CN115624510B - Whitening essence and preparation method thereof - Google Patents
Whitening essence and preparation method thereof Download PDFInfo
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- CN115624510B CN115624510B CN202211093789.0A CN202211093789A CN115624510B CN 115624510 B CN115624510 B CN 115624510B CN 202211093789 A CN202211093789 A CN 202211093789A CN 115624510 B CN115624510 B CN 115624510B
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- whitening
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- transdermal absorption
- essence
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- 238000002360 preparation method Methods 0.000 title claims abstract description 46
- 239000000203 mixture Substances 0.000 claims abstract description 33
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
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- 238000000034 method Methods 0.000 claims abstract description 13
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Cosmetics (AREA)
Abstract
The invention provides a whitening essence and a preparation method thereof, which belong to the technical field of cosmetics and are prepared from the following raw materials: a pH regulator, a humectant, a plant whitening composition, a chelating agent, a natural preservative, an emollient, an emulsifier, a thickener, a transdermal absorption enhancer and water. The preparation method of the whitening skin care essence provided by the invention has the advantages of easily obtained raw materials, low cost and simple method, and is easy to realize industrial production. The traditional preparation method of the essence liquid comprises the steps of firstly heating a system, thereby improving the solubility of each component, then reducing the temperature of the system, and then subpackaging and blending. In the preparation process of the whitening essence, heating treatment is not needed, the material structure of the active components is not damaged, and meanwhile, the simplified preparation method is better in effect and has a wide application prospect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a whitening essence and a preparation method thereof.
Background
Asian women generally belong to yellowish myoma, but traditional culture promotes fair skin color, so whitening essence becomes necessary care product for various manufacturers and many young women.
The principle of the whitening product is mainly to inhibit tyrosinase of human body to control the formation of melanin. The types of whitening cosmetics in the market are increasing, but a certain whitening effect can be achieved in a short period of time when the cosmetics are used, but the skin can have certain dependence on the effect, and once the cosmetics are not used, the skin can become dull and grow a lot of spots. The use of cosmetics containing heavy metals also causes certain side effects on the skin.
Skin aging is mainly in the form of natural aging (i.e., endogenous aging) and photoaging (i.e., exogenous aging), and natural aging is mainly caused by genetic factors of the body, is limited to the whole body part, is obviously characterized by wrinkles and laxity, and has pigmentation and other phenomena. Photoaging is mainly skin aging caused by accumulation of ultraviolet damage, is the result of combined action of natural aging and ultraviolet irradiation, is limited to exposed parts of skin, and is mainly characterized by rough and matt skin, thickening and deepening of roughness, deepening of pigmentation, deterioration of skin microcirculation, deformation of elastic tissues, and the phenomena of skin surface such as scavenging capacity, collagen and elastin synthesis capacity and immunity decline, thinning of dermis thickness, easy occurrence of allergic inflammation and the like.
Chinese herbal medicines have been used for thousands of years for treating and caring for various skin diseases. In recent years, due to the doubt about the toxicity and irritation of chemical cosmetics, more and more scientific researchers tend to find safe and efficient whitening active substances from natural plants.
CN104013563a discloses a freckle-removing and whitening essence and a preparation method thereof, wherein the freckle-removing and whitening essence composition comprises the following components: deionized water, rose hydrosol, lavender hydrosol, lemon extract, osmanthus fragrans extract, tomato juice, lily extract, pearl powder, honey, collagen, polyglutamic acid and carbomer.
CN106726884a discloses a freckle-removing and whitening essence, which is mainly prepared from the following raw materials: grape seed extract, carbomer, hyaluronic acid, lavender essential oil, rose essential oil, banana leaf extract, mulberry leaf extract, calendula extract, pearl powder, avocado extract, lecithin, rhodiola rosea extract, silk fibroin, a traditional Chinese medicine composition, polyglutamic acid and deionized water, wherein the raw materials of the traditional Chinese medicine composition comprise: astragalus root, lily bulb, ligusticum wallichii, dahurian angelica root, magnolia bark, fleece-flower root, peppermint, albizia flower and matrimony vine.
