CN101978887A - Health-care food with auxiliary lipid-lowering efficacy - Google Patents
Health-care food with auxiliary lipid-lowering efficacy Download PDFInfo
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- CN101978887A CN101978887A CN201010277310XA CN201010277310A CN101978887A CN 101978887 A CN101978887 A CN 101978887A CN 201010277310X A CN201010277310X A CN 201010277310XA CN 201010277310 A CN201010277310 A CN 201010277310A CN 101978887 A CN101978887 A CN 101978887A
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Abstract
The invention relates to the field of health-care foods, and aims to provide a health-care food with an auxiliary lipid-lowering efficacy. The health-care food comprises the following active ingredients in part by mass: 4 to 6 parts of Pu'er tea extract, 5 to 9 parts of ginkgo leaf extract and 10 to 16 parts of pueraria extract. A preparation method for the Pu'er tea extract comprises the following steps of: continuously leaching a cooked Pu'er tea raw material twice in boiling distilled water in a volume which is 10 times mass of the cooked Pu'er tea raw material, wherein the leaching time is 10 minutes each time; merging leaching liquor after filtering; and performing spray-drying after concentrating the merged leaching liquor under a reduced pressure to obtain dust-color powder, namely the Pu'er tea extract. Physicochemical property appraisal, toxicological safety evaluation and functional experiments show that the health-care food of the invention has definite components, high stability, no toxic or side effect and remarkable lipid lowering function, and is the health-care food with the auxiliary lipid-lowering efficacy.
Description
Technical field
The present invention relates to field of health care food, be specifically related to a kind of health food with auxiliary antilipemic effect.
Background technology
Continuous quickening along with urban work rhythm, people's diet nutritional composition takes in that science and unbalanced problem are more and more not general, a large amount of absorptions of high sugar, high animal tallow, add unsound life styles such as the part crowd lacks exercise, smoking, heavy drinking, cause that blood lipid metabolism is unusual in the body, finally cause the problem of hyperlipemia.
Blood fat is the general name of lipid in blood plasma or the serum, comprises cholesterol, triglycerides, phosphatide etc., when blood in human body in fat metabolic disorder and when causing that lipid content surpasses normal concentration, medically is called hyperlipidemia.At present, China's hyperlipidemia incidence has remarkable ascendant trend.And clinically to hyperlipidemia mainly based on drug therapy, yet, along with growth in the living standard, the modern society crowd is more prone to strengthen the prevention to hyperlipemia, especially takes safety and health food effective people's a kind of preventive means of taking like a shot especially.For this reason, be raw material with the natural products that from plant, extracts, invent a kind of health food and have great importance with remarkable blood fat reducing function.
Summary of the invention
The technical problem to be solved in the present invention is, overcomes deficiency of the prior art, and a kind of health food with auxiliary antilipemic effect is provided.
Be the technical solution problem, the invention provides a kind of health food, comprise the active ingredient of following mass parts with auxiliary antilipemic effect:
4～6 parts of Pu'er teas
5～9 parts of ginkgo biloba p.es
10～16 parts of kudzu root extracts
The preparation method of described Pu'er tea is: with the continuously lixiviate 2 times in the distilled water that boils of 10 times of mass volume ratios of ripe Pu'er tea raw material, each extraction time is 10min; Filter the back and merge leaching liquor, decompression concentrates the back spray-drying, obtains the taupe powder, is Pu'er tea.
Ginkgo biloba p.e among the present invention and kudzu root extract all can obtain with procurement method from market.
The preparation method of ginkgo biloba p.e provided by the invention is: with the ginkgo leaf raw material in 40% ethanolic solution of 8 times of quality volumes, twice of lixiviate continuously under 80 ℃ the temperature; Leaching liquor concentrates, and reclaims ethanol; Polyamide column on the concentrate; The pure water of 2 times of column volumes is washed assorted; 70% ethanol elution is to colourless; Eluent is concentrated the back spray-drying, obtain pale brown toner end, be ginkgo biloba p.e.
The preparation method of kudzu root extract provided by the invention is: in 60% ethanol of 6 times of quality volumes, continuous lixiviate is twice under 65 ℃ the temperature with root of kudzu vine raw material; Leaching liquor concentrates, and reclaims ethanol; Polyamide column on the concentrate; The pure water of 2 times of column volumes is washed assorted; Use 75% ethanol elution to colourless again; Eluent is concentrated the back spray-drying, obtain pale brown toner end, be kudzu root extract.
As a kind of improvement, the present invention is made up of any one peroral dosage form acceptable auxiliary commonly used in described active ingredient and preparation soft capsule, hard shell capsules, tablet, granule or the oral liquid.
Among the present invention, described auxiliary material is an auxiliary material used when the preparation tablet: sodium carboxymethyl starch, pregelatinized starch and dolomol.
