CN115475199A - Traditional Chinese medicine compound blood-enriching granules and preparation method thereof - Google Patents
Traditional Chinese medicine compound blood-enriching granules and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine compound blood-enriching granule and a preparation method thereof, wherein the traditional Chinese medicine compound blood-enriching granule is prepared from the following raw materials in parts by weight: 4 parts of donkey-hide gelatin, 4 parts of Chinese date, 4 parts of astragalus root, 2 parts of black fungus and 1 part of rose. The invention can play the effects of enriching blood and nourishing yin, tonifying middle-jiao and Qi, nourishing blood and promoting the production of body fluid, achieves the aim of relieving various anemia, has the characteristics of convenient carrying and taking and quick action, and has a formula consisting of medicinal and edible components, so that various people can take the composition for a long time.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine granule preparation, and in particular relates to a traditional Chinese medicine compound blood-enriching granule and a preparation method thereof.
Background
The blood deficiency syndrome refers to the condition of blood deficiency in the body, malnutrition of viscera, meridians and body, usually with pale or sallow complexion, pale nails, dizziness, palpitation, dreaminess, numbness of hands and feet, scanty menstruation, pale color, later stage or amenorrhea, thready pulse and other common symptoms, mostly due to irregular diet, overstrain, excessive blood loss, chronic disease or weak body, the medicine has good clinical basis for treating blood deficiency, and has good clinical effect.
E, donkey-hide gelatin: sweet in nature and flavor, neutral in nature and entering lung, liver and kidney meridians. Has the effects of enriching blood, nourishing yin, moistening dryness and stopping bleeding. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, vexation, insomnia, endogenous deficient wind, cough due to dryness of lung, overstrain cough, hemoptysis, hematemesis, hematuria, hematochezia, metrorrhagia, and gestational fetal leakage. It is called "blood-enriching holy medicine".
Chinese date: sweet taste and warm nature, can tonify middle-jiao and Qi, nourish blood and promote the production of body fluid, and is used for treating diseases such as spleen weakness, anorexia and loose stool, deficiency of both qi and blood, and the like.
Astragalus root: sweet in nature and taste, mild in nature and warm in nature, enters lung and spleen meridians, and is used for qi deficiency and hypodynamia, collapse of middle-jiao, chronic diarrhea and rectocele, hematochezia and metrorrhagia, exterior deficiency and spontaneous perspiration, edema due to qi deficiency, internal heat and diabetes, blood deficiency and sallow complexion, hemiplegia, carbuncle-abscess, ulcer and unhealed ulcer, and unhealed ulcer.
Black fungus: sweet in nature and taste and mild in nature. It enters lung, spleen, large intestine and liver meridians. Has effects in invigorating qi, nourishing blood, moistening lung, stopping bleeding, lowering blood pressure, and resisting cancer. Can be used for treating deficiency of qi and blood, tetany of extremities, chronic cough due to lung deficiency, hemoptysis, hematemesis, epistaxis, bloody flux, hemorrhoid hemorrhage, female metrorrhagia, hypertension, constipation, eyeground hemorrhage, cervical cancer of subsidiary organs, vaginal cancer, and traumatic injury.
And (3) rose: sweet in nature and taste, slightly bitter and warm. It enters liver and spleen meridians. Has effects in promoting qi circulation, relieving depression, regulating blood circulation, and relieving pain. Can be used for treating liver and stomach qi pain, anorexia, emesis, menoxenia, traumatic injury, and pain.
The existing blood-enriching granules mostly take donkey-hide gelatin or angelica as main medicines, and when the donkey-hide gelatin is taken as the main medicine, the donkey-hide gelatin occupies a great proportion in the formula, so that the cost is increased to a great extent, and the price is high; the granule containing angelica in the formula cannot be taken by pregnant women, and women in the physiological period should use the granule with cautions, which has great limitation.
Disclosure of Invention
In order to overcome the technical problems, the invention aims to provide a traditional Chinese medicine compound blood-enriching granule and a preparation method thereof, which can achieve the effects of enriching blood, nourishing yin, strengthening the middle warmer, tonifying qi, nourishing blood and promoting the production of body fluid, achieve the aim of relieving various anemias, have the characteristics of convenience in carrying and taking and rapid action, are prepared from medicinal and edible components, and can be taken by various people for a long time.
In order to achieve the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine compound blood-enriching granule is prepared from the following raw materials in parts by weight: 4 parts of donkey-hide gelatin, 4 parts of Chinese date, 4 parts of astragalus root, 2 parts of black fungus and 1 part of rose.
