CN105796674B - Traditional Chinese medicine composition for preventing and treating metabolic syndrome - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition capable of preventing and treating metabolic syndrome, which is prepared from plantain seeds, coptis chinensis and other raw materials.

Description

Traditional Chinese medicine composition for preventing and treating metabolic syndrome

Technical Field

The invention relates to a traditional Chinese medicine composition for preventing and treating metabolic syndrome as well as a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines.

Background

The Metabolic Syndrome (MS) is a syndrome combining hypertension and glucose and lipid metabolism disorder, the pathogenesis and mechanism of which are not fully understood at present, and is mainly considered to be caused by insulin resistance caused by fat accumulation at present, the diagnosis standard of which is generally two of central obesity and high triglyceride, low-level high-density lipoprotein-cholesterol, hypertension and high fasting blood sugar, namely, the symptoms of hypertension, hyperglycemia and hyperlipidemia are combined.

Semen plantaginis is a commonly used traditional Chinese medicine, is listed as a superior product in Shen nong's herbal Jing, has the effects of clearing heat, promoting urination, excreting dampness, treating stranguria, improving eyesight, eliminating phlegm and the like, and is traditionally used for treating acute glomerulonephritis, cough and asthma, icterohepatitis and the like. Recently, the extract of plantain seeds of plantago in plantago can obviously reduce the systolic pressure of rats with primary hypertension, and the active ingredient acteoside of the extract has obvious angiotensin converting enzyme inhibition effect; semen plantaginis can also be used for treating senile hypertension. Meanwhile, the plantain seed extract also has certain effects of reducing blood sugar and regulating blood fat for diabetic mice caused by alloxan, has an inhibiting effect on the formation of a glycosylation end product and the like, and shows a potential clinical effect of treating diabetes and dyslipidemia.

Huang Lian was recorded in Shen nong Ben Cao Jing: "major heat qi eye pain, angular injury, abdominal pain and dysentery, and female yin swelling and pain", has the effects of clearing heat, eliminating dampness, purging fire and removing toxicity. Modern researches show that the coptis chinensis mainly contains various alkaloids such as berberine, has pharmacological activities of resisting bacteria, reducing blood sugar, resisting tumors, resisting arrhythmia and the like, and can be used for treating diseases such as bacillary dysentery, acute gastroenteritis, chronic cholecystitis, pulmonary tuberculosis, lung abscess, respiratory tract infection, diphtheria, pertussis, arrhythmia, hypertension, diabetes, atrophic rhinitis, acute conjunctivitis, trachoma, herpes simplex virus keratitis, suppurative otitis media, burn and the like. The pharmacological activities of coptis and berberine which is a main component of coptis for treating diabetes and complications thereof, dyslipidemia and the like have been reported early. However, in recent years, the main alkaloids of coptis chinensis have certain time-dependent and dose-dependent cytotoxicity, wherein the cytotoxicity of berberine serving as a main component is the strongest; after a rat is continuously perfused with a large dose of coptis decoction for 10 days, the coptis decoction has obvious influence on rat gastrointestinal hormones motilin, gastrin and the like, and can cause the reduction of the level of gastric mucosa PGE2, the activity of oxygen free radical system metabolism and the accumulation of lipid peroxidation products of the gastric mucosa, thereby causing the rat gastrointestinal dysfunction and even death; adverse reactions of coptis and berberine preparations are frequently reported in clinical application. Therefore, the coptis chinensis or the berberine has obvious drug effect, but the safe dosage range of the application is narrow, the safety is not good, and certain risks exist in preclinical research and clinical use.

Plantain seed powder is prepared from Plantain seed and Coptis root in the book of Sheng Ji Zong Lu (holy Ji Zong Lu) with simple formula, and is prepared from Plantain seed and Coptis root in a ratio of 1:1, and can be used for treating wind-heat, dark and astringent pain of eyes. The invention points out that the composition of the plantain seed and the coptis root has new application in preventing and treating metabolic syndrome. Meanwhile, the plantain seed has the characteristic of homology of medicine and food, can play a role in attenuation and efficiency enhancement when being used with the coptis root, and has good innovation.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for preventing and treating metabolic syndrome, and a preparation method and application of the traditional Chinese medicine composition.

