CN111317141A - Health food for improving diabetes and preparation method thereof - Google Patents

Abstract

The invention provides a health food for improving diabetes and a preparation method thereof, and particularly relates to a health food mainly prepared from extracts of undaria pinnatifida, eucheuma, bitter gourd, wolfberry fruit, purslane, pumpkin seed, mulberry, fructus cannabis, mussel, hippocampus, mint, elsholtzia, Japanese ardisia herb, schisandra chinensis, torsemilia japonica, honeysuckle, cynomorium songaricum, epimedium, gardenia root, cynanchum paniculatum, melastoma dodecandrum, fennel root, uncinata spikemoss herb, pipewort flower, divaricate saposhnikovia root, fibraurea recina, amomum cardamomum, piper cubeba, rhubarb, fructus kochiae, hops, cortex lycii radicis, white lotus, rosin and calcined gypsum. The functional food provided by the invention is prepared by compounding effective extracts of medicinal and edible materials from sea sources and land sources. Pharmacodynamics verifies that the functional food can obviously reduce fasting blood glucose value of diabetes, prevent and assist in treating diabetes, and can be prepared into capsules, granules, tablets, pills or solutions.

Description

Health food for improving diabetes and preparation method thereof

Technical Field

The invention relates to the technical field of health products, in particular to a health food for improving diabetes and a preparation method thereof.

Background

Diabetes is a metabolic disorder characterized by hyperglycemia due to a defect in insulin secretion, and is a chronic, lifelong metabolic disease. Chronic hyperglycemia accompanying diabetes causes long-term damage to tissues and organs of a human body, particularly eyes, kidneys, nerves, heart, cardiovascular and other tissues, and causes dysfunction. At present, the medicines for treating diabetes have adverse reactions, and the prevention and treatment effects on diabetic complications are not ideal.

With the rise of marine drugs, the research on seaweed active substances has become a hot point of research at home and abroad, and particularly, seaweed polysaccharide is rich in content, has various physiological activities, and has remarkable effects and advantages in the aspects of controlling blood sugar and the development of chronic complications as a natural high molecular compound. The seaweed such as Undaria pinnatifida and Eucheuma muricatum has blood sugar lowering activity, and can effectively regulate insulin content and sensitivity.

Many medicinal and edible foods, such as balsam pear and medlar, have the function of reducing blood sugar. The crude extract of Momordica charantia contains insulin-like substances, and has obvious effect of lowering blood sugar. The fructus Lycii extract contains guanidine derivatives, and also has blood sugar lowering effect.

The compounding of the functional components in the sea-source and land-source food can generate synergy and/or synergism, reduce the dosage and even derive new effects, and further improve the quality of the food. According to the invention, the seaweed from sea sources such as undaria pinnatifida, eucheuma and the like are compounded with the bitter gourd, the wolfberry, the purslane, the pumpkin seed and the like which are homologous to land sources in medicine and food, so that the effects are complemented, the blood sugar reducing effect is synergized, the flavors are mutually masked, optimized and enhanced, the using amount and the cost are reduced, the composite product is more economical and effective, the processing technological properties of various aspects of the health care product can be met, and the composite product can be used in a wider range.

Disclosure of Invention

The invention aims to provide a health food for improving diabetes and a preparation method thereof. The health food mainly comprises extracts of undaria pinnatifida, eucheuma, bitter gourd, wolfberry, purslane, pumpkin seeds, mulberries, fructus cannabis, mussel flowers, hippocampus, mint, elsholtzia, Japanese ardisia herb, schisandra chinensis, Jasminum Ampelopsis, honeysuckle, cynomorium songaricum, epimedium, gardenia roots, cynanchum paniculatum, melastoma dodecandrum, fennel roots, uncinata spikemoss herbs, pipewort, divaricate saposhnikovia roots, fibraurea recisappan stems, cardamom, piper cubeba, rheum officinale, fructus kochiae, hops, cortex lycii radicis, white lotus, rosin and calcined gypsum. The invention aims to solve the technical problem of providing a compound for assisting in treating diabetes by marine and terrestrial compound with good curative effect, which can be applied to health-care food or functional food.

In order to achieve the purpose, the invention adopts the following technical scheme:

a health food for improving diabetes is characterized in that: the composite material comprises the following main raw materials in parts by weight: 80-100 parts of undaria pinnatifida, 80-100 parts of eucheuma, 20-40 parts of bitter gourd, 20-40 parts of wolfberry, 20-40 parts of purslane, 20-40 parts of pumpkin seed, 20-40 parts of mulberry, 10-20 parts of fructus cannabis, 10-20 parts of mussel flower, 10-20 parts of sea horse, 10-20 parts of mint, 10-20 parts of elsholtzia, 10-20 parts of Japanese ardisia herb, 5-10 parts of schisandra chinensis, 5-10 parts of Jasminum giraldii Hance, 5-10 parts of honeysuckle, 5-10 parts of cynomorium songaricum, 5-10 parts of epimedium, 2-5 parts of gardenia root, 2-5 parts of cynanchum paniculatum, 2-5 parts of melastoma dodecandrum, 2-5 parts of anise root, 2-5 parts of uncinata spikemoss herb, 2-5 parts of pipewort, 2-5 parts of divaricate saposhnikovia root, 1-3 parts of fibraurea, 1-3 parts of cubeb litsea cubeba, 1-3 parts of rhubarb, 1-3 parts of belvedere fruit, 1-3 parts of lupulus, 1-2 parts of cortex lycii radicis, 1-2 parts of white lotus, 1-2 parts of rosin and 1-2 parts of calcined gypsum.

