CN115350132B - Traditional Chinese medicine compound, traditional Chinese medicine mask and preparation method of traditional Chinese medicine compound - Google Patents
Traditional Chinese medicine compound, traditional Chinese medicine mask and preparation method of traditional Chinese medicine compound Download PDFInfo
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title abstract description 17
- 239000000284 extract Substances 0.000 claims abstract description 110
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims abstract description 31
- 229930003944 flavone Natural products 0.000 claims abstract description 31
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims abstract description 31
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 27
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 27
- ILRCGYURZSFMEG-UHFFFAOYSA-N Salidroside Natural products OC1C(O)C(O)C(CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-UHFFFAOYSA-N 0.000 claims abstract description 26
- ILRCGYURZSFMEG-RQICVUQASA-N salidroside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-RQICVUQASA-N 0.000 claims abstract description 26
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- 229940010747 sodium hyaluronate Drugs 0.000 claims description 17
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 17
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- 229940049638 carbomer homopolymer type c Drugs 0.000 claims description 13
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- 238000000227 grinding Methods 0.000 claims description 9
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- 238000001914 filtration Methods 0.000 claims description 6
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- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 claims description 3
- 239000003480 eluent Substances 0.000 claims description 3
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- 230000000694 effects Effects 0.000 abstract description 35
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- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 6
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- 239000000758 substrate Substances 0.000 abstract description 3
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract description 3
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine compound, a traditional Chinese medicine mask and a preparation method thereof, belonging to the technical field of skin care products, wherein the traditional Chinese medicine compound comprises a salidroside extract, a ophiopogon root extract and a safflower flavone extract; when applied to a traditional Chinese medicine mask, the three traditional Chinese medicine extracts mainly contain flavonoid or phenolic glycoside compounds, and have more phenolic hydroxyl groups, so that the traditional Chinese medicine mask has good antioxidation effect; meanwhile, part of phenolic glycoside compounds have hydroquinone structures, are similar to the substrate tyrosine structure of tyrosinase, can competitively inhibit the activity of tyrosinase and influence the generation of melanin, and thus have the effects of whitening and resisting aging. Therefore, the traditional Chinese medicine compound provided by the embodiment of the application can improve the effect of the whitening anti-aging mask.
Description
Technical Field
The application relates to the technical field of skin care products, in particular to a traditional Chinese medicine compound, a traditional Chinese medicine mask and a preparation method thereof.
Background
The application of cosmetics taking traditional Chinese medicines as raw materials has been thousands of years, and the traditional Chinese medicine mask has low toxicity, does not contain mercury, lead, hormone and other bad substances, has pure naturalness and nonirritating property of traditional Chinese medicines and contains certain effects such as whitening and the like, so that the traditional Chinese medicine mask is deeply favored in recent years, and has strong market competition potential.
At present, the most popular among the efficacy type traditional Chinese medicine masks is a whitening type and anti-aging type mask. At present, a plurality of whitening type and anti-aging type masks exist on the market, but the number of masks which simultaneously take the effects of the whitening type and the anti-aging type is relatively small. The traditional whitening and anti-aging mask in the market adopts traditional Chinese medicine mixed powder for direct external application, which is easy to cause that the effective components are not easy to be absorbed effectively, thus causing poor efficacy, and the formula components are complex and the cost is high.
Disclosure of Invention
The embodiment of the application provides a traditional Chinese medicine compound, a traditional Chinese medicine mask and a preparation method thereof, so as to solve the technical problems that the existing whitening anti-aging mask is not easy to absorb and has poor effect.
In a first aspect, embodiments of the present application provide a traditional Chinese medicine complex, the traditional Chinese medicine complex comprising the following components: rhodiola rosea glycosides extract, ophiopogon root extract and safflower flavone extract.
Further, the weight ratio of the salidroside extract to the ophiopogon root extract to the safflower flavone extract is 1-3: 1 to 3:3.
further, the salidroside extract is prepared by the following steps:
pulverizing rhodiola root Chinese medicinal materials, extracting with ethanol solution at 50-70 ℃, filtering, and concentrating the filtered filtrate to obtain an extract;
eluting the extracting solution by macroporous resin, and washing with water and ethanol solution to obtain eluent;
concentrating, drying and grinding the liquid positive to obtain salidroside extract.
