JP2023517245A - 新たな組換え溶解素及びグラム陰性細菌感染の治療におけるその使用 - Google Patents

新たな組換え溶解素及びグラム陰性細菌感染の治療におけるその使用 Download PDF

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JP2023517245A
JP2023517245A JP2022554850A JP2022554850A JP2023517245A JP 2023517245 A JP2023517245 A JP 2023517245A JP 2022554850 A JP2022554850 A JP 2022554850A JP 2022554850 A JP2022554850 A JP 2022554850A JP 2023517245 A JP2023517245 A JP 2023517245A
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マルティネス ロベルト ディエス
アレイサーガ マリア モラレス
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テラム セラピューティクス エセ．エレ．
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01028—N-Acetylmuramoyl-L-alanine amidase (3.5.1.28)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022554850A 2020-03-11 2021-03-11 新たな組換え溶解素及びグラム陰性細菌感染の治療におけるその使用 Pending JP2023517245A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025231925A JP2026041893A (ja) 2020-03-11 2025-12-04 新たな組換え溶解素及びグラム陰性細菌感染の治療におけるその使用

Applications Claiming Priority (5)

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EP20382177.2 2020-03-11
EP20382177 2020-03-11
EP20382254.9 2020-03-31
EP20382254 2020-03-31
PCT/EP2021/056264 WO2021180892A1 (en) 2020-03-11 2021-03-11 New recombinant lysin and its use in the treatment of gram-negative bacterial infections

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JP2025231925A Division JP2026041893A (ja) 2020-03-11 2025-12-04 新たな組換え溶解素及びグラム陰性細菌感染の治療におけるその使用

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JP2023517245A true JP2023517245A (ja) 2023-04-24
JP2023517245A5 JP2023517245A5 (enExample) 2024-03-21

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JP2022554850A Pending JP2023517245A (ja) 2020-03-11 2021-03-11 新たな組換え溶解素及びグラム陰性細菌感染の治療におけるその使用
JP2025231925A Pending JP2026041893A (ja) 2020-03-11 2025-12-04 新たな組換え溶解素及びグラム陰性細菌感染の治療におけるその使用

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US (1) US20230138922A1 (enExample)
EP (1) EP4118192A1 (enExample)
JP (2) JP2023517245A (enExample)
CN (2) CN115605587B (enExample)
AU (1) AU2021236351A1 (enExample)
CA (1) CA3175024A1 (enExample)
MX (1) MX2022011291A (enExample)
WO (1) WO2021180892A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025005276A1 (ja) * 2023-06-30 2025-01-02 国立大学法人 岡山大学 グラム陰性菌の外膜透過性ポリペプチド、該ポリペプチドを含む抗菌性タンパク質、抗菌剤又は消毒剤、医薬組成物並びに抗菌剤組成物又は消毒剤組成物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023139605A1 (en) * 2022-01-20 2023-07-27 Techinvention Lifecare Pvt. Ltd. Lysin polypeptides and compositions thereof against urinary tract infection caused by drug-resistant gram- negative bacteria
CN114774391B (zh) * 2022-03-09 2023-03-14 华南农业大学 一种抗大肠杆菌的噬菌体内溶素及其应用
CN121079100A (zh) * 2023-05-09 2025-12-05 百欧恩泰欧洲股份公司 加德纳菌属内溶素的阴道内制剂
EP4719330A1 (en) * 2023-06-02 2026-04-08 L'oreal Cosmetic composition comprising an endolysin derived from a staphylococcus aureus phage and an aromatic alcohol
FR3149209B1 (fr) * 2023-06-02 2026-04-03 Oreal Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique
TW202541833A (zh) * 2023-12-12 2025-11-01 德商拜恩技術股份公司 包含內溶素之組合物及其用途
CN118420716B (zh) * 2024-05-28 2025-10-31 青岛农业大学 一种多肽125、包含多肽125的生物材料及应用

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* Cited by examiner, † Cited by third party
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EP3263588A1 (en) * 2008-07-03 2018-01-03 The Rockefeller University Isolated staphylococcus-specific soluble binding molecule
DK2445515T3 (en) 2009-06-26 2016-07-04 Univ Leuven Kath antimicrobial agents
SG178440A1 (en) 2009-08-24 2012-04-27 Univ Leuven Kath New endolysin obpgplys
EP2468856A1 (en) * 2010-12-23 2012-06-27 Lysando Aktiengesellschaft Antimicrobial Agents
AU2015279705B2 (en) 2014-06-26 2021-04-01 The Rockefeller University Acinetobacter lysins
AU2016324307B2 (en) 2015-09-17 2021-10-21 Contrafect Corporation Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby
AU2018248060B2 (en) * 2017-04-03 2024-05-23 Sasinapas Co., Ltd. Engineered Gram-negative endolysins
CN111420037B (zh) * 2020-03-26 2022-05-10 中国农业科学院饲料研究所 噬菌体裂解酶Lysep3在制备广谱抗菌药物中的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GENPEPT，ACCESSION NO. YP_009284326，[ONLINE], JPN6025008235, 13 August 2018 (2018-08-13), ISSN: 0005542867 *
J. MICROBIOL., vol. 55, no. 5, JPN6025008236, 2017, pages 403 - 408, ISSN: 0005542866 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025005276A1 (ja) * 2023-06-30 2025-01-02 国立大学法人 岡山大学 グラム陰性菌の外膜透過性ポリペプチド、該ポリペプチドを含む抗菌性タンパク質、抗菌剤又は消毒剤、医薬組成物並びに抗菌剤組成物又は消毒剤組成物

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EP4118192A1 (en) 2023-01-18
CA3175024A1 (en) 2021-09-16
AU2021236351A1 (en) 2022-10-06
CN115605587B (zh) 2026-02-13
MX2022011291A (es) 2022-12-08
WO2021180892A1 (en) 2021-09-16
JP2026041893A (ja) 2026-03-10
CN115605587A (zh) 2023-01-13
CN121422198A (zh) 2026-01-30
US20230138922A1 (en) 2023-05-04

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