CN100391444C - Mammary aggregation elimination capsule and its preparation method - Google Patents
Mammary aggregation elimination capsule and its preparation method Download PDFInfo
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- CN100391444C CN100391444C CNB2005101367447A CN200510136744A CN100391444C CN 100391444 C CN100391444 C CN 100391444C CN B2005101367447 A CNB2005101367447 A CN B2005101367447A CN 200510136744 A CN200510136744 A CN 200510136744A CN 100391444 C CN100391444 C CN 100391444C
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Abstract
The present invention relates to a breast disease eliminating soft capsule which is composed of a capsule shell and a capsule core arranged in the shell, wherein the capsule shell is prepared by 200 g of gelatin, 60 g of glycerin, 305.2 g of water and 1.5 g of red iron oxide, and the capsule core is prepared by that after 118.7 g of dandelions, 462.9 g of kelp, 47.48 g of trichosanthes root powder, 118.7 g of spatholobus stems, 118.7 g of notoginseng, 35.6 g of red peony roots, 231.46 g of seaweed, 71.2 g of radix, 94.96 g of aucklandia roots, 118.7 g of scrophularia roots, 166.18 g of tree peony bark, 118.7 g of spica prunellae, 47.48 g of forsythia fruit, the ethanol deposition of 71.2 g of safflowers, the ethanol eluate of column chromatography separation, and the extract of 178.04 g of antlers are dried and pulverized into a mixture, 10 g of beeswax, 75 g of vitamin E and 500 g of soybean oil are added. The preparing method of the breast disease eliminating soft capsule of the present invention has the advantages that the large and thick size, and the black color of the traditional breast disease eliminating extract are overcome, active ingredients are extracted, ineffective ingredients are removed, antler glue, polysaccharide, flavone and triterpenes compounds are determined as the main active ingredients. The quality and the stability of the medicine are increased.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine, particularly a kind of hard masses softening and resolving, invigorate blood circulation disappear the pain, heat-clearing and toxic substances removing Chinese patent medicine and preparation technology thereof.
(2) background technology
For a long time, the Chinese medicine preparation of China production ubiquity technology is simple and crude, kind is single, the backward situation of difficult quality guarantee, has become the serious hindrance that Chinese medicine goes to the world.Therefore, in order to revitalize Chinese medicine, give full play to the advantage of Chinese medicine compound, integrate with international most advanced level, improve the international competitiveness of tcm product, Chinese medicine industry, adopt modern science and technology research compound Chinese medicinal preparation, it is very necessary and very urgent formulating novel modern Chinese medicine.
The BUPIXIAO PIAN of Xiao Shouing derives from old docter of TCM's proved recipe in the market, is the Chinese patent medicine of the treatment cyclomastopathy formed of ten Chinese medicine of the five flavours materials, now records in one one of Chinese Pharmacopoeia version in 2005, has hard masses softening and resolving, an effect of pain, heat-clearing and toxic substances removing of disappearing of invigorating blood circulation.The BUPIXIAO PIAN curative effect is clear and definite, toxic and side effects is low, is the main Chinese patent medicine preparation for the treatment of the young and middle-aged women hyperplasia of mammary glands at present, and market sale has good prospects.But, since historical reasons, the BUPIXIAO PIAN of development and production in 1984, research levels such as its extracting method, preparation process, quality standard, pharmacological effect have lagged far behind the medical standards and norms of the present current international practice, the RUPIXIAO extract is big, and thick, black, quality stability is poor.The method for making of present known BUPIXIAO PIAN is: prescription ten five tastes, and Radix Scrophulariae, Radix Notoginseng, Cornu Cervi three flavor pulverize separately become fine powder, and are standby; 12 flavors such as all the other Herba Taraxacis decoct with water secondary, add 8 times in water for the first time, decoct 3 hours, add for the second time 6 times of amounts of water, decocted 2 hours, and filtered, decocting liquid merges, be concentrated into the clear paste of relative density 1.30 (55～60 ℃), with above-mentioned fine powder and an amount of auxiliary materials and mixing, make granule, drying, be pressed into 1000, sugar coating promptly.This shows, the former preparation of BUPIXIAO PIAN, production technology simple coarse, efficacy component is indeterminate, and dosage form is single, and is with low content of technology.Can't satisfy of technology and the requirement of domestic and international main flow market, be difficult to take part in international competition even might influence the domestic market share the modern Chinese medicine product.
