CN104126838B - A kind of food of clearing away the heart fire and tranquillizing, health products or pharmaceutical composition - Google Patents
A kind of food of clearing away the heart fire and tranquillizing, health products or pharmaceutical composition Download PDFInfo
- Publication number
- CN104126838B CN104126838B CN201410390594.1A CN201410390594A CN104126838B CN 104126838 B CN104126838 B CN 104126838B CN 201410390594 A CN201410390594 A CN 201410390594A CN 104126838 B CN104126838 B CN 104126838B
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- fresh bamboo
- bamboo juice
- lily
- tranquillizing
- health products
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Classifications
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- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
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- A23L2/39—Dry compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention provides a kind of food of clearing away the heart fire and tranquillizing, health products or pharmaceutical composition, its raw material comprises the component of following proportioning: fresh bamboo juice: lily=10 ~ 50ml:0.5 ~ 10g.Present invention also offers preparation method and the purposes of said composition.Research shows, composition provided by the invention, possesses good clearing away the heart fire and tranquillizing effect, can be used as calmness, the food of hypnosis, health products or medicine and uses.
Description
Technical field
The present invention relates to a kind of food of clearing away the heart fire and tranquillizing, health products or pharmaceutical composition.
Background technology
Insomnia, referring to fall asleep maybe cannot keep sleep state, causes not having enough sleep.Also known as DIMS (DlMS), for a variety of causes cause that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of common disease.Insomnia often brings painful and psychological burden greatly to patient, can damage other every aspects of health again because of abuse insomnia drug.Along with the development of economic society, occur that crowd's quantity of insomnia increases gradually.
Traditional Chinese medical science integration of drinking and medicinal herbs theory is thought, much food is food is also medicine, food the same with medicine same can disease preventing and treating.In ancient times in primitive society, people have found nature and flavor and effect of various food and medicine in the process of search of food, and recognize that much food can be medicinal, many medicines are also edible, this is the basis of " integration of drinking and medicinal herbs " theory, is also dietetic basis.
Therefore, the integration of drinking and medicinal herbs product being representative with natural herb beverage, be endowed deep Chinese medical culture, it is emphasized " health, environmental protection, succinct, practical, reasonable price ", it is the third generation drink after carbonic acid, beverage made of fruits or vegetables, compare common beverages, plant beverage natural, green component is higher.With plant beverage be the natural prodcuts of representative owing to innately possessing the product category feature of " natural, green, nutrition, health ", meet low-carbon (LC) food market development trend and trend, more and more like by consumer.
Summary of the invention
The object of the present invention is to provide a kind of food of clearing away the heart fire and tranquillizing, health products or pharmaceutical composition.Another object of the present invention is to the purposes that said composition is provided.
Particularly, the invention provides a kind of food of clearing away the heart fire and tranquillizing, health products or pharmaceutical composition, its raw material comprises the component of following proportioning:
Fresh bamboo juice: lily=10 ~ 50ml:0.5 ~ 10g.
Further, its raw material comprises the component of following proportioning: fresh bamboo juice: lily=10 ~ 20ml:0.5 ~ 1g;
Preferably, raw material comprises the component of following proportioning: fresh bamboo juice: lily=14.5 ~ 20ml:0.6 ~ 0.8g.
Further, its raw material is made up of following proportioning component: fresh bamboo juice: lily=10 ~ 50ml:0.5 ~ 10g.
Further, its raw material is made up of following proportioning component: fresh bamboo juice: lily=10 ~ 20ml:0.5 ~ 1g; Preferably, raw material is made up of following proportioning: fresh bamboo juice: lily=14.5 ~ 20ml:0.6 ~ 0.8g.
Wherein, described fresh bamboo juice is with the fresh stem of gramineous bamboo department linoleic plant for raw material, gets prepare through squeezing or water extraction.Raw material sources of the present invention, in gramineous bamboo department linoleic plant, as mao bamboon, bitter bamboo, Lei Zhu, just bamboo, China pink, arrow bamboo etc., preferably can use the tender bamboo of life in 1 ~ 2 year.
