CN115487267B - A Chinese medicinal extract with sleep improving effect, and its preparation method - Google Patents

A Chinese medicinal extract with sleep improving effect, and its preparation method Download PDF

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CN115487267B
CN115487267B CN202211184880.3A CN202211184880A CN115487267B CN 115487267 B CN115487267 B CN 115487267B CN 202211184880 A CN202211184880 A CN 202211184880A CN 115487267 B CN115487267 B CN 115487267B
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CN115487267A (en
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杨再文
鲁艳柳
谭道鹏
冉义斌
刘杰
罗晓琴
周孝红
赵娅
余鹏
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Guizhou Huiteng Extraction Technology Application Research Institute Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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Abstract

The application discloses a traditional Chinese medicine extract with a sleep improving effect in the technical field of medicines, which comprises the following components in percentage by mass: 6-methoxyquinoline oxynitride, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percentages of the substances are not lower than 5.0 percent. The traditional Chinese medicine extract in the scheme can obviously shorten the sleep latency period and obviously prolong the sleep duration time, so that the traditional Chinese medicine extract has an exact function of promoting sleep, and the problems that common sleep-promoting medicines have larger toxic and side effects of livers and kidneys, are easy to generate bad symptoms such as dizziness and amnesia, and are easy to generate dependence on the medicines can be well solved.