(3) summary of the invention
Purpose of the present invention provides a kind of new mammary aggregation elimination capsule and preparation technology's method of mammary aggregation elimination capsule, with quality and the stability that improves this medicine, enhances one's market competitiveness.
The technical scheme that adopts is:
Mammary aggregation elimination capsule, be by softgel shell and be installed in the intravital capsule heart of shell and constitute, the capsule heart is by 178-179g Cornu Cervi extract and 118-119g Herba Taraxaci, the 462-463g Thallus Laminariae (Thallus Eckloniae), the 47-48g Radix Trichosanthis, the 118-119g Caulis Spatholobi, the 118-119g Radix Notoginseng, 35-36g Radix Paeoniae Rubra, the 231-232g Sargassum, the 71-72g Radix Rhapontici, the 94-95g Radix Aucklandiae, the 118-119g Radix Scrophulariae, the 166-167g Cortex Moutan, the 118-119g Spica Prunellae, the 47-48g Fructus Forsythiae, the ethanol precipitation thing of 71-72g Flos Carthami and cross post ethanol elution thing drying pulverize mix after, add Cera Flava 10-11g, vitamin E 0.75-1g, soybean oil 500-501g is mixed with.
Softgel shell is mixed with by gelatin 200201g, glycerol 60-61g, water 305.2-306.2g, red ferric oxide 1.5-2.5g.
The preparation method of mammary aggregation elimination capsule, be to get Cornu Cervi 178-179g, Herba Taraxaci 118-119g, Thallus Laminariae (Thallus Eckloniae) 462-463g, Radix Trichosanthis 47-48g, Caulis Spatholobi 118-119g, Radix Notoginseng 118-119g, Radix Paeoniae Rubra 35-36g, Sargassum 231-232g, Radix Rhapontici 71-72g, Radix Aucklandiae 94-95g, Radix Scrophulariae 118-119g, Cortex Moutan 166-167g, Spica Prunellae 118-119g, Fructus Forsythiae 4748g, Flos Carthami 71-72g, pulverize separately or shred, standby; Except that Cornu Cervi, 14 flavor medical materials such as all the other Herba Taraxacis decoct with water twice, add 8 times in water for the first time, decoct 3h, add 6 times in water for the second time, decoct 2h, filter, and filtrate merges, and concentrating under reduced pressure (thickening temperature is 60 ℃) to every milliliter of concentrated solution contains raw medicinal herbs 0.5g.Get this concentrated solution and carry out D101 macroporous adsorption resin chromatography (medical material is 0.8: 1 with the resin demand ratio, and the chromatographic column ratio of height to diameter is 15: 1, measures the resin bed volume).Last sample and reception penetrate liquid, and this penetrates liquid and goes up sample twice repeatedly, and static absorption was about 1 hour after last sample finished, and used 20% ethanol of the water of 5 times of resin bed volumes, 6 times of resin bed volumes, 75% ethanol gradient elution of 3 times of resin bed volumes more successively.Last sample and elution flow rate: per hour be 1 times of resin bed volume (1BV/h).Merging penetrates liquid and water elution liquid, and reclaim under reduced pressure to 1/20th back of cumulative volume adds 95% ethanol, makes determining alcohol reach 70%, standing over night, and decompress filter gets pure hypostasis, and vacuum drying promptly gets pure hypostasis polysaccharide.Discard behind the precipitate with ethanol supernatant decompression recycling ethanol.Merge 20% ethanol and 75% ethanol elution thing, be evaporated to do not have the alcohol flavor after, spray drying promptly got the eluate of post alcohol.Above-mentioned Cornu Cervi is sawn into segment (10-15cm), pulverizing the back decocts 3 times with 8 times of water gagings, each 2h, filter, filtrate merges, and is static, get clear filtrate, to thick paste shape (every milliliter of concentrated solution is equivalent to Cornu Cervi 2g), vacuum drying promptly gets Colla cornus cervi, wears into fine powder with slow fire concentrating under reduced pressure (thickening temperature is 60 ℃).With gained alcohol hypostasis polysaccharide, the alcohol eluate of mistake post and Cornu Cervi rubber powder three mix homogeneously, wear into fine powder, promptly get the RUPIXIAO extract.The RUPIXIAO extract adds soybean oil 500-501g, adjuvants such as vitamin E 0.75-1g, Cera Flava 10-11g, colloid mill grinds evenly, make the capsule heart, with the softgel shell that is mixed with by gelatin 200-1g, glycerol 60-1g, water 305.2-306.2g, red ferric oxide 1.5-2.5g, be pressed into 1000 of soft capsules, every contains the 500-501mg medicinal liquid.
