CN104523822A - Pharmaceutical composition for preventing and treating animal diarrheal diseases and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for preventing and treating animal diarrheal diseases and preparation method of pharmaceutical composition Download PDFInfo
- Publication number
- CN104523822A CN104523822A CN201410817273.5A CN201410817273A CN104523822A CN 104523822 A CN104523822 A CN 104523822A CN 201410817273 A CN201410817273 A CN 201410817273A CN 104523822 A CN104523822 A CN 104523822A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- garlicin
- animal
- parts
- herba origani
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a pharmaceutical composition for preventing and treating animal diarrheal diseases and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared by mixing the following components in parts by weight: 2.5-30 parts of baicalin-Zn, 2.5-30 parts of origanum oil and 5-30 parts of allicin. The pharmaceutical composition has favorable preventing and treating effects on animal diarrheal diseases, has the effects of trapping and improving the intestinal florae of animals, and can be used for effectively improving the immunities of the animals, promoting the treatment of the diseases and promoting the growth of the animals if being added for a long term.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, especially a kind ofly prevent and treat pharmaceutical composition of animal diarrhea disease and preparation method thereof.
Background technology
In recent years, China's cultivation animal husbandry obtained and powerfully to develop fast, and along with this development, corresponding Animal diseases get more and more, and the animal diarrhea disease wherein caused by antibacterial, virus, parasite etc. is almost with each stage of growth of animal.Diarrhoea becoming thin and the disorder of intestinal microbial population often along with animal.Up to the present antibiotic has played significant role in the development of animal husbandry, and the drug use amount of the treatment such as fluoroquinolones, aminoglycoside, tetracycline animal diarrhea significantly increases.But antibiotic can not solve the problem of microbial population of animal intestinal tract disorder, the death of profitable strain in intestinal can be accelerated on the contrary, and can cause that the medicine received much concern is residual, drug resistance, problem of environmental pollution.Therefore the enzyme of no drug residue, environmental protection, Chinese herbal and crude drugs preparations, microbial ecological agent etc. are more and more developed and use.
Application number be 200810055634.1 application for a patent for invention disclose a kind of anti-bacteria agent for feeding, to be made up of Herba Origani oil 2-10 part and garlicin 2-10 part, but in actual applications, to find that antibacterial effect is not good enough in treatment animal diarrhea disease.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition preventing and treating animal diarrhea disease.
Another technical problem to be solved by this invention is to provide above-mentioned preparation method of preventing and treating the pharmaceutical composition of animal diarrhea disease.
For solving the problems of the technologies described above, technical scheme of the present invention is:
Prevent and treat a pharmaceutical composition for animal diarrhea disease, be made up of baicalin zinc, Herba Origani oil and garlicin, by its weight parts baicalin zinc 2.5-30 part, Herba Origani oil 2.5-30 part, garlicin 5-30 part.
Preferably, the above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, by its 5 parts, weight parts baicalin zinc, Herba Origani oil 10 parts, garlicin 20 parts.
Preferably, the above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, can be prepared into any pharmaceutically useful preparation by the different adjuvant of interpolation and conventional formulation preparation method, uses for drinking-water, spice, injection or spraying.
Preferably, the above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, described preparation comprises tablet, capsule, granule, dry suspension, pulvis, Emulsion, suspensoid, solution, injection or spray.
Preferably, the above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, described preparation is that pulvis uses for spice; Preparation is that Emulsion uses for drinking-water, spraying, injection; Preparation is that solution uses for drinking-water, spraying, injection.
Preferably, the above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, adjuvant composition when described preparation is pulvis is one or more in potato starch, calcium carbonate, beta-schardinger dextrin-, modified starch, Semen Maydis powder, Pulvis Talci, Oleum Brassicae campestris or Oleum Glycines, more preferably potato starch.
