CN115487267A - A Chinese medicinal extract with sleep improving effect, and its preparation method - Google Patents

A Chinese medicinal extract with sleep improving effect, and its preparation method Download PDF

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CN115487267A
CN115487267A CN202211184880.3A CN202211184880A CN115487267A CN 115487267 A CN115487267 A CN 115487267A CN 202211184880 A CN202211184880 A CN 202211184880A CN 115487267 A CN115487267 A CN 115487267A
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sleep
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chinese medicine
sodium
extract
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CN115487267B (en
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杨再文
鲁艳柳
谭道鹏
冉义斌
刘杰
罗晓琴
周孝红
赵娅
余鹏
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Guizhou Huiteng Extraction Technology Application Research Institute Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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Abstract

The application discloses a traditional Chinese medicine extract with sleep improvement effect in the technical field of medicines, which comprises the following components in percentage by mass: 6-methoxyquinoline oxynitride, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percent of the substances is not less than 5.0%. The traditional Chinese medicine extract in the scheme can obviously shorten the sleep latency and obviously prolong the sleep duration, so that the traditional Chinese medicine extract has an exact sleep promoting effect, and the problems that common sleep promoting medicines have large toxic and side effects of liver and kidney, are easy to produce adverse symptoms such as dizziness and amnesia and are easy to generate dependence on medicines can be well solved.