Preferably, the health food containing enteromorpha for improving diabetes is characterized in that: the composite material comprises the following main raw materials in parts by weight: 90 parts of undaria pinnatifida, 90 parts of eucheuma, 30 parts of bitter gourd, 30 parts of medlar, 30 parts of purslane, 30 parts of pumpkin seeds, 30 parts of mulberry, 15 parts of fructus cannabis, 15 parts of mussel flower, 15 parts of sea horse, 15 parts of mint, 15 parts of elsholtzia, 15 parts of Japanese ardisia herb, 7 parts of schisandra chinensis, 7 parts of celastrus orbiculatus, 7 parts of honeysuckle, 7 parts of cynomorium songaricum, 7 parts of epimedium, 3 parts of gardenia root, 3 parts of paniculate swallowwort root, 3 parts of mountain melastoma dodecandrum, 3 parts of anisum root, 3 parts of uncinata spikemoss herb, 3 parts of pipewort, 3 parts of divaricate saposhnikovia root, 2 parts of fibraurea recina, 2 parts of fructus amomi, 2 parts of piper cubeba, 2 parts of rhubarb, 2 parts of fructus kochiae, 2 parts of hops, 1 part of cortex lyci.

The preparation method comprises the following steps:

(1) washing thallus laminariae and Eucheuma Gelatinosum with clear water for 3 times to remove impurities such as salt, and oven drying at 60 deg.C; weighing 80-100 parts of undaria pinnatifida, 80-100 parts of eucheuma, 20-40 parts of bitter gourd, 20-40 parts of wolfberry, 20-40 parts of purslane, 20-40 parts of pumpkin seed, 20-40 parts of mulberry, 10-20 parts of fructus cannabis, 10-20 parts of mussel flower, 10-20 parts of sea horse, 10-20 parts of mint, 10-20 parts of elsholtzia, 10-20 parts of Japanese ardisia herb, 5-10 parts of schisandra chinensis, 5-10 parts of Jasminum giraldii, 5-10 parts of honeysuckle, 5-10 parts of cynomorium songaricum, 5-10 parts of epimedium, 2-5 parts of gardenia root, 2-5 parts of cynanchum paniculatum, 2-5 parts of melastoma dodecandrum, 2-5 parts of anethomsonii, 2-5 parts of cumm marigold root, 2-5 parts of uncinata spikemoss herb, 1-3 parts of radix sileris, 1-3 parts of amur galangal fruit, 1-3 parts of cubeb litsea cubeba, 1-3 parts of rhubarb, 1-3 parts of fructus kochiae, 1-3 parts of lupulus, 1-2 parts of cortex lycii radicis, 1-2 parts of white lotus, 1-2 parts of rosin and 1-2 parts of calcined gypsum, and respectively carrying out superfine grinding and sieving by a 80-mesh sieve;

(2) mixing the superfine powder of the undaria pinnatifida and the sea horse prepared in the step (1), soaking for 2 hours, decocting for 30min at 100 ℃ after the weight-volume ratio (g/mL) of the powder to distilled water is 1:9, filtering to obtain a supernatant, carrying out 2-time operation on filter residues according to the steps, combining decoction, carrying out suction filtration and concentration to obtain a seaweed water extract, freezing, drying, crushing, and sieving with a 80-mesh sieve to obtain a sea source compound;

(3) taking the bitter gourd, the medlar, the purslane, the pumpkin seed, the mulberry, the fructus cannabis, the mussel flower, the mint, the elsholtzia, the Japanese ardisia herb, the schisandra chinensis, the Jatropha curcas, the honeysuckle, the cynomorium songaricum, the epimedium, the gardenia root, the cynanchum polycephalum, the melastoma dodecandrum, the anisum root, the uncinata spikemoss herb, the pipewort flower, the divaricate saposhnikovia root, the fibraurea recisa, the amomum cardamomum, the cubeb, the rhubarb, the fructus kochiae, the hops, the cortex lycii radicis, the white lotus, the rosin and the calcined gypsum ultra-fine powder prepared in the step (1) to mix, decocting for 30min at 100 ℃, filtering to obtain a supernatant, filtering residues for 2 times according to the steps, combining the decoction, filtering and concentrating to obtain an aqueous extract, freezing and drying, crushing and sieving by a sieve;

(4) uniformly mixing the compound of the sea source prepared in the step (2) and the compound of the land source prepared in the step (3) according to the weight ratio of 1:1, and uniformly mixing the mixture and distilled water according to the weight-volume ratio (g/mL) of 1:4 to prepare a compound extract;

(5) taking 80-100 parts of eucheuma processed in the step (1), cutting into pieces, putting into a NaOH solution with the mass concentration of 10%, wherein the weight ratio of the eucheuma to the alkali liquor is 1:9, soaking for 24 hours, and stirring once every 8 hours;

(6) 80-100 parts of eucheuma processed in the step (5) are decocted for 60min at 100 ℃ according to the weight-volume ratio g/mL of eucheuma fronds to distilled water of 1:20, filtered by a 80-mesh sampling sieve to remove residues when the eucheuma fronds are hot, and cooled to room temperature;

(7) adding 95% ethanol with 4 times volume of the product obtained in the step (6) into the product to precipitate, crosslinking the content of the glue solution, and filtering to obtain gel;

(8) and (3) adding the compound extract mixed in the step (4) into the gel prepared in the step (7), uniformly mixing in the same volume, preparing a soft material, and then preparing capsules, granules, tablets, pills or solutions.

