CN115607749A - 用于全植入式人工耳蜗生物相容性的材料结构与制备 - Google Patents
用于全植入式人工耳蜗生物相容性的材料结构与制备 Download PDFInfo
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- 239000000463 material Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 210000003477 cochlea Anatomy 0.000 title claims abstract description 10
- 238000002513 implantation Methods 0.000 title description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract description 24
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000138 intercalating agent Substances 0.000 claims abstract description 9
- 238000009210 therapy by ultrasound Methods 0.000 claims abstract description 8
- 238000009830 intercalation Methods 0.000 claims abstract description 7
- 239000010410 layer Substances 0.000 claims abstract description 7
- 229910009818 Ti3AlC2 Inorganic materials 0.000 claims abstract description 5
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 claims abstract description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims abstract description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000011114 ammonium hydroxide Nutrition 0.000 claims abstract description 4
- 239000007864 aqueous solution Substances 0.000 claims abstract description 4
- 239000004202 carbamide Substances 0.000 claims abstract description 4
- 238000005530 etching Methods 0.000 claims abstract description 4
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 4
- 239000002356 single layer Substances 0.000 claims abstract description 4
- 238000001039 wet etching Methods 0.000 claims abstract description 4
- 239000012954 diazonium Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- -1 aryl diazonium sodium salt Chemical class 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 3
- 150000001989 diazonium salts Chemical class 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000003313 weakening effect Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 125000000524 functional group Chemical group 0.000 abstract description 3
- 230000002687 intercalation Effects 0.000 abstract description 3
- 238000000527 sonication Methods 0.000 abstract description 3
- 239000000560 biocompatible material Substances 0.000 description 3
- 239000007943 implant Substances 0.000 description 2
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- 239000007777 multifunctional material Substances 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
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- 229910052723 transition metal Inorganic materials 0.000 description 1
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- C01—INORGANIC CHEMISTRY
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Abstract
本发明公开了用于全植入式人工耳蜗生物相容性的材料结构与制备。多层MXenes制备，采用湿法刻蚀技术，利用HF水溶液作为刻蚀剂，将MAX相Ti3AlC2中的Al刻蚀掉，制备出Ti3C2Tx；通过后续超声处理，压缩结构转换为类似“手风琴”的松散层状结构。单层MXenes制备：方法一，使用极性有机分子作为插层剂来剥离MXenes，加入插层剂后，需同时进行超声处理。所述极性有机分子插层剂为二甲基亚砜(DMSO)、二甲基甲酰胺(DMF)、水合肼(HM)、氨水、尿素中的一种或多种。MXenes具有大比表面积、高导电性、丰富的表面功能基团、良好的生物相容性。
Description
技术领域
本发明涉及人工耳蜗类医疗器械，具体为用于全植入式人工耳蜗生物相容性的材料结构与制备。
背景技术
人工耳蜗是一种有效治疗听力障碍的医疗器械，现有的部分植入式人工耳蜗一般采用的是陶瓷压电传感器，生物相容性较差且导电性能不足。二维过渡金属碳化物、氮化物和碳氮化物，也被称为MXenes，由于其可调节的结构和丰富的表面化学性质，是一种多功能材料，而且二维材料MXenes具有高导电性和生物相容性，能够更加贴合植入的传感器且效果更加显著。
