CN115316528A - Feed additive for preventing and treating piglet diarrhea - Google Patents

Feed additive for preventing and treating piglet diarrhea Download PDF

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Publication number
CN115316528A
CN115316528A CN202210780347.7A CN202210780347A CN115316528A CN 115316528 A CN115316528 A CN 115316528A CN 202210780347 A CN202210780347 A CN 202210780347A CN 115316528 A CN115316528 A CN 115316528A
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feed additive
parts
preventing
piglet diarrhea
chinese herbal
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Inventor
王广聚
高延玲
朱利峰
秦军波
邓炎晗
华会杰
赵建闯
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Henan Baodao Tongsheng Feed Technology Co ltd
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Henan Baodao Tongsheng Feed Technology Co ltd
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Priority to CN202210780347.7A priority Critical patent/CN115316528A/en
Publication of CN115316528A publication Critical patent/CN115316528A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/284—Atractylodes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
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    • A61P31/04—Antibacterial agents
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

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Abstract

The invention discloses a feed additive formula for preventing and treating piglet diarrhea, which comprises the following components in percentage by weight: 40-50% of montmorillonite, 5-10% of antibacterial peptide, 5-15% of yolk antibody and 15-25% of Chinese herbal medicine additive. According to the feed additive formula, through the addition of montmorillonite, antibacterial peptide, egg yolk antibody and Chinese herbal medicines, the components have synergistic effect, the daily gain and the feed conversion rate of the fed piglets are obviously improved, harmful components such as antibiotics are not added, the feed additive is green, efficient and safe, the problems of drug resistance, harmful residues and the like cannot be generated after long-term use, the feed additive can be used for preventing and treating diarrhea of the piglets, the intestinal environment of the piglets can be improved, the digestion function and the immune function of an organism are enhanced, and the anti-stress response and the anti-disease capability of the piglets are improved.