The raw materials adopted by the invention respectively have the following pharmacological effects:

wakame seaweed: contains multiple nutritional components, and according to preliminary analysis, each hundred grams of dry product contains 11.6g of crude protein, 0.32g of essential fat, 37.81g of saccharides, 18.93g of ash and multiple vitamins. Undaria pinnatifida is a natural treasury of trace elements and minerals, and contains more than ten kinds of amino acids essential to human body, minerals such as calcium, iodine, zinc, selenium, vitamin A, B, C, and folic acid. The calcium content of the undaria pinnatifida is 10 times of that of the milk for supplementing calcium, and the zinc content of the undaria pinnatifida is 3 times of that of the beef for supplementing zinc. 500g of undaria pinnatifida contains 10kg of spinach with iron content, 750g of carrot with vitamin C content and 1.5 sea cucumbers with protein content.

Eucheuma muricatum: salty and mild in nature and taste. It enters lung and kidney meridians. Has the functions of eliminating phlegm and clearing heat. Mainly treats scrofula, cough, goiter, hemorrhoids and the like. Contains D-galactose, 3, 6-anhydro-D-galactose, D-glucuronic acid, galactose sulfate calcium salt, D-xylose, etc.

Bitter gourd: bitter and cold in root, vine, leaf and fruit. Clear heat and remove toxicity, improve eyesight. Can be used for treating heatstroke, fever, toothache, diarrhea, dysentery, and hematochezia.

And (4) wolfberry fruit: contains betaine, zeaxanthin, physalin, lycium barbarum polysaccharide, carotene, riboflavin, nicotinic acid, vitamin C, etc. The efficacy is as follows: nourishing liver, replenishing kidney essence, moistening lung. Can be used for treating asthenia, soreness of waist and knees, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision. The medlar has the function of reducing blood sugar: 6g/kg of fructus lycii extract can reduce the blood sugar of the rabbit by about 13% within 2-3 hours by intraperitoneal injection, and then the blood sugar is gradually recovered. It is thought that the hypoglycemic effect is due to the guanidine derivatives contained therein.

Purslane: sour and cold. Clear heat and remove toxicity, cool blood and stop bleeding. Has effects in clearing away heat, promoting diuresis, removing toxic materials, relieving swelling, relieving inflammation, quenching thirst, and promoting urination. Can be used for treating dysentery with bloody pus, stranguria with heat, leukorrhagia, carbuncle, suppurative sore, and erysipelas. Modern medicine research proves that high-concentration noradrenaline in the purslane can promote the secretion of insulin in a human body, so that the purslane can play a role in regulating carbohydrate metabolism, reducing blood sugar concentration and keeping blood sugar stable, and therefore, the purslane can play a role in food therapy for diabetes mellitus after being frequently eaten. The purslane is rich in potassium, and can effectively reduce blood pressure. The purslane is rich in vitamin A and vitamin C in the body, and the trace elements can help to recover and enhance the physiological function of epithelial cells, so that the purslane has magical curative effects on ulcer diseases and skin diseases caused by most of damp heat.

Pumpkin seeds: sweet in flavor and neutral in nature. It enters stomach and large intestine meridians. Has anthelmintic effect. Is mainly used for treating taeniasis and schistosomiasis.

And (3) mulberry fruit: the main nutrient components comprise moisture, sugar, crude protein, ash, crude fiber, free acid, soluble nitrogen-free substances and the like. The mulberry also contains amino acids necessary for human bodies, polysaccharide easy to absorb, abundant vitamins, haematochrome and minerals such as calcium, iron, zinc, selenium and the like which are deficient in human bodies, has the effects of enhancing immunity, promoting growth of hematopoietic cells, promoting metabolism and the like, and has abundant nutritional value and certain pharmacological value.

Fructus cannabis: sweet in flavor and neutral in nature. It enters spleen, stomach and large intestine meridians. To moisten intestines and relax bowels. Can be used for treating constipation due to intestinal dryness caused by blood deficiency and body fluid deficiency.

Mussel flower: sweet, bland and cool. The functions are mainly used for clearing heat and eliminating phlegm, and cooling blood and stopping dysentery. Can be used for treating cough due to lung dryness, hemoptysis, pertussis, tuberculous lymphadenitis, dysentery, and hematochezia.

Sea horse: warm in nature, sweet and salty in taste. It enters liver and kidney meridians. Warming kidney, strengthening yang, dissipating nodulation and relieving swelling. They belong to yang tonics classified under deficiency tonics. The ethanol extract of Hippocampus has sex hormone-like effect, and can induce and prolong estrus of female mouse and mouse, and promote estrus of castrated mouse. In addition, the water and alcohol extracts of the composition also have the effects of delaying senility, promoting immunologic function, resisting thrombus, resisting fatigue and resisting tumors. The sea horse contains steroid compounds such as cholesterol, etc., is rich in protein with a content of more than 70%, and also contains 17 amino acids such as threonine, valine, methionine, etc., and 13 fatty acids.

Mint: has dual functions of medical use and eating, and the main edible parts are stems and leaves, and can also be taken by juicing. Is a common Chinese medicine, the tender stem tip can be eaten as a dish, the whole herb can be used as a medicine, and the Chinese medicine is used for treating symptoms such as cold, fever, laryngalgia, headache, conjunctival congestion, muscle pain, skin rubella, pruritus, measles without adequate eruption and the like, and is also effective for carbuncle, gangrene, scabies, tinea and dermatitis. The mint contains menthol, and the substance can refresh breath, has various medicinal properties, can relieve abdominal pain and gallbladder problems such as spasm, and also has antiseptic, antibacterial, diuretic, expectorant, stomach invigorating and digestion promoting effects. Eating a large amount of mint can cause insomnia, but eating a small amount of mint can help sleep.