Further, the ophiopogon root extract is prepared by the following steps:
pulverizing radix Ophiopogonis, soaking in ethanol solution, extracting, and concentrating the extractive solution to obtain paste extract;
freezing the pasty extract for 3-5h at-70 to-90 ℃, then freeze-drying for 20-28 h at-30 to-50 ℃, and grinding to powder after drying to obtain the ophiopogon root extract.
Further, the safflower flavone extract is prepared by the following steps:
soaking safflower in water for 50-70 min, then carrying out ultrasonic extraction at 30-50 ℃, and filtering the extracted extract to obtain filtrate;
concentrating the filtrate, extracting with petroleum ether, concentrating the water layer to syrup, freeze drying, and grinding to obtain Carthami flos flavone extract.
In a second aspect, embodiments of the present application provide a traditional Chinese medicine mask, where the traditional Chinese medicine mask is made of the traditional Chinese medicine compound according to the first aspect.
Further, the traditional Chinese medicine mask also comprises the following components: thickener, humectant, water supplementing agent, antiseptic and water.
Further, the thickener is carbomer 940, the humectant is glycerin and propylene glycol, the water supplementing agent is sodium hyaluronate, and the preservative is ethyl parahydroxybenzoate.
Further, the dosage ratio of the traditional Chinese medicine compound, carbomer 940, glycerol, propylene glycol, sodium hyaluronate, ethyl p-hydroxybenzoate and water is 3g:6 to 6.75g: 30-36 g: 30-40 g:1.5g:0.3g: 200-250 ml.
In a third aspect, an embodiment of the present application provides a method for preparing the traditional Chinese medicine mask according to the second aspect, where the method includes:
mixing a thickening agent and a humectant, adding water, stirring uniformly, heating in a water bath at 40-60 ℃ for 1-1.5 h, and placing in a shade place to swell overnight after heating to obtain a mixed matrix 1;
mixing the humectant and the moisturizing agent, adding the preservative, and uniformly stirring to obtain a mixed matrix 2;
adding the mixed matrix 2 into the mixed matrix 1, and uniformly stirring to obtain a mixed matrix 3;
adding salidroside extract, radix Ophiopogonis extract and Carthami flos flavone extract into the mixed matrix 3, and stirring to obtain traditional Chinese medicine facial mask.
Compared with the prior art, the technical scheme provided by the embodiment of the application has the following advantages:
the embodiment of the application provides a traditional Chinese medicine compound, which comprises a salidroside extract, a radix ophiopogonis extract and a safflower flavone extract; when applied to a traditional Chinese medicine mask, the three traditional Chinese medicine extracts mainly contain flavonoid or phenolic glycoside compounds, and have more phenolic hydroxyl groups, so that the traditional Chinese medicine mask has good antioxidation effect; meanwhile, part of phenolic glycoside compounds have hydroquinone structures, are similar to the substrate tyrosine structure of tyrosinase, can competitively inhibit the activity of tyrosinase and influence the generation of melanin, and thus have the effects of whitening and resisting aging. Therefore, the traditional Chinese medicine compound provided by the embodiment of the application can improve the effect of the whitening anti-aging mask.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.
In order to more clearly illustrate the embodiments of the invention or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, and it will be obvious to a person skilled in the art that other drawings can be obtained from these drawings without inventive effort.
Fig. 1 is a schematic flow chart of a preparation method of a traditional Chinese medicine mask according to an embodiment of the present application.
Detailed Description
The advantages and various effects of the present invention will be more clearly apparent from the following detailed description and examples. It will be understood by those skilled in the art that these specific embodiments and examples are intended to illustrate the invention, not to limit the invention.
Throughout the specification, unless specifically indicated otherwise, the terms used herein should be understood as meaning as commonly used in the art. Accordingly, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification will control.
Unless otherwise specifically indicated, the various raw materials, reagents, instruments, equipment and the like used in the present invention are commercially available or may be prepared by existing methods.
The application of cosmetics taking traditional Chinese medicines as raw materials has been thousands of years, and the traditional Chinese medicine mask has low toxicity, does not contain mercury, lead, hormone and other bad substances, has pure naturalness and nonirritating property of traditional Chinese medicines and contains certain effects such as whitening and the like, so that the traditional Chinese medicine mask is deeply favored in recent years, and has strong market competition potential.