A preparation method of Chinese medicinal compound blood-tonifying granule comprises the following steps;
(1) Drying colla Corii Asini, pulverizing, and sieving with 100 mesh sieve;
(2) Decocting radix astragali in water twice, mixing decoctions, filtering, concentrating the filtrate, adding ethanol, stirring, standing, collecting supernatant, recovering ethanol, concentrating into fluid extract, controlling relative density to make the viscosity of the fluid extract in a proper range, and influencing the addition amount of adjuvants, to facilitate granulation and improve granule quality;
(3) Soaking Auricularia in warm water, blanching in hot water, drying, pulverizing, sieving with 100 mesh sieve, ultrasonic extracting with water as extractive solution, filtering, and concentrating the filtrate to obtain soft extract;
(4) Ultrasonic extracting fructus Jujubae and flos Rosae Rugosae with water and ethanol respectively, filtering, and concentrating to obtain soft extract;
(5) Mixing dextrin and lactose as filler, mixing the filler with colla Corii Asini powder, sequentially adding fructus Jujubae, radix astragali, auricularia and flos Rosae Rugosae extract to obtain soft extract, adding appropriate amount of ethanol, mixing, granulating with 14 mesh sieve, drying, sieving with 14 mesh sieve, grading, and packaging.
Decocting the astragalus membranaceus in water twice in the step (2), wherein the first time lasts for 3 hours, the second time lasts for 2 hours, combining decoction liquids, filtering, concentrating the filtrate until the relative density is about 1.21-1.24, adding ethanol to enable the ethanol content to be 70%, stirring uniformly, standing, taking supernate, recovering ethanol, and concentrating the supernate into clear paste with the relative density of 1.31-1.33.
The extraction conditions in the step (3) are as follows: the material-liquid ratio is 1: 40, the ultrasonic power is 100W, the extraction temperature is 50 ℃, the ultrasonic time is 20min, the filtration is carried out after the extraction, and the filtrate is concentrated into thick paste.
The extraction conditions of the Chinese dates in the step (4) are as follows: performing ultrasonic extraction with water as solvent at a ratio of 1: 12, ultrasonic power of 100W, extraction temperature of 55 deg.C and ultrasonic time of 90min; and (3) rose extraction conditions: performing ultrasonic extraction with 75% ethanol as solvent at a material-liquid ratio of 1: 10 with ultrasonic power of 100W, extraction temperature of 40 deg.C, and ultrasonic time of 30min. Ultrasonic extracting, filtering, and concentrating the filtrate into soft extract.
And (5) mixing dextrin and lactose in a ratio of 1: 2 to obtain a filler, uniformly mixing 15 parts of the filler and 4 parts of donkey-hide gelatin powder, sequentially adding 4 parts of Chinese date, 4 parts of astragalus, 2 parts of black fungus and 1 part of rose flower to obtain thick paste, finally adding a proper amount of 70% ethanol, uniformly mixing to prepare a soft material, sieving with a 14-mesh sieve to granulate, drying, and sieving with a 14-mesh sieve to granulate.
The invention has the beneficial effects that:
the donkey-hide gelatin, chinese date and astragalus are used as main raw materials, and black fungus and rose are matched, so that the donkey-hide gelatin oral liquid has the effects of enriching blood and nourishing yin, tonifying middle-jiao and Qi, promoting qi circulation and removing depression, activating blood and relieving pain, nourishing blood and promoting fluid production and the like, and can be used as a dietary therapy means in daily life to achieve the purposes of improving the physical condition of people and relieving anemia.
Among many types of anemia, iron-deficiency anemia is a condition that has the highest incidence and affects the most people. Compared with the conventional formula, the invention adds two raw materials of black fungus and rose besides the Chinese date and the astragalus root for tonifying qi. The edible fungus contains rich iron element, and vitamin C in rose and Chinese date can be chelated with the iron element, so that the iron absorption rate of a human body is increased, and the treatment can be performed on iron-deficiency anemia; the flos Rosae Rugosae has analgesic effect, and is suitable for women in physiological stage.
Detailed Description
The present invention will be described in further detail with reference to examples.
A traditional Chinese medicine compound blood-enriching granule is prepared from the following raw materials in parts by weight: 4 parts of donkey-hide gelatin, 4 parts of Chinese date, 4 parts of astragalus root, 2 parts of black fungus and 1 part of rose.
Taking a small amount of preparation as an example, the preparation method comprises the following steps:
(1) Weighing 8g of donkey-hide gelatin, crushing into fine powder, and sieving with a 100-mesh sieve for later use.
(2) Weighing 4g of agaric, cleaning, soaking in warm water, blanching with hot water, drying in a drying oven, pulverizing into fine powder, adding 40 times of water, performing ultrasonic extraction at 50 ℃ for 30min under the condition of 100W of power, filtering, and concentrating the filtrate into thick paste for later use.
(3) Decocting 8g of astragalus mongholicus in water twice, the first time lasts for 3 hours, the second time lasts for 2 hours, the decoction liquid is merged and filtered, the filtrate is concentrated to the relative density of about 1.21-1.24, ethanol is added to ensure that the ethanol content is 70%, the mixture is stirred evenly and stands, supernatant liquid is taken to recover the ethanol, and the ethanol is concentrated into clear paste with the relative density of 1.31-1.33 for later use.