Preferably, the above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, adjuvant composition when described preparation is Emulsion is: emulsifying agent 0.5-20%, co-emulsifier 0.5-10%, antiseptic 0.01-1%, antioxidant 0.005-01%, and surplus is purified water; Described emulsifying agent is one or more mixture in tween 20, Tween-60, tween 80, soybean phospholipid, lecithin or glycerol monostearate, more preferably tween 80; Described co-emulsifier is one or more in n-butyl alcohol, ethylene glycol, ethanol, propylene glycol, glycerol or polyglycerin ester, more preferably propylene glycol; Described oil phase is one or more in soybean oil, Oleum Ricini, Oleum Arachidis hypogaeae semen or Oleum Camelliae, more preferably Oleum Arachidis hypogaeae semen; Described antiseptic is one or more in ethyl hydroxybenzoate, phenol, benzoic acid or sorbic acid, more preferably ethyl hydroxybenzoate, described antioxidant is one or more mixture, more preferably VE in Butylated hydroxyanisole, dibenzylatiooluene, citric acid monoglyceride, thioglycerol or VE.
Preferably, the above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, adjuvant composition when described preparation is solution is: dimethyl sulfoxide 5-30%, dehydrated alcohol 5-60%, propylene glycol 5-50%, PEG-4000 5-30%, pH adjusting agent is appropriate, surplus is water for injection, and pH scope is at 4-8; Described pH adjusting agent is one or both in lactic acid, citric acid, sodium hydroxide or ethanolamine.
Preferably, the above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, directly can add in feedstuff as feed additive and use, also can make premix material, concentrate feed or mixed feed.
Above-mentioned preparation method of preventing and treating the pharmaceutical composition of animal diarrhea disease, concrete preparation process is as follows:
(1) take baicalin zinc, Herba Origani oil and garlicin by prescription amount, and cross 60-200 mesh sieve respectively;
(2) by baicalin zinc, Herba Origani oil and garlicin mix homogeneously and get final product.
The invention has the beneficial effects as follows:
The above-mentioned pharmaceutical composition preventing and treating animal diarrhea disease, adopt baicalin zinc and Herba Origani oil and garlicin composite, significantly improve Herba Origani oil and garlicin and combinationally use prevention effect for animal diarrhea disease, said composition has good preventive and therapeutic effect to animal diarrhea disease, and there is food calling and improve microbial population of animal intestinal tract effect, effectively can improve animal immunizing power, promote the rehabilitation of disease, long-term interpolation, growth of animal can be promoted, safety, pollution-free, noresidue, have no drug resistance generation, be mainly used in the control of animal diarrhea disease, and raising animal immunizing power, improve animal appetite, safeguard that gastrointestinal bacterial flora balances, promote growth of animal, its preparation method is simple, is applicable to the needs that large-scale industrial is produced.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
Prevent and treat a pharmaceutical composition for animal diarrhea disease, be made up of baicalin zinc, Herba Origani oil and garlicin, by its 5 parts, weight parts baicalin zinc, Herba Origani oil 10 parts, garlicin 20 parts.
Above-mentioned preparation method of preventing and treating the pharmaceutical composition of animal diarrhea disease, concrete preparation process is as follows:
(1) take baicalin zinc, Herba Origani oil and garlicin by prescription amount, and cross 100 mesh sieves respectively;
(2) by baicalin zinc, Herba Origani oil and garlicin mix homogeneously and get final product.
Embodiment 2
Prevent and treat a pharmaceutical composition for animal diarrhea disease, be made up of baicalin zinc, Herba Origani oil, garlicin and potato starch, by its 5 parts, weight parts baicalin zinc, Herba Origani oil 10 parts, garlicin 30 parts, potato starch 55 parts.
Above-mentioned preparation method of preventing and treating the pharmaceutical composition of animal diarrhea disease, concrete preparation process is as follows:
(1) take baicalin zinc, Herba Origani oil, garlicin and potato starch by prescription amount, and cross 60 mesh sieves respectively;
(2) namely baicalin zinc, Herba Origani oil, garlicin and potato starch mix homogeneously are obtained pulvis.
Embodiment 3
Prevent and treat a pharmaceutical composition for animal diarrhea disease, primarily of baicalin zinc, Herba Origani oil and garlicin composition, by its 10 parts, weight parts baicalin zinc, Herba Origani oil 20 parts, garlicin 30 parts.
Above-mentioned preparation method of preventing and treating the pharmaceutical composition of animal diarrhea disease, concrete preparation process is as follows:
(1) get baicalin zinc, Herba Origani oil and garlicin as crude drug, and cross 200 mesh sieves respectively;
(2) baicalin zinc 10%, Herba Origani oil 20%, garlicin 30%, tween 80 3%, propylene glycol 0.5%, Oleum Arachidis hypogaeae semen 15%, ethyl hydroxybenzoate 0.5%, VE 0.01% is taken by weight percentage, all the other are water for injection, the crude drug taken is added in high pressure dispersing emulsification machine with adjuvant and water for injection and mixs homogeneously, stir evenly 10min, pour out, embedding, sterilizing, Emulsion.