At present, the most popular among the efficacy type traditional Chinese medicine masks is a whitening type and anti-aging type mask. At present, a plurality of whitening type and anti-aging type masks exist on the market, but the number of masks which simultaneously take the effects of the whitening type and the anti-aging type is relatively small. The traditional whitening and anti-aging mask in the market adopts traditional Chinese medicine mixed powder for direct external application, which is easy to cause that the effective components are not easy to be absorbed effectively, thus causing poor efficacy, and the formula components are complex and the cost is high.
The technical scheme provided by the embodiment of the invention aims to solve the technical problems, and the overall thought is as follows:
in a first aspect, embodiments of the present application provide a traditional Chinese medicine complex, the traditional Chinese medicine complex comprising the following components: rhodiola rosea glycosides extract, ophiopogon root extract and safflower flavone extract.
The embodiment of the application provides a traditional Chinese medicine compound, which comprises a salidroside extract, a radix ophiopogonis extract and a safflower flavone extract; when applied to a traditional Chinese medicine mask, the three traditional Chinese medicine extracts mainly contain flavonoid or phenolic glycoside compounds, and have more phenolic hydroxyl groups, so that the traditional Chinese medicine mask has good antioxidation effect; meanwhile, part of phenolic glycoside compounds have hydroquinone structures, are similar to the substrate tyrosine structure of tyrosinase, can competitively inhibit the activity of tyrosinase and influence the generation of melanin, and thus have the effects of whitening and resisting aging. Therefore, the traditional Chinese medicine compound provided by the embodiment of the application can improve the effect of the whitening anti-aging mask.
As an implementation mode of the embodiment of the invention, the weight ratio of the salidroside extract to the ophiopogon root extract to the safflower flavone extract is 1-3: 1 to 3:3.
in the application, the effect of controlling the salidroside extract, the dwarf lilyturf tuber extract and the safflower flavone extract to be in the dosage relationship is that the traditional Chinese medicine compound has better free radical scavenging capability and tyrosinase inhibition capability. In some specific embodiments, the weight ratio of the salidroside extract, the ophiopogon root extract and the safflower flavone extract may be 3:3: 3. 1:1: 3. 3:1: 3. 2:2: 3. 3:2:3.
as an implementation mode of the embodiment of the invention, the salidroside extract is prepared by the following steps:
pulverizing rhodiola root Chinese medicinal materials, extracting with ethanol solution at 50-70 ℃, filtering, and concentrating the filtered filtrate to obtain an extract;
eluting the extracting solution by macroporous resin, and washing with water and ethanol solution to obtain eluent;
concentrating, drying and grinding the liquid positive to obtain salidroside extract.
In the application, the effective components in the rhodiola root traditional Chinese medicine are extracted, so that the rhodiola root traditional Chinese medicine is easier to be effectively absorbed by skin, and the effects of effectively removing free radicals and inhibiting tyrosinase activity are achieved.
As an embodiment of the present embodiment, the ophiopogon root extract is prepared by the following steps:
pulverizing radix Ophiopogonis, soaking in ethanol solution, extracting, and concentrating the extractive solution to obtain paste extract;
freezing the pasty extract for 3-5h at-70 to-90 ℃, then freeze-drying for 20-28 h at-30 to-50 ℃, and grinding to powder after drying to obtain the ophiopogon root extract.
In the application, the effective components in the dwarf lilyturf tuber are extracted, so that the dwarf lilyturf tuber is easier to be effectively absorbed by skin, and the effects of effectively removing free radicals and inhibiting tyrosinase activity are achieved.
As an embodiment of the present invention, the safflower flavone extract is prepared by the following steps:
soaking safflower in water for 50-70 min, then carrying out ultrasonic extraction at 30-50 ℃, and filtering the extracted extract to obtain filtrate;
concentrating the filtrate, extracting with petroleum ether, concentrating the water layer to syrup, freeze drying, and grinding to obtain Carthami flos flavone extract.
In the application, the effective components in the safflower are extracted, so that the safflower is easier to be effectively absorbed by skin, and the effects of effectively removing free radicals and inhibiting tyrosinase activity are achieved.
In a second aspect, embodiments of the present application provide a traditional Chinese medicine mask, where the traditional Chinese medicine mask is made of the traditional Chinese medicine compound according to the first aspect.