发明内容
本发明针对人工耳蜗材料生物相容性差的问题，采用新的二维材料MXenes用于制作人工耳蜗传感器生物相容性材料。
本发明的设计方案如下：用于全植入式人工耳蜗生物相容性的材料结构与制备，制备方法如下：
多层MXenes制备，采用湿法刻蚀技术，利用HF水溶液作为刻蚀剂，将MAX相Ti3AlC2中的Al刻蚀掉，制备出Ti3C2Tx；通过后续超声处理，压缩结构转换为类似“手风琴”的松散层状结构。
单层MXenes制备：
方法一，使用极性有机分子作为插层剂来剥离MXenes，加入插层剂后，需同时进行超声处理。所述极性有机分子插层剂为二甲基亚砜(DMSO)、二甲基甲酰胺(DMF)、水合肼(HM)、氨水、尿素中的一种或多种。
方法二，将Ti3CNTx、V2CTx、Nb2CTx等MXenes粉体进行有机碱、TBAOH处理，使其显著膨胀，削弱MXenes层间的键合，轻微摇动5min或水中超声可获得大量MXenes单晶片；
方法三，利用芳基重氮钠盐对Ti3C2Tx进行分层，Na＋首先插层Ti3C2Tx，重氮盐缓慢插层,在0~5℃搅拌大约4小时。
MXenes材料主要用作蛋白质、生物酶、生物发光材料等的固定化基质，以利用其大比表面积、高导电性的特性，提高电子传质效率和速率，从而达到提高传感灵敏度、降低检测限的目的；生物/气体电阻传感是基于MXenes材料对外来吸附分子(生物分子或气体分子)造成的电导率扰动的灵敏性反映，而MXenes材料对外来生物分子或气体分子的吸附是基于其丰富的功能基团(主要为-OH、-F、-O、-Cl等)与这些分子之间的相互作用。
MXenes 具有大比表面积、高导电性、丰富的表面功能基团、良好的生物相容性，以及可利用各种聚合物或纳米颗粒进行表面功能化，使其可应用于精准的生物传感，应用在全植入式人工耳蜗中。
具体实施方式
下面结合具体实施例对本发明作进一步说明。此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明。
实施例：用于全植入式人工耳蜗生物相容性的材料结构与制备，
多层MXenes制备，将MAX相Ti3AlC2作为基材，采用湿法刻蚀技术，利用HF水溶液作为刻蚀剂，将MAX相Ti3AlC2中的Al刻蚀掉，制备出Ti3C2Tx；通过后续超声处理，压缩结构转换为类似“手风琴”的松散层状结构。
单层MXenes制备：
方法一，使用极性有机分子作为插层剂来剥离MXenes，加入插层剂后，需同时进行超声处理。所述极性有机分子插层剂为二甲基亚砜(DMSO)、二甲基甲酰胺(DMF)、水合肼(HM)、氨水、尿素中的一种或多种。
方法二，将Ti3CNTx、V2CTx、Nb2CTx等MXenes粉体进行有机碱、TBAOH处理，使其显著膨胀，削弱MXenes层间的键合，轻微摇动5min或水中超声可获得大量MXenes单晶片；
方法三，利用芳基重氮钠盐对Ti3C2Tx进行分层，Na＋首先插层Ti3C2Tx，重氮盐缓慢插层,在0~5℃搅拌大约4小时。
二维MXenes具有独特的平面纳米结构，而由结构决定的系列优良的物理化学性质，又给了其在传感领域中广泛应用的潜能，且具有较好的药用性能和生物相容性，能增加植入传感器的生物相容性，降低损害。
综上所述是本发明较佳的实施例，凡依本发明技术方案所做的改变，所生产的功能作用未超出本发明技术方案的范围时均属于本发明的保护范围。
Claims (2)
1.用于全植入式人工耳蜗生物相容性的材料结构与制备，其特征在于，制备方法如下：
多层MXenes制备，采用湿法刻蚀技术，利用HF水溶液作为刻蚀剂，将MAX相Ti3AlC2中的Al刻蚀掉，制备出Ti3C2Tx；通过后续超声处理，压缩结构转换为类似“手风琴” 的松散层状结构；
单层MXenes制备：方法一，使用极性有机分子作为插层剂来剥离MXenes， 加入插层剂后，需同时进行超声处理；
方法二，将Ti3CNTx、V2CTx、Nb2CTx等MXenes粉体进行有机碱、TBAOH处理，使其显著膨胀，削弱MXenes层间的键合，轻微摇动5min或水中超声可获得大量MXenes单晶片；
方法三，利用芳基重氮钠盐对Ti3C2Tx进行分层，Na＋首先插层Ti3C2Tx，重氮盐缓慢插层,在0~5℃搅拌大约4小时。
2.根据权利要求1所述的用于全植入式人工耳蜗生物相容性的材料结构与制备，其特征在于，所述极性有机分子插层剂为二甲基亚砜(DMSO)、二甲基甲酰胺(DMF)、水合肼(HM)、氨水、尿素中的一种或多种。
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108375564A (zh) * | 2017-07-03 | 2018-08-07 | 天津大学 | 自支撑层状材料MXenes的制备方法及其作为拉曼基底的应用 |
| CN109650444A (zh) * | 2019-01-22 | 2019-04-19 | 河海大学 | 一种二维层状Nb4C3Tx材料及其制备方法 |
| CN110534741A (zh) * | 2019-09-06 | 2019-12-03 | 浙江大学 | 一种少层MXenes的快速制备方法及应用 |
| CN111686585A (zh) * | 2020-06-01 | 2020-09-22 | 天津工业大学 | 一种改性聚合物膜及其制备方法和用途 |
| CN114361433A (zh) * | 2021-12-17 | 2022-04-15 | 华南理工大学 | 一种锂电池负极材料MXene及其制备方法与应用 |
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- 2022-07-07 CN CN202210792611.9A patent/CN115607749A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108375564A (zh) * | 2017-07-03 | 2018-08-07 | 天津大学 | 自支撑层状材料MXenes的制备方法及其作为拉曼基底的应用 |
| CN109650444A (zh) * | 2019-01-22 | 2019-04-19 | 河海大学 | 一种二维层状Nb4C3Tx材料及其制备方法 |
| CN110534741A (zh) * | 2019-09-06 | 2019-12-03 | 浙江大学 | 一种少层MXenes的快速制备方法及应用 |
| CN111686585A (zh) * | 2020-06-01 | 2020-09-22 | 天津工业大学 | 一种改性聚合物膜及其制备方法和用途 |
| CN114361433A (zh) * | 2021-12-17 | 2022-04-15 | 华南理工大学 | 一种锂电池负极材料MXene及其制备方法与应用 |
Non-Patent Citations (1)
| Title |
|---|
| 韩璐等编: "导电纳米复合材料", 30 November 2020, 北京：科学技术文献出版社, pages: 124 * |
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