CN115605587B - 新型重组溶素及其在治疗革兰氏阴性菌感染中的用途 - Google Patents

新型重组溶素及其在治疗革兰氏阴性菌感染中的用途

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Publication number
CN115605587B
CN115605587B CN202180034907.8A CN202180034907A CN115605587B CN 115605587 B CN115605587 B CN 115605587B CN 202180034907 A CN202180034907 A CN 202180034907A CN 115605587 B CN115605587 B CN 115605587B
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gram
protein
ikb206
seq
negative bacteria
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CN115605587A (zh
Inventor
罗伯托·迪兹·马丁内斯
玛丽亚·莫拉莱斯·阿雷扎加
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Telum Therapy Co ltd
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Telum Therapy Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01028—N-Acetylmuramoyl-L-alanine amidase (3.5.1.28)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202180034907.8A 2020-03-11 2021-03-11 新型重组溶素及其在治疗革兰氏阴性菌感染中的用途 Active CN115605587B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511878710.9A CN121422198A (zh) 2020-03-11 2021-03-11 新型重组溶素及其在治疗革兰氏阴性菌感染中的用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP20382177.2 2020-03-11
EP20382177 2020-03-11
EP20382254.9 2020-03-31
EP20382254 2020-03-31
PCT/EP2021/056264 WO2021180892A1 (en) 2020-03-11 2021-03-11 New recombinant lysin and its use in the treatment of gram-negative bacterial infections

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202511878710.9A Division CN121422198A (zh) 2020-03-11 2021-03-11 新型重组溶素及其在治疗革兰氏阴性菌感染中的用途

Publications (2)

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CN115605587A CN115605587A (zh) 2023-01-13
CN115605587B true CN115605587B (zh) 2026-02-13

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CN202180034907.8A Active CN115605587B (zh) 2020-03-11 2021-03-11 新型重组溶素及其在治疗革兰氏阴性菌感染中的用途
CN202511878710.9A Pending CN121422198A (zh) 2020-03-11 2021-03-11 新型重组溶素及其在治疗革兰氏阴性菌感染中的用途

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Country Status (8)

Country Link
US (1) US20230138922A1 (enExample)
EP (1) EP4118192A1 (enExample)
JP (2) JP2023517245A (enExample)
CN (2) CN115605587B (enExample)
AU (1) AU2021236351A1 (enExample)
CA (1) CA3175024A1 (enExample)
MX (1) MX2022011291A (enExample)
WO (1) WO2021180892A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023139605A1 (en) * 2022-01-20 2023-07-27 Techinvention Lifecare Pvt. Ltd. Lysin polypeptides and compositions thereof against urinary tract infection caused by drug-resistant gram- negative bacteria
CN114774391B (zh) * 2022-03-09 2023-03-14 华南农业大学 一种抗大肠杆菌的噬菌体内溶素及其应用
CN121079100A (zh) * 2023-05-09 2025-12-05 百欧恩泰欧洲股份公司 加德纳菌属内溶素的阴道内制剂
EP4719330A1 (en) * 2023-06-02 2026-04-08 L'oreal Cosmetic composition comprising an endolysin derived from a staphylococcus aureus phage and an aromatic alcohol
FR3149209B1 (fr) * 2023-06-02 2026-04-03 Oreal Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique
CN121420063A (zh) * 2023-06-30 2026-01-27 国立大学法人 冈山大学 可穿透革兰氏阴性菌外膜的多肽、包含所述多肽的抗菌蛋白、抗菌剂或消毒剂、药物组合物、以及抗菌剂组合物或消毒剂组合物
TW202541833A (zh) * 2023-12-12 2025-11-01 德商拜恩技術股份公司 包含內溶素之組合物及其用途
CN118420716B (zh) * 2024-05-28 2025-10-31 青岛农业大学 一种多肽125、包含多肽125的生物材料及应用

Citations (1)

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CN111420037A (zh) * 2020-03-26 2020-07-17 中国农业科学院饲料研究所 噬菌体裂解酶Lysep3在制备广谱抗菌药物中的应用

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EP3263588A1 (en) * 2008-07-03 2018-01-03 The Rockefeller University Isolated staphylococcus-specific soluble binding molecule
DK2445515T3 (en) 2009-06-26 2016-07-04 Univ Leuven Kath antimicrobial agents
SG178440A1 (en) 2009-08-24 2012-04-27 Univ Leuven Kath New endolysin obpgplys
EP2468856A1 (en) * 2010-12-23 2012-06-27 Lysando Aktiengesellschaft Antimicrobial Agents
AU2015279705B2 (en) 2014-06-26 2021-04-01 The Rockefeller University Acinetobacter lysins
AU2016324307B2 (en) 2015-09-17 2021-10-21 Contrafect Corporation Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby
AU2018248060B2 (en) * 2017-04-03 2024-05-23 Sasinapas Co., Ltd. Engineered Gram-negative endolysins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111420037A (zh) * 2020-03-26 2020-07-17 中国农业科学院饲料研究所 噬菌体裂解酶Lysep3在制备广谱抗菌药物中的应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Morita M等.Functional analysis of antibacterial activity of Bacillus amyloliquefaciens phage endolysin against Gram-negative bacteria.《FEBS Lett》.2001,(第500期),摘要，第1页第2.1节，图1，表1. *
putative endolysin [Enterobacter phage Arya];Tikhe C 等;《GeneBank》;20180813;Accession: YP_009284326 *
The antibacterial activity of E. coli bacteriophage lysin lysep3 is enhanced by fusing the Bacillus amyloliquefaciens bacteriophage endolysin binding domain D8 to the C-terminal region;Wang S 等;《J Microbiol》;20170126;第55卷(第5期);第403-408页 *
Tikhe C 等.putative endolysin [Enterobacter phage Arya].《GeneBank》.2018,Accession：YP_009284326. *

Also Published As

Publication number Publication date
EP4118192A1 (en) 2023-01-18
CA3175024A1 (en) 2021-09-16
AU2021236351A1 (en) 2022-10-06
MX2022011291A (es) 2022-12-08
WO2021180892A1 (en) 2021-09-16
JP2026041893A (ja) 2026-03-10
CN115605587A (zh) 2023-01-13
CN121422198A (zh) 2026-01-30
US20230138922A1 (en) 2023-05-04
JP2023517245A (ja) 2023-04-24

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