In a specific embodiment party of the present invention, the preparation method of described fresh bamboo juice is as follows: the fresh stem getting Bambusoideae, and pressure extracting juice flows out to without juice, collects the juice of outflow and get final product.
In a specific embodiment party of the present invention, the Bambusoideae used is green bamboo genus, Phyllostachys plant, such as green bamboo, China pink etc.
Further, also honeysuckle is contained in its raw material.
Preferably, raw material is made up of following proportioning: fresh bamboo juice: lily: honeysuckle=10 ~ 20ml:0.5 ~ 1g:0.5 ~ 1g; Preferably, raw material is made up of following proportioning: fresh bamboo juice: lily: honeysuckle=14.5 ~ 20ml:0.6 ~ 0.8g:0.6 ~ 0.8g.
Wherein, it be by the medicinal powder of described raw material, water extract or/and extractive with organic solvent is active component, add the preparation that pharmaceutically conventional auxiliary material or complementary composition are prepared from.
Further, described organic solvent is ethanol or ethanol water.
Water extract or be used as medicine with medicinal powder is all Chinese medicine tradition occupation modes, and after water extraction, because the soluble end of water is wide, can, by most of active ingredient stripping, medicine is more easily absorbed by the body, onset be faster, the form of medication such as such as decoction; Be used as medicine with former powder, the surface area of medicinal powder is larger, also active ingredient absorption in vivo in medicinal material is conducive to, but medicinal material un-extracted, active ingredient still needs stripping in vivo to absorb again, and the relative water extract of its onset is comparatively slow, but also weakens the toxicity that in medicinal material, harmful components cause human body simultaneously, be suitable for long-term taking, as former powder is prepared into the form of medication such as pill.At present in pharmacy procedure, ethanol extracts medicine as solvent, also be one of the most common extracting mode, ethanol is semi-polarity solvent, solubility property circle is between polarity and non-polar solven, some composition water miscible can be dissolved, also some compositions that non-polar solven dissolves can be dissolved, usually decocting is replaced with alcohol extract, thus avoid the stripping of a large amount of invalid components, improve concentration and the extraction efficiency of active ingredient, but comparatively water is expensive for the price of ethanol, in the large production of modern pharmaceutical industry, in order to save production cost, usually still based on decocting.
Pharmaceutically acceptable auxiliary material of the present invention includes but are not limited to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, conditioning agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, disintegrant etc.Adhesive comprises syrup, Arabic gum, gelatin, sorbierite, tragacanth, cellulose and its derivates (as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or HPMC etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.; Filler comprises lactose, Icing Sugar, dextrin, starch and derivative thereof, cellulose and its derivates, inorganic calcium salt (as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate etc.), sorbierite or glycine etc.; Lubricant comprises superfine silica gel powder, dolomol, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, polyethylene glycol etc.; Disintegrant comprises starch and derivative (as sodium carboxymethyl starch, Explotab, pregelatinized starch, modified starch, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.; Wetting agent comprises lauryl sodium sulfate, water or alcohol etc.; Antioxidant packages is containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.; Bacteriostatic agent comprises 0.5% phenol, 0.3% cresols, 0.5% anesin etc.; Conditioning agent comprises hydrochloric acid, citric acid, potassium hydroxide (sodium), sodium citrate and buffer (comprising phosphoric acid dioxy sodium and sodium hydrogen phosphate) etc.; Emulsifier package containing Tween-80, do not have that sour sorb is smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.; Solubilizer comprises Tween-80, bile, glycerine etc.
Described pharmaceutically acceptable complementary composition, it has certain physiologically active, but adding of this composition can not change above-mentioned food, health products or pharmaceutical composition in disease treatment or to the leading position in human body physiological function improvement process, and only play auxiliary effect, these auxiliary effects are only the utilizations to this composition known activity, are the usual supplementary modes of field of medicaments or healthcare field.