The side separates:
Cornu Cervi Cheng Wen goes into the Liver and kidney warp, by the merit of promoting the circulation of blood detumescence.Be used for acute mastitis from the beginning of, swelling and pain due to blood stasis, the arduous temperature of the Radix Aucklandiae is returned spleen, all warps of stomach, " for transferring all gas key medicines " (" medicine justice "), can " dispersing liver-energy " promoting the circulation of QI to relieve pain (" book on Chinese herbal medicine converge speech "), so " book on Chinese herbal medicine justice " title: " the hernia abdominal mass is gathered, and this is necessary medicine ".Two medicines close and are usefulness, become blood circulation promoting and blood stasis dispelling altogether, the effect of the reason stagnation of QI.The sweet little bitter temperature of Radix Notoginseng is gone into liver stomach warp, is longer than the dissipating blood stasis hemostasis, subduing swelling and relieving pain, the bitter sweet temperature of Caulis Spatholobi is returned the Liver and kidney warp, energy " blood stasis removing blood; tissue regeneration promoting blood, popular passages through which vital energy circulates " (" decoction pieces is newly joined "): the Radix Paeoniae Rubra hardship is slightly cold, and goes into Liver Channel, be good at blood stasis dispelling, " clear and coherent blood vessels " (" Mingyi Bielu "), " removing arthralgia due to stagnation of blood, broken hard long-pending " (" herbal classic "); The hot temperature of Flos Carthami, the GUIXIN Liver Channel, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain have " disease of disharmony between QI and blood, non-Flos Carthami can not be transferred " (reputation of " book on Chinese herbal medicine converges and says "; The Cortex Moutan toil is slightly cold, and also goes into Liver and kidney, is blood circulation promoting and blood stasis dispelling product commonly used, " benefaction stasis " (" book on Chinese herbal medicine justice "), and this five tastes mutual reinforcement between is a usefulness, helps the merit of Cornu Cervi blood circulation promoting and blood stasis dispelling altogether.Herba Taraxaci is bitter sweet cold, goes into liver stomach warp, can heat-clearing and toxic substances removing, and Spica Prunellae is arduous cold, returns the liver and gall warp, can " row irritability, mass dissipating and swelling eliminating is used for acute mastitis and swells and ache ", the Fructus Forsythiae hardship is slightly cold, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds is controlled " all blood agglomeration gas are poly-" (" medicine justice "); The sweet little hardship of Radix Trichosanthis is slightly cold, can " eliminating pathogen in the liver is strongly fragrant, slow liver anxious " (" the medical center bun be wanted "), and " relieving stagnation " (" book on Chinese herbal medicine converge speech ") and " kind current meridians " (" Records of Tradition Chinese and Western Medicine in Combination ").This four flavor is associated with, and closes and helps Radix Aucklandiae dispersing liver-energy, separates stagnation of liver-QI, the stagnant gas of row, the crux of loosing.The auxilliary monarch drug blood-activating and qi-promoting eliminating stagnation in last nine flavor footpaths, Yu Fangzhong all takes charge of the duty of ministerial drug.