Embodiment 4
Prevent and treat a pharmaceutical composition for animal diarrhea disease, primarily of baicalin zinc, Herba Origani oil and garlicin composition, by its 30 parts, weight parts baicalin zinc, Herba Origani oil 2.5 parts, garlicin 5 parts.
Above-mentioned preparation method of preventing and treating the pharmaceutical composition of animal diarrhea disease, concrete preparation process is as follows:
(1) get baicalin zinc, Herba Origani oil and garlicin as crude drug, and cross 120 mesh sieves respectively;
(2) take baicalin zinc 30%, Herba Origani oil 2.5%, garlicin 5%, dimethyl sulfoxide 20%, dehydrated alcohol 20%, propylene glycol 20% by weight percentage, all the other are for water for injection, first baicalin zinc is added in dimethyl sulfoxide and dissolve completely, then successively propylene glycol, dehydrated alcohol, Herba Origani oil, garlicin is added, dissolve completely, add surplus water for injection, pH adjusting agent regulate pH to 6, filtration, embedding, sterilizing, solution.
Embodiment 5
Prevent and treat a pharmaceutical composition for animal diarrhea disease, be made up of baicalin zinc, Herba Origani oil and garlicin, by its 10 parts, weight parts baicalin zinc, Herba Origani oil 15 parts, garlicin 20 parts.
Above-mentioned preparation method of preventing and treating the pharmaceutical composition of animal diarrhea disease, concrete preparation process is as follows:
(1) take baicalin zinc, Herba Origani oil and garlicin by prescription amount, and cross 60 mesh sieves respectively;
(2) by baicalin zinc, Herba Origani oil and garlicin mix homogeneously and get final product.
Embodiment 6
Emulsion above-described embodiment 3, embodiment 4 prepared, solution are filled in aerosol apparatus, spray, sprayable use, promptly prevents and treats.
The recipe principle of pharmaceutical composition of the present invention is as follows:
Herba Origani oil, garlicin etc., as generally regarded as safe green natural medicine, widely use in fields such as food, medicine, feedstuffs.Wherein Herba Origani oil is again dysentery relieving grass, is the volatile essential oils extracted from plant Adeps Bovis seu Bubali, has stronger penetrating odor.Herba Origani oil is a kind of broad spectrum antimicrobicide, and it is to G
+bacterium and G
-bacterium all has height antibacterial activity, to gut bacteria disease as diarrhoea, feedstuff just etc. have specially good effect, also there is certain parasiticide effect, " Herba Origani oil is on the impact of Intestine of Broiler microorganism species " article shows, Herba Origani oil can improve Intestine of Broiler microbial bacteria group structure, promotes that bacillus bifidus and lactobacillus quantity increase and suppresses escherichia coli quantity.
Garlicin is present in the bulb of liliaceous plant Bulbus Allii, and under large allinase effect, transform generation by the garlic aminoacid existed, garlicin is to G
+bacterium and G
-the bacterium such as bacterium have and significantly suppress killing action, also have certain parasiticide effect, its special garlic odour taste, can strengthen the palatability of feedstuff, increase gastric secretion and gastrointestinal peristalsis, stimulate appetite and the effect of facilitating digestion.Oral garlicin is mainly used in treatment animal enteritis, dysentery, inappetence etc. clinically.
Herba Origani oil and garlicin are that compatibility conventional on market is for preventing and treating the medicine of animal diarrhea disease, the two all has very strong preventive and therapeutic effect to animal diarrhea, adding of baicalin zinc, make the mutual potentiation of three's compatibility, to by antibacterial, virus, stress, the animal diarrhea diseases prevention and treatment Be very effective that causes such as coccidiosis, and improve animal immunizing power fast, increase animal feed intake, promote the recovery of disease, add for a long time, effectively can promote growth of animal.
Test example
The pharmaceutical composition preventing and treating animal diarrhea disease of the present invention is on the impact of piglet growth performance and diarrhoea
1) test period and place
Test is carried out on certain pig farm in Tianjin, and the situation of part piglet diarrhea appears in this pig farm.Test schedules to last totally 30 days.