CN105878109a discloses a whitening and freckle-removing essence containing jasmine essential oil, and the main raw materials of the essence comprise: jasmine essential oil, aloe extract, ginkgo leaf extract, licorice extract, trehalose, betaine, green source acid and deionized water. However, the effect is not ideal by adding plant components as main whitening components only to the whitening and freckle removing products.
Disclosure of Invention
The invention aims to provide a whitening essence and a preparation method thereof, wherein raw materials are easy to obtain, the cost is low, and the method is simple and easy to realize industrial production. The traditional preparation method of the essence liquid comprises the steps of firstly heating a system, thereby improving the solubility of each component, then reducing the temperature of the system, and then subpackaging and blending. In the preparation process of the whitening essence, heating treatment is not needed, the material structure of the active components is not damaged, and meanwhile, the simplified preparation method is better in effect and has a wide application prospect.
The technical scheme of the invention is realized as follows:
the invention provides a whitening essence which is prepared from the following raw materials: a pH adjuster, a humectant, a plant whitening composition, a chelating agent, a natural preservative, an emollient, an emulsifier, a thickener, a transdermal absorption enhancer, and water;
wherein the structure of the transdermal absorption promoter is shown as formula I:
as a further improvement of the invention, the invention is prepared from the following raw materials in parts by weight: 0.1-2 parts of pH regulator, 5-10 parts of humectant, 7-12 parts of plant whitening composition, 0.01-0.1 part of chelating agent, 0.1-1 part of natural preservative, 0.5-1 part of emollient, 1-2 parts of emulsifier, 0.2-0.8 part of thickener, 0.5-1 part of transdermal absorption enhancer and 70-100 parts of water.
As a further improvement of the present invention, the method for preparing the percutaneous absorption promoter comprises the following steps:
s1, enabling pentaerythritol and thionyl chloride to react to obtain an intermediate A, wherein the structure is as follows:
s2, reacting the intermediate A with azepin-2-ketone to obtain the transdermal absorption accelerator.
As a further improvement of the invention, the reaction temperature in the step S1 is 0-4 ℃ and the reaction time is 30-50min; the ratio of the mass of the pentaerythritol to the mass of the thionyl chloride is 1:4-4-2.
As a further improvement of the invention, the azepan-2-one in step S2 is firstly reacted with sodium hydride for 0.5 to 1 hour, then an intermediate A is added, and the reaction is continued for 12 to 15 hours; the ratio of the amounts of the azepan-2-one, sodium hydride and intermediate A is 4-4.1:5-7:1.
As a further improvement of the present invention, the preparation method of the percutaneous absorption promoter specifically comprises the following steps:
s1, dissolving 1mol of pentaerythritol in 50mL of dichloromethane, keeping the temperature of the system at 0-4 ℃, dissolving 4-4.2mol of thionyl chloride in 20mL of dichloromethane, dropwise adding the mixture into the system, carrying out heat preservation reaction for 30-50min, filtering, washing and drying to obtain an intermediate A;
s2, dissolving 4-4.1mol of azepine-2-one and 5-7mol of sodium hydride in 100mL of dichloromethane, carrying out reflux reaction for 0.5-1h, adding 1mol of intermediate A, continuing to carry out heat preservation and stirring reaction for 12-15h, filtering, washing and drying to obtain the transdermal absorption accelerator.
As a further improvement of the present invention, the preparation method of the plant whitening composition is as follows: peeling fructus Actinidiae chinensis, mixing with radix Dauci Sativae, fructus Citri Limoniae and fructus Cucumidis Sativi, squeezing to obtain juice, performing enzymolysis with ficin and pectase, inactivating enzyme, and concentrating to obtain plant whitening composition; the mass ratio of the ficin to the pectase is 3-5:7.
as a further improvement of the present invention, the pH adjuster is at least one selected from the group consisting of citric acid, potassium citrate, lactic acid, tartaric acid, fumaric acid, and trisodium bicarbonate; the humectant is selected from at least one of butanediol, propylene glycol and glycerol; the chelating agent is at least one selected from disodium EDTA and EDTA; the natural preservative is at least one selected from tea polyphenol, catechin, vitamin C and resveratrol; the emollient is at least one selected from myristic acid bean ester, caprylic acid octyl ester, oleyl oleate, hexyl laurate, isopropyl palmitate, PEG-6 caprylic/capric triglyceride, PEG-60 corn oil glycerol mixed ester, PEG-7 olive oleate, lauryl alcohol, oleyl alcohol, octyl dodecanol and hexyl decyl alcohol; the thickener is at least one selected from methylcellulose, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, hydroxyethyl cellulose, gelatin, sodium alginate, casein, guar gum, chitosan, gum arabic, xanthan gum and soybean protein gum; the emulsifier is at least one of Tween-80, carbomer and span-80.