The traditional Chinese medicine composition for preventing and treating metabolic syndrome comprises the following components:

pulverizing dried semen plantaginis and Coptidis rhizoma, and sieving to obtain crude drug powder;

or taking dried semen plantaginis and coptis chinensis, decocting or reflux-extracting with 5-12 times of water or ethanol in different proportions for 2-6 times, each time for 1-5 hours, and combining the extracting solutions to obtain an extracting solution;

or taking dried semen plantaginis and coptis chinensis, decocting or extracting the dried semen plantaginis and coptis chinensis by using 5-12 times of water or ethanol in different proportions for 2-6 times with 1-5 hours each time, combining extracting solutions, and drying under reduced pressure to obtain an extract.

The traditional Chinese medicine composition for preventing and treating metabolic syndrome can be used for preparing a medicine or health-care product preparation for preventing or treating metabolic syndrome singly or together with a pharmaceutically acceptable medicine carrier.

The pharmaceutical formulation may be in any pharmaceutically acceptable dosage form including: decoction, powder, granule, capsule, pill, tablet, tincture or oral liquid, etc.

Mixing the plantain seed and the coptis root according to the mass ratio of 1: 1-6: 1, crushing, sieving by a 100-mesh sieve, and preparing into powder.

Mixing the plantain seed and the coptis root according to the mass ratio of 1: 1-6: 1, decocting the mixture for multiple times with 5-15 times of water for 1-3 hours each time, and combining extracting solutions to prepare decoction.

Mixing the plantain seed and the coptis root according to the mass ratio of 1: 1-6: 1, decocting the mixture for multiple times with 5-15 times of water for 1-3 hours each time, combining extracting solutions, adding a proper amount of flavoring agent, and preparing the oral liquid.

Mixing the plantain seed and the coptis chinensis according to the mass ratio of 1: 1-6: 1, performing reflux extraction for multiple times by using 5-15 times of 30-80% ethanol, performing reflux extraction for 1-3 hours each time, combining extracting solutions, performing appropriate concentration, and performing vacuum drying on an extract; making into unguent.

Mixing the semen plantaginis and the coptis chinensis according to the mass ratio of 1: 1-6: 1, decocting for 1-4 hours for many times by using 5-15 times of water, combining extracting solutions, concentrating a proper amount, and performing vacuum drying on an extract; according to 10-40g of extract, 500g of lactose 200, 10-30g of silica gel micropowder, 10-40g of sodium carboxymethyl starch, 50-200g of soluble starch and 1-4g of magnesium stearate, uniformly mixing and preparing the mixture into tablets.

Mixing the plantain seed and the coptis chinensis according to the mass ratio of 1: 1-6: 1, performing reflux extraction for multiple times by using 5-15 times of 30-80% ethanol, performing reflux extraction for 1-4 hours each time, combining extracting solutions, performing appropriate concentration, and performing vacuum drying on an extract; mixing the extract 10-40g, starch 20-80g, dextrin 10-40g, pulvis Talci 1-3g, and magnesium stearate 1-3g, and making into granule.

Mixing the plantain seed and the coptis chinensis according to the mass ratio of 1: 1-6: 1, performing reflux extraction for multiple times by using 5-15 times of 30-80% ethanol, performing reflux extraction for 1-4 hours each time, combining extracting solutions, performing appropriate concentration, and performing vacuum drying on an extract; mixing the above extracts 10-40g, starch 20-80g, and dextrin 10-40g, and making into capsule.

The metabolic syndrome comprises any one or more of abdominal obesity, insulin resistance, lipid metabolism disorder, atherosclerosis, type 2 diabetes, and hypertension.

The invention utilizes the primary hypertension rat, the high fat feed combined with streptozotocin induced type II diabetes rat, the fructose feed induced metabolic syndrome rat, db/db mouse, the alloxan induced type I diabetes mouse and the high fat feed induced metabolic syndrome mouse to carry out in vivo efficacy experiment, and the result shows that: the traditional Chinese medicine composition provided by the invention can obviously reduce the levels of blood pressure, serum triglyceride, cholesterol, low-density lipoprotein and the like of model animals, improve the tolerance of blood sugar, glucose and insulin, inhibit the weight gain caused by high-fat diet, and show good medicinal value for treating metabolic syndrome.