In the application, the traditional Chinese medicine mask takes rhodiola rosea, dwarf lilyturf tuber and safflower active extracts as raw materials, and has good whitening and anti-aging effects.
As an implementation mode of the embodiment of the invention, the traditional Chinese medicine mask further comprises the following components: thickener, humectant, water supplementing agent, antiseptic and water.
In the application, the traditional Chinese medicine mask is a pure traditional Chinese medicine formula, no free radical scavenging and tyrosine inhibiting substances are added into the matrix, and the traditional Chinese medicine mask has no side effect and wide application range. By adding the thickener, the humectant, the moisturizing agent, the preservative and the water, the mask is fine and uniform and is easy to spread, and the state under normal temperature needs to be kept in a gel form all the time.
As an implementation mode of the embodiment of the invention, the thickener is carbomer 940, the humectant is glycerin and propylene glycol, the moisturizing agent is sodium hyaluronate, and the preservative is ethyl parahydroxybenzoate.
Carbomer 940 is often used as a thickener in gel formulations and also has the effect of protecting the skin. The glycerol and the propylene glycol are used as the humectant, and have the functions of moisturizing and water locking. The sodium hyaluronate is used as a moisturizing agent, has a certain repairing effect on the cornea, and is low in price. The ethyl p-hydroxybenzoate is used as mask antiseptic to prevent mask spoilage.
As an implementation mode of the embodiment of the invention, the dosage ratio of the traditional Chinese medicine compound, carbomer 940, glycerin, propylene glycol, sodium hyaluronate, ethyl parahydroxybenzoate and water is 3g:6 to 6.75g: 30-36 g: 30-40 g:1.5g:0.3g: 200-250 ml.
In the application, the whitening and anti-aging effects of the mask disease can be good by controlling the proportion of each component, and the mask disease has good morphology, good texture, good stability and good spreadability.
In a third aspect, an embodiment of the present application provides a method for preparing the traditional Chinese medicine mask according to the second aspect, where the method includes:
mixing a thickening agent and a humectant, adding water, stirring uniformly, heating in a water bath at 40-60 ℃ for 1-1.5 h, and placing in a shade place to swell overnight after heating to obtain a mixed matrix 1;
mixing the humectant and the moisturizing agent, adding the preservative, and uniformly stirring to obtain a mixed matrix 2;
adding the mixed matrix 2 into the mixed matrix 1, and uniformly stirring to obtain a mixed matrix 3;
adding salidroside extract, radix Ophiopogonis extract and Carthami flos flavone extract into the mixed matrix 3, and stirring to obtain traditional Chinese medicine facial mask.
In the application, the preparation process of the traditional Chinese medicine mask is simple, and the traditional Chinese medicine mask can be used for mass production.
The invention will be further illustrated with reference to specific examples. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention. The experimental procedures, which are not specified in the following examples, are generally determined according to national standards. If the corresponding national standard does not exist, the method is carried out according to the general international standard, the conventional condition or the condition recommended by the manufacturer.
Example 1:
a traditional Chinese medicine mask and a preparation method thereof are characterized by comprising the following steps:
(1) Raw material selection: 1g of salidroside extract, 1g of ophiopogon root extract, 1g of safflower flavone extract, 9406.75g of carbomer, 36g of glycerin, 30g of propylene glycol, 1.5g of sodium hyaluronate, 0.3g of ethyl p-hydroxybenzoate, 3g of sweet orange essential oil and 234ml of deionized water;
(2) The preparation of the traditional Chinese medicine mask comprises the following steps:
mixing carbomer 940 and 15g glycerol, stirring, adding deionized water, stirring, heating in a water bath at 50deg.C for 1.2 hr, stirring every 5min, taking out, standing in shade, and swelling overnight to obtain mixed matrix 1;
after 21g of glycerin and sodium hyaluronate are mixed and stirred uniformly, methyl parahydroxybenzoate, sweet orange essential oil and propylene glycol are added and stirred uniformly to obtain a mixed matrix 2;
adding the mixed matrix 2 into the mixed material 1, and uniformly stirring to obtain a mixed matrix 3;
adding salidroside extract, radix Ophiopogonis extract, and Carthami flos flavone extract into the mixed matrix 3, and stirring to obtain traditional Chinese medicine facial mask.
