The using method comprises the following steps: when needed, the five wonderful incense is burnt and inhaled.
EXAMPLE 3 preparation of the drug of the invention-Wumiaoxiang
The formula comprises the following components: musk 0.1g, cynomorium songaricum 20g, ambergris 10g, asarum herb 5g, aconite 5g, pricklyash peel 5g and ylang-ylang flower essential oil 10ml.
The preparation method comprises the following steps: pulverizing Moschus, herba Cynomorii, ambergris, herba asari, radix Aconiti and fructus Zanthoxyli into powder, adding ylang flower essential oil, rubbing into 10cm long, 0.4cm diameter line incense, and drying in shade.
The using method comprises the following steps: when needed, the five wonderful incense is burnt and inhaled.
The advantageous effects of the present invention are described below by way of test examples.
Test example 1 clinical study
1.1 general data
The selected patients are all the patients with the symptoms of liver depression and blood stasis type impotence (liver failure and diarrhea in traditional Chinese medicine differentiation, qi movement disorder, qi stagnation and blood stasis, and malnutrition of the tendons and the impotent, which are clinically manifested by depression of the rare language, fullness and distention of the chest and rib, pain of the testis or the lower abdomen, wiry and unsmooth pulse, dark purple tongue or ecchymosis at the edge) which are confirmed by the traditional Chinese medicine hospitals in south-fill city of the three-dimensional hospitals, wherein 22 patients in the observation group have the disease course of 6-12 months, the average disease course (15.34+/-2.68) for months, the age of 22-48 years, the average age (34.45 +/-9.67) for years, 22 patients in the control group have the disease course of 6-12 months, the average disease course (15.98+/-2.45) for months, the age of 26-46 years and the average age (37.05 +/-9.98) for years. The male international erection function scores of the selected patients are all below 22 points, the compliance of the patients is good, no history of mental diseases exists, the basic communication capability is provided, and all the patients and families agree with the study. The selected patients have no endocrine system diseases or allergic reactions to the drugs used in the treatment.
1.2 method
Patients in the control group are treated conventionally, 50mg of Wankui (Coprinus pharmaceutical Co., ltd., national drug standard H20020527) each time is taken within 0.5-4 hours before sexual activity; the patients in the observation group were treated with the five wonder notes prepared in example 1 on the basis of the administration of the patients in the control group. Two groups of patients were continuously administered for 4 weeks, the international erectile function score of the patients was evaluated, and the cure rate of the patients was counted.
1.3 efficacy observation index
Evaluating the treatment effect of the patient according to the guidelines of clinical study of new traditional Chinese medicine, and curing: within 3 months, the patient has a penis erection angle of more than 90 degrees, and the success rate of intercourse is more than 75 percent, and the effect is obvious: within approximately 3 months of the patient, the penile erection angle is less than or equal to 90 °, there is less than 75% to more than 50% success rate in intercourse opportunities, and no efficacy: little or no improvement in erectile function is achieved and sexual activity is difficult to accomplish.
And after the medicine taking is finished, carrying out follow-up investigation on the patient, measuring the recovery condition of the patient every month, evaluating the final effect, taking the average value of three detection results, and counting the treatment effect of the patient within 3 months. Patients were evaluated for international erectile function scores before and after treatment, and differences between the two groups after treatment were compared.
1.4 statistical methods
All data were statistically analyzed using SPSS20.0 software, with metering data (x- + -s) indicated, t-test, counting data (%) indicated, χ indicated 2 The difference is statistically significant when P < 0.05 is detected.
2 results
2.1 therapeutic effects of two groups of patients have a certain recovery of erectile function after intervention treatment, wherein the cure rate of the patients in the observation group is 77.27% and the cure rate of the patients in the control group is 40.90%.
2.2 International erectile function scoring status for two groups of patients
The patients had improved international erectile function scores after treatment, with the observed group of patients having a score of (23.01.+ -. 1.78) and the control group of patients having a score of (18.67.+ -. 1.29).
In conclusion, the solid incense prepared from the composition can obviously improve the erectile function of patients with liver depression and blood stasis type impotence. Because the preparation is inhaled, the preparation does not pass through the gastrointestinal tract, avoids liver and intestine circulation, has high safety and has practical popularization and application values.
Claims (10)
1. A composition for the adjuvant treatment of impotence, characterized in that: the material is prepared from the following raw materials in parts by weight:
0.1 to 1 part by weight of musk, 20 to 40 parts by weight of cynomorium songaricum, 10 to 30 parts by weight of ambergris, 5 to 15 parts by weight of asarum, 5 to 15 parts by weight of aconite, 5 to 15 parts by weight of pepper and 10 to 30 parts by volume of ylang-ylang essential oil.
2. The composition of claim 1, wherein: the material is prepared from the following raw materials in parts by weight:
0.5 part of musk, 30 parts of cynomorium songaricum, 20 parts of ambergris, 10 parts of asarum, 10 parts of aconite, 10 parts of pepper, and 20 parts of orchid essential oil.
3. Composition according to claim 1 or 2, characterized in that: the preparation is prepared by taking powder of raw materials or water or organic solvent extracts of raw materials as active ingredients and adding pharmaceutically acceptable auxiliary materials.
4. A composition according to claim 3, characterized in that: the preparation is an external preparation; the external preparation is an inhalation preparation; the inhalation formulation comprises a liquid or solid incense.
5. A process for the preparation of a composition as claimed in any one of claims 1 to 4, characterized in that: it comprises the following steps:
1) Weighing the raw materials according to the proportion;
2) Pulverizing Moschus, herba Cynomorii, ambergris, herba asari, radix Aconiti and fructus Zanthoxyli, adding essential oil of flos ylanicae to obtain incense stick, and drying.
6. The composition of claim 5, wherein: the length of the joss sticks is 5-15 cm, and the diameter is 0.1-1 cm.
7. Use of a composition according to any one of claims 1 to 4 in the manufacture of a medicament for the adjuvant treatment of impotence.
8. Use of a composition according to any one of claims 1 to 4 in combination with vanguard in the manufacture of a medicament for the treatment of impotence, characterized in that: the mass ratio of the composition to the vannamei is 8-9 g:50mg.
9. Use according to claim 7 or 8, characterized in that: the medicine is a medicine for assisting in treating liver depression and blood stasis type impotence.
10. Use according to claim 9, characterized in that: the medicine is a medicine for improving erection function.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311712564.3A CN117599122A (en) | 2023-12-13 | 2023-12-13 | Five-wonderful incense and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311712564.3A CN117599122A (en) | 2023-12-13 | 2023-12-13 | Five-wonderful incense and preparation method and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN117599122A true CN117599122A (en) | 2024-02-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311712564.3A Pending CN117599122A (en) | 2023-12-13 | 2023-12-13 | Five-wonderful incense and preparation method and application thereof |
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| Country | Link |
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