Wherein, described formulation is through gastrointestinal administration formulation.Such as, tablet, powder, pill, capsule, granule or oral liquid.
Present invention also offers the preparation method of above-mentioned food, health products or pharmaceutical composition, it comprises following operating procedure:
(1) raw material is got by proportioning;
(2) get other raw materials outside fresh bamboo juice, extracting in water, Aqueous extracts merges preparation with fresh bamboo juice again.
Present invention also offers fresh bamboo juice or above-mentioned food, health products or the pharmaceutical composition purposes in the food of preparation clearing away the heart fire and tranquillizing, health products or medicine.
Present invention also offers that fresh bamboo juice or above-mentioned food, health products or pharmaceutical composition are calm in preparation, purposes in the food of hypnosis, health products or medicine.
Research shows, composition provided by the invention, possesses good clearing away the heart fire and tranquillizing effect, can be used as calmness, the food of hypnosis, health products or medicine and uses.
Obviously, according to foregoing of the present invention, according to ordinary technical knowledge and the means of this area, not departing under the present invention's above-mentioned basic fundamental thought prerequisite, the amendment of other various ways, replacement or change can also be made.
Below by way of the form of specific embodiment, foregoing of the present invention is described in further detail again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Detailed description of the invention
In specific embodiment party of the present invention, press the fresh bamboo juice of extracting juice gained for green bamboo genus or the fresh stem of Phyllostachys plant, the reasonability of compatibility of the present invention is described.
Embodiment 1 plant beverage
[prescription] raw material: fresh bamboo juice 250ml honeysuckle 10g lily 10g
Auxiliary material: isomaltoketose 50g xylitol 50g strawberry essence 1g
[method for making] gets recipe quantity honeysuckle and lily, and add water after appropriate immersion 30min, heating is extracted for several times, collects extracting liquid filtering, merging extract, leaves standstill after letting cool and adds the mixing of fresh bamboo juice.Stir and evenly mix after adding auxiliary material, add water to 1500ml, filling, sterilizing, to obtain final product.
Embodiment 2 solid beverage particle
[prescription] raw material: fresh bamboo juice 250ml honeysuckle 10g lily 10g
Auxiliary material: maltose 100g xylitol 50g grape essence 1g
[method for making] gets recipe quantity honeysuckle and lily, and add water after appropriate immersion 30min, heating is extracted for several times, collects extracting liquid filtering, and merging extract adds the mixing of fresh bamboo juice, is evaporated to suitable density.Add maltose, xylitol mixing, granulate, dry, whole grain, sieves, and adds grape essence, and mixing, packing, to obtain final product.
Embodiment 3 lozenge
[prescription] raw material: fresh bamboo juice 1500ml honeysuckle 60g lily 60g
Auxiliary material: maltose 100g sweet mellow wine 50g menthol 1g dolomol 1.5g
[method for making] gets recipe quantity honeysuckle and lily, and add water after appropriate immersion 30min, heating is extracted for several times, collects extracting liquid filtering, and merging extract adds the mixing of fresh bamboo juice, is evaporated to suitable density.Add maltose, sweet mellow wine mixing, granulate, dry, whole grain, adds menthol, dolomol, mixes, and is pressed into 150, and packaging, to obtain final product.
Embodiment 4 candy
[prescription] raw material: fresh bamboo juice 1500ml honeysuckle 60g lily 60g
Auxiliary material: white granulated sugar 450g grape essence 1g
[method for making] gets recipe quantity honeysuckle and lily, and add water after appropriate immersion 30min, heating is extracted for several times, collects extracting liquid filtering, merge extract, add the mixing of fresh bamboo juice, be evaporated to suitable density, add auxiliary materials and mixing, adopt suitable equipment to prepare according to sugar refining technology, to obtain final product.