2) experimental animal
Choose close, the doubtful length suffering from piglet epidemic diarrhea of (28 ± 2) age in days body weight white × DABAI two-way cross ablactational baby pig 120, male and female half and half, is divided into 5 groups at random, often organizes 24, each 2 repetitions, each repetition 12.
3) EXPERIMENTAL DESIGN and medicine
Test group 1: baicalin zinc group, is mixed by baicalin zinc+potato starch, is provided by Tiaozhan (Tianjin) Animal Pharmceutical Co., Ltd.; Every 100 kg of water add this product 50g, freely drink, and are used in conjunction 30 days;
Test group 2: Adeps Bovis seu Bubali line of oils, Herba Origani oil purchased from raw material of Chinese medicine pharmaceutical factory, Sichuan, prescription: Herba Origani oil 30%+ potato starch polishing, conventional method mix homogeneously is prepared from; Every 100 kg diet add this product 100g, freely feeding, are used in conjunction 30 days;
Test group 3: garlicin group, garlicin purchased from raw material of Chinese medicine pharmaceutical factory, Sichuan, prescription: garlicin 30%+ potato starch polishing, conventional method mix homogeneously is prepared from; Every 100 kg diet add this product 100g, freely feeding, are used in conjunction 30 days;
Test group 4: Herba Origani oil and garlicin mixture group, Herba Origani oil and garlicin are all purchased from raw material of Chinese medicine pharmaceutical factory, Sichuan, and the two is pressed: Herba Origani oil 10%+ garlicin 20%+ potato starch polishing, and conventional method mix homogeneously is prepared from; Every 100 kg diet add this product 100g, freely feeding, are used in conjunction 30 days;
Test group 5: pharmaceutical composition group, is prepared from described in embodiment 1; Every 100 kg diet add this product 100g, freely feeding, are used in conjunction 30 days;
Test group 6: baicalin zinc+olaquindox group, olaquindox purchased from Shandong fine chemistry industry company, prescription: baicalin zinc 5%+ olaquindox 10%+ potato starch polishing, conventional mix homogeneously is prepared from; Every 100 kg diet add this product 100g, freely feeding, are used in conjunction 30 days.(note: olaquindox is that veterinary drug is conventional for preventing and treating animal diarrhea, promoting the feed additive of growth of animal clinically, but because of its medicine residual, forbidden in poultry, be only allowed for the piglet within 35kg).
Test group 7: blank group, do not deal with, normally feed.
4) feeding and management and diseases prevention and treatment
Weigh on an empty stomach respectively at formal test the 1st day, the 31st day early morning, the body weight of piglet tested in record often group, and every day, record often organized piglet diarrhea situation simultaneously.Duration of test, allows piglet free choice feeding every day, records the feed intake of each group; Incidence is often organized for duration of test and carries out record, and do necessary timely process.
5) Testing index calculates
Daily gain=(test end weighs-test starting weight)/test natural law
Feed-weight ratio=total feed consumption rate/total augment weight
Average daily ingestion amount=every total the feed intake of hurdle pig/(every hurdle pig's head number × test natural law)
Diarrhoea cure rate (%)=total diarrhoea cures head number/test pig's head number × 100%
Non-cure rate (%)=total dead head number/test pig's head number × 100%, note: non-cure rate refers to the case proportion that also there is symptom of diarrhea or death.
6) statistical analysis
After test data Excel software processes, adopt SPSS11.5 statistical software to carry out " One-Way ANOVA:Options " and analyze, then laterally carry out Duncan method multiple comparisons.Result of the test represents with " average ".
7) results and analysis, result of the test is in table 1.
Table 1
Note: the different lower case person of colleague's data shoulder mark represents significant difference (P ﹤ 0.05), and identical person represents that difference is not remarkable.