Description

A Chinese medicinal extract with sleep improving effect, and its preparation method
Technical Field
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine extract with a sleep improving effect and a preparation method thereof.
Background
Along with the development of science and technology and the progress of society, people pay more and more attention to health, and sleep difficulty, sleep depth or too short frequency, early waking, sleep duration deficiency or sleep quality poor and other insomnia situations caused by various reasons occur, so that the health care pillow has become a common disease puzzling the public. Sleep is extremely precise symbiotic activity, and if abnormal brain waves occur at a certain stage in the sleep process or even in the whole sleep process, insomnia is possibly caused, and is always accompanied by mental disorder, and insomnia is a pre-stage obstacle which causes drug dependence, alcohol dependence, gunpowder poisoning and the like of sleeping drugs and the like, so that the method has social significance on how to overcome the insomnia and prevent the occurrence of the problems.
At present, aiming at the treatment of insomnia symptoms, the traditional Chinese medicines and the western medicines have different methods, wherein the western medicines often use large-dose sleep-promoting medicines to achieve the effect of promoting sleep by generating different degrees of inhibition effects on various links of various parts of a central nervous system, and the existing researches show that the sleeping-promoting medicines or medicines containing melatonin have the following defects: 1. has larger toxic and side effects of liver and kidney; 2. the aim of thoroughly and radically treating insomnia is difficult to achieve; 3. bad symptoms such as dizziness, amnesia and the like are easy to occur; 4. long-term administration may be dependent on the drug; and 5, requiring doctor instruction to take the medicine, not all sleep disorder persons can take the medicine. Therefore, the search for the development of safe and effective sleep-promoting medicaments has very important meaning and value.
The traditional Chinese medicine has very good curative effect in improving sleep, for example, chinese medicinal materials such as the wild jujube seed and the like are recorded by the traditional Chinese medicine books for the past, and have exact sleep improving effect.
Dendrobium nobile (Dendrobium nobile Lindl.) is also called herba Hedyotidis Diffusae, radix Oenotherae Erythrosepalae, etc., which is a plant of Dendrobium genus of Orchidaceae family, is a traditional and famous and precious medicinal plant in our country, and has been listed as the top grade in Shennong Ben Cao Jing as one of "Jiudaxiancao". The medicinal part is fresh or dry stem, and has effects of strengthening yin, replenishing vital essence, thickening intestine and stomach, and reducing weight for prolonging life. Modern pharmacological researches show that the main active ingredients of dendrobium nobile lindl are alkaloids and polysaccharide compounds, and have multiple effects of resisting tumor, resisting oxidation and aging, enhancing immunity, regulating gastrointestinal movement, reducing blood sugar and blood fat and the like. The inventor sends out the dendrobium nobile flower CO in the study in the early stage 2 The supercritical extract has good sleep improving effect.
Based on the reasons, the invention provides the dendrobium nobile flower CO 2 The supercritical extract solves the problems that the current common sleep-promoting medicine has larger toxic and side effects of liver and kidney, is easy to generate adverse symptoms such as dizziness, amnesia and the like, and is easy to generate dependence on the medicine.
Disclosure of Invention
The invention aims to provide a dendrobium nobile flower CO 2 The supercritical extract solves the problems that the current common sleep-promoting medicine has larger toxic and side effects of liver and kidney, is easy to generate adverse symptoms such as dizziness, amnesia and the like, and is easy to generate dependence on the medicine.
In order to solve the technical problems, the invention provides the following technical scheme: a Chinese medicinal extract with sleep improving effect comprises the following components in percentage by mass: 6-methoxyquinoline oxynitride, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percentages of the substances are not lower than 5.0 percent.
A preparation method of a traditional Chinese medicine extract with sleep improving effect comprises the following steps:
s1: taking dendrobium nobile flower and loading CO 2 Extracting in an extraction kettle of a supercritical extraction instrument, wherein the pressure of the extraction kettle is set to be 27.5MPa, the temperature is 46-47 ℃, and the extraction is carried out for 180min;
s2: from CO after extraction is completed 2 Separating out the dendrobium nobile flower CO from the separating kettle of the supercritical extractor 2 Supercritical extract, partial pressure I during separation: 6.9MPa; i, temperature: 38-39 ℃; II partial pressure: 5.9MPa; II, temperature: 44-45 ℃.
Further, the traditional Chinese medicine extract is used for preparing a medicinal preparation, wherein the medicinal preparation comprises capsules, tablets, granules, oral liquid, paste, fog, dripping pills, mixture, slurry, powder or teabags.
Further, the pharmaceutical preparation also comprises pharmaceutical excipients.
Further, the pharmaceutical excipients comprise one or more of diluents, disintegrants, binders, preservatives, antioxidants, flavoring agents, suspending agents and emulsifiers;
the diluent is one or more of mannitol, sucrose, lactose, sorbitol, xylitol, polyethylene glycol, propylene glycol, vegetable oil and mineral oil;
the disintegrating agent is one or more of croscarmellose sodium, colloidal silicon dioxide and citric acid;
the adhesive is one or more of starch slurry, ethanol, water and povidone alcohol solution;
the antiseptic is one or more of ethyl p-hydroxybenzoate, propyl hydroxybenzoate, sorbic acid, potassium sorbate, calcium propionate, sodium dehydroacetate, sodium diacetate and sodium lactate;
the antioxidant is one or more of ethylenediamine tetraacetic acid, disodium ethylenediamine tetraacetate, dibutyl hydroxy toluene, glycine, inositol, ascorbic acid, sodium ascorbate, lecithin, malic acid, hydroquinone, citric acid, succinic acid and sodium metabisulfite;
the flavoring agent is one or more of aspartame, sucrose, xylitol, stevioside, sodium cyclamate, sorbitol, cocoa, pure vanilla, vanillin, ethyl vanillin, chocolate, malt, and herba Menthae;
the suspending agent is one or more of xanthan gum, polyvinylpyrrolidone, sodium alginate, aluminum stearate and hydrogenated vegetable oil;
the emulsifier is one or more of alkyl sulfate, soap, dodecylbenzene sulfonate, lactate, sulfosuccinate, monoglyceride sulfonate, phosphate, siloxane, and taurine salt.
Further, the pharmaceutical preparation is added into a medicament, food or health care product for preventing or treating sleep disorder or promoting sleep after being prepared.