Pu'er tea is a feedstock production with the high-quality Pu'er tea, contain various active compositions such as Tea Polyphenols, tea polysaccharide, Tea Pigment and theanine, and contain a small amount of statin substance, discover that Pu'er tea can effectively reduce TG (triglycerides), TC (T-CHOL) and LDL-C (LDL-C) level, simultaneously can selectivity HMG CoA (HMG2CoA) reduction
Enzyme inhibitor can suppress the biosynthesis of cholesterol competitively, causes cell inner cholesterol content to reduce, and Pu'er tea safely, have no side effect, be suitable as very much the raw material of health food exploitation.
Ginkgo biloba p.e has two big active ingredients: flavone compound and terpene lactones compound.Flavone compound mainly is made of single flavones, flavonols and glucoside thereof and biflavone and catechin etc.Studies show that ginkgo biloba p.e has tangible reduction effectiveness to the hyperlipidemia rats blood lipid level, ginkgo biloba p.e can be corrected the lipid-metabolism of hyperlipidemia effectively, hyperlipidemia due to the high fat diet had the good preventing effect, also having the nerve conduction of raising and functions such as visual function, angiocardiopathy preventing and raising immunocompetence simultaneously, is the raw material that numerous health food is favored.
The pharmacological action of kudzu root extract is very extensive, have the expansion cardiovascular and cerebrovascular, reduce myocardium keto consumption, improve many effects such as myocardium shrinkage function and promotion microcirculation, wherein the active ingredient Puerarin has been used as injection and has been widely used in diseases such as treatment coronary heart disease, retina artery and vein obstruction and sudden deafness, ischemic cerebrovascular disease, diabetes.Discover that Puerarin can reduce the content of mice serum T-CHOL, the content of increasing high density lipoprotein reduces low-density lipoprotein and VLDL content, prevents the low-density lipoprotein over oxidation.And can further reduce fat, thereby reduce atherosclerotic incidence in the coronary arterial wall deposition.These studies have shown that kudzu root extract has tangible effect for reducing blood fat.
The present inventor is by discovering, the rational proportion between Pu'er tea, ginkgo biloba p.e and the kudzu root extract can be brought into play the effect that reduces lipid cholesterol content better, thereby plays the auxiliary antilipemic effect.The present invention verifies through Zhejiang Center For Disease Control and Prevention, takes the TC (T-CHOL) and the LDL-C (LDL-C) that make hyperlipemic patients after one month and descends more than 10%; TG (triglycerides) descends more than 20%; Total effective rate reaches 80%, meets in " health food check with assessment technique standard " (2003 editions) the evaluation requirement to health-care food for assisting blood fat lowering fully.
Beneficial effect of the present invention is:
Show by physicochemical property evaluation, toxicological assessment, functional experiment, health food definite ingredients of the present invention, good stability, have no side effect, hypolipemic function is remarkable, is a kind of health food with auxiliary antilipemic effect.
The specific embodiment
Below in conjunction with embodiments of the invention the present invention is further described.
What embodiment 1～3 disclosed is the preparation tablets of Ricipe for health care food of the present invention, and its auxiliary material comprises:
7～13 parts of sodium carboxymethyl starches
8～12 parts of pregelatinized starch
0.01～0.05 part of dolomol
Each raw material mass mixture ratio sees the following form:
According to the foregoing description with each composition according to the weight ratio mixing, compressing tablet after granulating, every heavy 0.45g, every contained active ingredient total amount＞400mg.Using method is that warm water takes, every day twice, each 2.
At last, it is also to be noted that, obviously the invention is not restricted to above embodiment, many distortion can also be arranged, all distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.
Claims (5)
1. health food with auxiliary antilipemic effect comprises the active ingredient of following mass parts:
4～6 parts of Pu'er teas
5～9 parts of ginkgo biloba p.es
10～16 parts of kudzu root extracts
The preparation method of described Pu'er tea is:
With the continuously lixiviate 2 times in the distilled water that boils of 10 times of mass volume ratios of ripe Pu'er tea raw material, each extraction time is 10min; Filter the back and merge leaching liquor, decompression concentrates the back spray-drying, obtains the taupe powder, is Pu'er tea.
2. according to the described health food of claim 1, it is characterized in that the preparation method of described ginkgo biloba p.e is with auxiliary antilipemic effect: with the ginkgo leaf raw material in 40% ethanolic solution of 8 times of quality volumes, twice of lixiviate continuously under 80 ℃ the temperature; Leaching liquor concentrates, and reclaims ethanol; Polyamide column on the concentrate; The pure water of 2 times of column volumes is washed assorted; 70% ethanol elution is to colourless; Eluent is concentrated the back spray-drying, obtain pale brown toner end, be ginkgo biloba p.e.