(4) Weighing 8g of Chinese dates, drying, crushing, adding 12 times of water, carrying out ultrasonic extraction for 90min at the power of 100W and the temperature of 55 ℃, filtering, and concentrating the filtrate into thick paste for later use.
(5) Weighing 2g of rose, drying, pulverizing, adding 10 times of water, performing ultrasonic extraction for 30min at 40 ℃ and 100W, filtering, and concentrating the filtrate into soft extract for later use.
(6) Dextrin and lactose were mixed at a ratio of 1: 2 as fillers. Mixing colla Corii Asini powder 8g and filler 30g, adding soft extract of fructus Jujubae, radix astragali, auricularia, and flos Rosae Rugosae, mixing, adding 70% ethanol, making into soft mass, sieving with 14 mesh sieve, granulating, drying at 60 deg.C for 2 hr, sieving with 14 mesh sieve, grading, and packaging.
(7) The yield of the qualified granules screened by the double-screening method can reach 94.83 percent.
Claims (6)
1. The traditional Chinese medicine compound blood-enriching granules are characterized by being prepared from the following raw materials in parts by weight: 4 parts of donkey-hide gelatin, 4 parts of Chinese date, 4 parts of astragalus root, 2 parts of black fungus and 1 part of rose.
2. The preparation method of the traditional Chinese medicine compound hematinic granule based on claim 1, which is characterized by comprising the following steps;
(1) Drying colla Corii Asini, pulverizing, and sieving with 100 mesh sieve;
(2) Decocting radix astragali in water twice, mixing decoctions, filtering, concentrating the filtrate, adding ethanol, stirring, standing, collecting supernatant, recovering ethanol, concentrating into fluid extract, controlling relative density to make the viscosity of the fluid extract in a proper range, and influencing the addition amount of adjuvants, to facilitate granulation and improve granule quality;
(3) Soaking Auricularia in warm water, blanching in hot water, drying, pulverizing, sieving, ultrasonically extracting with water as extractive solution, filtering, and concentrating the filtrate to obtain soft extract;
(4) Ultrasonic extracting fructus Jujubae and flos Rosae Rugosae with water and ethanol respectively, filtering, and concentrating to obtain soft extract;
(5) Mixing dextrin and lactose as filler, mixing the filler with colla Corii Asini powder, sequentially adding fructus Jujubae, radix astragali, auricularia, and flos Rosae Rugosae extract to obtain soft extract, adding appropriate amount of ethanol, mixing, sieving with 14 mesh sieve, granulating, drying, sieving with 14 mesh sieve, grading, and packaging.
3. The preparation method of the compound traditional Chinese medicine blood-enriching granule as claimed in claim 2, wherein the astragalus membranaceus in the step (2) is decocted with water twice, the first time lasts for 3 hours, the second time lasts for 2 hours, decoction solutions are combined and filtered, the filtrate is concentrated to a relative density of about 1.21-1.24, ethanol is added to make the ethanol content reach 70%, the mixture is stirred evenly and stood, supernatant is taken to recover the ethanol, and the ethanol is concentrated to a clear paste with a relative density of 1.31-1.33.
4. The preparation method of the compound traditional Chinese medicine blood-enriching granule as claimed in claim 2, wherein the extraction conditions in the step (3) are as follows: the material-liquid ratio is 1: 40, the ultrasonic power is 100W, the extraction temperature is 50 ℃, the ultrasonic time is 20min, the filtration is carried out after the extraction, and the filtrate is concentrated into thick paste.
5. The preparation method of the compound traditional Chinese medicine blood-enriching granule according to claim 2, wherein the extraction conditions in the step (4) are respectively as follows: the material-liquid ratio is 1: 12, the ultrasonic power is 100W, the extraction temperature is 55 ℃, and the ultrasonic time is 90min; and (3) rose: the solvent is extracted with 75% ethanol at a ratio of 1: 10, ultrasonic power of 100W, extraction temperature of 40 deg.C, and ultrasonic time of 30min, respectively filtering, and concentrating to obtain soft extract.
6. The preparation method of the compound traditional Chinese medicine blood-enriching granule as claimed in claim 2, wherein in the step (5), dextrin and lactose are mixed in a ratio of 1: 2 to serve as a filler, 15 parts of the filler is mixed with 4 parts of donkey-hide gelatin powder uniformly, 4 parts of Chinese date, 4 parts of astragalus, 2 parts of black fungus and 1 part of rose are added in sequence to obtain thick paste, finally, a proper amount of 70% ethanol is added to be mixed uniformly to prepare soft materials, the soft materials are sieved by a 14-mesh sieve to be granulated, dried and sieved by a 14-mesh sieve to be granulated.
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| CN116210901A (en) * | 2023-01-09 | 2023-06-06 | 贵州医科大学 | Health product for tonifying qi and nourishing blood, preparation method and content measurement |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116210901A (en) * | 2023-01-09 | 2023-06-06 | 贵州医科大学 | Health product for tonifying qi and nourishing blood, preparation method and content measurement |
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