CN115606805A - 一种后生元组合物及其在口腔健康中的应用 - Google Patents
一种后生元组合物及其在口腔健康中的应用 Download PDFInfo
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- CN115606805A CN115606805A CN202211196485.7A CN202211196485A CN115606805A CN 115606805 A CN115606805 A CN 115606805A CN 202211196485 A CN202211196485 A CN 202211196485A CN 115606805 A CN115606805 A CN 115606805A
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Abstract
本发明提供一种后生元组合物,包括:2‑25重量份的灭活型卷曲乳杆菌、5‑50重量份的酵母β‑葡聚糖、1‑10重量份的金银花粉。本发明提供的后生元组合物制备的口腔保健用品能够有效抑制口腔中的牙龈卟啉单胞菌、齿垢密螺旋体、变形链球菌,对口腔起到保护作用,具有良好的应用前景。
Description
技术领域
本发明属于口腔健康领域,具体涉及一种后生元组合物及其应用。
背景技术
健康的情况下,在口腔中定植的微生物处于动态平衡,良好的口腔微生态环境是维持口腔健康乃至人体健康的重要生物屏障,一旦平衡被打破,致病菌过度定植,就容易引起口腔微生态失衡。口腔疾病是口腔微生态失衡引起的一系列口腔问题,主要包括牙菌斑积累、龋齿、牙周炎症、口腔溃疡、口臭等,常见的口腔致病菌有变形链球菌、牙龈卟啉单胞菌、齿垢密螺旋体等。以变形链球菌为例,它能够附着在牙齿表面生长增殖,通过分泌胞外多糖形成生物膜,使普通的口腔护理难以干预破坏,它是牙菌斑的主要成分之一,另外,变形链球菌还具有产酸性和耐酸性,是口腔中主要的致龋菌,它能够快速利用口腔中不同碳水化合物,大量产酸,使局部pH降到4.5-5,所形成的生物膜同时阻隔唾液的缓冲作用,使牙齿局部长期处于酸性环境而遭到腐蚀,牙釉质被破坏,形成牙洞引起龋齿。传统的治疗方式旨在杀灭口腔中的致龋菌或其它致病菌,往往选择使用抗生素或广谱抑菌剂,然而这种治疗方式往往会进一步破坏口腔微生物环境,同时存在耐药性等问题,而且治疗效果一般,因此,使用益生菌类制剂改善或治疗口腔问题逐渐兴起。
常见的益生菌口腔解决方案主要分为两大类:1、日化产品,如含益生菌的牙膏、漱口水、牙线等;2、食品或功能食品,如含益生菌的固体饮料、口香糖、润喉糖、饮料等。这种益生菌口腔保健护理产品通常将益生菌和益生元以及某些植物提取物搭配,如金银花提取物、香蕈提取物、薄荷提取物、罗汉果提取物、甘草提取物、绿茶提取物等。
然而,此类解决方案仍存在技术缺陷,包括:1、不稳定,特别是乳酸菌属益生菌,其生产、储存条件严苛导致生产、储存成本高,否则容易在货架期受温度、湿度的影响而导致菌体失活,产品活菌数下降,使用或服用时达不到起效量;2、对配伍成分及其含量选择性高,特别是具有抑菌作用的植物提取物,需进行大量预实验确定能否配伍,否则容易导致货架期活菌数下降,或使产品最终效果受抑制;3、对剂型选择性高,考虑到稳定性和水溶性,活性益生菌产品的剂型一般以固体为主,如固体饮料,糖果、牙粉、漱口粉等,开发成液体剂型需要较高难度的配方技术和生产工艺,且一般需要更严格、更高成本的储存条件但只拥有更短的货架期;4、为确保益生菌的活性,通常选择的压片糖果、口腔含片等固体剂型会一定程度上限制产品效果的发挥,主要由于服用过程未能像液体剂型般充分地在口腔流动,使有效成分在牙齿缝隙、牙龈缝隙等各个口腔角落难以发挥作用。
