CN115605478A - 化合物和使用方法 - Google Patents
化合物和使用方法 Download PDFInfo
- Publication number
- CN115605478A CN115605478A CN202180030581.1A CN202180030581A CN115605478A CN 115605478 A CN115605478 A CN 115605478A CN 202180030581 A CN202180030581 A CN 202180030581A CN 115605478 A CN115605478 A CN 115605478A
- Authority
- CN
- China
- Prior art keywords
- alkylene
- oxy
- naphthyridin
- carboxamide
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062980954P | 2020-02-24 | 2020-02-24 | |
| US62/980,954 | 2020-02-24 | ||
| US202063121418P | 2020-12-04 | 2020-12-04 | |
| US63/121,418 | 2020-12-04 | ||
| PCT/US2021/019294 WO2021173591A1 (en) | 2020-02-24 | 2021-02-23 | Compounds and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115605478A true CN115605478A (zh) | 2023-01-13 |
Family
ID=74885066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180030581.1A Pending CN115605478A (zh) | 2020-02-24 | 2021-02-23 | 化合物和使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230151003A1 (https=) |
| EP (1) | EP4110779A1 (https=) |
| JP (1) | JP2023514725A (https=) |
| CN (1) | CN115605478A (https=) |
| AU (1) | AU2021226747A1 (https=) |
| CA (1) | CA3171473A1 (https=) |
| WO (1) | WO2021173591A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117343046A (zh) * | 2023-09-25 | 2024-01-05 | 辽宁大学 | 一种新型3-氧代-4-取代芳基-3,4-二氢吡嗪-2-甲酰胺类化合物及其应用 |
| CN118878515A (zh) * | 2024-06-19 | 2024-11-01 | 河北科技大学 | 一种取代苯胺嘧啶类化合物及其制备方法和用途 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022551422A (ja) | 2019-09-26 | 2022-12-09 | エグゼリクシス， インコーポレイテッド | ピリドン化合物およびタンパク質キナーゼの調節における使用の方法 |
| CA3211063A1 (en) | 2021-02-19 | 2022-08-25 | Exelixis, Inc. | Pyridone compounds and methods of use |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101248059A (zh) * | 2005-04-27 | 2008-08-20 | 安姆根有限公司 | 作为蛋白激酶抑制剂的取代的酰胺衍生物 |
| CN104072480A (zh) * | 2013-03-27 | 2014-10-01 | 沈阳药科大学 | 喹啉类化合物及其制备方法和应用 |
| CN105408312A (zh) * | 2013-07-24 | 2016-03-16 | 小野药品工业株式会社 | 喹啉衍生物 |
| CN105461687A (zh) * | 2014-08-26 | 2016-04-06 | 沈阳中海生物技术开发有限公司 | 含二氢哒嗪酮的喹啉类化合物及其用途 |
| EP3239147A1 (en) * | 2014-12-25 | 2017-11-01 | Ono Pharmaceutical Co., Ltd. | Quinoline derivative |
| CN109896997A (zh) * | 2017-12-08 | 2019-06-18 | 中国药科大学 | N－酰基苯胺类c－Met激酶抑制剂的制备方法及其用途 |
| CN110330479A (zh) * | 2019-07-19 | 2019-10-15 | 南京华威医药科技集团有限公司 | 一种用作axl抑制剂的抗肿瘤化合物及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
-
2021
- 2021-02-23 JP JP2022550164A patent/JP2023514725A/ja not_active Withdrawn
- 2021-02-23 EP EP21712651.5A patent/EP4110779A1/en active Pending
- 2021-02-23 US US17/800,084 patent/US20230151003A1/en active Pending
- 2021-02-23 WO PCT/US2021/019294 patent/WO2021173591A1/en not_active Ceased
- 2021-02-23 AU AU2021226747A patent/AU2021226747A1/en not_active Abandoned
- 2021-02-23 CA CA3171473A patent/CA3171473A1/en active Pending
- 2021-02-23 CN CN202180030581.1A patent/CN115605478A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101248059A (zh) * | 2005-04-27 | 2008-08-20 | 安姆根有限公司 | 作为蛋白激酶抑制剂的取代的酰胺衍生物 |
| CN104072480A (zh) * | 2013-03-27 | 2014-10-01 | 沈阳药科大学 | 喹啉类化合物及其制备方法和应用 |
| CN105408312A (zh) * | 2013-07-24 | 2016-03-16 | 小野药品工业株式会社 | 喹啉衍生物 |
| CN105461687A (zh) * | 2014-08-26 | 2016-04-06 | 沈阳中海生物技术开发有限公司 | 含二氢哒嗪酮的喹啉类化合物及其用途 |
| EP3239147A1 (en) * | 2014-12-25 | 2017-11-01 | Ono Pharmaceutical Co., Ltd. | Quinoline derivative |
| CN109896997A (zh) * | 2017-12-08 | 2019-06-18 | 中国药科大学 | N－酰基苯胺类c－Met激酶抑制剂的制备方法及其用途 |
| CN110330479A (zh) * | 2019-07-19 | 2019-10-15 | 南京华威医药科技集团有限公司 | 一种用作axl抑制剂的抗肿瘤化合物及其用途 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117343046A (zh) * | 2023-09-25 | 2024-01-05 | 辽宁大学 | 一种新型3-氧代-4-取代芳基-3,4-二氢吡嗪-2-甲酰胺类化合物及其应用 |
| CN118878515A (zh) * | 2024-06-19 | 2024-11-01 | 河北科技大学 | 一种取代苯胺嘧啶类化合物及其制备方法和用途 |
| CN118878515B (zh) * | 2024-06-19 | 2025-10-28 | 河北科技大学 | 一种取代苯胺嘧啶类化合物及其制备方法和用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023514725A (ja) | 2023-04-07 |
| US20230151003A1 (en) | 2023-05-18 |
| EP4110779A1 (en) | 2023-01-04 |
| AU2021226747A1 (en) | 2022-09-01 |
| CA3171473A1 (en) | 2021-09-02 |
| WO2021173591A1 (en) | 2021-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20251121 |
|
| AD01 | Patent right deemed abandoned |