3. according to the described health food with auxiliary antilipemic effect of claim 1, it is characterized in that the preparation method of described kudzu root extract is: in 60% ethanol of 6 times of quality volumes, continuous lixiviate is twice under 65 ℃ the temperature with root of kudzu vine raw material; Leaching liquor concentrates, and reclaims ethanol; Polyamide column on the concentrate; The pure water of 2 times of column volumes is washed assorted; Use 75% ethanol elution to colourless again; Eluent is concentrated the back spray-drying, obtain pale brown toner end, be kudzu root extract.
4. according to the described health food of claim 1, it is characterized in that, form by any one peroral dosage form acceptable auxiliary commonly used in described active ingredient and preparation soft capsule, hard shell capsules, tablet, granule or the oral liquid with auxiliary antilipemic effect.
5. according to the described health food of claim 4, it is characterized in that described auxiliary material is an auxiliary material used when the preparation tablet: sodium carboxymethyl starch, pregelatinized starch and dolomol with auxiliary antilipemic effect.
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| CN201010277310XA CN101978887A (en) | 2010-09-09 | 2010-09-09 | Health-care food with auxiliary lipid-lowering efficacy |
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| CN201010277310XA CN101978887A (en) | 2010-09-09 | 2010-09-09 | Health-care food with auxiliary lipid-lowering efficacy |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102613362A (en) * | 2012-04-17 | 2012-08-01 | 徐州绿之野生物食品有限公司 | Ginkgo kuding tea and preparation method thereof |
| CN102626156A (en) * | 2012-04-11 | 2012-08-08 | 徐州绿之野生物食品有限公司 | Ginkgo leaf extraction process and method for processing fermented ginkgo Pu'er tea |
| CN102726557A (en) * | 2011-04-02 | 2012-10-17 | 陕西功能食品工程中心有限公司 | Food possessing auxiliary hypolipidemic function |
| CN103505505A (en) * | 2012-06-28 | 2014-01-15 | 天津天狮生物发展有限公司 | Blood lipid reducing composition containing ginkgo leaves and preparation method of composition |
| CN104473148A (en) * | 2014-11-10 | 2015-04-01 | 浙江大学 | Health food with auxiliary blood fat reducing effect |
| CN109157584A (en) * | 2018-10-25 | 2019-01-08 | 雷允上药业集团有限公司 | A kind of composition and its preparation method and application with auxiliary lipid-lowering function |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1097552A (en) * | 1993-07-23 | 1995-01-25 | 邱芳龙 | A kind of health protection tea of adding ginkgo, kudzu root extract |
| CN1817162A (en) * | 2005-02-07 | 2006-08-16 | 云南金色生活生物产业技术开发有限公司 | Instant Pu'er tea, its production and use thereof |
| CN101306074A (en) * | 2008-04-01 | 2008-11-19 | 中国人民解放军空军航空医学研究所 | Anti-alcohol and liver- protection medicine composition |
-
2010
- 2010-09-09 CN CN201010277310XA patent/CN101978887A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097552A (en) * | 1993-07-23 | 1995-01-25 | 邱芳龙 | A kind of health protection tea of adding ginkgo, kudzu root extract |
| CN1817162A (en) * | 2005-02-07 | 2006-08-16 | 云南金色生活生物产业技术开发有限公司 | Instant Pu'er tea, its production and use thereof |
| CN101306074A (en) * | 2008-04-01 | 2008-11-19 | 中国人民解放军空军航空医学研究所 | Anti-alcohol and liver- protection medicine composition |
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| 《中国茶叶》 20040430 傅冬和等 茶叶降脂减肥作用研究进展 8-10全文 1-5 , 第2期 2 * |
| 《安徽农业科学》 20091231 周斌星等 普洱茶(熟茶)提取物泡腾片主体配方的研究 15410-15411,15416全文 1-5 第37卷, 第31期 2 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102726557A (en) * | 2011-04-02 | 2012-10-17 | 陕西功能食品工程中心有限公司 | Food possessing auxiliary hypolipidemic function |
| CN102626156A (en) * | 2012-04-11 | 2012-08-08 | 徐州绿之野生物食品有限公司 | Ginkgo leaf extraction process and method for processing fermented ginkgo Pu'er tea |
| CN102613362A (en) * | 2012-04-17 | 2012-08-01 | 徐州绿之野生物食品有限公司 | Ginkgo kuding tea and preparation method thereof |
| CN103505505A (en) * | 2012-06-28 | 2014-01-15 | 天津天狮生物发展有限公司 | Blood lipid reducing composition containing ginkgo leaves and preparation method of composition |
| CN104473148A (en) * | 2014-11-10 | 2015-04-01 | 浙江大学 | Health food with auxiliary blood fat reducing effect |
| CN109157584A (en) * | 2018-10-25 | 2019-01-08 | 雷允上药业集团有限公司 | A kind of composition and its preparation method and application with auxiliary lipid-lowering function |
| CN109157584B (en) * | 2018-10-25 | 2021-08-17 | 雷允上药业集团有限公司 | Composition with auxiliary blood fat reducing function and preparation method and application thereof |
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Application publication date: 20110223 |