申请号为CN202011368679.1的中国专利为含植物外泌体的改善口腔健康的产品,其中公开了一种改善口腔健康的产品品,包含燕窝肽、酵母β-葡聚糖、蘑菇提取物、红参、橄榄粉、红树莓浓缩汁、黑果腺肋花楸果浓缩汁、血橙浓缩汁、接骨木莓浓缩汁和罗汉果浓缩汁,还包含植物外泌体。该产品有两个剂型产品,其中改善口腔健康的含片中含有口腔健康的药食同源成分及益生菌,改善口腔健康的饮品中含有增强免疫力和富含维生素的原料,且添加益生元为益生菌提供食物,多种有益于口腔健康的物质相互协调,不仅可以改善口腔异味,而且可以改善口腔溃疡,提高免疫力。此专利功效成分既包括了酵母β-葡聚糖,又包括了益生菌,但益生菌为未经热封处理的活性益生菌,存在上述技术缺陷。另外,该专利对口腔健康改善的具体功效主要是强调其对口腔溃疡和口气的改善,未见针对常见的口腔问题(如牙菌斑积累、龋齿)的抑制效果。
申请号为CN202010849985.0的中国专利公开了用于预防和治疗口腔疾病的生物多糖及其应用。具体提供了β-葡聚糖的用途,用于制备制剂或组合物,所述制剂或组合物用于预防和/或治疗口腔疾病。所述β-葡聚糖有明显缓解和改善口腔疾病,控制口腔疾病的发生和发展的作用,可以用于制备口腔清洁用品。此专利利用特殊工艺制备不同来源的β-葡聚糖,包括裂褶菌β-葡聚糖、香菇β-葡聚糖、小核菌β-葡聚糖、灰树花β-葡聚糖、侧耳多糖、蘑菇β-葡聚糖、酵母β-葡聚糖、燕麦β-葡聚糖、或其组合,用于治疗或预防口腔疾病,改善牙菌斑、牙龈炎、牙敏感及牙齿色斑等,论证丰富,效果强大,但该专利所制得的β-葡聚糖未能吞服,削弱了产品的便利性,也未能发挥口腔之外的作用,如改善肠道功能和提高免疫力。
发明内容
为了解决上述问题,本发明以灭活型卷曲乳杆菌、酵母β-葡聚糖和金银花粉为主要成分,开发出一种用于改善口腔健康问题的可吞服组合物,应用剂型为液体、膏体或固体,即可应用于日化产品,又可应用于食品。该组合物的主要功效体现在:抑制或改善牙菌斑、预防龋齿,改善牙龈炎以及改善口臭,应用在可吞服产品时可同时起到改善肠道功能、提高免疫力的作用。
一方面,本发明提供了一种后生元组合物。
所述的后生元组合物中包括:2-25重量份的灭活型卷曲乳杆菌、5-50重量份的酵母β-葡聚糖、1-10重量份的金银花粉。
优选地,所述的后生元组合物中包括:3-20重量份卷曲乳杆菌KT-11、7-42重量份酵母β-葡聚糖、1-8重量份金银花粉。
更优选地,所述的后生元组合物中包括:5-10重量份的灭活型卷曲乳杆菌、20-30重量份的酵母β-葡聚糖、3-5重量份的金银花粉。
在一些实施例中,所述的后生元组合物中包括:8重量份卷曲乳杆菌KT-11、25重量份酵母β-葡聚糖、4重量份金银花粉。
在一些实施例中,所述的后生元组合物中包括:3重量份卷曲乳杆菌KT-11、7重量份酵母β-葡聚糖、1重量份金银花粉。
在一些实施例中,所述的后生元组合物中包括:20重量份卷曲乳杆菌KT-11、42重量份酵母β-葡聚糖、8重量份金银花粉。
优选地,所述的卷曲乳杆菌为灭活型卷曲乳杆菌KT-11(GenBank号:AP025162,FERM号:BP-11332),水分≤10%,细胞数≥4000亿/克。
