CN115279381A - Bcma定向性细胞免疫疗法组合物和方法 - Google Patents

Bcma定向性细胞免疫疗法组合物和方法 Download PDF

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CN115279381A
CN115279381A CN202180019394.3A CN202180019394A CN115279381A CN 115279381 A CN115279381 A CN 115279381A CN 202180019394 A CN202180019394 A CN 202180019394A CN 115279381 A CN115279381 A CN 115279381A
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seq
domain
several embodiments
bcma
chimeric antigen
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Chinese (zh)
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K.L.拉詹加姆
J.B.特雷格
L.G.布伦
C.郭
A.L.L.拉泽蒂克
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Nkarta Inc
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Nkarta Inc
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CN202180019394.3A 2020-01-13 2021-01-11 Bcma定向性细胞免疫疗法组合物和方法 Pending CN115279381A (zh)

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US202062960285P 2020-01-13 2020-01-13
US62/960,285 2020-01-13
PCT/US2021/012977 WO2021146147A1 (en) 2020-01-13 2021-01-11 Bcma-directed cellular immunotherapy compositions and methods

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US (1) US20230028399A1 (https=)
EP (1) EP4090337A4 (https=)
JP (1) JP2023512452A (https=)
KR (1) KR20220128650A (https=)
CN (1) CN115279381A (https=)
AU (1) AU2021207795A1 (https=)
CA (1) CA3164666A1 (https=)
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DK3143134T3 (da) 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
BR112019019917A2 (pt) 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
EP3749685A4 (en) 2018-02-09 2021-12-22 National University of Singapore ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
US20250034268A1 (en) * 2021-12-07 2025-01-30 Innovent Biologics (Suzhou) Co., Ltd. Antibody binding to bcma and use thereof
WO2025171383A2 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens and related methods and uses
WO2025171388A1 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens with modified domains and related methods and uses
WO2026006767A1 (en) 2024-06-28 2026-01-02 Dispatch Biotherapeutics, Inc. Tethered il-9/il-9r and related engineered cells and methods

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TW200613552A (en) * 2004-08-11 2006-05-01 Hoffmann La Roche Mutant interleukin-15 polypeptides
RU2766608C2 (ru) * 2012-04-11 2022-03-15 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток
DK2956175T3 (da) * 2013-02-15 2017-11-27 Univ California Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf
BR112017001183A2 (pt) * 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
GB201503742D0 (en) * 2015-03-05 2015-04-22 Ucl Business Plc Chimeric antigen receptor
US11655452B2 (en) * 2015-06-25 2023-05-23 Icell Gene Therapeutics Inc. Chimeric antigen receptors (CARs), compositions and methods of use thereof
BR112019019917A2 (pt) * 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
EP3749770B9 (en) * 2018-02-09 2025-12-17 The U.S.A. as represented by the Secretary, Department of Health and Human Services Tethered interleukin-15 and interleukin-21
TWI890660B (zh) * 2018-06-13 2025-07-21 瑞士商諾華公司 Bcma 嵌合抗原受體及其用途
CN109320615B (zh) * 2018-09-25 2023-09-22 上海恒润达生生物科技股份有限公司 靶向新型bcma的嵌合抗原受体及其用途
EP3773918A4 (en) * 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
AU2020288829A1 (en) * 2019-06-04 2021-12-02 Nkarta, Inc. Combinations of engineered natural killer cells and engineered T cells for immunotherapy

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WO2021146147A1 (en) 2021-07-22
EP4090337A1 (en) 2022-11-23
AU2021207795A1 (en) 2022-07-28
IL294518A (en) 2022-09-01
JP2023512452A (ja) 2023-03-27
CA3164666A1 (en) 2021-07-22
EP4090337A4 (en) 2024-04-24
KR20220128650A (ko) 2022-09-21
MX2022008638A (es) 2022-08-08

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