Example 2:
a traditional Chinese medicine mask and a preparation method thereof are characterized by comprising the following steps:
(1) Raw material selection: selecting 0.4g of salidroside extract, 1.3g of ophiopogon root extract, 1.3g of safflower flavone extract, 9406g of carbomer, 30g of glycerin, 35g of propylene glycol, 1.5g of sodium hyaluronate, 0.3g of ethyl p-hydroxybenzoate and 200ml of deionized water for later use;
(2) The preparation of the traditional Chinese medicine mask comprises the following steps:
mixing carbomer 940 and 13g of glycerol, stirring, adding deionized water, stirring, heating in a water bath at 40deg.C for 1.5 hr, stirring every 5min, taking out, standing in shade, and swelling overnight to obtain mixed matrix 1;
17g of glycerin and sodium hyaluronate are mixed and stirred uniformly, and then methyl parahydroxybenzoate, sweet orange essential oil and propylene glycol are added and stirred uniformly to obtain a mixed matrix 2;
adding the mixed matrix 2 into the mixed material 1, and uniformly stirring to obtain a mixed matrix 3;
adding salidroside extract, radix Ophiopogonis extract, and Carthami flos flavone extract into the mixed matrix 3, and stirring to obtain traditional Chinese medicine facial mask.
Example 3:
a traditional Chinese medicine mask and a preparation method thereof are characterized by comprising the following steps:
(1) Raw material selection: 1.3g of salidroside extract, 0.4g of ophiopogon root extract, 1.3g of safflower flavone extract, 9406.5g of carbomer, 33g of glycerin, 40g of propylene glycol, 1.5g of sodium hyaluronate, 0.3g of ethyl p-hydroxybenzoate and 250ml of deionized water are selected for standby;
(2) The preparation of the traditional Chinese medicine mask comprises the following steps:
mixing carbomer 940 and 14g of glycerol, stirring, adding deionized water, stirring, heating in a water bath at 60deg.C for 1 hr, stirring every 5min, taking out, standing in shade, and swelling overnight to obtain mixed matrix 1;
mixing and stirring 19g of glycerin and sodium hyaluronate uniformly, adding methyl parahydroxybenzoate, sweet orange essential oil and propylene glycol, and stirring uniformly to obtain a mixed matrix 2;
adding the mixed matrix 2 into the mixed material 1, and uniformly stirring to obtain a mixed matrix 3;
adding salidroside extract, radix Ophiopogonis extract, and Carthami flos flavone extract into the mixed matrix 3, and stirring to obtain traditional Chinese medicine facial mask.
Example 4:
a traditional Chinese medicine mask and a preparation method thereof are characterized by comprising the following steps:
(1) Raw material selection: 0.8g of salidroside extract, 1.1g of ophiopogon root extract, 1.1g of safflower flavone extract, 9406.3g of carbomer, 34g of glycerin, 37g of propylene glycol, 1.5g of sodium hyaluronate, 0.3g of ethyl p-hydroxybenzoate, 3g of sweet orange essential oil and 240ml of deionized water;
(2) The preparation of the traditional Chinese medicine mask comprises the following steps:
mixing carbomer 940 and 15g glycerol, stirring, adding deionized water, stirring, heating in a water bath at 50deg.C for 1.2 hr, stirring every 5min, taking out, standing in shade, and swelling overnight to obtain mixed matrix 1;
after 21g of glycerin and sodium hyaluronate are mixed and stirred uniformly, methyl parahydroxybenzoate, sweet orange essential oil and propylene glycol are added and stirred uniformly to obtain a mixed matrix 2;
adding the mixed matrix 2 into the mixed material 1, and uniformly stirring to obtain a mixed matrix 3;
adding salidroside extract, radix Ophiopogonis extract, and Carthami flos flavone extract into the mixed matrix 3, and stirring to obtain traditional Chinese medicine facial mask.