所述的酵母β-葡聚糖由酿酒酵母发酵后经酸碱水提制备,以β-1.3/1.6葡聚糖结构为主,含量≥80%(w/w),蛋白质含量≤3.5%(w/w),水分含量≤8%(w/w)。
所述的金银花粉木犀草苷≥0.05%(w/w),绿原酸≥0.2%(w/w)。
另一方面,本发明提供了前述的后生元组合物在制备普通食品、保健品或口腔保健护理产品中的应用。
所述的普通食品、保健品或口腔保健护理用品包括但不限于漱口水、漱口粉、牙膏、牙粉、口喷、糖果、固体饮料或休闲饮料。
所述的普通食品、保健品或口腔保健护理用品中包括前述的后生元组合物。
所述的普通食品、保健品或口腔保健护理产品中还包括食品或日化品上可接受的原料,如维生素、矿物质、益生元、甜味剂、酸味剂、凉味剂、果汁、果粉、填充剂、赋形剂中的一种或多种。
再一方面,本发明提供了一种口腔保健护理产品。
所述的口腔保健护理产品包括但不限于漱口水、漱口粉、牙膏、牙粉、口喷、糖果、固体饮料或休闲饮料。
所述的口腔保健护理用品中包括前述的后生元组合物。
所述的口腔保健护理产品中还包括食品或日化品上可接受的原料,如维生素、矿物质、益生元、甜味剂、酸味剂、凉味剂、果汁、果粉、填充剂、赋形剂中的一种或多种。
优选地,所述的口腔保健护理产品为漱口水,包括以下重量份的成分:2-25份卷曲乳杆菌KT-11、5-50份酵母β-葡聚糖、1-10份金银花粉、10-20份菊粉、30-40份木糖醇、0-0.5份香精、0-0.5份甜菊糖苷、0-0.5份黄原胶、300-400份水。
更优选地,所述的口腔保健护理产品为漱口水,包括以下重量份的成分:3-20份卷曲乳杆菌KT-11、7-42份酵母β-葡聚糖、1-8份金银花粉、10-20份菊粉、30-40份木糖醇、0-0.5份香精、0-0.5份甜菊糖苷、0-0.5份黄原胶、300-400份水。
进一步优选地,所述的口腔保健护理产品为漱口水,包括以下重量份的成分:3-20份卷曲乳杆菌KT-11、7-42份酵母β-葡聚糖、1-8份金银花粉、19份菊粉、37份木糖醇、0.06份香精、0.05份甜菊糖苷、0.38份黄原胶、380份水。
在一些实施例中,所述的口腔保健护理产品为漱口水,包括以下重量份的成分:8份卷曲乳杆菌KT-11、25份酵母β-葡聚糖、4份金银花粉、19份菊粉、37份木糖醇、0.06份香精、0.05份甜菊糖苷、0.38份黄原胶、380份水。
在一些实施例中,所述的口腔保健护理产品为漱口水,包括以下重量份的成分:3份卷曲乳杆菌KT-11、7份酵母β-葡聚糖、1份金银花粉、19份菊粉、37份木糖醇、0.06份香精、0.05份甜菊糖苷、0.38份黄原胶、380份水。
在一些实施例中,所述的口腔保健护理产品为漱口水,包括以下重量份的成分:20份卷曲乳杆菌KT-11、42份酵母β-葡聚糖、8份金银花粉、19份菊粉、37份木糖醇、0.06份香精、0.05份甜菊糖苷、0.38份黄原胶、380份水。
又一方面,本发明提供了一种口腔保健护理产品的制备方法。
所述的制备方法中包括添加前述的的后生元组合物。
所述的口腔保健护理产品为漱口水、漱口粉、牙膏、牙粉、口喷、糖果、固体饮料或休闲饮料。
所述的制备方法中还包括添加其他口腔保健护理产品常用的辅料,如食品或日化品上可接受的原料,如维生素、矿物质、益生元、甜味剂、酸味剂、凉味剂、果汁、果粉、填充剂、赋形剂。
卷曲乳杆菌:
卷曲乳杆菌(Lactobacillus crispatus)是婴儿出生时,在分娩过程中通过母亲的产道继承下来的,主要存在于女性阴道及婴儿的肠道中,是维持阴道微生态平衡最主要的菌种之一,其可产生乳酸和H2O2,达到抑菌作用,可通过调节免疫系统,达到降低肠道过敏和传染病的风险。目前,卷曲乳杆菌主要以活菌形式应用,通常应用于预防或治疗女性妇科炎症,改善及平衡阴道微生态,抑制致病菌黏附,改善炎症。
活性益生菌在进入人体后,仍具有发酵、新陈代谢的功能,可黏附并定植于上皮细胞,进入肠道后活性益生菌黏附于肠道,通过摄食肠道中的膳食纤维、低聚糖等益生元成分维持增殖,通过分泌乳酸降低肠道pH,从而抑制致病菌。而经过灭活处理的益生菌,是菌体成分本身通过刺激受体细胞,调节免疫反应,促进免疫赋活,促进抗体等免疫分子的分泌,从而抑制致病菌增殖、减轻炎症。
经过灭活后的卷曲乳杆菌KT-11,其SLP(S-layer protein,S层蛋白)、脂磷壁酸水平较灭活前高,使它对牙龈细胞或肠道细胞的免疫刺激作用较灭活前高,有更强的免疫调节作用,促进免疫分子水平的提高,如抗体IgA,从而有效抑制口腔或肠道中致病菌的增殖和黏附,进而发挥改善牙菌斑、调节口腔微生态环境、帮助改善口腔炎症、抑制口臭的效果;进入肠道后,卷曲乳杆菌KT-11通过刺激肠系淋巴细胞,增强肠道免疫功能,提高机体免疫力。
酵母β-葡聚糖:
酵母β-葡聚糖提取自酵母细胞壁,其特殊的β-1,3结构赋予其调节免疫、抵抗炎症的作用。酵母β-葡聚糖通过调节细胞因子的分泌,降低炎症因子水平、提高抗炎因子水平,从而发挥降低炎症的效果。酵母β-葡聚糖的分子结构对其改善炎症的效果有着决定性作用。
金银花粉:
金银花是忍冬科植物,从中医的角度出发,金银花具有清热解毒,疏风散热的作用。从现代医学角度出发,金银花富含黄酮类、皂苷类成分,具有抗病毒、抗菌、抗炎症的作用。金银花粉通过直接作用于致病菌,破坏其DNA,抑制蛋白质的合成,导致关键蛋白的缺失,DNA无法正常合成,从而抑制其在上皮细胞的定植。
本发明的有益效果:
1、灭活型卷曲乳杆菌KT-11、酵母β-葡聚糖、金银花粉三种成分按比例混合组合物对口腔中的牙龈卟啉单胞菌、齿垢密螺旋体、变形链球菌三种致病菌的抑制可起到协同增效作用;
2、本组合物为可食用成分,既可用于制备食品又可用于制备传统日化产品(如牙膏)或新型日化产品(如可吞服漱口水),突破传统活性益生菌由于稳定性差而导致的应用瓶颈;
3、本组合物用于制备可吞服口腔保健护理产品时可同时改善肠道功能和提升机体免疫力。
具体实施方式
下面结合具体实施例,对本发明作进一步详细的阐述,下述实施例不用于限制本发明,仅用于说明本发明。以下实施例中所使用的实验方法如无特殊说明,实施例中未注明具体条件的实验方法,通常按照常规条件,下述实施例中所使用的材料、试剂等,如无特殊说明,均可从商业途径得到。
本发明中的后生元组合物所采用的卷曲乳杆菌为卷曲乳杆菌KT-11(GenBank号:AP025162,FERM号:BP-11332)经过30分钟90℃高温灭活处理后得到,规格为4000亿细胞/克,水分≤10%,购自日本KiTii株式会社。
本发明中的组合物所采用的酵母β-葡聚糖由酿酒酵母发酵后经酸碱水提制备,以β-1.3/1.6葡聚糖结构为主,含量≥80%(w/w),蛋白质含量≤3.5%(w/w),水分含量≤8%(w/w),购自Lallemand集团。
本发明的金银花粉由金银花晒干后水提制备,木犀草苷≥0.05%(w/w),绿原酸≥0.2%(w/w),购自广东青云山药业。