Qi depression to blood stasis, combination of phlegm and heat is again when the product of assistant with hard masses softening and resolving.So, send the agent that Thallus Laminariae (Thallus Eckloniae), Sargassum Cheng Han are gone into liver, the hard masses softening and resolving of advocating, Thallus Laminariae (Thallus Eckloniae) " removing mass softening the hard mass " (" beautiful Chinese catalpa medicine is separated "), Sargassum " broken eliminating stagnation gas, the hard gas of lump in the abdomen " (" herbal classic ").Join Radix Scrophulariae again, removing heat from blood YIN nourishing, eliminating fire and detoxication, the merit of getting hard masses softening and resolving; Other goes into Radix Rhapontici, " softening the hard mass " (" Bencao Jingshu "), and " qualcomm meridian " (" book on Chinese herbal medicine justice ") has " hemostasis " (Compendium of Material Medica) effect concurrently.Four flavors match well, and are usefulness with hard masses softening and resolving, do making supporting movement to cut off enemy of all medicines of the monarch and his subjects.All lift the labor of adjuvant drug.
Full side 15 flavors, using medicines of both cold and hot natures simultaneously stresses blood circulation promoting and blood stasis dispelling to control the resistance of the blood agglomeration stasis of blood; And with the eliminating stagnation of regulating the flow of vital energy with harmonizing the functional activities of vital QI, promoting blood circulation and detumescence; Hold concurrently with hard masses softening and resolving heat-clearing and toxic substances removing.
Pharmacodynamics test:
The hyperplasia of mammary gland model rat is after the continuous irrigation stomach gives the mammary aggregation elimination capsule treatment, and its cyclomastopathy characteristic index all has certain improvement, and the hormone disturbance level obtains balance, and pathological change has certain recovery.Result of the test shows, BUPIXIAO PIAN 4g crude drug/kg body weight has certain therapeutical effect to cyclomastopathy, mammary aggregation elimination capsule 2g crude drug/kg body weight therapeutic effect is not remarkable, and mammary aggregation elimination capsule 4g crude drug/kg body weight and 8g crude drug/continuous gastric infusion of kg body weight is remarkable to the outgrowth therapeutic effect of rat mammary gland.Mammary aggregation elimination capsule is better than the BUPIXIAO PIAN of clinical extensive use to the outgrowth curative effect of rat mammary gland.
Function with cure mainly
Hard masses softening and resolving, the pain that disappears of invigorating blood circulation, heat-clearing and toxic substances removing.Be used for nodules of the breast, mastalgia due to the combination of phlegm and heat, disease sees that breast tuberosity, number do not wait, size and form differs, the quality softness or puerperal breast caking, red heat pain; Cyclomastopathy, mastitis are seen above-mentioned disease person in early days.
Usage and consumption: oral, 3 times on the one, a 2-3 grain.
Specification: every dress 500mg.
The advantage of mammary aggregation elimination capsule preparation method of the present invention is: overcome that traditional RUPIXIAO extract is big, thick, the black flour hole, extract active constituent, remove invalid element, determine that main active ingredient is Colla cornus cervi, polysaccharide, flavone, triterpenoid compound, improved the quality and the stability of this medicine.
(4) specific embodiment
Mammary aggregation elimination capsule, be to constitute by the softgel shell and the capsule heart that is installed in the softgel shell, softgel shell is by gelatin 200g, glycerol 60g, water 305.2g, red ferric oxide 1.5g is mixed with, the capsule heart is by 178.04g Cornu Cervi extract and 118.7g Herba Taraxaci, 462.9g Thallus Laminariae (Thallus Eckloniae), 47.48g Radix Trichosanthis, 118.7g Caulis Spatholobi, 118.7g Radix Notoginseng, 35.6g Radix Paeoniae Rubra, 231.46g Sargassum, 71.2g Radix Rhapontici, 94.96g the Radix Aucklandiae, 118.7g Radix Scrophulariae, 166.18g Cortex Moutan, 118.7g Spica Prunellae, 47.48g Fructus Forsythiae, 71.2g the ethanol precipitation thing of Flos Carthami and cross post ethanol elution thing drying pulverize mix after, add Cera Flava 10g, vitamin E 0.75g, soybean oil 500g is mixed with.