Detailed Description

The present invention will be described in more detail and fully with reference to the following examples.

Example 1

Mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 6:1, pulverizing, sieving with 100 mesh sieve, and making into powder.

Example 2

Mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 3:1, decocting with 10 times of water for 3 times, each for 2 hr, mixing extractive solutions, and making into decoction.

Example 3

Mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 3:1, decocting with 10 times of water for 3 times, each for 2 hr, mixing extractive solutions, adding appropriate amount of aspartame as correctant, and making into oral liquid.

Example 4

Mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 1:1, extracting with 8 times of 60% ethanol under reflux for 3 hr for 4 times, mixing extractive solutions, concentrating, and vacuum drying; making into unguent.

Example 5

Mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 3:1, decocting with 10 times of water for 3 times, each for 2 hr, mixing extractive solutions, concentrating, and vacuum drying the extract; and uniformly mixing 20g of extract, 400g of lactose, 20g of aerosil, 20g of sodium carboxymethyl starch, 100g of soluble starch and 2g of magnesium stearate, and preparing the mixture into tablets.

Example 6

Mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 1:1, extracting with 8 times of 60% ethanol under reflux for 3 hr for 4 times, mixing extractive solutions, concentrating, and vacuum drying; mixing the extract 20g, starch 50g, dextrin 20g, pulvis Talci 1g, and magnesium stearate 1g, and making into granule.

Example 7

Mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 1:1, extracting with 8 times of 60% ethanol under reflux for 3 hr for 4 times, mixing extractive solutions, concentrating, and vacuum drying; mixing the above extracts 20g, starch 50g, and dextrin 20g, and making into capsule.

Example 8

A normal group was selected as male Wistar rats of Kyoto species (200. + -. 20 g). The (200 +/-20) g of SHR rats with male essential hypertension are randomly divided into a model group, an administration group 1, an administration group 2 and an administration group 3. Wherein the administration group 1, 2 and 3 are respectively administered with semen plantaginis, Coptidis rhizoma, and semen plantaginis-Coptidis rhizoma (1:1) extract, and the preparation method comprises:

plantain seed extract: pulverizing semen plantaginis, extracting with 10 times of 30% ethanol under reflux for 3 times, each for 3 hr, mixing extractive solutions, and concentrating;

the coptis chinensis extract: pulverizing Coptidis rhizoma, reflux-extracting with 10 times of 30% ethanol for 3 times, each for 3 hr, mixing extractive solutions, and concentrating;

plantain seed-coptis (1:1) extract: mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 1:1, extracting with 10 times of 30% ethanol under reflux for 3 times, each for 3 hr, mixing extractive solutions, and concentrating.

The administration group orally administered with 2.5g crude drug/kg per day for 2 weeks, and after the administration, the blood pressure value of SHR rat was measured. The experimental data were analyzed for variance and the results are expressed in x ± s.

TABLE 1 antihypertensive effect of the above Chinese medicinal composition on essential hypertension rats

Note:^###P<0.001, compared to the normal group; p<0.05，**P<0.01, compared to the model set.

As can be seen from table 1: compared with a model group, the traditional Chinese medicine composition has a remarkable effect of reducing blood pressure value, shows a good effect of treating hypertension, and has the effect of reducing blood pressure superior to that of singly using plantain seed or coptis chinensis.

Example 9

Selecting (200 +/-20) g of healthy male wistar rats, randomly dividing the rats into a normal group and a high-fat group (88% common feed + 10% lard oil + 2% cholesterol), feeding for 4 weeks, injecting 35mg/kg of streptozotocin into the abdominal cavity of the high-fat group, measuring random blood sugar by cutting the tail after five days, screening the rats with blood sugar values of more than 16.7 mmol/L for experiments, and dividing the rats into a model group, an administration group 1, an administration group 2 and an administration group 3, wherein the administration group 1, the administration group 2 and the administration group 3 are respectively administered with extracts of plantain seed, coptis root and plantain seed-coptis root (1:1), and the preparation method is as follows:

plantain seed extract: pulverizing semen plantaginis, reflux-extracting with 5 times of 75% ethanol for 2 times, each for 1 hr, mixing extractive solutions, and concentrating;

the coptis chinensis extract: pulverizing Coptidis rhizoma, reflux-extracting with 5 times of 75% ethanol for 2 times, each for 1 hr, mixing extractive solutions, and concentrating;

plantain seed-coptis (1:1) extract: mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 1:1, extracting with 5 times of 75% ethanol under reflux for 2 times, each for 1 hr, mixing extractive solutions, and concentrating.