一种可吞服漱口水由后生元组合物、菊粉、木糖醇、薄荷香精、甜菊糖苷和黄原胶以及食用水制成,实施例1-3和对比例1-4各组配方如表1所示,各组分用量均用重量份数表示。
表1实施例1-3和对比例1-4可食用漱口水配方
实验例
人体临床验证检测对象:招募270名18-60岁受口腔问题困扰的志愿者,筛选标准如下:
1.四周内无接受过抗生素治疗;
2.变形链球菌、牙龈卟啉单胞菌和齿垢密螺旋体初筛阳性者;
3.近一个月出现轻度或中度肠道不适症状≥4次,包括便秘、腹泻、肠鸣、肠绞痛等;
4.正在接受牙齿正畸者排除;
5.正在使用益生菌产品者排除;
6.两个月内,进行过洗牙、使用过漱口水或服用过益生菌者排除。
实验方法:
将志愿者平均且随机分成阳性对照组、实施例1组、实施例2组、实施例3组、对比例1组、对比例2组、对比例3组、对比例4组和安慰剂组共九组,每组30人。阳性对照组志愿者使用洗必泰漱口水,安慰剂组使用不含本组合物的可吞服漱口水。具体配方如表1所示。
每位志愿者使用指定牙膏(不含氟)刷牙,维持原有的刷牙习惯不变(早晚两次),在刷牙30min后使用指定样品漱口。其中,实验组和安慰剂组取对应样品30mL漱口1min后吞服,阳性对照组使用30mL洗必泰漱口1min后吐出;
试验持续14天,分别在第0天、第7天、第14天的上午(8-11点)收集志愿者牙垢唾液样品,在收集前90min应避免进食(水除外),样品应在3小时内转交至实验室进行变形链球菌、牙龈卟啉单胞菌和齿垢密螺旋体、唾液IgA水平的检测;在第0天和第14天对受试者的口气和牙龈炎改善程度进行评分。
评价方法
1.口腔致病菌检测:遵循医学检验手册规定的方法对牙垢唾液混合样品中的变形链球菌、牙垢密螺旋体和牙龈卟啉单胞菌进行检测,测试结果以单位菌落总数CFU/mL表示;
2.牙龈指数评价,牙龈指数评价标准:0=牙龈健康;1=牙龈轻度炎症:牙龈的颜色有轻度改变并轻度水肿,探诊不出血;2=牙龈中等炎症:牙龈色红,水肿光亮,探诊出血;3=牙龈严重炎症:牙龈明显红肿或有溃疡,并有自动出血倾向;
3.口气评价,使用Tanita口气测试仪HC-212S进行测定,分0-5档,越高档表明口气越强烈;
4.肠道功能改善以志愿者自评改善程度表示,分别是痊愈、显著改善、轻度改善和无变化。
性能检测结果:
由表2可见,经过实施例1-3的干预,受试者口腔中变形链球菌的数量极显著下降,实施例1组和实施例3组和阳性对照组无显著性差异,实施例2组和实施例3组无显著性差异,与阳性对照组差异小,可见在特定比例下本组合物对变形链球菌的抑制效果和洗必泰漱口水相当。而单独或结合使用卷曲乳杆菌KT-11(对比例1组)和酵母β-葡聚糖(对比例2组)进行干预的效果虽然与干预前有显著改善,但改善效果远不如将两者加上金银花粉按特定比例组合使用,这说明,在特定比例下,三者对口腔中变形链球菌的抑制作用具有协同增效的效果。
表2干预前后口腔中变形链球菌的平均检出量
第0天 | 第14天 | 平均变化率 | |
安慰剂组 | 1667 | 1703 | 2.19%<sup>e</sup> |
实施例1 | 1728 | 210 | -87.83%<sup>**a</sup> |
实施例2 | 1709 | 356 | -79.16%<sup>**b</sup> |
实施例3 | 1707 | 220 | -87.14%<sup>**ab</sup> |