Description

Feed additive for preventing and treating piglet diarrhea
Technical Field
The invention relates to the field of feed additives, in particular to a feed additive formula for preventing and treating piglet diarrhea.
Background
The piglet diarrhea is a common disease caused by multiple factors in a large-scale pig farm. The disease has wide prevalence range, almost causes the disease in the whole year, has high morbidity, is slow to grow even if the sick piglets are healed, and has low feed reward. Piglet diarrhea is also one of the important causes of piglet death. The death number of piglets caused by diarrhea accounts for 39.8 percent of the death total of the piglets, and huge economic loss is brought to the pig raising industry. The piglet diarrhea is one kind of diarrhea, antibiotics are usually added into the feed before to reduce the risk of infecting bacteria and ice viruses of piglets, improve the infection resistance of piglets, treat diarrhea diseases of piglets and the like, but the long-term use of the antibiotics can cause the generation of drug resistance, meanwhile, the residue in animal products and environment can also seriously affect the health of human beings, and the green feed additive for preventing and treating the piglet diarrhea has wide application prospect along with the arrival of forbidden resistance of the feed. Therefore, the development of an antibiotic-free, green, efficient and safe feed additive for preventing and treating piglet diarrhea is urgently needed.
Disclosure of Invention
The invention aims to provide a feed additive formula for preventing and treating piglet diarrhea, and aims to solve the problems in the prior art.
In order to achieve the purpose, the invention provides the following scheme:
the invention provides a feed additive formula for preventing and treating piglet diarrhea, which comprises the following components in percentage by weight: 40-50% of montmorillonite, 5-10% of antibacterial peptide, 5-15% of yolk antibody and 15-25% of Chinese herbal medicine additive.
In the feed additive formula for preventing and treating piglet diarrhea, as a preferred scheme, the antibacterial peptide is one or more of cecropin, defensin, swine-derived PR39 antibacterial peptide and antibacterial peptide P5.
In the formula of the feed additive for preventing and treating piglet diarrhea, as a preferred scheme, the Chinese herbal medicine additive is composed of the following components in parts by weight: 20-30 parts of honeysuckle, 10-20 parts of perilla, 10-15 parts of codonopsis pilosula, 15-20 parts of bighead atractylodes rhizome, 15-20 parts of coptis chinensis, 10-15 parts of poria cocos and 15-20 parts of liquorice.
The invention also provides a preparation method of the feed additive formula for preventing and treating piglet diarrhea, which comprises the following steps:
(1) Weighing montmorillonite, antibacterial peptide and Chinese herbal medicines according to the weight parts;
(2) Mixing flos Lonicerae, perillae herba, radix Codonopsis, atractylodis rhizoma, coptidis rhizoma, poria, and Glycyrrhrizae radix, pulverizing, and sieving to obtain Chinese herbal mixture A;
(3) Adding distilled water into the Chinese herbal medicine mixture, uniformly stirring, and performing freezing treatment to obtain a mixture B;
(4) Drying, crushing and sieving the mixture B after the freezing treatment to obtain a mixture C;
(5) And (3) uniformly mixing the mixture C with the montmorillonite and the yolk antibody, adding the antibacterial peptide, and uniformly mixing to obtain the antibacterial peptide.
In the feed additive formula for preventing and treating piglet diarrhea, as a preferable scheme, the crushed powder in the step (2) is sieved by a 50-100-mesh sieve.
In the above feed additive formulation for preventing and treating diarrhea of piglets, as a preferred scheme, the amount of the distilled water added in the step (3) is 0.4-0.6 times of the amount of the Chinese herbal medicine mixture.
In the feed additive formula for preventing and treating piglet diarrhea, as a preferred scheme, the freezing treatment in the step (3) is freezing for 8-10 hours at the temperature of-90 ℃ to-70 ℃.
In the feed additive formula for preventing and treating piglet diarrhea, as a preferred scheme, the feed additive is subjected to freezing treatment, crushed and sieved by a 100-200-mesh sieve.
The invention also provides application of the feed additive formula for preventing and treating piglet diarrhea in medicines for preventing and treating piglet diarrhea.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a feed additive formula for preventing and treating piglet diarrhea, which consists of montmorillonite, antibacterial peptide and Chinese herbal medicines. By utilizing the adsorption function of the montmorillonite and the function of the intestinal mucosa protective agent, the antibacterial and antidiarrheal agent can adsorb bacteria and toxins in the digestive tract, reduce the stimulation to the intestinal tract and reduce the symptoms of diarrhea, can form a protective layer on the surface of the mucosa, promote the adsorption of mucus, reduce the stimulation of pathogens and toxins thereof to the gastrointestinal tract, play a role in stopping diarrhea, and can also be used as a carrier; the antibacterial peptide has unique antibacterial activity, can kill harmful flora in intestinal tracts, reduces the diarrhea rate of piglets, is not easy to generate drug resistance, and can obviously reduce the number of escherichia coli in intestinal tracts of pigs; the yolk antibody IgY can resist the digestion of trypsin and chymotrypsin in intestinal tracts of young animals, and prevent and treat infection of various pathogenic bacteria and the like; meanwhile, by adding natural Chinese herbal medicines and utilizing the compatibility of medicine properties of the medicinal materials, the feed additive has the effects of resisting bacteria, diminishing inflammation, resisting viruses and the like, and has a good effect of relieving piglet diarrhea.
The feed additive disclosed by the invention is green, efficient and safe in formula without adding harmful components such as antibiotics and the like, can be used for preventing and treating diarrhea of piglets without generating problems such as drug resistance and harmful residues after long-term use, and can also be used for improving the intestinal environment of the piglets, enhancing the digestive function and the immune function of organisms and improving the anti-stress response and anti-disease capability of the piglets.