Herba Moslae: pungent in flavor and slightly warm in nature. It enters lung, spleen and stomach meridians. Induce sweat and relieve summer-heat, harmonize the middle warmer and remove dampness. It can be used for treating sunstroke, cold, anhidrosis, abdominal pain, emesis, diarrhea, edema, and tinea pedis. Contains volatile oil, wherein the main ingredients are elsholtzia ketone, sesquiterpene, etc. The pharmacological actions are sweating, fever reduction and diuresis.

Japanese ardisia herb: neutral in nature, pungent and slightly bitter in flavor, entering lung and liver meridians. Resolve phlegm and stop cough, remove dampness by diuresis, activate blood. Can be used for treating cough, bloody sputum, chronic bronchitis, jaundice due to damp-heat pathogen, and traumatic injury.

Schisandra chinensis: is a famous traditional Chinese medicine, and the fruit of the traditional Chinese medicine contains schisandra essence, vitamin C, resin, tannin and a small amount of sugar. The efficacy is as follows: astringe lung, nourish kidney, promote the production of body fluid, astringe sweat and astringe essence. It can be used for treating lung deficiency, asthma, cough, xerostomia, spontaneous perspiration, night sweat, fatigue, marasmus, nocturnal emission, chronic diarrhea, and chronic dysentery.

Twisting the tripe: slightly bitter taste and cool nature. It enters liver, spleen and kidney meridians. The efficacy is as follows: clear heat, promote diuresis, remove toxicity. It is commonly used for dysentery due to damp-heat, abdominal pain, tenesmus, arthralgia due to wind-damp-heat, swelling and pain of limbs, scrofula, and scabies.

Honeysuckle flower: is sweet and cold in nature, has the functions of clearing away heat and toxic materials, diminishing inflammation and relieving swelling, and is effective on bacillary dysentery and various pyogenic diseases. The honeysuckle preparation is prepared into honeysuckle detoxicating tablet, honeysuckle injection, etc. The honeysuckle distillate is aromatic volatile oil and water-soluble distillate extracted from honeysuckle by a distillation method, is a good product for clearing fire and removing toxicity, and can be used for treating infantile carbuncle, furuncle, fever, oral diseases and the like; it can replace tea in summer, and can be used for warm heat, eruption, acne and bloody dysentery. The active ingredients of honeysuckle are reported to be chlorogenic acid and isochlorogenic acid.

And (3) locking the positive: has effects in invigorating kidney, replenishing vital essence, and moistening dryness, and can be used for treating sexual impotence, spermatorrhea, soreness of waist and knees, constipation due to intestinal dryness, paralysis, and sexual hypofunction.

Herba epimedii: pungent and sweet in flavor and warm in nature. It is a key herb for tonifying the vital gate, replenishing essence and qi, strengthening tendons and bones, tonifying kidney and strengthening yang, and is clinically used to treat impotence, spermatorrhea, premature ejaculation, urinary incontinence and infertility. Modern researches show that epimedium contains icariin, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin E and other components. Can excite sexual function, and promote semen secretion for animals. It also has blood pressure lowering (peripheral vasodilation inducing), blood glucose lowering, diuretic, antitussive, expectorant, and vitamin E-like effects. Pharmacological experimental research shows that epimedium can increase blood flow of heart and cerebral vessels, promote hemopoiesis, immunity and bone metabolism, and has the functions of resisting senility, resisting tumor, etc.

Gardenia root: has the effects of clearing heat, promoting diuresis, cooling blood and stopping bleeding. Can be used for treating icterohepatitis, dysentery, cholecystitis, common cold, hyperpyrexia, hematemesis, epistaxis, urinary tract infection, nephritis edema, mastitis, toothache due to pathogenic wind-fire, skin sore, carbuncle, toxic swelling, and traumatic injury.

Every day panicle: pungent in flavor and warm in nature, entering stomach and liver meridians. Has the functions of dispelling wind, eliminating dampness, relieving pain and stopping itching. Can be used for treating rheumatalgia, gastralgia, toothache, traumatic injury, rubella, and eczema.

Twelve stamen melastoma herb: sweet and astringent in flavor, neutral in nature, entering liver and spleen meridians. Has the effects of nourishing blood, stopping bleeding, astringing intestine and controlling nocturnal emission. Can be used for treating blood deficiency, asthenia, hematemesis, epistaxis, excessive internal injury, hemoptysis, hematochezia, metrorrhagia, spermatorrhea, leukorrhagia, dysentery, rectocele, scald, and traumatic hemorrhage.

Fennel root: pungent and sweet in flavor, warm in nature, warm kidney and harmonize middle energizer, move qi and alleviate pain.

B, emerald green grass: sweet and bland in flavor and cool in nature. Clear heat and promote diuresis, stop bleeding, and relieve cough.

Pipewort: pungent and sweet in flavor and cool in nature. Dispel wind and heat, improve vision and remove nebula. It is indicated for nebula, night blindness, headache, toothache, throat impediment and epistaxis.

Wind prevention: pungent and sweet in flavor and warm in nature. Has effects in relieving exterior syndrome, inducing perspiration, dispelling pathogenic wind, and removing dampness, and can be used for treating wind-cold type common cold, headache, fever, joint pain, and tetanus.