对比例1 | 1729 | 976 | -43.52%<sup>**d</sup> |
对比例2 | 1710 | 1643 | -3.93%<sup>*e</sup> |
对比例3 | 1723 | 652 | -62.18%<sup>**c</sup> |
对比例4 | 1703 | 1672 | -1.82%<sup>e</sup> |
阳性对照组 | 1712 | 192 | -88.81%<sup>**a</sup> |
注:**表示第0天和第14天测得菌数P<0.01差异极显著性,*表示P<0.05差异显著;组间相同字母表示不具有显著性差异,不同字母表示具有显著性差异。
由表3可见,经过实施例1-3的干预,受试者口腔中牙龈卟啉单胞菌的数量极显著下降,且均与阳性对照组无显著性差异,可见在特定比例下本组合物对牙龈卟啉单胞菌的抑制效果明显,且和洗必泰漱口水的效果也是相当的。而单独或结合使用卷曲乳杆菌KT-11(对比例1组)和酵母β-葡聚糖(对比例2组)进行干预的效果虽然与干预前有显著改善,但改善效果远不如将两者加上金银花粉按特定比例组合使用,这说明,在特定比例下,三者对口腔中牙龈卟啉单胞菌的抑制作用具有协同增效的效果。
表3干预前后口腔中牙龈卟啉单胞菌的平均检出量
注:**表示第0天和第14天测得菌数P<0.01差异极显著性,*表示P<0.05差异显著;组间相同字母表示不具有显著性差异,不同字母表示具有显著性差异。
由表4可见,经过实施例1-3的干预,受试者口腔中齿垢密螺旋体的数量极显著下降,清除效果与阳性对照组相当,可见在特定比例下本组合物对牙龈卟啉单胞菌的抑制效果明显。单独或结合使用卷曲乳杆菌KT-11(对比例1组)和酵母β-葡聚糖(对比例2组)进行干预的效果虽然与干预前相比,齿垢密螺旋体测得菌数有显著下降,但下降程度远不如将两者加上金银花粉按特定比例组合使用,这说明,在特定比例下,三者对口腔中齿垢密螺旋体的抑制作用具有协同增效的效果。
表4干预前后口腔中齿垢密螺旋体的平均检出量
注:**表示第0天和第14天测得菌数P<0.01差异极显著性,*表示P<0.05差异显著;组间相同字母表示不具有显著性差异,不同字母表示具有显著性差异。
在干预前后测定受试者口腔中唾液IgA的含量,得到各组的唾液IgA平均水平,通过计算得到平均变化率。由表5可见,经过本组合物干预后,受试者口腔中唾液IgA水平提高了45%以上,是单独使用卷曲乳杆菌或者酵母β-葡聚糖的2-4倍。唾液IgA是口腔中主要的免疫球蛋白,是人体免疫力高低的重要指标之一。在健康人群中,唾液IgA是口腔抵抗致病菌感染的重要因子,同时是维持口腔微生态平衡的重要因素。本组合物通过刺激口腔中唾液IgA的分泌水平,提高受试者抵抗细菌感染和口腔炎症的能力,改善口腔问题。
表5干预后唾液IgA含量平均变化率
平均变化率 | |
安慰剂组 | -3.9%<sup>ef</sup> |
实施例1 | 63.8%<sup>a</sup> |
实施例2 | 46.7%<sup>b</sup> |
实施例3 | 60.5%<sup>a</sup> |
对比例1 | 15.1%<sup>d</sup> |
对比例2 | 15.1%<sup>d</sup> |
对比例3 | 38.4%<sup>b</sup> |
对比例4 | 1.8%<sup>e</sup> |
阳性对照组 | -8.6%<sup>f</sup> |
注:组间相同字母表示不具有显著性差异,不同字母表示具有显著性差异。