The invention has the beneficial effects that: the traditional Chinese medicine extract in the scheme can obviously shorten the sleep latency period and obviously prolong the sleep duration time, so that the traditional Chinese medicine extract has an exact function of promoting sleep, and the problems that common sleep-promoting medicines have larger toxic and side effects of livers and kidneys, are easy to generate bad symptoms such as dizziness and amnesia, and are easy to generate dependence on the medicines can be well solved.
Drawings
FIG. 1 is a graph showing the effect of the extract of Chinese medicinal materials on sleep latency in an embodiment of the present invention;
FIG. 2 is a graph showing the effect of the extract of Chinese medicinal materials on sleep duration according to the embodiment of the present invention.
Detailed Description
The diluent is one or more of mannitol, sucrose, lactose, sorbitol, xylitol, polyethylene glycol, propylene glycol, vegetable oil and mineral oil;
the disintegrating agent is one or a mixture of several of croscarmellose sodium, colloidal silicon dioxide and citric acid;
the adhesive is one or a mixture of more of starch slurry, ethanol, water and povidone alcohol solution;
the preservative is one or more of ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sorbic acid, potassium sorbate, calcium propionate, sodium dehydroacetate, sodium diacetate and sodium lactate;
the antioxidant is one or more of ethylenediamine tetraacetic acid, disodium ethylenediamine tetraacetate, dibutyl hydroxy toluene, glycine, inositol, ascorbic acid, sodium ascorbate, lecithin, malic acid, hydroquinone, citric acid, succinic acid and sodium metabisulfite;
the flavoring agent is one or more of aspartame, sucrose, xylitol, stevioside, sodium cyclamate, sorbitol, cocoa, pure vanilla, vanillin, ethyl vanillin, chocolate, malt, and herba Menthae;
the suspending agent is one or more of xanthan gum, polyvinylpyrrolidone, sodium alginate, aluminum stearate and hydrogenated vegetable oil;
the emulsifier is one or more of alkyl sulfate, soap, dodecyl benzene sulfonate, lactate, sulfosuccinate, monoglyceride sulfonate, phosphate, siloxane, and taurine.
Example 1
A Chinese medicinal extract with sleep improving effect comprises the following components in percentage by mass: 6-methoxyquinoline oxynitride, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percentages of the substances are not lower than 5.0 percent.
Adding medicinal adjuvants into the Chinese medicinal extract, wherein the medicinal adjuvants are mixture of diluent, disintegrating agent and binder.
And preparing the traditional Chinese medicine extract added with the medicinal auxiliary materials into one of capsules, tablets, granules, oral liquid, ointment, mist, dripping pills, mixture, slurry, powder or teabags.
Example 2
A Chinese medicinal extract with sleep improving effect comprises the following components in percentage by mass: 6-methoxyquinoline oxynitride, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percentages of the substances are not lower than 5.0 percent.
Adding medicinal adjuvants into the Chinese medicinal extract, wherein the medicinal adjuvants are mixture of antiseptic, antioxidant and flavoring agent.
And preparing the traditional Chinese medicine extract added with the medicinal auxiliary materials into one of capsules, tablets, granules, oral liquid, ointment, mist, dripping pills, mixture, slurry, powder or teabags.
Example 3
A Chinese medicinal extract with sleep improving effect comprises the following components in percentage by mass: 6-methoxyquinoline oxynitride, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percentages of the substances are not lower than 5.0 percent.
Adding medicinal adjuvants into the Chinese medicinal extract, wherein the medicinal adjuvants are mixture of diluent, suspending agent and emulsifying agent.
And preparing the traditional Chinese medicine extract added with the medicinal auxiliary materials into one of capsules, tablets, granules, oral liquid, ointment, mist, dripping pills, mixture, slurry, powder or teabags.
The preparation method of the traditional Chinese medicine extract in the embodiments 1-3 comprises the following steps:
s1: taking dendrobium nobile flower and loading CO 2 Extracting in an extraction kettle of a supercritical extraction instrument, wherein the pressure of the extraction kettle is set to be 27.5MPa, the temperature is 46 ℃ or 47 ℃ during extraction, and the extraction is carried out for 180min;
s2: from CO after extraction is completed 2 Separating out the dendrobium nobile flower CO from the separating kettle of the supercritical extractor 2 Supercritical extract, partial pressure I during separation: 6.9MPa; i, temperature: 38 ℃ or 39 ℃; II partial pressure: 5.9MPa; II, temperature: 44-45 ℃.
Sleep improvement effect observation experiment of dendrobium nobile flower CO2 supercritical extract
1) Experimental method
ICR mice (20-24 g) were purchased from St Bei Fu (Beijing) Biotechnology Co., ltd. [ license number: SCXK (Beijing) 2019-0010, and feeding the rice in an environment with alternating illumination and darkness for 12 hours at room temperature of 20+/-2 ℃ and relative humidity of 50% -70%, and drinking water and diet freely during the period.
The mice were randomly divided into a blank control group, a positive control group, an extract high dose group, an extract medium dose group, and an extract low dose group, 5 groups of 10 animals each. Filling the blank control group with distilled water with corresponding volume; positive control group was intragastric diazepam (1.5 mg/kg); the mice of each group were asleep by intraperitoneal injection of sodium pentobarbital at a dose of 40mg/kg after 1h of gastric administration, which was a high dose of extract (100 mg/kg), medium dose of extract (50 mg/kg) and low dose of extract (25 mg/kg). The latency to sleep and duration of sleep were recorded for each group of mice during the experiment.
2) Experimental results
The experimental results are shown in fig. 1 and fig. 2, the experimental data are expressed as mean ± standard deviation (x±s), fig. 1 is the experimental result of the sleep latency period of the mice, and fig. 2 is the experimental result of the sleep duration period of the mice. Wherein, compared to the blank group, x represents P <0.05; * Represents P <0.01.
The results show that: the positive control group had significantly shortened sleep latency, significantly increased sleep duration, and had very significant differences (P < 0.01) compared to the placebo group. In terms of sleep latency, the sleep latency of the high-dose group and the medium-dose group of dendrobium nobile flower extract is significantly shortened (P < 0.05) compared with that of a blank control group; in terms of sleep duration, the sleep duration of the high and medium dose groups of dendrobium nobile flower extract was significantly prolonged (P < 0.05) compared to the blank control group. The experimental results show that the dendrobium nobile flower CO2 supercritical extract has an exact function of improving sleep.