The preparation method of mammary aggregation elimination capsule, be to get Cornu Cervi 178.04g, Herba Taraxaci 118.7g, Thallus Laminariae (Thallus Eckloniae) 462.9g, Radix Trichosanthis 47.48g, Caulis Spatholobi 118.7g, Radix Notoginseng 118.7g, Radix Paeoniae Rubra 35.6g, Sargassum 231.46g, Radix Rhapontici 71.2g, Radix Aucklandiae 94.96g, Radix Scrophulariae 118.7g, Cortex Moutan 166.18g, Spica Prunellae 118.7g, Fructus Forsythiae 47.48g, Flos Carthami 71.2g, pulverize separately or shred, standby; Except that Cornu Cervi, 14 flavors such as all the other Herba Taraxacis decoct with water twice, add 8 times in water for the first time, decoct 3h, add 6 times in water for the second time, decoct 2h, filter, and filtrate merges, and concentrating under reduced pressure (thickening temperature is 60 ℃) to every milliliter of concentrated solution contains raw medicinal herbs 0.5g.Get this concentrated solution and carry out D101 macroporous adsorption resin chromatography (medical material is 0.8: 1 with the resin demand ratio, and the chromatographic column ratio of height to diameter is 15: 1, measures the resin bed volume).Last sample and reception penetrate liquid, and this penetrates liquid and goes up sample twice repeatedly, and static absorption was about 1 hour after last sample finished, and used 20% ethanol of the water of 5 times of resin bed volumes, 6 times of resin bed volumes, 75% ethanol gradient elution of 3 times of resin bed volumes more successively.Last sample and elution flow rate: per hour be 1 times of resin bed volume (1BV/h).Merging penetrates liquid and water elution liquid, and reclaim under reduced pressure to 1/20th back of cumulative volume adds 95% ethanol, makes determining alcohol reach 70%, standing over night, and decompress filter gets pure hypostasis, and vacuum drying promptly gets pure hypostasis polysaccharide.Discard behind the precipitate with ethanol supernatant decompression recycling ethanol.Merge 20% ethanol and 75% ethanol elution thing, be evaporated to do not have the alcohol flavor after, spray drying promptly got the eluate of post alcohol.Above-mentioned Cornu Cervi is sawn into segment (10-15cm), pulverizing the back decocts 3 times with 8 times of water gagings, each 2h, filter, filtrate merges, and is static, get clear filtrate, to thick paste shape (every milliliter of concentrated solution is equivalent to Cornu Cervi 2g), vacuum drying promptly gets Colla cornus cervi, wears into fine powder with slow fire concentrating under reduced pressure (thickening temperature is 60 ℃).With gained alcohol hypostasis polysaccharide, the alcohol eluate of mistake post and Cornu Cervi rubber powder three mix homogeneously, wear into fine powder, promptly get the RUPIXIAO extract.The RUPIXIAO extract adds soybean oil 500g, adjuvants such as vitamin E 0.75g, Cera Flava 10g, colloid mill grinds evenly, makes the capsule heart, with the softgel shell that is mixed with by gelatin 200g, glycerol 60g, water 305.2g, red ferric oxide 1.5g, be pressed into 1000 of soft capsules, every contains the 500mg medicinal liquid.