Beneficial effect of the present invention is illustrated below by way of test example.
The Study on Physiological Activity of test example 1 present composition
1. material
1.1 test medicine
(1) fresh bamboo juice: get green bamboo, clean bamboo or belong to the fresh stem of (green bamboo belongs to, Phyllostachys) plant together, be split into small pieces, be placed in squeezer squeezing and flow out to without juice, collect the juice of outflow and get final product.
(2) honeysuckle;
(3) lily.
1.2 animal subject
SPF level KM mouse, male and female half and half, body weight 18.5 ~ 22.5g.
1.3 laboratory apparatus, reagent
Electronic balance, stopwatch, 1ml syringe are some.
1.4 medicine grouping and preparation methods
(1) to fill a prescription 1. group: fresh bamboo juice+honeysuckle group.
(2) to fill a prescription 2. group: fresh bamboo juice+lily group.
(3) to fill a prescription 3. group: fresh bamboo juice+honeysuckle+lily group.
Three formulas all arrange high, medium and low dosage group, and 1. basic, normal, high dosage group drug ratio of wherein filling a prescription is respectively: fresh bamboo juice: honeysuckle=2.0ml:0.08g, fresh bamboo juice: honeysuckle=15ml:0.6g, fresh bamboo juice: honeysuckle=145ml:7g; 2,4,10g/kg dosage is respectively:; Formula 2. basic, normal, high dosage group drug ratio is respectively: fresh bamboo juice: lily=2ml:0.08g, fresh bamboo juice: lily=15ml:0.6g, fresh bamboo juice: lily=145ml:7g; 2,4,10g/kg dosage is respectively:; 2,4,10g/kg formula 3. basic, normal, high dosage group drug ratio is respectively: fresh bamboo juice: honeysuckle: lily=2ml:0.08g:0.08g, fresh bamboo juice: honeysuckle: lily=15ml:0.6g:0.6g, fresh bamboo juice: honeysuckle: lily=150ml:7g:7g, and dosage is respectively:.Fresh bamboo juice group dosage is 4g/kg; Honeysuckle group dosage is 2g/kg; Lily group dosage is 2g/kg.In the present invention's test, dosage is all in crude drug.
Take medicinal material in proportion in grams, prepare sample respectively, its decocting method is: honeysuckle, or/and lily is suitably pulverized, adds water and decocts for several times in right amount, collect decoction liquor, filter, merging filtrate.Fresh bamboo juice is added in proportion, mixing after letting cool, for subsequent use.
2. pharmacological evaluation---on the impact of yellow Jackets subliminal hypnosis effect
Mouse is divided into 11 groups at random: control group, positive group, formula 1. ~ 3. high, medium and low dosage group, separately establish fresh bamboo juice group, lily group and honeysuckle group, often organize 10.Prescription drug group respectively by formula 1. ~ 3. prepared given the test agent gavage 0.2ml/10g, fresh bamboo juice group, lily group and honeysuckle group press the corresponding drug extract of 0.2ml/10g dosage gavage respectively, control group gives isopyknic pure water, every day 1 time, successive administration 7d.1h before positive group experiment, lumbar injection stabilizes 2mg/kg.70min after last administration, lumbar injection yellow Jackets 30mg/kg, in the rear 15min of record injection, mouse righting reflex loss reaches the mouse number of more than 1min is sleep number of animals, to survey mice sleep incidence.
2.1 impacts on mouse sleep rate
The results are shown in Table 1.
Table 1 on the impact of mouse sleep rate (
n=10)
Note: compare with control group, * * P<0.01, * P<0.05, compare with fresh bamboo juice group,
△ △p<0.05,
△p<0.05, compares with honeysuckle group,
▲ ▲p<0.05,
▲p<0.05, compares with lily group,
■ ■p<0.05,
■p<0.05.