Description

A Chinese medicinal extract with sleep improving effect, and its preparation method
Technical Field
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine extract with a function of improving sleep and a preparation method thereof.
Background
With the development of science and technology and the advancement of society, people pay more and more attention to health, and insomnia caused by various reasons, such as difficulty in falling asleep, too short sleep depth or frequency, early awakening, insufficient sleep duration or poor sleep quality, often occurs, and is a common disease which troubles the public. The sleep is extremely precise symbiotic activity, if the brain waves in a certain stage of the sleep process and even in the whole sleep process are abnormal, insomnia can be caused, the insomnia is always accompanied with mental disorder, the insomnia is an early-stage obstacle of drug dependence, alcohol dependence, narcotic poisoning and the like of sleep drugs and the like, and social significance is provided for overcoming the insomnia and preventing the problems.
At present, different methods are adopted for treating insomnia symptoms by using Chinese medicines and western medicines, wherein western medicines often use large-dose sleep-promoting medicines to achieve the effect of promoting sleep by generating inhibitory effects of different degrees on all parts of a central nervous system, and the following defects can be found in the fact that sleep promotion by using the sleep-promoting medicines or the medicines containing melatonin is implemented through the existing research: 1. has larger toxic and side effects on liver and kidney; 2. the purpose of thoroughly and radically curing insomnia is difficult to achieve; 3. easily causing dizziness, amnesia and other adverse symptoms; 4. long-term administration may cause drug dependence; and 5, the medicine can be taken only by the guidance of doctors, and not all sleep disorder people can take the medicine. Therefore, the research and development of safe and effective sleep-promoting medicaments are of great significance and value.
The traditional Chinese medicine has a very good curative effect on improving sleep, and for example, the traditional Chinese medicine such as the spina date seed and the like has an exact sleep improving effect recorded by medical books of past generations.
Dendrobium nobile (Dendrobium nobile lindl.) also called flat yellow grass, woody hawthorns and the like is a Dendrobium plant in the family of Orchidaceae, is a traditional famous and precious medicinal plant in China, is listed as the top quality in Shen nong Ben Cao Jing as early time and is known as one of the nine major immortals grass. The medicinal part is fresh or dry stem, and has effects of nourishing yin, replenishing vital essence, improving gastrointestinal function, reducing weight and prolonging life. Modern pharmacological research shows that the main effective components of dendrobium nobile are alkaloids and polysaccharide compounds, and the dendrobium nobile lindl has multiple effects of resisting tumor, oxidation and aging, enhancing immunity, regulating gastrointestinal motility, reducing blood sugar, reducing blood fat and the like. The inventor discovers dendrobium nobile flower CO in earlier period of research 2 The supercritical extract has good sleep improving effect.
Based on the reasons, the invention provides dendrobium nobile flower CO 2 The supercritical extract is used for solving the problems that the prior common sleep-promoting medicine has larger toxic and side effects of liver and kidney, is easy to produce adverse symptoms such as dizziness, amnesia and the like, and is easy to generate dependence on the medicine.
Disclosure of Invention
The invention aims to provide a dendrobium nobile flower CO 2 The supercritical extract is used for solving the problems that the prior common sleep-promoting medicine has larger toxic and side effects of liver and kidney, is easy to produce adverse symptoms such as dizziness, amnesia and the like, and is easy to generate dependence on the medicine.
In order to solve the technical problems, the invention provides the following technical scheme: a traditional Chinese medicine extract with the effect of improving sleep comprises the following components in percentage by mass: 6-methoxyquinoline nitroxide, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percentage of the substances is not less than 5.0%.
A preparation method of traditional Chinese medicine extract with sleep improving effect comprises the following steps:
s1: taking dendrobium stem flower, filling CO 2 Extracting in an extraction kettle of a supercritical extractor, wherein the pressure of the extraction kettle is 27.5MPa, the temperature is 46-47 ℃ and the extraction is carried out for 180min;
s2: from CO after extraction is complete 2 Separating out dendrobium nobile flower CO in separating kettle of supercritical extraction apparatus 2 Supercritical extract, separation at I part pressure: 6.9MPa; temperature I: 38-39 ℃; II partial pressure: 5.9MPa; II, temperature division: 44-45 ℃.
Further, the traditional Chinese medicine extract is used for preparing pharmaceutical preparations, and the pharmaceutical preparations comprise capsules, tablets, granules, oral liquid, paste, mists, dropping pills, mixtures, slurries, powder or tea bags.
Further, the pharmaceutical preparation also comprises pharmaceutic adjuvants.
Further, the pharmaceutic adjuvant comprises one or more of a diluent, a disintegrating agent, an adhesive, a preservative, an antioxidant, a flavoring agent, a suspending agent and an emulsifying agent;
the diluent is one or more of mannitol, sucrose, lactose, sorbitol, xylitol, polyethylene glycol, propylene glycol, vegetable oil and mineral oil;
the disintegrant is one or more of croscarmellose sodium, colloidal silicon dioxide and citric acid;
the adhesive is one or more of starch slurry, ethanol, water and polyvidone alcohol solution;
the preservative is one or more of ethyl paraben, propyl paraben, sorbic acid, potassium sorbate, calcium propionate, sodium dehydroacetate, sodium diacetate and sodium lactate;
the antioxidant is one or more of ethylene diamine tetraacetic acid, disodium ethylene diamine tetraacetic acid, dibutyl hydroxy toluene, glycine, inositol, ascorbic acid, sodium ascorbate, lecithin, malic acid, hydroquinone, citric acid, succinic acid, and sodium metabisulfite;
the flavoring agent is one or more of aspartame, sucrose, xylitol, stevioside, sodium cyclamate, sorbitol, cacao, pure vanilla, vanillin, ethyl vanillin, chocolate, fructus Hordei Germinatus, and herba Menthae;
the suspending agent is one or more of xanthan gum, polyvinylpyrrolidone, sodium alginate, aluminum stearate, and hydrogenated vegetable oil;
the emulsifier is one or more of alkyl sulfate, soap, dodecyl benzene sulfonate, lactate, sulfosuccinate, monoglyceride sulfonate, phosphate, siloxane, and taurate.
Further, the pharmaceutical preparation is added to a drug, food or health product for preventing or treating sleep disorder or promoting sleep after preparation.