由表6可见,干预前,各组志愿者的牙龈指数评分为1.8-2.1之间,处于患有轻度至中度偏中度牙龈炎状况。不同组志愿者经过不同方案干预14天后,除了安慰剂组外,各组的都具有不同程度的改善,其中,实施例1-3组的牙龈指数平均评分改善效果虽略弱于阳性对照组,但优于对比例1-4组,经过实施例1-3方案干预后,平均牙龈炎严重程度由中度炎症改善为轻度炎症,经过对比例1-4方案干预的志愿者,平均牙龈炎严重程度依旧处于轻度至中度炎症,由此可见,按特定比例组成的本组合物对牙龈炎症的抑制效果优于单独使用本组合物成分,证明三者针对改善牙龈炎具有协同增效。
表6干预前后牙龈指数变化情况
由表7可见,干预前,各组志愿者平均口气测试评分值高,普遍伴随口气问题,经过实施例1-3方案干预后,平均分数有了明显下降,平均降幅达到60%-71%,与阳性对照组75%接近,由数据可见,按特定比例组成的本组合物对口气的改善效果优于单独使用本组合物成分,说明三者对口气的改善能够协同增效。
表7干预前后口气评分变化情况
肠道不适症状改善结果见表8,各志愿者根据干预前后肠道不适症状(如腹泻、便秘、胀气)的变化情况,进行“痊愈”、“显著改善”和“轻度改善”三级自我评价。根据评价结果可见,由于阳性对照组采用的是传统外用漱口水,只针对改善口腔问题,因此在本功效评价无参照意义。而实施例1-3、对比例1-4与传统外用漱口水相比,具有可食用/可吞服的特性,里面的后生元成分能够稳定通过消化道进入肠道,根据组合比例差异,不同程度地激活肠道免疫系统发挥作用。由表8可见,按特定比例组成的本组合物对肠道不适症状的改善效果明显,大部分志愿者感到有改善,优于单独使用本组合物成分,说明三者对肠道不适症状的改善效能够协同增效。
表8肠道症状改善结果
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (9)
1.一种后生元组合物,其特征在于,包括:2-25重量份的灭活型卷曲乳杆菌、5-50重量份的酵母β-葡聚糖、1-10重量份的金银花粉。
2.根据权利要求1所述的后生元组合物,其特征在于,包括:5-10重量份的灭活型卷曲乳杆菌、20-30重量份的酵母β-葡聚糖、3-5重量份的金银花粉。
3.根据权利要求1所述的后生元组合物,其特征在于,所述的灭活型卷曲乳杆菌为卷曲乳杆菌KT-11经过30分钟90℃高温处理后得到的灭活卷曲乳杆菌KT-11。
4.根据权利要求3所述的后生元组合物,其特征在于,所述的灭活卷曲乳杆菌水分≤10%,细胞数≥4000亿/克。
5.根据权利要求1所述的后生元组合物,其特征在于,所述的酵母β-葡聚糖主链和支链结构以β-1,3键连接,主链与支链之间以β-1,6键连接,含量≥80%w/w,水分含量<8%w/w。
6.权利要求1-5任一项所述的后生元组合物在制备普通食品、保健品或口腔保健护理产品中的应用。
7.根据权利要求6所述的应用,其特征在于,所述普通食品、保健品或口腔保健护理产品为漱口水、漱口粉、牙膏、牙粉、口喷、糖果、固体饮料或休闲饮料。
8.一种口腔保健护理产品,其特征在于,包括权利要求1-5任一项所述的后生元组合物。
9.根据权利要求8所述的口腔保健护理产品,其特征在于,还包括食品或日化品上可接受的原料,如维生素、矿物质、益生元、甜味剂、酸味剂、凉味剂、果汁、果粉、填充剂、赋形剂中的一种或多种。
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