The administration groups 1 and 2 are orally administrated with 8g crude drug/kg per day, the administration group 3 is orally administrated with 16g crude drug/kg per day, and the administration is continuously carried out for 2 weeks, and after the administration is finished, the fasting blood glucose value and the oral starch tolerance level of rats in each group are measured. The experimental data were analyzed for variance and the results are expressed in x ± s.

TABLE 2 Effect of the above Chinese medicinal composition on fasting blood glucose of type II diabetic rats

Note:^###P<0.001, compared to the normal group; p<0.05，***P<0.001, compared to the model group.

TABLE 3 influence of the above Chinese medicinal composition on starch tolerance of type II diabetic rats

Note:^###P<0.001, compared to the normal group; p<0.05，**P<0.01，***P<0.001, compared to the model group.

As can be seen from tables 2 and 3: compared with the normal group, the fasting blood glucose value of the rat in the model group is obviously increased, which indicates that the model of the type II diabetes mellitus model is successfully modeled. Meanwhile, compared with a model group, the traditional Chinese medicine composition has the obvious effects of reducing fasting blood sugar and improving the tolerance of oral starch of rats, and the blood sugar reducing effect and the regulation capability of the starch tolerance are obviously superior to those of the plantain seed or the coptis chinensis which are singly used.

Example 10

Healthy male wistar rats (200 +/-20) g were selected and randomly divided into normal groups and building groups, and the latter were fed with fructose feed (fructose 65%, casein 20%, corn oil 5%, cellulose 5%, complex minerals 3.5%, complex vitamins 1%, methionine 0.3%, bile salts of tartaric acid 0.2%) for 4 weeks. After 4 weeks of molding, the molding groups were divided into a model group and an administration group according to the fasting blood glucose value. The administration group is administered with semen plantaginis-Coptidis rhizoma (6:1) extract, and the preparation method comprises:

plantain seed-coptis (6:1) extract: mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 6:1, extracting with 12 times of water under reflux for 5 times, each time for 4 hr, mixing extractive solutions, and concentrating.

The administration group orally administrates 12g crude drug/kg daily for 4 weeks, and measures the weight, blood pressure, fasting blood glucose, serum triglyceride and total cholesterol level of rats after administration. The experimental data were analyzed for variance and the results are expressed in x ± s.

TABLE 4 Effect of the above Chinese medicinal composition on systolic blood pressure, fasting blood glucose and blood lipid of rats with fructose-induced metabolic syndrome

Note:^#P<0.05，^###P<0.001, compared to the normal group; p<0.05，**P<0.01，***P<0.001, compared to the model group.

As can be seen from table 4: compared with the normal group, the weight, the blood pressure and the serum triglyceride level of the rats in the model group are obviously increased, and the fasting blood glucose and the serum total cholesterol level are also increased to a certain extent, which indicates that the model building of the metabolic syndrome model is successful. Meanwhile, compared with a model group, the traditional Chinese medicine composition has the obvious effects of reducing weight, blood pressure and serum triglyceride, and has a certain regulating effect on fasting blood glucose and serum total cholesterol, so that the traditional Chinese medicine composition has a good effect of treating metabolic syndrome.

Example 11

Taking 8-week-old C57B L/6 mice as a normal group, and taking male and female halves, taking 8-week-old db/db mice, and taking male and female halves, randomly dividing the mice into a model group and an administration group according to the fasting blood sugar value, wherein the administration group is administered with the plantain seed-coptis chinensis (3:1) extract, and the preparation method is as follows:

plantain seed-coptis (3:1) extract: mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 3:1, extracting with 8 times of 95% ethanol under reflux for 2 times, each for 2 hr, mixing extractive solutions, and concentrating.

The administration group orally administrates 12g crude drug/kg per day for 2 weeks, measures fasting blood glucose level of animals after administration, and performs glucose tolerance and insulin tolerance test. Blood from the mice was collected to determine serum indices. The experimental data were analyzed for variance and the results are expressed in x ± s.