The invention has the beneficial effects that: the traditional Chinese medicine extract in the scheme can obviously shorten the sleep latency and obviously prolong the sleep duration, so that the traditional Chinese medicine extract has an exact sleep promoting effect, and the problems that common sleep promoting medicines have large toxic and side effects of liver and kidney, are easy to produce adverse symptoms such as dizziness and amnesia and are easy to generate dependence on medicines can be well solved.
Drawings
FIG. 1 is a graph showing the effect of the extract of the herb in the present invention on sleep latency;
FIG. 2 is a graph of the effect of herbal extracts on sleep duration in an example of the present invention.
Detailed Description
The diluent is one or more of mannitol, sucrose, lactose, sorbitol, xylitol, polyethylene glycol, propylene glycol, vegetable oil and mineral oil;
the disintegrant is one or more of croscarmellose sodium, colloidal silicon dioxide and citric acid;
the adhesive is one or more of starch slurry, ethanol, water and polyvidone alcoholic solution;
the preservative is one or a mixture of more of ethyl paraben, propyl paraben, sorbic acid, potassium sorbate, calcium propionate, sodium dehydroacetate, sodium diacetate and sodium lactate;
the antioxidant is one or more of ethylenediamine tetraacetic acid, disodium salt of ethylenediamine tetraacetic acid, dibutyl hydroxy toluene, glycine, inositol, ascorbic acid, sodium ascorbate, lecithin, malic acid, hydroquinone, citric acid, succinic acid, sodium pyrosulfite;
the flavoring agent is one or more of aspartame, sucrose, xylitol, stevioside, sodium cyclamate, sorbitol, cacao, pure vanilla, vanillin, ethyl vanillin, chocolate, fructus Hordei Germinatus, and herba Menthae;
the suspending agent is one or more of xanthan gum, polyvinylpyrrolidone, sodium alginate, aluminum stearate, and hydrogenated vegetable oil;
the emulsifier is one or more of alkyl sulfate, soap, dodecyl benzene sulfonate, lactate, sulfosuccinate, monoglyceride sulfonate, phosphate, siloxane, and taurate.
Example 1
A traditional Chinese medicine extract with sleep improvement effect comprises the following components by mass percent: 6-methoxyquinoline nitroxide, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percentage of the substances is not less than 5.0%.
Adding the traditional Chinese medicine extract into a pharmaceutic adjuvant which is a mixture of a diluent, a disintegrating agent and an adhesive.
Then the Chinese medicinal extract added with the pharmaceutic adjuvant is prepared into one of capsules, tablets, granules, oral liquid, paste, mists, dripping pills, mixtures, slurries, powder or tea bags.
Example 2
A traditional Chinese medicine extract with sleep improvement effect comprises the following components by mass percent: 6-methoxyquinoline oxynitride, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percent of the substances is not less than 5.0%.
Adding the traditional Chinese medicine extract into a pharmaceutic adjuvant which is a mixture of a preservative, an antioxidant and a flavoring agent.
Then the Chinese medicinal extract added with the pharmaceutic adjuvant is prepared into one of capsules, tablets, granules, oral liquid, paste, mists, dripping pills, mixtures, slurries, powder or tea bags.
Example 3
A traditional Chinese medicine extract with the effect of improving sleep comprises the following components in percentage by mass: 6-methoxyquinoline oxynitride, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percent of the substances is not less than 5.0%.
Adding the Chinese medicinal extract into pharmaceutical adjuvants, wherein the pharmaceutical adjuvants are mixture of diluent agent, suspending agent and emulsifier.
Then the traditional Chinese medicine extract added with the pharmaceutic adjuvant is prepared into one of capsules, tablets, granules, oral liquid, paste, mists, dropping pills, mixtures, slurries, powder or tea bags.
The preparation method of the traditional Chinese medicine extract in the embodiment 1 to 3 comprises the following steps:
s1: taking herba Dendrobii flower, and charging CO 2 Extracting in an extraction kettle of a supercritical extraction instrument at the temperature of 46 ℃ or 47 ℃ under the pressure of 27.5MPa for 180min;
s2: from CO after extraction is complete 2 Separating out dendrobium nobile flower CO in separating kettle of supercritical extraction apparatus 2 Supercritical extract, separation pressure I part: 6.9MPa; temperature I: 38 ℃ or 39 ℃; II partial pressure: 5.9MPa; II, temperature division: 44-45 ℃.
Observation experiment for improving sleep effect of dendrobium nobile flower CO2 supercritical extract
1) Experimental method
ICR mice (20-24 g) were purchased from sbefu (beijing) biotechnology limited [ license number: SCXK (Beijing) 2019-0010], which is bred in an environment with room temperature of 20 +/-2 ℃, relative humidity of 50-70% and 12h alternating illumination and darkness, and during which people can drink water and eat freely.
The mice were randomly divided into 5 groups of 10 mice each, namely a blank control group, a positive control group, an extract high dose group, an extract medium dose group and an extract low dose group. Perfusing distilled water with corresponding volume in the blank control group; a positive control group of perimidine (1.5 mg/kg); the mice in each group were subjected to intraperitoneal injection of 40mg/kg sodium pentobarbital to cause the mice to sleep after the intragastric administration for 1h in the extract high dose group (100 mg/kg), the extract medium dose group (50 mg/kg) and the extract low dose group (25 mg/kg). The sleep latency and sleep duration of each group of mice were recorded during the experiment.
2) Results of the experiment
The experimental results are shown in fig. 1 and fig. 2, the experimental data are expressed as mean ± standard deviation (x ± s), fig. 1 is the experimental result of the sleep latency of the mouse, and fig. 2 is the experimental result of the sleep duration of the mouse. Wherein, compared to the blank control group, indicates P <0.05; * Denotes P <0.01.
The results show that: compared with a blank control group, the sleep latency of the positive control group is obviously shortened, the sleep duration is obviously prolonged, and the positive control group has extremely obvious difference (P < 0.01). In the aspect of sleep latency, compared with a blank control group, the sleep latency of the dendrobium nobile lindl flower extract high-dose group and the dendrobium nobile lindl flower extract medium-dose group is obviously shortened (P is less than 0.05); in terms of sleep duration, the sleep duration of the dendrobium nobile flower extract high-dose group and the dendrobium nobile flower extract medium-dose group was significantly prolonged (P < 0.05) compared with the blank control group. The experimental results show that the CO2 supercritical extract of dendrobium nobile flowers has an exact sleep improving effect.