The preparation method is simple, can be used for large-scale production, and has wide market prospect.
Detailed Description
Reference will now be made in detail to various exemplary embodiments of the invention, the detailed description should not be construed as limiting the invention but as a more detailed description of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Further, for numerical ranges in this disclosure, it is understood that each intervening value, between the upper and lower limit of that range, is also specifically disclosed. Every smaller range between any stated value or intervening value in a stated range and any other stated or intervening value in a stated range is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated herein by reference to disclose and describe the methods and/or materials in connection with which the documents are cited. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the present disclosure without departing from the scope or spirit of the disclosure. Other embodiments will be apparent to those skilled in the art from consideration of the specification. The specification and examples are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are open-ended terms that mean including, but not limited to.
Example 1
A feed additive formula for preventing and treating piglet diarrhea comprises the following components in percentage by weight: 40% of montmorillonite, 5% of antibacterial peptide, 5% of yolk antibody and 25% of Chinese herbal medicine additive; wherein the antibacterial peptide is cecropin; the Chinese herbal medicine additive comprises the following components in parts by weight: 20 parts of honeysuckle, 10 parts of purple perilla, 10 parts of codonopsis pilosula, 15 parts of bighead atractylodes rhizome, 15 parts of coptis chinensis, 10 parts of poria cocos and 15 parts of liquorice.
Example 2
A feed additive formula for preventing and treating piglet diarrhea comprises the following components in percentage by weight: 50% of montmorillonite, 7% of antibacterial peptide, 15% of yolk antibody and 15% of Chinese herbal medicine additive; wherein the antibacterial peptide is porcine-derived PR39 antibacterial peptide; the Chinese herbal medicine additive comprises the following components in parts by weight: 30 parts of honeysuckle, 20 parts of purple perilla, 15 parts of codonopsis pilosula, 20 parts of bighead atractylodes rhizome, 20 parts of coptis chinensis, 15 parts of poria cocos and 20 parts of liquorice.
Example 3
A feed additive formula for preventing and treating piglet diarrhea comprises the following components in percentage by weight: 45% of montmorillonite, 8% of antibacterial peptide, 10% of yolk antibody and 20% of Chinese herbal medicine additive; wherein the antibacterial peptide is antibacterial peptide P5; the Chinese herbal medicine additive comprises the following components in parts by weight: 25 parts of honeysuckle, 15 parts of perilla, 12 parts of codonopsis pilosula, 18 parts of bighead atractylodes rhizome, 18 parts of coptis chinensis, 12 parts of poria cocos and 18 parts of liquorice.
Example 4
The difference from the embodiment 1 is that the antimicrobial peptide is formed by mixing cecropin and defensin according to the ratio of 1.
Example 5
The difference from example 1 is that; the antibacterial peptide is formed by mixing pig-derived PR39 antibacterial peptide and antibacterial peptide P5 according to the ratio of 1.
Example 6
The difference from the embodiment 1 is that the Chinese herbal medicine additive is composed of the following components in parts by weight: 25 parts of honeysuckle, 15 parts of purple perilla, 15 parts of codonopsis pilosula, 20 parts of bighead atractylodes rhizome, 18 parts of coptis chinensis, 13 parts of poria cocos and 18 parts of liquorice.
Example 7
The preparation method of the feed additive formula for preventing and treating piglet diarrhea in the embodiment 1 comprises the following steps:
(1) Weighing montmorillonite, antibacterial peptide and Chinese herbal medicines according to the weight parts;
(2) Mixing flos Lonicerae, perillae herba, radix Codonopsis, atractylodis rhizoma, coptidis rhizoma, poria, and Glycyrrhrizae radix, pulverizing, and sieving with 100 mesh sieve to obtain Chinese herbal mixture A;
(3) Adding distilled water according to the weight ratio of 1 to 0.4 into the Chinese herbal medicine mixture, uniformly stirring, and freezing at-90 ℃ for 8 hours to obtain a mixture B;
(4) Drying, crushing and sieving the frozen mixture B through a 200-mesh sieve to obtain a mixture C;
(5) And (3) uniformly mixing the mixture C with the montmorillonite, adding the antibacterial peptide, and uniformly mixing to obtain the antibacterial peptide.
Example 8
The difference from example 7 is that the crushed material in step (2) is passed through a 50-mesh sieve.
Example 9
The difference from example 7 is that distilled water is added in an amount of 0.6 times of the Chinese herbal medicine mixture in the step (3).
Example 10
The difference from the example 7 is that the freezing treatment in the step (3) is freezing at-70 ℃ for 10h.
Example 11
The difference from example 7 is that the frozen powder was sieved through a 100 mesh sieve.
Test examples
100 piglets with average weight of 10kg are selected, randomly divided into 4 groups, each group comprises 25 piglets, and comprises 3 experimental groups and a control group, the experimental groups 1-3 are respectively added with the feed additives of the examples 1-3 in the basal feed when feeding, the control group is only fed with the basal feed, during which the piglets are fed with free food and water, the piglets are fed for 50 days, and the growth condition/feed-meat ratio and the diarrhea rate of the piglets are recorded, and the specific test results are shown in table 1.
TABLE 1 growth of piglets
Group of Daily average weight gain (g/d) Meat ratio of materials Rate of draw-down/%)
Experimental group 1 523 1.51 0
Experimental group 2 519 1.58 0.34
Experimental group 3 520 1.53 0.89
Control group 425 1.87 0.75
Researches show that the feed additive formula added in the invention can effectively prevent piglets from diarrhea, and has obvious effect.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.