TABLE 5 Effect of the above Chinese medicinal composition on fasting blood glucose in db/db mice

Note:^###P<0.001, compared to the normal group; p<0.05, compared to the model set.

TABLE 6 influence of the above Chinese medicinal composition on glucose tolerance of db/db mouse

Note:^###P<0.001, compared to the normal group; p<0.05, compared to the model set.

TABLE 7 Effect of the above-mentioned Chinese medicinal compositions on insulin resistance in db/db mice

Note:^###P<0.001, compared to the normal group; p<0.05, compared to the model set.

TABLE 8 Effect of the above-mentioned Chinese medicinal compositions on serum biochemical indices of db/db mice

Note:^###P<0.001, compared to the normal group; p<0.05, compared to the model set.

As shown in tables 5-8, the traditional Chinese medicine composition can obviously reduce fasting blood glucose of db/db mice, improve glucose and insulin tolerance of the db/db mice, improve fasting blood lipid level of the db/db mice to a certain extent, reduce low-density lipoprotein content of serum of the db/db mice, and has a good effect of improving abnormal glycolipid metabolism.

Example 12

The method comprises the following steps of selecting 22 +/-2 g male ICR mice, randomly dividing the mice into a normal group and a modeling group, injecting a tetrapyridyl aqueous solution (45mg/kg) into the tail vein of the mice for modeling, feeding a 50% glucose aqueous solution 20m L/kg after 4.5h, so as to prevent the mice from dying due to hypoglycemia, measuring fasting plasma glucose of the mice 72h after modeling, screening the mice with blood glucose values of more than 11.1 mmol/L for experiments, and dividing the mice into a model group, an administration group 1, an administration group 2 and an administration group 3, wherein the administration group 1, the administration group 2 and the administration group 3 are respectively fed with extracts of semen plantaginis, rhizoma coptidis and semen plantaginis-rhizoma coptidis (1:1), and the preparation method comprises the following steps:

plantain seed extract: pulverizing semen plantaginis, extracting with 10 times of 60% ethanol under reflux for 3 times, each for 2 hr, mixing extractive solutions, and concentrating;

the coptis chinensis extract: pulverizing Coptidis rhizoma, reflux-extracting with 10 times of 60% ethanol for 3 times, each for 2 hr, mixing extractive solutions, and concentrating;

plantain seed-coptis (1:1) extract: mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 1:1, extracting with 10 times of 60% ethanol under reflux for 3 times, each for 2 hr, mixing extractive solutions, and concentrating.

The administration group orally administrates 12g crude drug/kg per day for 2 weeks, and measures fasting blood glucose of animals after administration. The experimental data were analyzed for variance and the results are expressed in x ± s.

TABLE 9 Effect of the above-mentioned Chinese medicinal composition on tetraoxypyrimidine-induced type I diabetic mice

Note:^###P<0.001, compared to the normal group; p<0.01，***P<0.001, compared to the model group.

As can be seen from table 9: the traditional Chinese medicine composition can obviously reduce fasting blood glucose of mice with type I diabetes induced by alloxan, and the traditional Chinese medicine composition has a good function of regulating blood glucose. Meanwhile, in the process of independently administering the coptis extract, the mice have the phenomena of grey and dark hair, poor mental state, diarrhea and the like, all die before the experiment is finished, and most dead animals have severe flatulence after dissection. The traditional Chinese medicine composition can obviously improve the living quality of mice and reduce the death rate, and shows that compared with the single use of the coptis chinensis, the traditional Chinese medicine composition provided by the invention can obviously improve the safety of the single use of the coptis chinensis and reduce the occurrence of adverse reactions, thereby playing the roles of reducing toxicity and enhancing efficiency.

