CN115379852A - 广谱抗病毒药物及其应用 - Google Patents

广谱抗病毒药物及其应用 Download PDF

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Publication number
CN115379852A
CN115379852A CN202080099698.0A CN202080099698A CN115379852A CN 115379852 A CN115379852 A CN 115379852A CN 202080099698 A CN202080099698 A CN 202080099698A CN 115379852 A CN115379852 A CN 115379852A
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China
Prior art keywords
virus
rna
methylation sensitive
associated enzyme
cell
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CN202080099698.0A
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English (en)
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陈奇涵
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Nanjing Maixike Biotechnology Co ltd
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Nanjing Maixike Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本公开提供了抗病毒药物，其包括2’‑O‑甲基化敏感RNA相关酶或2’‑O‑甲基化敏感RNA相关酶的编码核酸序列。本公开还提供了包括该2’‑O‑甲基化敏感RNA相关酶或2’‑O‑甲基化敏感RNA相关酶的编码核酸序列的制药用途。优选地，该2’‑O‑甲基化敏感RNA相关酶为来自生殖支原体的核糖核酸酶MgR。本公开提供的抗病毒药物具有广谱抗病毒效果，并且基本上无细胞毒性，可用于防止病毒对动植物和人的感染。

Description

PCT国内申请，说明书已公开。

Claims (49)

  1. PCT国内申请，权利要求书已公开。
CN202080099698.0A 2020-04-23 2020-12-28 广谱抗病毒药物及其应用 Pending CN115379852A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010325847 2020-04-23
CN2020103258472 2020-04-23
PCT/CN2020/139898 WO2021212892A1 (zh) 2020-04-23 2020-12-28 广谱抗病毒药物及其应用

Publications (1)

Publication Number Publication Date
CN115379852A true CN115379852A (zh) 2022-11-22

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ID=78271096

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080099698.0A Pending CN115379852A (zh) 2020-04-23 2020-12-28 广谱抗病毒药物及其应用

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CN (1) CN115379852A (zh)
WO (1) WO2021212892A1 (zh)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111197070A (zh) * 2018-11-16 2020-05-26 南京迈西可生物科技有限公司 鉴定rna分子中2`-o-甲基化修饰的方法及其应用
CN110923217B (zh) * 2019-12-11 2021-05-04 南京大学 可识别2’-o-甲基化修饰rna的核糖核酸酶r及其应用

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WO2021212892A1 (zh) 2021-10-28

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