Table 1 shows, and compares with control group, and three kinds of formulas all can significantly improve mouse sleep rate (P<0.05).With, compare with fresh bamboo juice group, honeysuckle group and lily group, three kinds of formula group mouse sleep rates are all significantly increased (P<0.05).
2.2 impacts on mouse time for falling asleep and sleep time
The results are shown in Table 2.
Table 2 on the impact of mouse sleep rate (
n=10)
Note: compare with control group, * * P<0.01, * P<0.05, compare with fresh bamboo juice group,
△ △p<0.05,
△p<0.05, compares with honeysuckle group,
▲ ▲p<0.05,
▲p<0.05, compares with lily group,
■ ■p<0.05,
■p<0.05.
Table 2 shows, and compares with control group, and three kinds of formulas all significantly can shorten mouse time for falling asleep (P<0.05), significant prolongation mouse sleep time (P<0.05).Compare with fresh bamboo juice group, honeysuckle group and lily group, three kinds of formula group mouse time for falling asleep, sleep times are all significantly increased (P<0.05).
3. conclusion
(1) the present invention studies discovery, after fresh bamboo juice and lily combinationally use, has good tranquilizing effect, and its activity is significantly better than alone fresh bamboo juice and lily, shows that combination of two of the present invention has played synergistic function.
(2) on fresh bamboo juice and lily composition basis, then add honeysuckle, its tranquilizing effect more has promotion trend, and its activity is significantly better than alone fresh bamboo juice, honeysuckle and lily, has played synergistic function after showing the present invention three taste material combination.
Claims (7)
1. health products for clearing away the heart fire and tranquillizing, is characterized in that: its raw material is made up of following proportioning component: fresh bamboo juice: lily: honeysuckle=15ml:0.6g:0.6g.
2. a pharmaceutical composition for clearing away the heart fire and tranquillizing, is characterized in that: its raw material is made up of following proportioning component: fresh bamboo juice: lily: honeysuckle=15ml:0.6g:0.6g.
3. pharmaceutical composition according to claim 2, is characterized in that: lily and honeysuckle adopt water extract as active component, add that pharmaceutically conventional auxiliary material or complementary composition be prepared from through gastrointestinal absorption formulation.
4. the preparation method of health products according to claim 1, is characterized in that: it comprises following operating procedure:
(1) raw material is got by proportioning;
(2) get other raw materials outside fresh bamboo juice, extracting in water, Aqueous extracts merges preparation with fresh bamboo juice again.
5. the preparation method of pharmaceutical composition according to claim 2, is characterized in that: it comprises following operating procedure:
(1) raw material is got by proportioning;
(2) get other raw materials outside fresh bamboo juice, extracting in water, Aqueous extracts merges preparation with fresh bamboo juice again.
6. health products described in claim 1 possess the purposes in the health products of clearing away the heart fire and tranquillizing, calmness or syngignoscism in preparation.
7. pharmaceutical composition described in claim 2 possesses the purposes in the medicine of clearing away the heart fire and tranquillizing, calmness or syngignoscism in preparation.
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CN1628742A (en) * | 2003-12-21 | 2005-06-22 | 施建敏 | Healthy nutrient product for tranquilizing mind |
CN102265959A (en) * | 2011-08-31 | 2011-12-07 | 唐夕蕾 | Fire-clearing and face-beautifying scented tea |
CN103444958A (en) * | 2013-09-06 | 2013-12-18 | 四川大学 | Micro-nano jujube kernel-lily soothing tea granules and preparation method thereof |
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CN102265959A (en) * | 2011-08-31 | 2011-12-07 | 唐夕蕾 | Fire-clearing and face-beautifying scented tea |
CN103845630A (en) * | 2012-11-29 | 2014-06-11 | 蒋国宏 | Summer-heat removing oral agent and preparation method thereof |
CN103444958A (en) * | 2013-09-06 | 2013-12-18 | 四川大学 | Micro-nano jujube kernel-lily soothing tea granules and preparation method thereof |
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