Example 5:
a traditional Chinese medicine mask and a preparation method thereof are characterized by comprising the following steps:
(1) Raw material selection: 1.1g of salidroside extract, 0.8g of ophiopogon root extract, 1.1g of safflower flavone extract, 9406.2g of carbomer, 32g of glycerin, 34g of propylene glycol, 1.5g of sodium hyaluronate, 0.3g of ethyl p-hydroxybenzoate, 3g of sweet orange essential oil and 220ml of deionized water;
(2) The preparation of the traditional Chinese medicine mask comprises the following steps:
mixing carbomer 940 and 15g glycerol, stirring, adding deionized water, stirring, heating in a water bath at 50deg.C for 1.2 hr, stirring every 5min, taking out, standing in shade, and swelling overnight to obtain mixed matrix 1;
after 21g of glycerin and sodium hyaluronate are mixed and stirred uniformly, methyl parahydroxybenzoate, sweet orange essential oil and propylene glycol are added and stirred uniformly to obtain a mixed matrix 2;
adding the mixed matrix 2 into the mixed material 1, and uniformly stirring to obtain a mixed matrix 3;
adding salidroside extract, radix Ophiopogonis extract, and Carthami flos flavone extract into the mixed matrix 3, and stirring to obtain traditional Chinese medicine facial mask.
Comparative example 1:
the procedure of example 1 was repeated except that the rhodiola rosea glycoside extract of example 1 was changed to 1.3g, the ophiopogon root extract was changed to 1g, and the safflower flavone extract was changed to 0.7 g.
Comparative example 2:
the procedure of example 1 was repeated except that the starting carbomer 940 was changed to 3g in example 1.
Comparative example 3:
the procedure of example 1 was repeated except that the propylene glycol used as a raw material in example 1 was changed to 45 g.
The traditional Chinese medicine masks of the examples and the comparative examples were tested for free radical removal rate, tyrosinase generating activity, morphology, centrifugal stability, spreadability, and presence or absence of bubbles, and the results are shown in table 1.
TABLE 1 free radical scavenging Rate, tyrosinase generating Activity, morphology, centrifugal stability, spreadability, and bubble test results
The two types of whitening masks with good sales in the market and the traditional Chinese medicine mask of the embodiment are compared in free radical clearance rate and tyrosine inhibition rate, and performance test is carried out:
the advantages and disadvantages of the traditional Chinese medicine whitening mask are analyzed by comparing the traditional Chinese medicine mask (X mask) with the whitening mask with good marketing quantity. Two whitening anti-aging masks are purchased randomly in the market, wherein one of the whitening anti-aging masks is a certain brand (Y mask) in China; the other is korea brand (Z mask). The three masks are respectively taken 1.25mg, 2.5mg, 5.0mg, 7.5mg and 10mg, respectively, and 1ml of extracting solution in the free radical scavenging kit is respectively added to prepare the different concentrations of 1.25mg/ml to 10 mg/ml. The results of the operation according to the methods of using the radical scavenging kit and the tyrosine production kit are shown in Table 2.
TABLE 2 radical scavenging and tyrosine formation values for three masks
As can be seen from Table 2, the free radical scavenging rate and the concentration of the traditional Chinese medicine mask in the example have obvious relation, the scavenging rate reaches 78.81% at the concentration of 1.25mg/ml, the free radical scavenging rate and the concentration relation of other two commercial masks are not obvious, and the free radical scavenging rate is less than 50% at each concentration. The radical scavenging rate of the domestic Y mask is firstly reduced and then increased along with the concentration, and the radical scavenging rate of the Korean Z mask is firstly reduced and then increased, but the total radical scavenging rate is better than that of the domestic Y mask. In addition, it is hypothesized that domestic Y mask and korean Z mask may be some additives in the matrix having an anti-radical effect.
As can be seen from table 2, in the tyrosine production experiment, the tyrosine production value of the traditional Chinese medicine mask of the example gradually decreases with increasing concentration, which shows that the inhibition effect of the tyrosine of the mask decreases with increasing concentration, while the domestic Y mask and the korean Z mask are not obvious before the concentration of 7.5mg/ml, and then the tyrosine production value suddenly and obviously decreases, which shows that the matrix of the Y, Z mask is added with obvious tyrosine inhibition substances instead of pure traditional Chinese medicine extract components.
In conclusion, the free radical scavenging capability and the tyrosine inhibition activity of the traditional Chinese medicine mask are obviously superior to those of the other two types of whitening masks purchased in the market, and the traditional Chinese medicine mask is a pure traditional Chinese medicine effect mask.