Fibraurea recisa pierre: bitter taste and cold nature. It enters heart and liver meridians. Clearing away heat and toxic materials; to remove dampness. Has antiinflammatory and antibacterial effects.

Round cardamom fruit: pungent and warm in flavor, entering lung, spleen and stomach meridians. Has the effects of eliminating dampness, promoting qi circulation, warming middle energizer, relieving vomiting, stimulating appetite and promoting digestion. Can be used for treating damp stagnation, incoordination between spleen and stomach, abdominal distention, anorexia, early stage of damp-warm syndrome, chest distress, emesis, and dyspepsia.

B, Piper cubeba: pungent taste and warm nature. It enters spleen and kidney meridians. Warm spleen and kidney, strengthen stomach and promote digestion. It can be used for treating dyspepsia, flatulence, abdominal psychroalgia, regurgitation, emesis, rugitus, diarrhea, and phlegm nodule.

Rhubarb: bitter and cold. Enter stomach, large intestine and liver meridians. Purging heat-toxin, breaking stagnation and removing blood stasis. Treating excessive heat constipation, delirium, fever, food stagnation, abdominal fullness, dysentery, tenesmus, stasis, amenorrhea, abdominal mass, epidemic heat, acute conjunctivitis, hematemesis, epistaxis, yang jaundice, edema, stranguria with turbid urine, carbuncle, sore, and injury due to fire and dampness. Purge heat and unblock intestines, cool blood and remove toxicity, dispel stasis and dredge meridians. Can be used for treating constipation due to excessive heat, abdominal pain due to stagnation, dysentery, and jaundice due to damp-heat.

The preparation method comprises the following steps of (1) preparing broom cypress fruit: pungent and bitter in flavor and cold in nature. It enters kidney and bladder meridians. Clear heat and promote diuresis, dispel wind and relieve itching. Can be used for treating difficult and painful urination, pruritus vulvae, leukorrhagia, rubella, eczema, and skin pruritus.

And (3) lupulus: mild in nature and bitter in taste. The functions are mainly used for strengthening stomach, promoting digestion, reducing phlegm, relieving cough, resisting tuberculosis, calming nerves and promoting urination. Can be used for treating anorexia, abdominal distention, pulmonary tuberculosis, pleuritis, insomnia, hysteria, edema, and cystitis. Contains humulone, isohumulone A and B, humulone, lupulone, colupulone, myrcene, humulene, linalool, lupeol, rutin, tannin, and choline.

Cortex lycii radicis: clear heat and cool blood. It is used to treat tidal fever and night sweat due to asthenia, cough and asthma due to lung heat, hematemesis, epistaxis, stranguria with blood, diabetes, hypertension, carbuncle, swelling, and skin ulcer.

White lotus: the lotus seed is neutral in nature and sweet and astringent in taste, and can nourish heart, tonify kidney, tonify spleen, arrest discharge, and be suitable for all people with deficiency of body, spermatorrhea and premature ejaculation, especially for spermatorrhea due to imbalance between heart and kidney. The lotus seed is rich in protein, carbohydrate, nicotinic acid, potassium, calcium, magnesium and other nutrient elements, and also has the effects of preventing and resisting cancer, reducing blood pressure, tonifying heart and soothing nerves, nourishing and tonifying deficiency, stopping spermatorrhea, arresting seminal emission and the like. Bailian is used for moistening lung to stop cough. The lotus plumule has extremely bitter taste, but has remarkable cardiotonic effect, and can dilate peripheral blood vessels and reduce blood pressure. The plumula Nelumbinis has good effect of removing heart fire, can be used for treating aphtha of the mouth and tongue, and is helpful for sleep. Is an excellent health food used as both medicine and food, and has high nutritive value and efficacy.

Rosin: bitter and sweet in taste and warm in nature. It enters liver and spleen meridians. Dispel wind and dry dampness, expel pus and remove toxicity, promote granulation and alleviate pain. It can be used for treating carbuncle, cellulitis, malignant boil, scrofula, flaccidity, scabies, alopecia areata, leprosy, arthralgia, incised wound, sprain, leukorrhagia, and thromboangiitis obliterans.

Calcining gypsum: consists of anhydrous calcium sulfate (CaSO 4). The product is white powder or loose block, and has reddish luster and opaque surface. Light weight, soft, fragile, and crumbly into powder. No smell, light taste. The functions are as follows: astringe dampness, promote granulation, heal wound and stop bleeding. It is suitable for treating unhealed ulcer, eczema, pruritus, scald due to hot water and fire, and traumatic hemorrhage by external application.

The invention has the advantages that:

(1) the functional food provided by the invention is prepared by compounding effective extracts of medicinal and edible materials from sea sources and land sources, and can be prepared into capsules, granules, tablets, pills, solutions and other dosage forms by utilizing the synergistic effect of the components. Pharmacodynamics verifies that the functional food has the effect of improving insulin resistance, can reduce fasting blood glucose value of diabetes, and can prevent and treat diabetes in an auxiliary way.

(2) The invention also provides a new idea for the diversified development of seaweed products. The raw materials are all natural substances and bioactive components thereof, the preparation conditions are mild, the effective components and the nutrient substances of the raw materials are retained to the maximum extent, no side effect is caused, the health and the safety are realized, and the development space is extremely wide.