The invention further provides a preparation method of the whitening essence, which comprises the following steps:
(1) Dissolving humectant, plant whitening composition, chelating agent and natural antiseptic in water, stirring for 15-20min to obtain phase A;
(2) Mixing the emollient, the transdermal absorption enhancer and the thickener, and stirring for 15-20min to obtain phase B;
(3) Mixing the phase A and the phase B, adding the pH regulator and the emulsifier, stirring and mixing for 30-50min, and discharging to obtain the whitening essence.
As a further improvement of the invention, the stirring speed is 500-1000r/min.
The invention has the following beneficial effects: the invention prepares a new transdermal absorption promoter, 4 molecules of azone are integrated on a molecular structure, so that the transdermal absorption promoter of the unit substance amount can further improve the efficiency of the active substance entering the skin, promote the skin to efficiently absorb the active substance, and play a better role in promoting whitening;
the plant whitening composition is prepared from kiwi fruits, carrots, lemon and cucumber, the prepared composition contains various vitamins, trace elements, antioxidant phenols and flavonoid substances, has the effects of whitening and removing freckles and inhibiting melanin formation, has main beauty effects of brightening skin, removing freckles, moisturizing skin, resisting skin aging and the like, and fruits such as lemon contain fruit acid components, can soften horny layers and enable the horny layers to fall off to achieve the effect of whitening and tendering the skin, but the attention is paid to the consumption of the whitening raw materials rich in the fruit acid components when the whitening raw materials are used, the skin is seriously fallen off due to the fact that the fruit acid content is too high, so that skin problems such as skin allergy and red swelling are caused, and the whitening and anti-aging effects of the essence can be obviously improved when the whitening essence is added;
the preparation method of the whitening skin care essence provided by the invention has the advantages of easily obtained raw materials, low cost and simple method, and is easy to realize industrial production. The traditional preparation method of the essence liquid comprises the steps of firstly heating a system, thereby improving the solubility of each component, then reducing the temperature of the system, and then subpackaging and blending. In the preparation process of the whitening essence, heating treatment is not needed, the material structure of the active components is not damaged, and meanwhile, the simplified preparation method is better in effect and has a wide application prospect.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Preparation example 1 preparation of transdermal absorption enhancer
The synthetic route is as follows:
the method comprises the following steps:
s1, dissolving 1mol of pentaerythritol in 50mL of dichloromethane, keeping the temperature of the system at 0 ℃, dissolving 4mol of thionyl chloride in 20mL of dichloromethane, dropwise adding the mixture into the system, carrying out heat preservation reaction for 30min, filtering, washing and drying to obtain an intermediate A;
s2, dissolving 4mol of azepan-2-one and 5mol of sodium hydride in 100mL of dichloromethane, carrying out reflux reaction for 0.5h, adding 1mol of intermediate A, continuing to carry out heat preservation and stirring reaction for 12h, filtering, washing and drying to obtain the transdermal absorption accelerator.
Preparation example 2 preparation of transdermal absorption enhancer
The method comprises the following steps:
s1, dissolving 1mol of pentaerythritol in 50mL of dichloromethane, keeping the temperature of the system at 4 ℃, dissolving 4.2mol of thionyl chloride in 20mL of dichloromethane, dropwise adding the mixture into the system, carrying out heat preservation reaction for 50min, filtering, washing and drying to obtain an intermediate A;
s2, dissolving 4.1mol of azepin-2-one and 7mol of sodium hydride in 100mL of dichloromethane, carrying out reflux reaction for 1h, adding 1mol of intermediate A, continuing to carry out heat preservation and stirring reaction for 15h, filtering, washing and drying to obtain the transdermal absorption accelerator.
