CN115485384A - 经修饰的短干扰核酸(siNA)分子和其用途 - Google Patents

经修饰的短干扰核酸(siNA)分子和其用途 Download PDF

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Publication number
CN115485384A
CN115485384A CN202180032666.3A CN202180032666A CN115485384A CN 115485384 A CN115485384 A CN 115485384A CN 202180032666 A CN202180032666 A CN 202180032666A CN 115485384 A CN115485384 A CN 115485384A
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nucleotides
nucleotide sequence
sina
nucleotide
methyl
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Chinese (zh)
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L·贝格尔曼
V·K·拉杰万希
M·霍斯巴赫
R·K·潘迪
洪劲
L·爱特普
S·M·蒙特罗
N·T·S·德科斯塔
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Aligos Therapeutics Inc
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Aligos Therapeutics Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN202180032666.3A 2020-03-06 2021-03-05 经修饰的短干扰核酸(siNA)分子和其用途 Pending CN115485384A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062986150P 2020-03-06 2020-03-06
US62/986,150 2020-03-06
US202063109196P 2020-11-03 2020-11-03
US63/109,196 2020-11-03
PCT/US2021/021199 WO2021178885A1 (en) 2020-03-06 2021-03-05 Modified short interfering nucleic acid (sina) molecules and uses thereof

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CN115485384A true CN115485384A (zh) 2022-12-16

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US (4) US20220364096A1 (https=)
EP (1) EP4121533A1 (https=)
JP (1) JP2023515664A (https=)
KR (1) KR20220163960A (https=)
CN (1) CN115485384A (https=)
AU (1) AU2021230601A1 (https=)
BR (1) BR112022017287A2 (https=)
CA (1) CA3170466A1 (https=)
CL (1) CL2022002379A1 (https=)
CO (1) CO2022014258A2 (https=)
GE (2) GEAP202416053A (https=)
IL (1) IL296045A (https=)
MX (1) MX2022011012A (https=)
PE (1) PE20221578A1 (https=)
PH (1) PH12022552163A1 (https=)
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CN117024485A (zh) * 2023-08-11 2023-11-10 江苏申基生物科技有限公司 一种2'-OMe腺苷的合成方法
CN117534717A (zh) * 2024-01-09 2024-02-09 凯莱英生命科学技术(天津)有限公司 5′-(e)-乙烯基磷酸酯的合成方法

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WO2023224979A1 (en) * 2022-05-16 2023-11-23 University Of Massachusetts Optimized sirna scaffolds
CN119421887A (zh) * 2022-06-14 2025-02-11 大睿生物医药科技(上海)有限公司 环膦酸酯修饰的核苷酸
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117024485A (zh) * 2023-08-11 2023-11-10 江苏申基生物科技有限公司 一种2'-OMe腺苷的合成方法
CN117534717A (zh) * 2024-01-09 2024-02-09 凯莱英生命科学技术(天津)有限公司 5′-(e)-乙烯基磷酸酯的合成方法

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GEAP202416053A (en) 2024-10-10
WO2021178885A1 (en) 2021-09-10
US20220177888A1 (en) 2022-06-09
AU2021230601A2 (en) 2022-10-20
CA3170466A1 (en) 2021-09-10
BR112022017287A2 (pt) 2022-11-16
US11549110B2 (en) 2023-01-10
EP4121533A1 (en) 2023-01-25
US20230365970A1 (en) 2023-11-16
JP2023515664A (ja) 2023-04-13
PH12022552163A1 (en) 2024-01-29
PE20221578A1 (es) 2022-10-06
KR20220163960A (ko) 2022-12-12
IL296045A (en) 2022-10-01
US20230332153A1 (en) 2023-10-19
GEP20257742B (en) 2025-03-10
AU2021230601A1 (en) 2022-10-06
US20220364096A1 (en) 2022-11-17
MX2022011012A (es) 2022-10-07

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