Claims (3)
1. mammary aggregation elimination capsule is made of at the intravital capsule heart of shell softgel shell and device; Make the Chinese crude drug of the capsule heart, comprise the 118-119g Herba Taraxaci, the 462-463g Thallus Laminariae (Thallus Eckloniae), the 47-48g Radix Trichosanthis, the 118-119g Caulis Spatholobi, the 118-119g Radix Notoginseng, 35-36g Radix Paeoniae Rubra, the 231-232g Sargassum, the 71-72g Radix Rhapontici, the 94-95g Radix Aucklandiae, the 118-119g Radix Scrophulariae, the 166-167g Cortex Moutan, the 118-119g Spica Prunellae, the 47-48g Fructus Forsythiae, 71-72g Flos Carthami and 178-179g Cornu Cervi, it is characterized in that the capsule heart is the aqueous extract by the 14 flavor Chinese crude drugs of all the other except that Cornu Cervi in the above-mentioned Chinese crude drug, is 0.8: 1 through medical material with the resin demand ratio, the chromatographic column ratio of height to diameter is 15: 1 a D101 macroporous adsorption resin chromatography, again through water/ethanol gradient elution, the Cornu Cervi rubber powder that the aqueous extract of the water extracting alcohol hypostasis of gained and mistake post eluate and above-mentioned Cornu Cervi makes, be mixed and pulverize back adding Cera Flava 10-11g, vitamin E 0.75-1g, soybean oil 500-501g makes 1000 capsule-cores; Softgel shell is mixed with 1000 softgel shells by gelatin 200-201g, glycerol 60-61g, water 305.2-306.2g, red ferric oxide .5-2.5g.
2. the preparation method of mammary aggregation elimination capsule according to claim 1, it is characterized in that it being to get Cornu Cervi 178-179g, Herba Taraxaci 118-119g, Thallus Laminariae (Thallus Eckloniae) 462-463g, Radix Trichosanthis 47-48g, Caulis Spatholobi 118-119g, Radix Notoginseng 118-119g, Radix Paeoniae Rubra 35-36g, Sargassum 231-232g, Radix Rhapontici 71-72g, Radix Aucklandiae 94-95g, Radix Scrophulariae 118-119g, Cortex Moutan 166-167g, Spica Prunellae 118-119g, Fructus Forsythiae 47-48g, Flos Carthami 71-72g, pulverize separately or shred, standby; Except that Cornu Cervi, above-mentioned all the other 14 flavor medical materials decoct with water twice, add for the first time 8 times in water, decoct 3h, add for the second time 6 times in water, decoct 2h, filter, filtrate merges, concentrating under reduced pressure, thickening temperature is 60 ℃, be evaporated to every milliliter of concentrated solution and contain raw medicinal herbs 0.5g, get this concentrated solution and carry out the D101 macroporous adsorption resin chromatography, medical material is 0.8: 1 with the resin demand ratio, the chromatographic column ratio of height to diameter is 15: 1, measure the resin bed volume, last sample and reception penetrate liquid, this penetrates liquid and goes up sample repeatedly twice, static absorption was about 1 hour after last sample finished, use the water of 5 times of resin bed volumes more successively, 20% ethanol of 6 times of resin bed volumes, 75% ethanol gradient elution of 3 times of resin bed volumes, last sample and elution flow rate: per hour be 1 times of resin bed volume, merge and penetrate liquid and water elution liquid, reclaim under reduced pressure to 1/20th back of cumulative volume adds 95% ethanol, make determining alcohol reach 70%, standing over night, decompress filter get pure hypostasis, and vacuum drying promptly gets pure hypostasis polysaccharide, discard behind the precipitate with ethanol supernatant decompression recycling ethanol, merge 20% ethanol and 75% ethanol elution thing, be evaporated to do not have the alcohol flavor after, spray drying promptly got the eluate of post alcohol, above-mentioned Cornu Cervi is sawn into the 10-15cm segment, pulverize the back and decoct 3 times with 8 times of water gagings, each 2h filters, filtrate merges, static, get clear filtrate, use the slow fire concentrating under reduced pressure, thickening temperature is 60 ℃ and is evaporated to the thick paste shape, be evaporated to every milliliter of concentrated solution and be equivalent to Cornu Cervi 2g, vacuum drying promptly gets Colla cornus cervi, wears into fine powder, with gained alcohol hypostasis polysaccharide, cross post alcohol eluate and Cornu Cervi rubber powder three mix homogeneously, wear into fine powder, promptly get the RUPIXIAO extract, the RUPIXIAO extract adds soybean oil 500g, vitamin E 0.75g, Cera Flava 10g adjuvant, colloid mill grinds evenly, make the capsule heart, and by gelatin 200g, glycerol 60g, water 305.2g, the softgel shell that red ferric oxide 1.5g is mixed with is pressed into 1000 of soft capsules.