Example 13

Selecting 6-week-old male C57B L/6 mice, randomly dividing into a blank group and a model building group, feeding the mice with low-fat feed (protein 20%, carbohydrate 70%, fat 10%) and high-fat feed (protein 20%, carbohydrate 20%, fat 60%) for 12 weeks, respectively, measuring fasting blood glucose of the mice, screening the mice with blood glucose value more than 11.1 mmol/L for experiment, and dividing into a model group, an administration group 1, an administration group 2, an administration group 3, an administration group 4 and an administration group 5, wherein the administration group 1, the administration group 2, the administration group 3, the administration group 4 and the administration group 5 are respectively administered with semen plantaginis, rhizoma coptidis, semen plantaginis-rhizoma coptidis (1:1), semen plantaginis-rhizoma coptidis (2:1) and semen plantaginis-rhizoma coptidis (3:1) extracts, and the preparation method is as follows:

plantain seed extract: pulverizing semen plantaginis, extracting with 10 times of 60% ethanol under reflux for 3 times, each for 2 hr, mixing extractive solutions, and concentrating;

the coptis chinensis extract: pulverizing Coptidis rhizoma, reflux-extracting with 10 times of 60% ethanol for 3 times, each for 2 hr, mixing extractive solutions, and concentrating;

plantain seed-coptis (1:1) extract: mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 1:1, extracting with 10 times of 60% ethanol under reflux for 3 times, each for 2 hr, mixing extractive solutions, and concentrating.

Plantain seed-coptis (2:1) extract: mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 22:1, extracting with 10 times of 60% ethanol under reflux for 3 times, each for 2 hr, mixing extractive solutions, and concentrating.

Plantain seed-coptis (3:1) extract: mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 3:1, extracting with 10 times of 60% ethanol under reflux for 3 times, each for 2 hr, mixing extractive solutions, and concentrating.

The administration group 1 orally administrates 9g crude drug/kg per day, the administration group 2 orally administrates 3g crude drug/kg per day, the administration groups 3, 4, 5 orally administrates 12g crude drug/kg per day, continuously administrates 2 weeks, and measures the weight, fasting blood sugar, glucose tolerance, insulin tolerance and blood lipid level of the mice after the administration. The experimental data were analyzed for variance and the results are expressed in x ± s.

TABLE 10 influence of the above Chinese medicinal composition on fasting blood glucose and blood lipid of mice with metabolic syndrome induced by high fat feed

Note:^###P<0.001, compared to blank; p<0.05，**P<0.01, compared to the model set.

TABLE 11 influence of the above Chinese medicinal composition on glucose tolerance of mice with high fat diet-induced metabolic syndrome

Note:^###P<0.001, compared to blank; p<0.05，**P<0.01，***P<0.001 compared to the model group.

TABLE 12 Effect of the above Chinese medicinal composition on insulin resistance of mice with high fat diet-induced metabolic syndrome

Note:^#P<0.05，^##P<0.01 vs blank; p<0.05，**P<0.01 compared to the model set.

As can be seen from tables 10-12: semen plantaginis, Coptidis rhizoma, and the above Chinese medicinal composition can significantly reduce the body weight, fasting blood glucose, and blood lipid level of mice with metabolic syndrome induced by high fat feed, and improve glucose and insulin tolerance of mice with metabolic syndrome induced by high fat feed. The traditional Chinese medicine composition has better drug effect than the single use of the plantain seed and the coptis, shows good effect of improving the abnormal glycolipid metabolism, and can obviously reduce the number of mice dead caused by the single use of the coptis, thereby showing that the traditional Chinese medicine composition can enhance the drug effect while improving the safety, and has great drug development potential and clinical application value.

Claims (3)

1. A decoction for preventing and treating metabolic syndrome is characterized in that:

mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 3:1, decocting with 10 times of water for 3 times, each for 2 hr, mixing extractive solutions, and making into decoction.

2. An oral liquid for preventing and treating metabolic syndrome, which is characterized in that:

mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 3:1, decocting with 10 times of water for 3 times, each for 2 hr, mixing extractive solutions, adding appropriate amount of aspartame as correctant, and making into oral liquid.

3. A tablet for preventing and treating metabolic syndrome, which is characterized in that:

mixing semen plantaginis and Coptidis rhizoma at a mass ratio of 3:1, decocting with 10 times of water for 3 times, each for 2 hr, mixing extractive solutions, concentrating, and vacuum drying the extract; and uniformly mixing 20g of extract, 400g of lactose, 20g of aerosil, 20g of sodium carboxymethyl starch, 100g of soluble starch and 2g of magnesium stearate, and preparing the mixture into tablets.