Claims (1)

1. The application of the traditional Chinese medicine extract in preparing the medicine with the function of improving sleep is characterized in that the preparation method of the traditional Chinese medicine extract comprises the following steps:
s1: putting dendrobium nobile flowers into an extraction kettle of a CO2 supercritical extractor for extraction, wherein the pressure of the extraction kettle is set to be 27.5MPa, the temperature is 46-47 ℃, and the extraction is carried out for 180min;
s2: separating the CO2 supercritical extract of the dendrobium nobile flower from a separating kettle of a CO2 supercritical extractor after the extraction is finished, and separating the CO2 supercritical extract by the partial pressure I: 6.9MPa; i, temperature: 38-39 ℃; II partial pressure: 5.9MPa; II, temperature: 44-45 ℃.
CN202211184880.3A 2022-09-27 2022-09-27 A Chinese medicinal extract with sleep improving effect, and its preparation method Active CN115487267B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107029115A (en) * 2017-03-30 2017-08-11 温岭市锦华铁皮石斛有限公司 A kind of natural hair-loss preventing and hair-restoring stem of noble dendrobium caul-fat
CN111643603A (en) * 2020-06-02 2020-09-11 西南医科大学附属中医医院 Dendrobium nobile extract for improving cognitive decline caused by stress and preparation method and application thereof
CN113069507A (en) * 2021-03-30 2021-07-06 龚德钦 Dendrobium stem capsule and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107029115A (en) * 2017-03-30 2017-08-11 温岭市锦华铁皮石斛有限公司 A kind of natural hair-loss preventing and hair-restoring stem of noble dendrobium caul-fat
CN111643603A (en) * 2020-06-02 2020-09-11 西南医科大学附属中医医院 Dendrobium nobile extract for improving cognitive decline caused by stress and preparation method and application thereof
CN113069507A (en) * 2021-03-30 2021-07-06 龚德钦 Dendrobium stem capsule and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
The Cognitive-Enhancing Effects of Dendrobium nobile Lindl Extract in Sleep Deprivation-Induced Amnesic Mice;Ning Jiang等;Frontiers in Psychiatry;20220119;第12卷;Article 596017 *
金钗石斛对慢性疲劳综合征大鼠肝脏及行为学的保护作用;陈莹;中国优秀硕士学位论文全文数据库 医药卫生科技(第8期);第6页第1段，第10页1.5实验方法部分，摘要 *

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