CN115397805B - 乙酰氨基酚的制造方法 - Google Patents

乙酰氨基酚的制造方法 Download PDF

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Publication number
CN115397805B
CN115397805B CN202180028618.7A CN202180028618A CN115397805B CN 115397805 B CN115397805 B CN 115397805B CN 202180028618 A CN202180028618 A CN 202180028618A CN 115397805 B CN115397805 B CN 115397805B
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reaction
synthetic adsorbent
metal
catalyst
acetaminophen
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Chinese (zh)
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CN115397805A (zh
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村井真人
谷池裕次
古场百合惠
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API Corp
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API Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/06—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/30—Catalysts, in general, characterised by their form or physical properties characterised by their physical properties
    • B01J35/391—Physical properties of the active metal ingredient
    • B01J35/394—Metal dispersion value, e.g. percentage or fraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/60—Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/61—Surface area
    • B01J35/615—100-500 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/60—Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/61—Surface area
    • B01J35/617—500-1000 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/60—Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/61—Surface area
    • B01J35/618—Surface area more than 1000 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/60—Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/63—Pore volume
    • B01J35/633—Pore volume less than 0.5 ml/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/60—Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/63—Pore volume
    • B01J35/635—0.5-1.0 ml/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/60—Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/63—Pore volume
    • B01J35/638—Pore volume more than 1.0 ml/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/60—Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/64—Pore diameter
    • B01J35/647—2-50 nm
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2235/00—Indexing scheme associated with group B01J35/00, related to the analysis techniques used to determine the catalysts form or properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/50—Catalysts, in general, characterised by their form or physical properties characterised by their shape or configuration

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
CN202180028618.7A 2020-05-18 2021-05-14 乙酰氨基酚的制造方法 Active CN115397805B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020086766 2020-05-18
JP2020-086766 2020-05-18
PCT/JP2021/018363 WO2021235335A1 (ja) 2020-05-18 2021-05-14 アセトアミノフェンの製造方法

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CN115397805A CN115397805A (zh) 2022-11-25
CN115397805B true CN115397805B (zh) 2025-05-30

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CN202180028618.7A Active CN115397805B (zh) 2020-05-18 2021-05-14 乙酰氨基酚的制造方法

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US (1) US20230192596A1 (https=)
JP (1) JP7690955B2 (https=)
CN (1) CN115397805B (https=)
WO (1) WO2021235335A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2023090315A1 (https=) * 2021-11-16 2023-05-25
PL448814A1 (pl) * 2024-06-13 2025-12-15 Uniwersytet Im. Adama Mickiewicza W Poznaniu Heterogeniczny katalizator platynowy dla procesów hydrosililowania, sposób jego wytwarzania oraz zastosowanie w procesach hydrosililowania

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
JPS5998048A (ja) * 1982-11-04 1984-06-06 モンサント・コンパニ− Ｎ−アセチル−ｐ−アミノフエノ−ルの製造方法
EP0622354B1 (en) * 1993-04-30 1999-06-02 Hoechst Celanese Corporation Improved process for preparing acyl aminophenols
JP4689691B2 (ja) * 2008-03-10 2011-05-25 独立行政法人科学技術振興機構 酸化反応用高分子担持金クラスター触媒、それを用いたカルボニル化合物の製法
WO2011111672A1 (ja) * 2010-03-10 2011-09-15 国立大学法人東京大学 カルボン酸エステルの製造方法、触媒及びその製造方法
CN102060729B (zh) * 2010-12-28 2013-05-08 刘瑞平 一种连续性高效制备对乙酰氨基苯酚的方法
CN102952032A (zh) * 2011-08-18 2013-03-06 南通贝思特科技咨询有限公司 制备对乙酰氨基苯酚的方法
JP5692704B2 (ja) * 2011-09-21 2015-04-01 Ｊｘ日鉱日石エネルギー株式会社 アミド化合物の製造方法とその触媒
CN104628592B (zh) * 2015-03-02 2017-08-01 河北工业大学 一种在乙酸溶液中硝基苯一步直接合成对乙酰氨基苯酚的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
4-ACETAMINOPHENOL AND 4-HYDROXYPHENYLSALICYLAMIDE SYNTHESIZED BY REDUCTIVE ACYLATION OF 4-NITROPHENOL ON PALLADIUM CATALYSTS;M. G. Abdullaev等;Pharmaceutical Chemistry Journal;20051231;第39卷(第12期);第656页表1 *

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WO2021235335A1 (ja) 2021-11-25
US20230192596A1 (en) 2023-06-22
CN115397805A (zh) 2022-11-25
JPWO2021235335A1 (https=) 2021-11-25
JP7690955B2 (ja) 2025-06-11

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