Detailed Description

Example 1

(1) Washing thallus laminariae and Eucheuma Gelatinosum with clear water for 3 times to remove impurities such as salt, and oven drying at 60 deg.C; weighing 90 parts of undaria pinnatifida, 90 parts of eucheuma, 30 parts of bitter gourd, 30 parts of medlar, 30 parts of purslane, 30 parts of pumpkin seeds, 30 parts of mulberry, 15 parts of fructus cannabis, 15 parts of mussel, 15 parts of sea horse, 15 parts of mint, 15 parts of elsholtzia, 15 parts of Japanese ardisia herb, 7 parts of schisandra chinensis, 7 parts of jatropha curcas, 7 parts of honeysuckle, 7 parts of cynomorium songaricum, 7 parts of epimedium, 3 parts of gardenia root, 3 parts of cynanchum paniculatum, 3 parts of melastoma dodecandrum, 3 parts of anisum root, 3 parts of uncinata spikemoss herb, 3 parts of pipewort, 3 parts of divaricate saposhnikovia root, 2 parts of fibraurea recisa, 2 parts of fructus amomi rotundus, 2 parts of piper cubeba, 2 parts of rhubarb, 2 parts of fructus kochiae, 2 parts of hops, 1 part of cortex lycii radicis, 1 part;

(2) mixing the superfine powder of the undaria pinnatifida and the sea horse prepared in the step (1), soaking for 2 hours, decocting for 30min at 100 ℃ after the weight-volume ratio (g/mL) of the powder to distilled water is 1:9, filtering to obtain a supernatant, carrying out 2-time operation on filter residues according to the steps, combining decoction, carrying out suction filtration and concentration to obtain a seaweed water extract, freezing, drying, crushing, and sieving with a 80-mesh sieve to obtain a sea source compound;

(3) taking the bitter gourd, the medlar, the purslane, the pumpkin seed, the mulberry, the fructus cannabis, the mussel flower, the mint, the elsholtzia, the Japanese ardisia herb, the schisandra chinensis, the Jatropha curcas, the honeysuckle, the cynomorium songaricum, the epimedium, the gardenia root, the cynanchum polycephalum, the melastoma dodecandrum, the anisum root, the uncinata spikemoss herb, the pipewort flower, the divaricate saposhnikovia root, the fibraurea recisa, the amomum cardamomum, the cubeb, the rhubarb, the fructus kochiae, the hops, the cortex lycii radicis, the white lotus, the rosin and the calcined gypsum ultra-fine powder prepared in the step (1) to mix, decocting for 30min at 100 ℃, filtering to obtain a supernatant, filtering residues for 2 times according to the steps, combining the decoction, filtering and concentrating to obtain an aqueous extract, freezing and drying, crushing and sieving by a sieve;

(4) uniformly mixing the compound of the sea source prepared in the step (2) and the compound of the land source prepared in the step (3) according to the weight ratio of 1:1, and uniformly mixing the mixture and distilled water according to the weight-volume ratio (g/mL) of 1:4 to prepare a compound extract;

(5) cutting 90 parts of eucheuma processed in the step (1) into pieces, putting the pieces into a 10% NaOH solution, soaking the eucheuma and an alkali liquor in a weight ratio of 1:9 for 24 hours, and stirring once every 8 hours;

(6) decocting Eucheuma Gelatinosum processed in step (5) at 100 deg.C for 60min according to the weight-volume ratio g/mL of Eucheuma Gelatinosum algae and distilled water of 1:20, filtering with 80 mesh sieve to remove residue, and cooling to room temperature;

(7) adding 95% ethanol with 4 times volume of the product obtained in the step (6) into the product to precipitate, crosslinking the content of the glue solution, and filtering to obtain gel;

(8) and (3) adding the compound extract mixed in the step (4) into the gel prepared in the step (7), uniformly mixing in the same volume, preparing a soft material, and then preparing capsules, granules, tablets, pills or solutions.

Example 2

(1) Washing thallus laminariae and Eucheuma Gelatinosum with clear water for 3 times to remove impurities such as salt, and oven drying at 60 deg.C; weighing 100 parts of undaria pinnatifida, 100 parts of eucheuma, 40 parts of bitter gourd, 40 parts of wolfberry, 40 parts of purslane, 40 parts of pumpkin seed, 40 parts of mulberry, 20 parts of fructus cannabis, 20 parts of mussel flower, 20 parts of sea horse, 20 parts of mint, 20 parts of elsholtzia, 20 parts of Japanese ardisia herb, 10 parts of schisandra chinensis, 10 parts of jatropha curcas, 10 parts of honeysuckle, 10 parts of cynomorium songaricum, 10 parts of epimedium, 5 parts of gardenia root, 5 parts of paniculate swallowwort, 5 parts of mountain melastoma dodecandrum, 5 parts of aniseed root, 2 parts of uncinata spikemoss herb, 2 parts of pipewort, 2 parts of divaricate saposhnikovia root, 1 part of fibraurea recina, 1 part of fructus amomi, 1 part of cubeba, 1 part of rhubarb, 1 part of fructus kochiae, 1 part of hops, 1 part of cortex lycii radicis, 1 part of white lotus, 1 part of;

(2) mixing the superfine powder of the undaria pinnatifida and the sea horse prepared in the step (1), soaking for 2 hours, decocting for 30min at 100 ℃ after the weight-volume ratio (g/mL) of the powder to distilled water is 1:9, filtering to obtain a supernatant, carrying out 2-time operation on filter residues according to the steps, combining decoction, carrying out suction filtration and concentration to obtain a seaweed water extract, freezing, drying, crushing, and sieving with a 80-mesh sieve to obtain a sea source compound;