Claims (6)

1. A traditional Chinese medicine extract with the function of improving sleep is characterized in that: comprises the following components in percentage by mass: 6-methoxyquinoline nitroxide, 2-fluoro-6-trifluoromethyl-3, 5-difluorophenyl ester and n-heptacosane, wherein the mass percentage of the substances is not less than 5.0%.
2. The preparation method of the traditional Chinese medicine extract with the sleep improving effect according to claim 1, which is characterized by comprising the following steps:
s1: taking dendrobium stem flower, filling CO 2 Extracting in an extraction kettle of a supercritical extractor, wherein the pressure of the extraction kettle is 27.5MPa, the temperature is 46-47 ℃ and the extraction is carried out for 180min;
s2: from CO after extraction 2 Separating out dendrobium nobile flower CO in separating kettle of supercritical extraction apparatus 2 Supercritical extract, separation at I part pressure: 6.9MPa; i minute temperature: 38-39 ℃; II partial pressure: 5.9MPa; II, temperature division: 44-45 ℃.
3. The traditional Chinese medicine extract with the sleep improving effect as claimed in claim 1, is characterized in that: the Chinese medicinal extract is used for preparing medicinal preparations, such as capsule, tablet, granule, oral liquid, unguent, misty preparation, dripping pill, mixture, slurry, powder or teabag.
4. The traditional Chinese medicine extract with the sleep improving effect as claimed in claim 3, is characterized in that: the pharmaceutical preparation also comprises pharmaceutic adjuvants.
5. The traditional Chinese medicine extract with sleep improvement effect according to claim 4, is characterized in that: the pharmaceutic adjuvant comprises one or more of a diluent, a disintegrating agent, an adhesive, a preservative, an antioxidant, a flavoring agent, a suspending agent and an emulsifying agent;
the diluent is one or more of mannitol, sucrose, lactose, sorbitol, xylitol, polyethylene glycol, propylene glycol, vegetable oil and mineral oil;
the disintegrant is one or more of croscarmellose sodium, colloidal silicon dioxide and citric acid;
the adhesive is one or more of starch slurry, ethanol, water and polyvidone alcohol solution;
the preservative is one or more of ethyl paraben, propyl paraben, sorbic acid, potassium sorbate, calcium propionate, sodium dehydroacetate, sodium diacetate and sodium lactate;
the antioxidant is one or more of ethylenediamine tetraacetic acid, disodium ethylenediamine tetraacetic acid, dibutyl hydroxy toluene, glycine, inositol, ascorbic acid, sodium ascorbate, lecithin, malic acid, hydroquinone, citric acid, succinic acid, sodium pyrosulfite;
the flavoring agent is one or more of aspartame, sucrose, xylitol, stevioside, sodium cyclamate, sorbitol, cacao, pure vanilla, vanillin, ethyl vanillin, chocolate, fructus Hordei Germinatus, and herba Menthae;
the suspending agent is one or more of xanthan gum, polyvinylpyrrolidone, sodium alginate, aluminum stearate, and hydrogenated vegetable oil;
the emulsifier is one or more of alkyl sulfate, soap, dodecyl benzene sulfonate, lactate, sulfosuccinate, monoglyceride sulfonate, phosphate, siloxane, and taurate.
6. The extract of a Chinese herb with sleep improving effect according to any one of claims 3 to 5, wherein: the pharmaceutical preparation can be added into medicine, food or health product for preventing or treating sleep disorder or promoting sleep.
CN202211184880.3A 2022-09-27 2022-09-27 A Chinese medicinal extract with sleep improving effect, and its preparation method Active CN115487267B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107029115A (en) * 2017-03-30 2017-08-11 温岭市锦华铁皮石斛有限公司 A kind of natural hair-loss preventing and hair-restoring stem of noble dendrobium caul-fat
CN111643603A (en) * 2020-06-02 2020-09-11 西南医科大学附属中医医院 Dendrobium nobile extract for improving cognitive decline caused by stress and preparation method and application thereof
CN113069507A (en) * 2021-03-30 2021-07-06 龚德钦 Dendrobium stem capsule and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107029115A (en) * 2017-03-30 2017-08-11 温岭市锦华铁皮石斛有限公司 A kind of natural hair-loss preventing and hair-restoring stem of noble dendrobium caul-fat
CN111643603A (en) * 2020-06-02 2020-09-11 西南医科大学附属中医医院 Dendrobium nobile extract for improving cognitive decline caused by stress and preparation method and application thereof
CN113069507A (en) * 2021-03-30 2021-07-06 龚德钦 Dendrobium stem capsule and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NING JIANG等: "The Cognitive-Enhancing Effects of Dendrobium nobile Lindl Extract in Sleep Deprivation-Induced Amnesic Mice", FRONTIERS IN PSYCHIATRY, vol. 12, 19 January 2022 (2022-01-19), pages 596017 *
陈莹: "金钗石斛对慢性疲劳综合征大鼠肝脏及行为学的保护作用", 中国优秀硕士学位论文全文数据库 医药卫生科技, no. 8, pages 6 *

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