PREPARATION EXAMPLE 3 preparation of transdermal absorption enhancer
The method comprises the following steps:
s1, dissolving 1mol of pentaerythritol in 50mL of dichloromethane, keeping the temperature of the system at 2 ℃, dissolving 4.1mol of thionyl chloride in 20mL of dichloromethane, dropwise adding the mixture into the system, carrying out heat preservation reaction for 40min, filtering, washing and drying to obtain an intermediate A;
s2, dissolving 4.05mol of azepin-2-one and 5-7mol of sodium hydride in 100mL of dichloromethane, carrying out reflux reaction for 1h, adding 1mol of intermediate A, continuing to carry out heat preservation and stirring reaction for 13.5h, filtering, washing and drying to obtain the transdermal absorption accelerator.
PREPARATION EXAMPLE 4 preparation of plant whitening composition
The method comprises the following steps: peeling 3-5 parts by weight of kiwi fruits, mixing with 1 part by weight of carrots, 0.5 part by weight of lemon and 2 parts by weight of cucumber, squeezing, adding 0.3 part by weight of ficin and 0.7 part by weight of pectase for enzymolysis, inactivating enzymes by ultraviolet rays, and concentrating until the relative density is 1.3 to obtain the plant whitening composition.
PREPARATION EXAMPLE 5 preparation of plant whitening composition
The method comprises the following steps: peeling 5 parts by weight of kiwi fruits, mixing with 3 parts by weight of carrots, 1 part by weight of lemon and 2-4 parts by weight of cucumber, squeezing, adding 0.5 part by weight of ficin and 0.7 part by weight of pectase for enzymolysis, inactivating enzyme by ultraviolet rays, and concentrating until the relative density is 1.5 to obtain the plant whitening composition.
PREPARATION EXAMPLE 6 preparation of plant whitening composition
The method comprises the following steps: peeling 4 parts by weight of kiwi fruits, mixing with 2 parts by weight of carrots, 0.7 part by weight of lemon and 3 parts by weight of cucumber, squeezing, adding 0.4 part by weight of ficin and 0.7 part by weight of pectase for enzymolysis, inactivating enzyme by ultraviolet rays, and concentrating until the relative density is 1.4 to obtain the plant whitening composition.
Example 1 whitening essence
The raw materials comprise the following components in parts by weight: 0.1 part of potassium citrate, 5 parts of glycerin, 7 parts of the plant whitening composition prepared in preparation example 4, 0.01 part of EDTA disodium, 0.1 part of catechin, 0.5 part of PEG-60 corn oil glycerin mixed ester, 80-80 parts of span, 0.2 part of sodium carboxymethyl cellulose, 0.5 part of the transdermal absorption promoter prepared in preparation example 1 and 70 parts of water.
The preparation method comprises the following steps:
(1) Dissolving glycerol, plant whitening composition, EDTA disodium and catechin in water, and stirring for 15min at 500r/min to obtain phase A;
(2) Mixing PEG-60 corn oil glycerol mixed ester, transdermal absorption promoter and sodium carboxymethylcellulose, and stirring for 15min at 500r/min to obtain phase B;
(3) Mixing the phase A and the phase B, adding potassium citrate and span-80, stirring and mixing for 30min at 500r/min, and discharging to obtain the whitening essence.
Example 2 whitening essence
The raw materials comprise the following components in parts by weight: 2 parts of tartaric acid, 10 parts of propylene glycol, 12 parts of the plant whitening composition prepared in preparation example 5, 0.1 part of EDTA disodium, 1 part of resveratrol, 1 part of hexyl laurate, 2 parts of carbomer, 0.8 part of hydroxypropyl methyl cellulose, 1 part of the transdermal absorption enhancer prepared in preparation example 2 and 100 parts of water.
The preparation method comprises the following steps:
(2) Dissolving propylene glycol, plant whitening composition, EDTA disodium and resveratrol in water, stirring at 1000r/min for 20min to obtain phase A;
(2) Mixing hexyl laurate, transdermal absorption promoter and hydroxypropyl methylcellulose, and stirring at 1000r/min for 20min to obtain phase B;
(3) Mixing the phase A and the phase B, adding tartaric acid and carbomer, stirring and mixing for 50min at 1000r/min, and discharging to obtain the whitening essence.