Claims (9)

1. A feed additive formula for preventing and treating piglet diarrhea is characterized in that: the feed additive formula comprises the following components in percentage by weight: 40-50% of montmorillonite, 5-10% of antibacterial peptide, 5-15% of yolk antibody and 15-25% of Chinese herbal medicine additive.
2. The feed additive formulation for preventing and treating piglet diarrhea according to claim 1, wherein the feed additive formulation comprises: the antibacterial peptide is one or more of cecropin, defensin, porcine-derived PR39 antibacterial peptide and antibacterial peptide P5.
3. The feed additive formulation for preventing and treating piglet diarrhea according to claim 1, wherein the feed additive formulation comprises: the Chinese herbal medicine additive is composed of the following components in parts by weight: 20-30 parts of honeysuckle, 10-20 parts of perilla, 10-15 parts of codonopsis pilosula, 15-20 parts of bighead atractylodes rhizome, 15-20 parts of coptis chinensis, 10-15 parts of poria cocos and 15-20 parts of liquorice.
4. A method for preparing a feed additive formulation for preventing and treating piglet diarrhea according to any one of claims 1 to 3, which comprises the following steps: the preparation method comprises the following steps:
(1) Weighing montmorillonite, antibacterial peptide, yolk antibody and Chinese herbal medicines according to the weight parts;
(2) Mixing flos Lonicerae, perillae herba, radix Codonopsis, atractylodis rhizoma, coptidis rhizoma, poria, and Glycyrrhrizae radix, pulverizing, and sieving to obtain Chinese herbal mixture A;
(3) Adding distilled water into the Chinese herbal medicine mixture, uniformly stirring, and performing freezing treatment to obtain a mixture B;
(4) Drying, crushing and sieving the mixture B after the freezing treatment to obtain a mixture C;
(5) And (3) uniformly mixing the mixture C with the montmorillonite and the yolk antibody, adding the antibacterial peptide, and uniformly mixing.
5. The preparation method of the feed additive formula for preventing and treating piglet diarrhea according to claim 4, is characterized in that: and (3) sieving the crushed powder in the step (2) by a sieve of 50-100 meshes.
6. The method for preparing the feed additive formula for preventing and treating piglet diarrhea according to claim 4, is characterized in that: the amount of the distilled water added in the step (3) is 0.4-0.6 time of the Chinese herbal medicine mixture.
7. The method for preparing the feed additive formula for preventing and treating piglet diarrhea according to claim 6, is characterized in that: the freezing treatment in the step (3) is freezing for 8-10h at the temperature of minus 90-minus 70 ℃.
8. The preparation method of the feed additive formula for preventing and treating piglet diarrhea according to claim 7, is characterized in that: and after freezing treatment and crushing, sieving by a 100-200 mesh sieve.
9. Use of a feed additive formulation for the prevention and treatment of piglet diarrhea according to any one of claims 1 to 8 in the preparation of a medicament for the prevention and treatment of piglet diarrhea.
CN202210780347.7A 2022-07-04 2022-07-04 Feed additive for preventing and treating piglet diarrhea Pending CN115316528A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107518189A (en) * 2017-09-01 2017-12-29 山西碧云天饲料有限公司 A kind of child care pig starter feed for adding antibacterial peptide and Chinese herbal medicine and preparation method thereof
CN109770085A (en) * 2019-03-29 2019-05-21 遂宁市中通实业集团动物药业有限公司 A kind of biological feed additive and preparation method thereof prevented or treat diarrhea of pigs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107518189A (en) * 2017-09-01 2017-12-29 山西碧云天饲料有限公司 A kind of child care pig starter feed for adding antibacterial peptide and Chinese herbal medicine and preparation method thereof
CN109770085A (en) * 2019-03-29 2019-05-21 遂宁市中通实业集团动物药业有限公司 A kind of biological feed additive and preparation method thereof prevented or treat diarrhea of pigs

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