(3) taking the bitter gourd, the medlar, the purslane, the pumpkin seed, the mulberry, the fructus cannabis, the mussel flower, the mint, the elsholtzia, the Japanese ardisia herb, the schisandra chinensis, the Jatropha curcas, the honeysuckle, the cynomorium songaricum, the epimedium, the gardenia root, the cynanchum polycephalum, the melastoma dodecandrum, the anisum root, the uncinata spikemoss herb, the pipewort flower, the divaricate saposhnikovia root, the fibraurea recisa, the amomum cardamomum, the cubeb, the rhubarb, the fructus kochiae, the hops, the cortex lycii radicis, the white lotus, the rosin and the calcined gypsum ultra-fine powder prepared in the step (1) to mix, decocting for 30min at 100 ℃, filtering to obtain a supernatant, filtering residues for 2 times according to the steps, combining the decoction, filtering and concentrating to obtain an aqueous extract, freezing and drying, crushing and sieving by a sieve;

(4) uniformly mixing the compound of the sea source prepared in the step (2) and the compound of the land source prepared in the step (3) according to the weight ratio of 1:1, and uniformly mixing the mixture and distilled water according to the weight-volume ratio (g/mL) of 1:4 to prepare a compound extract;

(5) cutting 100 parts of eucheuma processed in the step (1) into pieces, putting the pieces into a 10% NaOH solution, soaking the eucheuma and an alkali liquor in a weight ratio of 1:9 for 24 hours, and stirring once every 8 hours;

(6) decocting Eucheuma Gelatinosum processed in step (5) at 100 deg.C for 60min according to the weight-volume ratio g/mL of Eucheuma Gelatinosum algae and distilled water of 1:20, filtering with 80 mesh sieve to remove residue, and cooling to room temperature;

(7) adding 95% ethanol with 4 times volume of the product obtained in the step (6) into the product to precipitate, crosslinking the content of the glue solution, and filtering to obtain gel;

(8) and (3) adding the compound extract mixed in the step (4) into the gel prepared in the step (7), uniformly mixing in the same volume, preparing a soft material, and then preparing capsules, granules, tablets, pills or solutions.

Example 3

(1) Washing thallus laminariae and Eucheuma Gelatinosum with clear water for 3 times to remove impurities such as salt, and oven drying at 60 deg.C; weighing 80 parts of undaria pinnatifida, 80 parts of eucheuma, 20 parts of bitter gourd, 20 parts of wolfberry, 20 parts of purslane, 20 parts of pumpkin seed, 20 parts of mulberry, 10 parts of fructus cannabis, 10 parts of mussel flower, 10 parts of sea horse, 10 parts of mint, 100 parts of elsholtzia, 10 parts of Japanese ardisia herb, 5 parts of schisandra chinensis, 10 parts of Jasminum grandiflorum, 5 parts of honeysuckle, 5 parts of cynomorium songaricum, 5 parts of epimedium, 2 parts of gardenia root, 2 parts of cynanchum paniculatum, 2 parts of mountain melastoma dodecandrum, 2 parts of aniseed root, 5 parts of uncinata spikemoss herb, 5 parts of pipewort, 5 parts of divaricate saposhnikovia root, 3 parts of fibraurea recina, 3 parts of fructus amomi rotundus, 3 parts of cubeb litsea cubeba, 3 parts of rhubarb, 3 parts of fructus kochiae, 3 parts of hops, 2 parts of cortex lycii radicis;

(2) mixing the superfine powder of the undaria pinnatifida and the sea horse prepared in the step (1), soaking for 2 hours, decocting for 30min at 100 ℃ after the weight-volume ratio (g/mL) of the powder to distilled water is 1:9, filtering to obtain a supernatant, carrying out 2-time operation on filter residues according to the steps, combining decoction, carrying out suction filtration and concentration to obtain a seaweed water extract, freezing, drying, crushing, and sieving with a 80-mesh sieve to obtain a sea source compound;

(3) taking the bitter gourd, the medlar, the purslane, the pumpkin seed, the mulberry, the fructus cannabis, the mussel flower, the mint, the elsholtzia, the Japanese ardisia herb, the schisandra chinensis, the Jatropha curcas, the honeysuckle, the cynomorium songaricum, the epimedium, the gardenia root, the cynanchum polycephalum, the melastoma dodecandrum, the anisum root, the uncinata spikemoss herb, the pipewort flower, the divaricate saposhnikovia root, the fibraurea recisa, the amomum cardamomum, the cubeb, the rhubarb, the fructus kochiae, the hops, the cortex lycii radicis, the white lotus, the rosin and the calcined gypsum ultra-fine powder prepared in the step (1) to mix, decocting for 30min at 100 ℃, filtering to obtain a supernatant, filtering residues for 2 times according to the steps, combining the decoction, filtering and concentrating to obtain an aqueous extract, freezing and drying, crushing and sieving by a sieve;

(4) uniformly mixing the compound of the sea source prepared in the step (2) and the compound of the land source prepared in the step (3) according to the weight ratio of 1:1, and uniformly mixing the mixture and distilled water according to the weight-volume ratio (g/mL) of 1:4 to prepare a compound extract;

(5) cutting 80 parts of eucheuma processed in the step (1) into pieces, putting the pieces into a 10% NaOH solution, soaking the eucheuma and an alkali liquor in a weight ratio of 1:9 for 24 hours, and stirring once every 8 hours;

(6) decocting Eucheuma Gelatinosum processed in step (5) at 100 deg.C for 60min according to the weight-volume ratio g/mL of Eucheuma Gelatinosum algae and distilled water of 1:20, filtering with 80 mesh sieve to remove residue, and cooling to room temperature;

(7) adding 95% ethanol with 4 times volume of the product obtained in the step (6) into the product to precipitate, crosslinking the content of the glue solution, and filtering to obtain gel;

(8) and (3) adding the compound extract mixed in the step (4) into the gel prepared in the step (7), uniformly mixing in the same volume, preparing a soft material, and then preparing capsules, granules, tablets, pills or solutions.