Example 3 whitening essence
The raw materials comprise the following components in parts by weight: 1 part of citric acid, 7 parts of butanediol, 10 parts of the plant whitening composition prepared in preparation example 6, 0.05 part of EDTA disodium, 0.5 part of vitamin C, 0.7 part of myristate, 1.5 parts of emulsifier, 0.5 part of sodium alginate, 0.7 part of transdermal absorption accelerator prepared in preparation example 3 and 85 parts of water.
The preparation method comprises the following steps:
(3) Dissolving butanediol, plant whitening composition, EDTA disodium and vitamin C in water, and stirring at 700r/min for 17min to obtain phase A;
(2) Mixing myristate, transdermal absorption promoter and sodium alginate, and stirring at 700r/min for 17min to obtain phase B;
(3) Mixing the phase A and the phase B, adding citric acid and an emulsifier, stirring and mixing for 40min at 700r/min, and discharging to obtain the whitening essence.
Comparative example 1
In comparison with example 3, the transdermal absorption enhancer prepared in preparation 3 was not added, and the other conditions were not changed.
Comparative example 2
In comparison with example 3, the plant whitening composition prepared in preparation example 6 was not added, and the other conditions were not changed.
Test example 1
The capacitance method is used for measuring the moisture content of the skin horny layer of a human body, the dielectric constants of the skin horny layer and other substances are obviously different, the capacitance value of the skin is different according to the difference of the moisture content of the skin horny layer, and the parameters can represent the moisture content of the skin.
100 testers 18-35 years old were randomly selected and divided into 5 groups of 20. The whitening essences prepared in examples 1-3 and comparative examples 1-2 were used by 5 groups of testers once a day in the morning and evening for 30 days.
Skin moisture content was measured with a skin moisture content tester on days 0 and 30, and the moisture content of the skin before and after the use of the whitening essence was evaluated.
The results are shown in Table 1.
TABLE 1
Group of | Day 0 moisture content (%) | Day 30 moisture content (%) | Moisture content increase Rate (%) |
Example 1 | 24.5 | 32.4 | 32.2 |
Example 2 | 25.2 | 33.5 | 32.9 |
Example 3 | 24.7 | 33.6 | 36.0 |
Comparative example 1 | 24.4 | 28.9 | 18.4 |
Comparative example 2 | 24.9 | 26.4 | 6.0 |
As can be seen from Table 1, the skin moisture content of the whitening essence prepared in examples 1 to 3 of the present invention was remarkably improved after 30 days, which indicates that the whitening essence of the present invention has good moisturizing effect.
Test example 2
Principle of skin melanin and heme test: mexameter MX18 is based on the principle of spectral absorption (RGB) and determines the melanin and heme content of the skin by measuring the amount of reflection of light of a specific wavelength upon the skin of a human. The emitter of the instrument probe emits light with three wavelengths of 568nm, 660nm and 880nm to the skin surface, and the receiver measures the reflected light of the skin. Since the amount of emitted light is constant, the amount of light absorbed by the skin can be measured, and the skin melanin and heme content can be measured. The measurement range of the instrument is 0-999, and the higher the measurement value is, the higher the melanin and heme content in the skin is.
100 trials 19-37 years old were randomly selected and divided into 5 groups of 20 trials each. The whitening essences prepared in examples 1-3 and comparative examples 1-2 were used by 5 groups of testers once a day in the morning and evening for 30 days.
Before the test part is smeared with the sample, the test part is cleaned, dried and smeared with the sample. The left and right arm cheeks of the subject were sequentially labeled: areas of 4 x 4cm size were used as test and blank control areas; the subjects used the test article twice in the experimental area at 8 a day and 8 a day at night, the blank control area used clear water, and the subjects could not apply any other cosmetics at the experimental part during the experiment. After the subject used the test substance continuously for week 0 and week four, the subject washed the smeared parts at the same time, and the content of the smeared parts was measured using a Mexameter MX18 tester and a MicroSkin II multifunctional dermoscope image analysis system. Five measurements were taken at each point and averaged. The results are shown in Table 2.