3. the preparation method of mammary aggregation elimination capsule according to claim 2, it is characterized in that getting Cornu Cervi 178.04g, Herba Taraxaci 118.7g, Thallus Laminariae (Thallus Eckloniae) 462.9g, Radix Trichosanthis 47.48g, Caulis Spatholobi 118.7g, Radix Notoginseng 118.7g, Radix Paeoniae Rubra 35.6g, Sargassum 231.46g, Radix Rhapontici 71.2g, Radix Aucklandiae 94.96g, Radix Scrophulariae 118.7g, Cortex Moutan 166.18g, Spica Prunellae 118.7g, Fructus Forsythiae 47.48g, Flos Carthami 71.2g, pulverize separately or shred, standby; Except that Cornu Cervi, 14 flavors such as all the other Herba Taraxacis decoct with water twice, add for the first time 8 times in water, decoct 3h, add for the second time 6 times in water, decoct 2h, filter, filtrate merges, concentrating under reduced pressure, thickening temperature is 60 ℃, be evaporated to every milliliter of concentrated solution and contain raw medicinal herbs 0.5g, get this concentrated solution and carry out the D101 macroporous adsorption resin chromatography, medical material is 0.8: 1 with the resin demand ratio, the chromatographic column ratio of height to diameter is 15: 1, measure the resin bed volume, last sample and reception penetrate liquid, this penetrates liquid and goes up sample repeatedly twice, static absorption was about 1 hour after last sample finished, use the water of 5 times of resin bed volumes more successively, 20% ethanol of 6 times of resin bed volumes, 75% ethanol gradient elution of 3 times of resin bed volumes, last sample and elution flow rate: per hour be 1 times of resin bed volume, merge and penetrate liquid and water elution liquid, reclaim under reduced pressure to 1/20th back of cumulative volume adds 95% ethanol, make determining alcohol reach 70%, standing over night, decompress filter gets pure hypostasis, vacuum drying promptly gets pure hypostasis polysaccharide, discard behind the precipitate with ethanol supernatant decompression recycling ethanol, merge 20% ethanol and 75% ethanol elution thing, after being evaporated to nothing alcohol flavor, spray drying promptly got the eluate of post alcohol, above-mentioned Cornu Cervi is sawn into the 10-15cm segment, pulverizing the back decocts 3 times with 8 times of water gagings, each 2h, filter, filtrate merges, static, get clear filtrate, use the slow fire concentrating under reduced pressure, thickening temperature is 60 ℃, be evaporated to the thick paste shape, every milliliter of concentrated solution is equivalent to Cornu Cervi 2g, and vacuum drying promptly gets Colla cornus cervi, wear into fine powder, with gained alcohol hypostasis polysaccharide, cross post alcohol eluate and Cornu Cervi rubber powder three mix homogeneously, wear into fine powder, promptly get the RUPIXIAO extract, the RUPIXIAO extract adds soybean oil 500g, vitamin E 0.75g, Cera Flava 10g adjuvant, colloid mill grinds evenly, makes the capsule heart, and by gelatin 200g, glycerol 60-61g, water 305.2g, the softgel shell that red ferric oxide 1.5g is mixed with, be pressed into 1000 of soft capsules, every contains the 500mg medicinal liquid.
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| CN105381122A (en) * | 2015-11-30 | 2016-03-09 | 潘素荣 | Hard lump-resolving preparation for treating hyperplasia of mammary glands and preparation method for hard lump-resolving preparation |
| CN108553606A (en) * | 2018-05-04 | 2018-09-21 | 四川生命源健康管理有限公司 | Breast dissipates tumor dissipating bind creams |
| CN111297971B (en) * | 2019-12-27 | 2021-10-08 | 辽宁上药好护士药业（集团）有限公司 | Composition for treating breast cancer and preparation method and application thereof |
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| 中华人民共和国要典. 国家药典委员会，一部528页，化学工业出版社. 1995 * |
| 卫生部颁标准. X31-70. 2000 中华人民共和国要典. 国家药典委员会，一部528页，化学工业出版社. 1995 |
| 卫生部颁标准. X31-70. 2000 * |
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