Performance test:
60 female volunteers 18-22 years old are selected and randomly divided into 3 groups, after each group of 20 people has a clean face, the face is still sitting for about 15 minutes, 15g of each traditional Chinese medicine mask and the commercial mask Y, Z of the example are respectively and evenly smeared on the face after the face and the external environment are balanced, the face is washed with warm water after 20 minutes, the operation is repeated for 1 time a day and 1 month, and the effect is shown in Table 3.
Table 3 three mask use cases
As can be seen from Table 3, the traditional Chinese medicine mask of the example has significantly better whitening and anti-aging effects than the two commercially available masks, and has no obvious rebound change after being used for a period of time.
In summary, the embodiment of the application provides a traditional Chinese medicine compound, which comprises a salidroside extract, a radix ophiopogonis extract and a safflower flavone extract; when applied to a traditional Chinese medicine mask, the skin-whitening and anti-aging facial mask has good free radical clearance and tyrosine generation inhibition effects. Therefore, the traditional Chinese medicine compound provided by the embodiment of the application can improve the effect of the whitening anti-aging mask.
It should be understood that the endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and that the range or value is to be understood as encompassing values close to the range or value. For numerical ranges, one or more new numerical ranges may be found between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point value, in combination with each other, and are to be considered as specifically disclosed herein.
It should be noted that in this document, relational terms such as "first" and "second" and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. In addition, the term "and/or" appearing herein is merely an association relationship describing the associated object, and means that three relationships may exist, for example, a and/or B may mean: a exists alone, A and B exist together, and B exists alone.
The foregoing is only a specific embodiment of the invention to enable those skilled in the art to understand or practice the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (1)
1. The traditional Chinese medicine mask is characterized by comprising a traditional Chinese medicine compound, carbomer 940, glycerin, propylene glycol, sodium hyaluronate, ethyl p-hydroxybenzoate and water, wherein the dosage ratio of the traditional Chinese medicine compound, carbomer 940, glycerin, propylene glycol, sodium hyaluronate, ethyl p-hydroxybenzoate and water is 3g:6 to 6.75g: 30-36 g: 30-40 g:1.5g:0.3g: 200-250 ml, wherein the traditional Chinese medicine compound comprises the following components: the rhodiola rosea extract, the ophiopogon root extract and the safflower flavone extract, wherein the weight ratio of the rhodiola rosea extract to the ophiopogon root extract to the safflower flavone extract is 1-3: 1 to 3:3, a step of; the salidroside extract is prepared by the following steps:
pulverizing rhodiola root Chinese medicinal materials, extracting with ethanol solution at 50-70 ℃, filtering, and concentrating the filtered filtrate to obtain an extract;
eluting the extracting solution by macroporous resin, and washing with water and ethanol solution to obtain eluent;
concentrating, drying and grinding the liquid positive to obtain salidroside extract;
the ophiopogon root extract is prepared by the following steps:
pulverizing radix Ophiopogonis, soaking in ethanol solution, extracting, and concentrating the extractive solution to obtain paste extract;
freezing the pasty extract at-70 to-90 ℃ for 3-5h, then freeze-drying at-30 to-50 ℃ for 20-28 h, and grinding to powder to obtain the ophiopogon root extract;
the safflower flavone extract is prepared by the following steps:
soaking safflower in water for 50-70 min, then carrying out ultrasonic extraction at 30-50 ℃, and filtering the extracted extract to obtain filtrate;
concentrating the filtrate, extracting with petroleum ether, concentrating the water layer to syrup, freeze drying, and grinding to obtain Carthami flos flavone extract.
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| CN104706566A (en) * | 2015-03-31 | 2015-06-17 | 海南医学院 | Pawpaw seed oil antiwrinkling sleeping mask and preparation method thereof |
| CN107753404A (en) * | 2017-12-01 | 2018-03-06 | 翁剑 | Facial treatment mask containing traditional Chinese medicine ingredients |
| JP2019019077A (en) * | 2017-07-18 | 2019-02-07 | ポーラ化成工業株式会社 | Skin external composition |
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| CN104706566A (en) * | 2015-03-31 | 2015-06-17 | 海南医学院 | Pawpaw seed oil antiwrinkling sleeping mask and preparation method thereof |
| JP2019019077A (en) * | 2017-07-18 | 2019-02-07 | ポーラ化成工業株式会社 | Skin external composition |
| CN107753404A (en) * | 2017-12-01 | 2018-03-06 | 翁剑 | Facial treatment mask containing traditional Chinese medicine ingredients |
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