Melanin reduction rate (%) = [ this first melanin content (%) -first melanin content (%) ] first melanin content (%) 100%
Table 2 comparison of test results for each group
As shown in Table 1, the melanin content of the whitening essence prepared in the embodiments 1-3 is reduced after four applications, and the melanin content reduction rate of the embodiments 1-3 is obviously better than that of the comparative embodiments 1-2, and the melanin reduction rate reaches 49%, so that the whitening essence has a good whitening effect.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (5)
1. The whitening essence is characterized by being prepared from the following raw materials in parts by weight: 0.1-2 parts of pH regulator, 5-10 parts of humectant, 7-12 parts of plant whitening composition, 0.01-0.1 part of chelating agent, 0.1-1 part of natural preservative, 0.5-1 part of emollient, 1-2 parts of emulsifier, 0.2-0.8 part of thickener, 0.5-1 part of transdermal absorption enhancer and 70-100 parts of water;
wherein the structure of the transdermal absorption promoter is shown as formula I:
the preparation method of the plant whitening composition comprises the following steps: peeling fructus Actinidiae chinensis, mixing with radix Dauci Sativae, fructus Citri Limoniae and fructus Cucumidis Sativi, squeezing to obtain juice, performing enzymolysis with ficin and pectase, inactivating enzyme, and concentrating to obtain plant whitening composition; the mass ratio of the ficin to the pectase is 3-5:7, preparing a base material;
the preparation method of the transdermal absorption promoter comprises the following steps:
s1, enabling pentaerythritol and thionyl chloride to react to obtain an intermediate A, wherein the structure is as follows:the reaction temperature is 0-4 ℃ and the reaction time is 30-50min; the ratio of the mass of the pentaerythritol to the mass of the thionyl chloride is 1:4-4-2;
s2, reacting the intermediate A with azepin-2-ketone to obtain a transdermal absorption accelerator; firstly, reacting the azepin-2-ketone with sodium hydride for 0.5-1h, then adding an intermediate A, and continuing to react for 12-15h; the ratio of the amounts of the azepan-2-one, sodium hydride and intermediate A is 4-4.1:5-7:1.
2. The whitening essence according to claim 1, wherein the preparation method of the percutaneous absorption promoter comprises the following specific steps:
s1, dissolving 1mol of pentaerythritol in 50mL of dichloromethane, keeping the temperature of the system at 0-4 ℃, dissolving 4-4.2mol of thionyl chloride in 20mL of dichloromethane, dropwise adding the mixture into the system, carrying out heat preservation reaction for 30-50min, filtering, washing and drying to obtain an intermediate A;
s2, dissolving 4-4.1mol of azepine-2-one and 5-7mol of sodium hydride in 100mL of dichloromethane, carrying out reflux reaction for 0.5-1h, adding 1mol of intermediate A, continuing to carry out heat preservation and stirring reaction for 12-15h, filtering, washing and drying to obtain the transdermal absorption accelerator.
3. The whitening essence according to claim 1, wherein the pH adjustor is at least one selected from the group consisting of citric acid, potassium citrate, lactic acid, tartaric acid, fumaric acid, and trisodium bicarbonate; the humectant is selected from at least one of butanediol, propylene glycol and glycerol; the chelating agent is at least one selected from disodium EDTA and EDTA; the natural preservative is at least one selected from tea polyphenol, catechin, vitamin C and resveratrol; the emollient is at least one selected from myristic acid bean ester, caprylic acid octyl ester, oleyl oleate, hexyl laurate, isopropyl palmitate, PEG-6 caprylic/capric triglyceride, PEG-60 corn oil glycerol mixed ester, PEG-7 olive oleate, lauryl alcohol, oleyl alcohol, octyl dodecanol and hexyl decyl alcohol; the thickener is at least one selected from methylcellulose, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, hydroxyethyl cellulose, gelatin, sodium alginate, casein, guar gum, chitosan, gum arabic, xanthan gum and soybean protein gum; the emulsifier is at least one of Tween-80, carbomer and span-80.
4. A method for preparing the whitening essence according to any one of claims 1 to 3, comprising the steps of:
(1) Dissolving humectant, plant whitening composition, chelating agent and natural antiseptic in water, stirring for 15-20min to obtain phase A;
(2) Mixing the emollient, the transdermal absorption enhancer and the thickener, and stirring for 15-20min to obtain phase B;
(3) Mixing the phase A and the phase B, adding the pH regulator and the emulsifier, stirring and mixing for 30-50min, and discharging to obtain the whitening essence.
5. The method according to claim 4, wherein the stirring speed is 500-1000r/min.
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