Table 1 shows, and after test 30 days by a definite date, daily gain, the feed-weight ratio of test group 1,2,3,4,5,6 are all significantly better than test group 7, illustrates that six groups of medicines add all certain growth promoting function; Wherein the daily gain of test group 5 is the highest, and is significantly higher than test group 1,2,3, illustrates that test group 5 (i.e. pharmaceutical composition of the present invention) has animal and has significant growth promoting function and be better than single component group; The feed-weight ratio of test group 1,2,3,4,5,6 is all remarkable in test group 7, wherein test group 5 feed-weight ratio is minimum, but not remarkable with test group 4,6 difference, illustrate that test group 5 (i.e. pharmaceutical composition of the present invention) significantly can promote feed conversion rate; The diarrhoea cure rate of test group 1,2,3,4,5,6 is all significantly higher than test group 7, wherein the diarrhoea cure rate of test group 5 is 100%, but not remarkable with the difference of test group 6, illustrate that the prevention effect of test group 5 (i.e. pharmaceutical composition of the present invention) to diarrhoea is remarkable.
To sum up, in raising daily gain, reduce feed-weight ratio, cure on diarrhea rate, test group 5 (i.e. pharmaceutical composition of the present invention) is significantly higher than test group 1 (baicalin zinc group), test group 2 (Herba Origani oil and garlicin mixture group), test group 3 (garlicin group), test group 4 (Herba Origani oil and garlicin mixture group), with test group 6 (baicalin zinc+antibiotic group) there is equivalent effect, explanation present invention incorporates baicalin zinc and Herba Origani oil, the advantage of garlicin, three's compatibility, cure diarrhoea Be very effective, significantly can promote the rehabilitation of disease and the growth of animal, and compare test group 6, the present invention has green, the advantages such as no drug residue, meet the requirement of sustainable development, it is following veterinary drug development direction.
Above-mentioned reference embodiment is to this kind of detailed description of preventing and treating pharmaceutical composition of animal diarrhea disease and preparation method thereof and carrying out; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. prevent and treat a pharmaceutical composition for animal diarrhea disease, it is characterized in that: be made up of baicalin zinc, Herba Origani oil and garlicin, by its weight parts baicalin zinc 2.5-30 part, Herba Origani oil 2.5-30 part, garlicin 5-30 part.
2. the pharmaceutical composition preventing and treating animal diarrhea disease according to claim 1, is characterized in that: by its 5 parts, weight parts baicalin zinc, Herba Origani oil 10 parts, garlicin 20 parts.
3. preparation method of preventing and treating the pharmaceutical composition of animal diarrhea disease according to claim 1, is characterized in that: concrete preparation process is as follows:
(1) take baicalin zinc, Herba Origani oil and garlicin by prescription amount, and cross 60-200 mesh sieve respectively;
(2) by baicalin zinc, Herba Origani oil and garlicin mix homogeneously and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410817273.5A CN104523822B (en) | 2014-12-24 | 2014-12-24 | A kind of pharmaceutical composition and preparation method thereof preventing and treating animal diarrhea disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410817273.5A CN104523822B (en) | 2014-12-24 | 2014-12-24 | A kind of pharmaceutical composition and preparation method thereof preventing and treating animal diarrhea disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104523822A true CN104523822A (en) | 2015-04-22 |
| CN104523822B CN104523822B (en) | 2019-02-26 |
Family
ID=52839578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410817273.5A Active CN104523822B (en) | 2014-12-24 | 2014-12-24 | A kind of pharmaceutical composition and preparation method thereof preventing and treating animal diarrhea disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104523822B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878369A (en) * | 2016-06-22 | 2016-08-24 | 江苏省农业科学院 | Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus |
| CN106667915A (en) * | 2016-10-24 | 2017-05-17 | 武汉轻工大学 | Baicalin-aluminum dry suspension for treating pigling diarrhoea |
| CN108185148A (en) * | 2018-03-23 | 2018-06-22 | 四川省畜牧科学研究院 | A kind of easy processing compound premix for improving wean rabbit diarrhea |
| CN110665002A (en) * | 2019-10-29 | 2020-01-10 | 信阳市动物疫病预防控制中心 | Antibody preparation for preventing and treating bovine viral diarrhea and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101473897A (en) * | 2008-01-04 | 2009-07-08 | 北京因科瑞斯医药科技有限公司 | Natural anti-bacteria agent for feeding and preparation method thereof |