Experimental example 4: blood sugar reduction test of tetraoxypyrimidine hyperglycemic model mouse

A hyperglycemic model was established with healthy adult male ICR mice. Before modeling, 30 mice are randomly taken and fasted for 3h to measure the blood sugar, and the blood sugar is used as the basic blood sugar. After 24h (free drinking) of mice is fasted, injecting 75mg/kg alloxan into tail vein, after 5 days, fasting for 3h, screening 90 mice with blood sugar value more than 10mmol/L, randomly dividing the mice into 1 positive drug control group, 1 hyperglycemia model control group and 1 functional food group according to blood sugar level, wherein each group comprises 30 mice, the functional food group is given 150mg/kg test object, the positive drug control group is given metformin, the hyperglycemia model control group is given distilled water, continuously gavage for 28 days, measuring fasting blood sugar value (before fasting and test), comparing the blood sugar value of each group of animals, and observing the influence of the compound on the fasting blood sugar of the alloxan hyperglycemia model mice.

TABLE 1 Effect of the functional foods of the present invention on fasting plasma glucose in hyperglycemia model mice

The functional food of the invention has the following effects on fasting plasma glucose of a alloxan hyperglycemic model mouse: the fasting blood glucose of 30 animals measured before molding is 5.5 +/-1.1 mmol/L, and as can be seen from table 1, the fasting blood glucose of each group of animals after molding is obviously increased, and the difference is significant (P is less than 0.01) compared with that before molding, which indicates that the model is established. After 150mg/kg of the functional food is given for 28 days, the fasting blood glucose of mice in the functional food group is obviously lower than that of mice in the model group (P is less than 0.01), which shows that the functional food has the function of reducing the fasting blood glucose of the mice in the alloxan hyperglycemic model.

Example 5

Han Yi, female, 68 years old, type II diabetes mellitus for more than 20 years. Metformin is administered orally to control blood sugar. With regular metformin administration, fasting plasma glucose averaged 9.2 mmoles/l. After taking the health food of the invention for two weeks, the patients consciously improve the symptoms, and have 7.2 millimoles/liter of fasting blood sugar. After the metformin is stopped taking, the fasting blood sugar is 5.7 millimoles/liter after the health food of the invention is continuously taken for one month. The functional food has obvious effect on reducing blood sugar.

The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.

Claims (2)

1. A health food for improving diabetes is characterized in that: the composite material comprises the following main raw materials in parts by weight: 80-100 parts of undaria pinnatifida, 80-100 parts of eucheuma, 20-40 parts of bitter gourd, 20-40 parts of wolfberry, 20-40 parts of purslane, 20-40 parts of pumpkin seed, 20-40 parts of mulberry, 10-20 parts of fructus cannabis, 10-20 parts of mussel flower, 10-20 parts of sea horse, 10-20 parts of mint, 10-20 parts of elsholtzia, 10-20 parts of Japanese ardisia herb, 5-10 parts of schisandra chinensis, 5-10 parts of Jasminum giraldii Hance, 5-10 parts of honeysuckle, 5-10 parts of cynomorium songaricum, 5-10 parts of epimedium, 2-5 parts of gardenia root, 2-5 parts of cynanchum paniculatum, 2-5 parts of melastoma dodecandrum, 2-5 parts of anise root, 2-5 parts of uncinata spikemoss herb, 2-5 parts of pipewort, 2-5 parts of divaricate saposhnikovia root, 1-3 parts of fibraurea, 1-3 parts of cubeb litsea cubeba, 1-3 parts of rhubarb, 1-3 parts of belvedere fruit, 1-3 parts of lupulus, 1-2 parts of cortex lycii radicis, 1-2 parts of white lotus, 1-2 parts of rosin and 1-2 parts of calcined gypsum.

2. The health food for improving diabetes according to claim 1, wherein: the composite material comprises the following main raw materials in parts by weight: 90 parts of undaria pinnatifida, 90 parts of eucheuma, 30 parts of bitter gourd, 30 parts of medlar, 30 parts of purslane, 30 parts of pumpkin seeds, 30 parts of mulberry, 15 parts of fructus cannabis, 15 parts of mussel flowers, 15 parts of sea horses, 15 parts of mint, 15 parts of elsholtzia, 15 parts of Japanese ardisia herb, 7 parts of schisandra chinensis, 7 parts of jatropha curcas, 7 parts of honeysuckle, 7 parts of cynomorium songaricum, 7 parts of epimedium, 3 parts of gardenia root, 3 parts of paniculate swallowwort, 3 parts of kadsura pepper, 3 parts of anise root, 3 parts of uncinata spikemoss herb, 3 parts of pipewort, 3 parts of divaricate saposhnikovia root, 2 parts of fibraurea recina, 2 parts of cubeb litsea cubeba, 2 parts of rhubarb, 2 parts of fructus kochiae, 2 parts of hops, 1 part of cortex lycii radicis, 1 part of white.