CN115531553A - 内体g蛋白-偶联的受体的三部分调节剂 - Google Patents

内体g蛋白-偶联的受体的三部分调节剂 Download PDF

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Publication number
CN115531553A
CN115531553A CN202210637197.4A CN202210637197A CN115531553A CN 115531553 A CN115531553 A CN 115531553A CN 202210637197 A CN202210637197 A CN 202210637197A CN 115531553 A CN115531553 A CN 115531553A
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CN
China
Prior art keywords
endosomal
compound
nk1r
optionally
formula
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Pending
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CN202210637197.4A
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English (en)
Chinese (zh)
Inventor
N.W.邦尼特
C.J.H.波特
D.科尔
G.希克斯
J.希赖
G.赫斯特
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication date
Priority claimed from AU2015905333A external-priority patent/AU2015905333A0/en
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of CN115531553A publication Critical patent/CN115531553A/zh
Pending legal-status Critical Current

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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
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  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
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  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CN202210637197.4A 2015-12-22 2016-12-21 内体g蛋白-偶联的受体的三部分调节剂 Pending CN115531553A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AU2015905333 2015-12-22
AU2015905333A AU2015905333A0 (en) 2015-12-22 Modulators of Endosomal G Protein-Coupled Receptors
US201662291161P 2016-02-04 2016-02-04
US62/291,161 2016-02-04
CN201680074910.1A CN108712913B (zh) 2015-12-22 2016-12-21 内体g蛋白-偶联的受体的三部分调节剂
PCT/US2016/068075 WO2017112792A1 (en) 2015-12-22 2016-12-21 Tripartite modulators of endosomal g protein-coupled receptors

Related Parent Applications (1)

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CN201680074910.1A Division CN108712913B (zh) 2015-12-22 2016-12-21 内体g蛋白-偶联的受体的三部分调节剂

Publications (1)

Publication Number Publication Date
CN115531553A true CN115531553A (zh) 2022-12-30

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CN202210637197.4A Pending CN115531553A (zh) 2015-12-22 2016-12-21 内体g蛋白-偶联的受体的三部分调节剂
CN201680074910.1A Active CN108712913B (zh) 2015-12-22 2016-12-21 内体g蛋白-偶联的受体的三部分调节剂

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Country Link
US (3) US11324832B2 (https=)
EP (1) EP3393519A1 (https=)
JP (3) JP7074673B2 (https=)
CN (2) CN115531553A (https=)
AU (3) AU2016377658B2 (https=)
CA (1) CA3009325A1 (https=)
EA (1) EA201891472A1 (https=)
WO (1) WO2017112792A1 (https=)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
ES2824552T3 (es) 2015-03-04 2021-05-12 Vanda Pharmaceuticals Inc Método de tratamiento con tradipitant
CN115531553A (zh) * 2015-12-22 2022-12-30 武田药品工业株式会社 内体g蛋白-偶联的受体的三部分调节剂
WO2017197463A1 (en) * 2016-05-20 2017-11-23 Monash University Treatment of pain
CN119074729A (zh) * 2017-11-17 2024-12-06 万达制药公司 使用川地匹坦治疗胃肠疾病的方法
IT202200018780A1 (it) * 2022-09-14 2024-03-14 Alberto Chiarugi Modulatori degli effetti della chemioterapia
IT202200018768A1 (it) * 2022-09-14 2024-03-14 Alberto Chiarugi Trattamento della nausea e vomito da chemioterapia

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WO2005097199A1 (en) * 2004-04-08 2005-10-20 Jadolabs Gmbh Tripartite conjugates containing a structure interacting with cell membrane rafts and their use
WO2006004195A1 (en) * 2004-07-02 2006-01-12 Tanabe Seiyaku Co., Ltd. Piperidine compound and process for preparing the same
US20130253029A1 (en) * 2010-09-28 2013-09-26 Panacea Biotec Ltd Novel bicyclic compounds
WO2014168721A2 (en) * 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents

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PT1035115E (pt) * 1999-02-24 2005-01-31 Hoffmann La Roche Derivados de 4-fenilpiridina e a sua utilizacao como antagonistas do receptor nk-1
KR100437587B1 (ko) 1999-02-24 2004-06-30 에프. 호프만-라 로슈 아게 3-페닐피리딘 유도체 및 그의 뉴로키닌-1 수용체길항제로서의 용도
US7696168B2 (en) * 2000-04-21 2010-04-13 Tufts Medical Center, Inc. G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
TWI287003B (en) 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
CN101023062A (zh) 2004-06-30 2007-08-22 詹森药业有限公司 由立体有择性脱水制造α，β－不饱和酯和酸
JP6427491B2 (ja) 2013-07-03 2018-11-21 武田薬品工業株式会社 複素環化合物
CN115531553A (zh) * 2015-12-22 2022-12-30 武田药品工业株式会社 内体g蛋白-偶联的受体的三部分调节剂

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005097199A1 (en) * 2004-04-08 2005-10-20 Jadolabs Gmbh Tripartite conjugates containing a structure interacting with cell membrane rafts and their use
WO2006004195A1 (en) * 2004-07-02 2006-01-12 Tanabe Seiyaku Co., Ltd. Piperidine compound and process for preparing the same
US20130253029A1 (en) * 2010-09-28 2013-09-26 Panacea Biotec Ltd Novel bicyclic compounds
WO2014168721A2 (en) * 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents

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JP7458681B2 (ja) 2024-04-01
CN108712913A (zh) 2018-10-26
AU2025201136A1 (en) 2025-03-06
JP2019503356A (ja) 2019-02-07
JP2024073581A (ja) 2024-05-29
BR112018012425A2 (pt) 2018-12-18
AU2016377658B2 (en) 2022-09-29
CA3009325A1 (en) 2017-06-29
CN108712913B (zh) 2022-06-24
JP7074673B2 (ja) 2022-05-24
EA201891472A1 (ru) 2018-12-28
WO2017112792A1 (en) 2017-06-29
US20230119819A1 (en) 2023-04-20
AU2022291659A1 (en) 2023-02-02
JP2022113164A (ja) 2022-08-03
EP3393519A1 (en) 2018-10-31
AU2016377658A1 (en) 2018-06-21
US20250235544A1 (en) 2025-07-24
US20190000981A1 (en) 2019-01-03
US11324832B2 (en) 2022-05-10

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