| CN103655593A (en) * | 2013-12-12 | 2014-03-26 | 挑战（天津）动物药业有限公司 | Composite medicine preparation for prevention and treatment of bacterium and virus polyinfection diseases of livestock as well as preparation method and application thereof |
-
2014
- 2014-12-24 CN CN201410817273.5A patent/CN104523822B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101473897A (en) * | 2008-01-04 | 2009-07-08 | 北京因科瑞斯医药科技有限公司 | Natural anti-bacteria agent for feeding and preparation method thereof |
| CN103655593A (en) * | 2013-12-12 | 2014-03-26 | 挑战（天津）动物药业有限公司 | Composite medicine preparation for prevention and treatment of bacterium and virus polyinfection diseases of livestock as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 沈国权，等。: "黄芩解毒散对仔猪细菌性腹泻的治疗试验", 《广东畜牧兽医科技》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878369A (en) * | 2016-06-22 | 2016-08-24 | 江苏省农业科学院 | Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus |
| CN106667915A (en) * | 2016-10-24 | 2017-05-17 | 武汉轻工大学 | Baicalin-aluminum dry suspension for treating pigling diarrhoea |
| CN106667915B (en) * | 2016-10-24 | 2019-09-13 | 武汉轻工大学 | It is a kind of for treating the scutelloside aluminium dry suspensoid agent of grice diarrhoea |
| CN108185148A (en) * | 2018-03-23 | 2018-06-22 | 四川省畜牧科学研究院 | A kind of easy processing compound premix for improving wean rabbit diarrhea |
| CN110665002A (en) * | 2019-10-29 | 2020-01-10 | 信阳市动物疫病预防控制中心 | Antibody preparation for preventing and treating bovine viral diarrhea and preparation method thereof |
| CN110665002B (en) * | 2019-10-29 | 2023-01-24 | 信阳市动物疫病预防控制中心 | Antibody preparation for preventing and treating bovine viral diarrhea and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104523822B (en) | 2019-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104146182B (en) | A kind of biology feed additive preventing and treating grice diarrhoea | |
| AU2009325395B2 (en) | Feed for preventing and/or treating diseases caused by Clostridium bacterium in livestock, and agent against Clostridium | |
| CN103583922B (en) | Poultry used disease-resistant growth promotion green feed additive and preparing method thereof | |
| CN108323641A (en) | A kind of health food and preparation method thereof for improving pet dog cat function of intestinal canal | |
| CN103609899B (en) | Pig anti diar rhea growth promotion green feed additive and preparation method thereof | |
| CN110692863A (en) | Plant extract feed additive for improving liver and intestine protecting capability of tilapia | |
| CN104523822B (en) | A kind of pharmaceutical composition and preparation method thereof preventing and treating animal diarrhea disease | |
| CN106879826A (en) | A kind of animal feed additive comprising plant extracts and organic acid and application | |
| CN107950774A (en) | A kind of feeding composite functional plants essential oil, preparation method and applications | |
| US20130209612A1 (en) | Use of a mixture of probiotic bacteria in a mixture with short-chain fatty acids | |
| CN110892944A (en) | Weaned pig feed additive capable of replacing antibiotics and application thereof | |
| AU2015306904A1 (en) | Anti-diarrhea formulation which avoids antimicrobial resistance | |
| CN109480111A (en) | A kind of pig feed additive of strengthen immunity and its application | |
| CN111436542A (en) | Feed additive capable of replacing antibiotics to prevent diarrhea of chicks and improve growth and application of feed additive | |
| CN104258007B (en) | It is a kind of to be fattened somatotrophic Chinese medicine preparation and preparation method thereof for pig | |
| CN111000033A (en) | Bacillus subtilis viable bacteria fermented traditional Chinese medicine preparation containing thyme oil and traditional Chinese medicine, preparation process and application | |
| CN110037184A (en) | High-protein plant essential oil compounds pig feed additive and its preparation method and application | |
| CN107594072A (en) | A kind of green feed additive of effectively preventing and treating grice diarrhoea | |
| CN113558143A (en) | Feed additive for resisting and promoting growth, preparation method and application thereof | |
| KR20120018505A (en) | A manufacturing process of feed using black garlic | |
| CN112136970A (en) | Piglet nursing compound feed and preparation method thereof | |
| CN111149919A (en) | Glycerol butyrate compound for poultry as well as preparation method and application thereof | |
| KR101834233B1 (en) | Feed additive for relaxing stress of livestock and method for relaxing stress of livestock using the same | |
| Hadiya et al. | Accelerated Growth Programme with Polyherbal Formulations for Dairy Calves. | |
| CN102846681A (en) | Medicament for treating livestock diarrhea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |