CN115252507A - Bacteriostatic facial cleanser containing peony flowers - Google Patents
Bacteriostatic facial cleanser containing peony flowers Download PDFInfo
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- CN115252507A CN115252507A CN202211109109.XA CN202211109109A CN115252507A CN 115252507 A CN115252507 A CN 115252507A CN 202211109109 A CN202211109109 A CN 202211109109A CN 115252507 A CN115252507 A CN 115252507A
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- Prior art keywords
- peony
- hydrogel
- powder
- parts
- bacteriostatic
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- 241000736199 Paeonia Species 0.000 title claims abstract description 81
- 235000006484 Paeonia officinalis Nutrition 0.000 title claims abstract description 81
- 230000001815 facial effect Effects 0.000 title claims abstract description 36
- 230000003385 bacteriostatic effect Effects 0.000 title claims description 17
- 239000000843 powder Substances 0.000 claims abstract description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 53
- 239000000284 extract Substances 0.000 claims abstract description 43
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- 238000000605 extraction Methods 0.000 claims abstract description 32
- 229920001661 Chitosan Polymers 0.000 claims abstract description 30
- 239000000839 emulsion Substances 0.000 claims abstract description 29
- 238000004140 cleaning Methods 0.000 claims abstract description 24
- 241000894006 Bacteria Species 0.000 claims abstract description 16
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 11
- -1 alkyl glycoside Chemical class 0.000 claims abstract description 11
- 150000001412 amines Chemical class 0.000 claims abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 11
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims abstract description 11
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims abstract description 11
- 229960002152 chlorhexidine acetate Drugs 0.000 claims abstract description 11
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims abstract description 11
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 11
- 229930182470 glycoside Natural products 0.000 claims abstract description 11
- 239000003755 preservative agent Substances 0.000 claims abstract description 11
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000011734 sodium Substances 0.000 claims abstract description 11
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 11
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 230000002401 inhibitory effect Effects 0.000 claims abstract 3
- 239000000017 hydrogel Substances 0.000 claims description 69
- 238000003756 stirring Methods 0.000 claims description 31
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 28
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 25
- 238000005470 impregnation Methods 0.000 claims description 23
- 239000008367 deionised water Substances 0.000 claims description 22
- 229910021641 deionized water Inorganic materials 0.000 claims description 22
- 239000011248 coating agent Substances 0.000 claims description 15
- 238000000576 coating method Methods 0.000 claims description 15
- 229960000583 acetic acid Drugs 0.000 claims description 14
- 239000012362 glacial acetic acid Substances 0.000 claims description 14
- 239000007921 spray Substances 0.000 claims description 13
- 238000001291 vacuum drying Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 239000001913 cellulose Substances 0.000 claims description 11
- 229920002678 cellulose Polymers 0.000 claims description 11
- 239000002121 nanofiber Substances 0.000 claims description 11
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 9
- 239000000661 sodium alginate Substances 0.000 claims description 9
- 235000010413 sodium alginate Nutrition 0.000 claims description 9
- 229940005550 sodium alginate Drugs 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 7
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 238000005507 spraying Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 238000000889 atomisation Methods 0.000 claims description 5
- 238000009924 canning Methods 0.000 claims description 5
- 239000000919 ceramic Substances 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000004927 clay Substances 0.000 claims description 5
- 238000005520 cutting process Methods 0.000 claims description 5
- 239000000686 essence Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
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- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 3
- 230000008021 deposition Effects 0.000 claims description 2
- 229960003415 propylparaben Drugs 0.000 claims description 2
- 238000001132 ultrasonic dispersion Methods 0.000 claims description 2
- 229940045110 chitosan Drugs 0.000 claims 1
- 229960000587 glutaral Drugs 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 5
- 238000005406 washing Methods 0.000 abstract description 5
- 244000236658 Paeonia lactiflora Species 0.000 abstract 2
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- 230000000052 comparative effect Effects 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 9
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- 239000002537 cosmetic Substances 0.000 description 6
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- 210000003780 hair follicle Anatomy 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 244000304217 Brassica oleracea var. gongylodes Species 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
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- 241001391944 Commicarpus scandens Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
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- 238000004132 cross linking Methods 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
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- 230000000996 additive effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000009647 facial growth Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention discloses a Paeonia lactiflora antibacterial cleansing emulsion which comprises water, chlorhexidine acetate, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerol, essence, a preservative, dipotassium glycyrrhizinate, citric acid and Paeonia lactiflora extraction essence. This face cleaning emulsion is when using, under the kneading of external force, the fracture takes place easily for the chitosan envelope material on peony extraction essence surface, make external acidizing fluid and the contact of aquogel powder, cause the mesh hole increase in the aquogel, make partial peony extract can flow out fast, clear away facial bacterium, and simultaneously, after using, partial peony extraction essence can be long-time attached to facial skin, and through the mode of the remaining peony extract of slow release, can play long-time inhibitory action to the bacterial growing of face, make people after washing the face, can realize long-time facial cleanness, thereby realize providing permanent protection to skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a peony antibacterial cleansing emulsion.
Background
The facial cleanser is also called facial cleanser, is a cleaning product for cleaning dirt on the face, such as sweat, dust, color cosmetics and the like, has smaller stimulation to the skin than the soap for cleaning the face, is easier to wash, and can clean even the concave and convex positions of the face. Generally, a facial cleanser is a liquid product composed of components such as an oil phase substance, a water phase substance, a surfactant, a humectant, a nutrient and the like, and the surfactant in the facial cleanser has five effects of moistening, dispersing, foaming, decontamination and emulsification and is a main active substance of the facial cleanser. Moreover, with the increase of environmental pollution and the increase of working and living pressure of people, sebaceous gland secretion is increased, sebum is decomposed by bacteria in hair follicles to generate fatty acid, and the fatty acid stimulates the hair follicles to cause inflammation, so that the hair follicle wall is damaged and ruptured, and the hair follicle content enters the dermis, thereby causing inflammatory reaction with different degrees around the hair follicles. Therefore, the facial cleanser needs to have not only the function of removing facial dirt but also a certain bacteriostatic function.
For example, patent publication No. CN105853296a discloses a facial cleansing cosmetic containing kohlrabi extract and a preparation method thereof, wherein the facial cleansing cosmetic contains kohlrabi extract, minerals, facial cleansing surfactants, anti-inflammatory and anti-allergic agents, whitening agents, moisturizing agents, potassium hydroxide, thickening agents, emulsifiers, preservatives and deionized water; the kohlrabi extract in the patent is used as a plant extract, has small side effect, and can effectively eliminate bacteria breeding on the face by utilizing the antibacterial effect of the kohlrabi extract; however, this kind of facial cleansing cosmetics can only carry out effectual cleaing away to the bacterium that the face has bred, and people often will wash the face with clear water after using, washes the foam of facial cleansing cosmetics clean, and at this moment, kohlrabi extract then can be washed away along with the foam by rivers together to make the face after washing not contain antibacterial substance, can't restrain breeding of later stage bacterium, thereby still have the inflammatory response that the degree is unequal around the hair follicle that leads to face after washing.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the peony antibacterial cleansing emulsion, when the antibacterial cleansing emulsion is used, under the rubbing action of an external force, a chitosan coating material on the surface of peony extraction essence is easy to break, so that an external acid liquid is contacted with hydrogel powder, grid pores in hydrogel are enlarged, a part of peony extract can flow out quickly, bacteria on the face can be eliminated, meanwhile, after the antibacterial cleansing emulsion is used, a part of peony extraction essence can be attached to the skin of the face for a long time, and the antibacterial cleansing emulsion can play a long-time inhibition role on the bacteria on the face by slowly releasing the rest peony extract, so that the long-time face cleaning can be realized after people wash the face, the long-term protection on the skin can be realized, and the facial inflammation can be better prevented.
In order to achieve the purpose, the invention provides the following technical scheme:
the peony antibacterial cleansing emulsion comprises the following components in parts by weight: 680-730 parts of water, 0.2-0.8 part of chlorhexidine acetate, 0.05-0.08 part of cetylpyridinium chloride, 12-17 parts of amine oxide, 5-10 parts of cocamidopropyl betaine, 1-3 parts of alkyl glycoside, 2-5 parts of sodium lauryl amphoacetate, 2-5 parts of glycerol, 0.1-0.2 part of essence, 0.2-0.4 part of preservative, 0.03-0.08 part of dipotassium glycyrrhizinate, 0.2-0.5 part of citric acid and 0.01-0.05 part of peony extraction essence.
As a further preferable embodiment of the present invention, the preservative is at least one selected from methylparaben and propylparaben.
As a further preferred embodiment of the present invention, the preparation method of the peony extraction essence is as follows:
1) Adding deionized water and glacial acetic acid into a container, adding sodium alginate and chitosan, stirring uniformly, adding a glutaraldehyde solution, stirring at room temperature at 80-130r/min for 23-28h, gelling, vacuum drying, cutting into blocks, soaking in deionized water for 20-30h, and vacuum drying at room temperature to constant weight to obtain hydrogel blocks;
2) Immersing the hydrogel block in a peony extracting solution in a vacuum impregnation tank, impregnating at 0-3 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel block, drying at room temperature in vacuum to constant weight, grinding to obtain hydrogel powder, and performing coating treatment on the hydrogel powder to obtain the required peony extraction essence.
As a further preferable scheme of the invention, the dosage proportion of the deionized water, the glacial acetic acid, the sodium alginate, the chitosan and the glutaraldehyde solution is (20-30) mL: (5-8) mL: (0.2-0.6) g: (0.3-0.5) g: (1.0-1.3) mL;
the concentration of the glutaraldehyde solution is 23-28g/L;
in the deionized water soaking process, water needs to be replaced every 10-12 hours.
As a further preferable scheme of the invention, the peony extract is obtained by adding peony into a ceramic purple clay pot, adding 6-10 times of water, turning to soft fire for 65-90min after 12-20min of strong fire.
In a further preferred embodiment of the present invention, the impregnation is performed in an alternating manner of negative pressure and positive pressure, and comprises the steps of:
placing the hydrogel block in a vacuum impregnation tank, vacuumizing the impregnation tank to 10-60Pa, injecting radix Paeoniae extract, pressurizing the impregnation tank to 0.5-1.0MPa after the radix Paeoniae extract completely covers the hydrogel block, maintaining for 10-30min, intermittently turning on ultrasonic wave with frequency of 25-30KHz and power of 100-150W, starting for 1-5min and turning off for 3-10min, and repeating the above operation for 1-3 times.
In a further preferred embodiment of the present invention, the hydrogel powder is coated by the following method:
1) Adding glacial acetic acid into deionized water, stirring uniformly, adding chitosan powder, stirring until the chitosan powder is completely dissolved, adding glutaraldehyde solution, continuing stirring until the glutaraldehyde solution is uniformly dispersed, adding cellulose nanofiber, performing ultrasonic dispersion for 5-15min, and standing at room temperature for 20-25h to obtain a film forming solution for later use;
2) Adding the film-forming solution into an atomizer for atomization to obtain film-forming solution spray, simultaneously spraying the hydrogel powder and the film-forming solution spray into a container, mixing by convection contact, controlling the temperature to be 60-70 ℃, and drying the obtained product in vacuum to constant weight.
Furthermore, in the step 1), the dosage proportion of the glacial acetic acid, the deionized water, the chitosan powder, the glutaraldehyde solution and the cellulose nano-fiber is (1-5) mL: (100-300) mL: (2-5) g: (0.1-0.3) mL: (0.2-0.5) g;
the concentration of the glutaraldehyde solution is 23-28g/L.
Further, in the step 2), the flow rate of spraying the deposition solution is 10-15m/s;
the powder feeding rate of the hydrogel powder is 60-80kg/h.
The peony flower bacteriostatic facial cleanser comprises the following production processes:
weighing the components in parts by weight, fully dissolving chlorhexidine acetate in warm water at 52-56 ℃, then putting the mixture, water, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerol, essence, preservative, dipotassium glycyrrhizinate, citric acid and peony extraction essence into a stainless steel homogenizing reaction kettle, fully stirring, filtering, canning and packaging to obtain the required face cleaning emulsion.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, glutaraldehyde solution is used as a cross-linking agent, chitosan is used as a polycation component, sodium alginate is used as a polyanion component, hydrogel is prepared by cross-linking, chitosan has good water absorption performance, and chitosan and sodium alginate are cross-linked to form a large number of cross-linked grids, through a negative pressure-positive pressure impregnation mode and matching with ultrasonic treatment, the permeability can be improved, the permeation of the peony extract into the grid pores of the hydrogel is accelerated, so that the peony extract is loaded, and on one hand, the stability of the peony extract is improved, so that the peony extract is not easy to oxidize and deteriorateMeanwhile, the cleansing emulsion is acidic due to the citric acid contained in the cleansing emulsion, and the-NH in the hydrogel is generated under the acidic condition 2 by-NH + 3 Due to the electrostatic repulsion, the pores of each grid in the hydrogel are enlarged, the pore channels are unblocked, and the loaded peony extract is easy to flow out, so that the sustained-release effect of the peony extract is realized, the utilization rate of the peony extract is improved, and the interface emulsion can perform long-term bacteriostatic protection on the face after being used.
In order to ensure that the peony extract loaded by hydrogel does not flow out during storage and only slowly release the peony extract during use, the hydrogel loaded with the peony extract is subjected to coating treatment, glutaraldehyde solution is used as a cross-linking agent, cellulose nano-fiber is used as an additive to prepare a cross-linked chitosan coating material, and the hydrogel powder is in convective contact with the film-forming solution to cover the film-forming solution on the hydrogel powder so as to form a protective film, so that the hydrogel powder is isolated from the external acidic environment, and the peony extract loaded in the hydrogel powder cannot flow out during the storage of the facial cleanser; when people use the face cleaning emulsion, under the rubbing of external force, the chitosan coating material on the surface of the peony extraction essence is broken, so that external acid liquid is contacted with hydrogel powder, the mesh pores in the hydrogel are enlarged, and the peony extract is easier to flow out, so that bacteria on the face can be inhibited and killed; and on one hand, the cellulose nanofibers added in the film forming solution form a net structure through mutual crosslinking, so that the strength of the chitosan film is improved, the chitosan film cannot be damaged during normal stirring and shaking, the hydrogel powder in the chitosan film can be better protected, meanwhile, when the film forming solution is cured on the surface of the hydrogel powder to form a film, part of the cellulose nanofibers can be exposed on the surface of the film, and a large number of nanometer 'tentacles' are formed on the surface of the film, so that the contact area between the peony extraction essence and the skin is increased, the bonding strength between the peony extraction essence and the skin is improved, a part of the peony extraction essence can be attached to the skin of the face after people use the facial cleansing emulsion to clean the face, and the growth of bacteria on the face can be inhibited for a long time through a mode of slowly releasing the peony extraction solution, so that the people can clean the face for a long time after washing the face.
When the face cleaning emulsion is used, under the rubbing action of an external force, a chitosan coating material on the surface of the peony extraction essence is easy to break, so that external acid liquid is in contact with hydrogel powder, the mesh pores in the hydrogel are enlarged, part of the peony extraction liquid can flow out quickly to remove facial bacteria, and meanwhile, after the face cleaning emulsion is used, part of the peony extraction essence can be attached to facial skin for a long time, and the mode of slowly releasing the rest of the peony extraction liquid can play a long-time inhibition role in bacterial growth of the face, so that after people wash the face, long-time face cleaning can be realized, the skin can be protected for a long time, and the facial inflammation can be prevented from being generated better.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The bacteriostatic facial cleanser containing the peony flower comprises the following components in parts by weight: 680 parts of water, 0.2 part of chlorhexidine acetate, 0.05 part of cetylpyridinium chloride, 12 parts of amine oxide, 5 parts of cocamidopropyl betaine, 1 part of alkyl glycoside, 2 parts of sodium lauryl amphoacetate, 2 parts of glycerol, 0.1 part of essence, 0.2 part of methyl hydroxybenzoate, 0.03 part of dipotassium glycyrrhizinate, 0.2 part of citric acid and 0.01 part of peony extraction essence;
the production process of the cleansing emulsion comprises the following steps:
weighing the components in parts by weight, fully dissolving chlorhexidine acetate in warm water at 52 ℃, then putting the mixture, water, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerol, essence, preservative, dipotassium glycyrrhizinate, citric acid and peony extraction essence into a stainless steel homogenizing reaction kettle, fully stirring, filtering, canning and packaging to obtain the required face cleaning emulsion.
The preparation method of the peony extraction essence comprises the following steps:
1) Adding 20mL of deionized water and 5mL of glacial acetic acid into a container, adding 0.2g of sodium alginate and 0.3g of chitosan, stirring uniformly, adding 1.0mL of 23g/L glutaraldehyde solution, stirring at 80r/min for 23h at room temperature, carrying out vacuum drying after gelling, cutting, soaking for 20h with deionized water, changing water every 10h, and carrying out vacuum drying at room temperature to constant weight to obtain hydrogel blocks;
2) Immersing the hydrogel block in a peony extracting solution in a vacuum impregnation tank, impregnating at 0 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel block, drying at room temperature in vacuum to constant weight, grinding to obtain hydrogel powder, and coating the hydrogel powder to obtain the required peony extraction essence;
wherein, negative pressure-positive pressure alternate mode carries out the flooding, includes the following step:
placing the hydrogel block in a vacuum impregnation tank, vacuumizing the impregnation tank to 10Pa, injecting a peony extract, pressurizing the impregnation tank to 0.5MPa after the hydrogel block is completely covered by the peony extract, keeping for 10min, intermittently starting ultrasonic waves with the frequency of 25KHz and the power of 100W in the pressurizing process, starting for 1min, closing for 3min, and repeating the operation for 1 time.
The radix Paeoniae extract is obtained by adding radix Paeoniae into ceramic purple clay pot, adding 6 times of water, and extracting with strong fire for 12min and then with slow fire for 65 min.
The method for coating the hydrogel powder comprises the following steps:
1) Adding 1mL of glacial acetic acid into 100mL of deionized water, uniformly stirring, adding 2g of chitosan powder, stirring until the chitosan powder is completely dissolved, adding 0.1mL of 23g/L glutaraldehyde solution, continuously stirring until the glutaraldehyde solution is uniformly dispersed, adding 0.2g of cellulose nanofiber, ultrasonically dispersing for 5min at 100W, and standing at room temperature for 20h to obtain a film forming solution for later use;
2) Adding the film-forming solution into an atomizer for atomization to obtain film-forming solution spray, simultaneously spraying hydrogel powder and the film-forming solution spray into a container, carrying out convection contact and mixing, and controlling the temperature to be 60 ℃, wherein the flow rate of the film-forming solution spray is 10m/s, the powder feeding rate of the hydrogel powder is 60kg/h, and carrying out vacuum drying on the obtained product until the weight is constant.
Example 2
The bacteriostatic facial cleanser containing the peony flower comprises the following components in parts by weight: 700 parts of water, 0.5 part of chlorhexidine acetate, 0.07 part of cetylpyridinium chloride, 15 parts of amine oxide, 7 parts of cocamidopropyl betaine, 2 parts of alkyl glycoside, 3 parts of sodium lauryl amphoacetate, 3 parts of glycerol, 0.1 part of essence, 0.3 part of methyl hydroxybenzoate, 0.05 part of dipotassium glycyrrhizinate, 0.3 part of citric acid and 0.03 part of peony extraction essence;
the production process of the cleansing emulsion comprises the following steps:
weighing the components in parts by weight, fully dissolving chlorhexidine acetate in warm water at 54 ℃, then putting the mixture, water, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerol, essence, preservative, dipotassium glycyrrhizinate, citric acid and peony extraction essence into a stainless steel homogenizing reaction kettle, fully stirring, filtering, canning and packaging to obtain the required face cleaning emulsion.
The preparation method of the peony extraction essence comprises the following steps:
1) Adding 25mL of deionized water and 7mL of glacial acetic acid into a container, adding 0.5g of sodium alginate and 0.4g of chitosan, stirring uniformly, adding 1.2mL of 25g/L glutaraldehyde solution, stirring at 100r/min for 25h at room temperature, carrying out vacuum drying after gelling, cutting, soaking for 25h with deionized water, changing water every 11h, and carrying out vacuum drying at room temperature to constant weight to obtain hydrogel blocks;
2) Immersing the hydrogel block in a peony extracting solution in a vacuum impregnation tank, impregnating at 1 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel block, drying at room temperature in vacuum to constant weight, grinding to obtain hydrogel powder, and performing coating treatment on the hydrogel powder to obtain the required peony extraction essence;
wherein, negative pressure-positive pressure alternate mode carries out the flooding, includes the following step:
placing the hydrogel block in a vacuum impregnation tank, vacuumizing the impregnation tank to 40Pa, injecting a peony extract, pressurizing the impregnation tank to 0.7MPa after the hydrogel block is completely covered by the peony extract, keeping for 20min, intermittently starting ultrasonic waves with the frequency of 30KHz and the power of 120W in the pressurizing process, starting for 2min and stopping for 5min, and repeating the operation for 2 times.
The radix Paeoniae extract is obtained by adding radix Paeoniae into ceramic purple clay pot, adding 8 times of water, and turning to slow fire for 70min after 15 min.
The method for coating the hydrogel powder comprises the following steps:
1) Adding 3mL of glacial acetic acid into 200mL of deionized water, uniformly stirring, adding 3g of chitosan powder, stirring until the chitosan powder is completely dissolved, adding 0.2mL of 25g/L glutaraldehyde solution, continuously stirring until the glutaraldehyde solution is uniformly dispersed, adding 0.3g of cellulose nanofiber, ultrasonically dispersing for 10min at 150W, and standing at room temperature for 23h to obtain a film forming solution for later use;
2) Adding the film-forming solution into an atomizer for atomization to obtain film-forming solution spray, simultaneously spraying hydrogel powder and the film-forming solution spray into a container, carrying out convection contact and mixing, and controlling the temperature to be 65 ℃, wherein the flow rate of the film-forming solution spray is 12m/s, the powder feeding rate of the hydrogel powder is 70kg/h, and carrying out vacuum drying on the obtained product until the weight is constant.
Example 3
The bacteriostatic facial cleanser containing the peony flower comprises the following components in parts by weight: 730 parts of water, 0.8 part of chlorhexidine acetate, 0.08 part of cetylpyridinium chloride, 17 parts of amine oxide, 10 parts of cocamidopropyl betaine, 3 parts of alkyl glycoside, 5 parts of sodium lauryl amphoacetate, 5 parts of glycerol, 0.2 part of essence, 0.4 part of methylparaben, 0.08 part of dipotassium glycyrrhizinate, 0.5 part of citric acid and 0.05 part of peony extraction essence;
the production process of the cleansing emulsion comprises the following steps:
weighing the components in parts by weight, fully dissolving chlorhexidine acetate in warm water at 56 ℃, then putting the mixture, water, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerol, essence, preservative, dipotassium glycyrrhizinate, citric acid and peony extraction essence into a stainless steel homogenizing reaction kettle, fully stirring, filtering, canning and packaging to obtain the required face cleaning emulsion.
The preparation method of the peony extraction essence comprises the following steps:
1) Adding 30mL of deionized water and 8mL of glacial acetic acid into a container, adding 0.6g of sodium alginate and 0.5g of chitosan, stirring uniformly, adding 1.3mL of glutaraldehyde solution with the concentration of 28g/L, stirring at 130r/min for 28h at room temperature, carrying out vacuum drying after gelling, cutting into blocks, soaking for 30h with deionized water, changing water every 12h, and carrying out vacuum drying at room temperature to constant weight to obtain hydrogel blocks;
2) Immersing the hydrogel block in a peony extracting solution in a vacuum impregnation tank, impregnating at 3 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel block, drying at room temperature in vacuum to constant weight, grinding to obtain hydrogel powder, and performing coating treatment on the hydrogel powder to obtain the required peony extraction essence;
wherein, negative pressure-positive pressure alternate mode carries out the flooding, includes the following step:
placing the hydrogel block in a vacuum impregnation tank, vacuumizing the impregnation tank to 60Pa, injecting a peony extract, pressurizing the impregnation tank to 1.0MPa after the hydrogel block is completely covered by the peony extract, keeping for 30min, intermittently starting ultrasonic waves with the frequency of 30KHz and the power of 150W in the pressurizing process, starting for 5min and stopping for 10min, and repeating the operation for 3 times.
The radix Paeoniae extract is obtained by adding radix Paeoniae into ceramic purple clay pot, adding 10 times of water, and turning to slow fire for 90min after 20 min.
The method for coating the hydrogel powder comprises the following steps:
1) Adding 5mL of glacial acetic acid into 300mL of deionized water, uniformly stirring, adding 5g of chitosan powder, stirring until the chitosan powder is completely dissolved, adding 0.3mL of glutaraldehyde solution with the concentration of 28g/L, continuously stirring until the glutaraldehyde solution is uniformly dispersed, adding 0.5g of cellulose nanofiber, ultrasonically dispersing for 15min at 200W, and then standing for 25h at room temperature to obtain a film forming solution for later use;
2) Adding the film-forming solution into an atomizer for atomization to obtain film-forming solution spray, simultaneously spraying hydrogel powder and the film-forming solution spray into a container, carrying out convection contact and mixing, and controlling the temperature to be 70 ℃, wherein the flow rate of the film-forming solution spray is 15m/s, the powder feeding rate of the hydrogel powder is 80kg/h, and carrying out vacuum drying on the obtained product until the weight is constant.
Comparative example 1: this comparative example is substantially the same as example 1 except that the peony extract essence is directly replaced with a peony extract.
Comparative example 2: this comparative example is substantially the same as example 1, except that conventional direct dipping is used instead of alternate negative-positive pressure dipping in the preparation of the peony extract.
Comparative example 3: the comparative example is substantially the same as example 1, except that ultrasonic assistance is omitted in the preparation process of the peony extract essence and in the alternate negative pressure-positive pressure impregnation process.
Comparative example 4: this comparative example is substantially the same as example 1 except that cellulose nanofibers were not added when the hydrogel powder was subjected to the coating treatment.
And (3) bacteriostatic test:
test strains: staphylococcus aureus (ATCC 6538) seventh generation, escherichia coli (8099) eighth generation, and Candida albicans (ATCC 10231) sixth generation, all available from North Nabia, suzhou, biotechnology Inc.
Recovering the strains, culturing to logarithmic phase, diluting to 100-101CFU/mL with culture medium, and uniformly coating the diluted bacteria liquid on nutrient agar culture medium by using a coater.
Performing a test on the face, sampling according to the requirement of measuring the total number of bacteria before cleaning the face, recording the number of bacterial colonies as S1, then cleaning the face by using a face cleaning emulsion according to a common face cleaning method, wherein the cleaning duration is 40-60S, finally flushing under flowing water, sampling after cleaning, diluting the collected sample, mixing with a liquefied agar culture medium, culturing at 37 ℃ for 24h, and calculating the total number of bacteria in the sample as S2 according to the number of bacterial colonies on the culture medium; after the face cleaning lotion is cleaned for 12 hours, the face cleaning lotion is directly washed by flowing water, sampling is carried out after the washing, the collected sample is diluted and then mixed with a liquefied agar culture medium, after the mixture is cultured for 24 hours at 37 ℃, the total number S3 of bacteria in the sample is calculated according to the number of bacterial colonies on the culture medium, and then the continuous bacteriostasis efficiency after the face cleaning lotion cleans the face is calculated;
the calculation formula is as follows: continuous bacteriostatic efficiency% = (S3-S2)/S1 × 100%.
The calculation results are shown in table 1.
TABLE 1
| Example 1 | Example 2 | Example 3 | |
| The continuous bacteriostasis efficiency% | 94.5 | 95.7 | 95.1 |
| Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| The continuous bacteriostasis efficiency% | 52.6 | 75.8 | 82.9 |
| Comparative example 4 | |||
| The continuous bacteriostasis efficiency% | 61.6 |
As can be seen from Table 1, the cleansing emulsion provided by the invention has a high-efficiency and durable bactericidal effect, can realize long-time facial cleansing, and can provide long-term protection for skin, so that facial inflammation can be better prevented.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (10)
1. The bacteriostatic facial cleanser with the peony flowers is characterized by comprising the following components in parts by weight: 680-730 parts of water, 0.2-0.8 part of chlorhexidine acetate, 0.05-0.08 part of cetylpyridinium chloride, 12-17 parts of amine oxide, 5-10 parts of cocamidopropyl betaine, 1-3 parts of alkyl glycoside, 2-5 parts of sodium lauryl amphoacetate, 2-5 parts of glycerol, 0.1-0.2 part of essence, 0.2-0.4 part of preservative, 0.03-0.08 part of dipotassium glycyrrhizinate, 0.2-0.5 part of citric acid and 0.01-0.05 part of peony extraction essence.
2. The bacteriostatic cleanser emulsion of claim 1, wherein the preservative is at least one selected from methyl hydroxybenzoate and propyl hydroxybenzoate.
3. The bacteriostatic facial cleanser of claim 1, wherein the peony extract is prepared by the following steps:
1) Adding deionized water and glacial acetic acid into a container, adding sodium alginate and chitosan, uniformly stirring, adding a glutaraldehyde solution, stirring at room temperature at 80-130r/min for 23-28h, gelling, performing vacuum drying, cutting into blocks, soaking in deionized water for 20-30h, and performing vacuum drying at room temperature to constant weight to obtain hydrogel blocks;
2) Immersing the hydrogel block in a peony extract in a vacuum impregnation tank, impregnating at 0-3 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel block, drying at room temperature in vacuum to constant weight, grinding to obtain hydrogel powder, and performing coating treatment on the hydrogel powder to obtain the required peony extract.
4. The bacteriostatic facial cleanser of claim 3, wherein the deionized water, glacial acetic acid, sodium alginate, chitosan and glutaraldehyde solution are used in the ratio of (20-30) mL: (5-8) mL: (0.2-0.6) g: (0.3-0.5) g: (1.0-1.3) mL;
the concentration of the glutaraldehyde solution is 23-28g/L;
in the deionized water soaking process, water needs to be replaced every 10-12 hours.
5. The peony bacteria inhibiting type face cleaning emulsion as claimed in claim 3, wherein the peony extract is obtained by adding peony into a ceramic purple clay pot, adding 6-10 times of water, turning to small fire for 65-90min after 12-20min with strong fire.
6. The bacteriostatic facial cleanser of claim 3, wherein said negative pressure and positive pressure are alternatively dipped, comprising the following steps:
placing the hydrogel block in a vacuum impregnation tank, vacuumizing the impregnation tank to 10-60Pa, injecting radix Paeoniae extract, pressurizing the impregnation tank to 0.5-1.0MPa after the radix Paeoniae extract completely covers the hydrogel block, maintaining for 10-30min, intermittently turning on ultrasonic wave with frequency of 25-30KHz and power of 100-150W, starting for 1-5min and turning off for 3-10min, and repeating the above operation for 1-3 times.
7. The bacteriostatic facial cleanser of claim 3, wherein said hydrogel powder is coated by the following method:
1) Adding glacial acetic acid into deionized water, stirring uniformly, adding chitosan powder, stirring until the chitosan powder is completely dissolved, adding glutaraldehyde solution, continuing stirring until the glutaraldehyde solution is uniformly dispersed, adding cellulose nanofiber, performing ultrasonic dispersion for 5-15min, and standing at room temperature for 20-25h to obtain a film forming solution for later use;
2) Adding the film-forming solution into an atomizer for atomization to obtain film-forming solution spray, simultaneously spraying the hydrogel powder and the film-forming solution spray into a container, mixing by convection contact, controlling the temperature to be 60-70 ℃, and drying the obtained product in vacuum to constant weight.
8. The bacteriostatic facial cleanser of claim 7, wherein in step 1), the ratio of the amounts of glacial acetic acid, deionized water, chitosan powder, glutaraldehyde solution and cellulose nanofiber is (1-5) mL: (100-300) mL: (2-5) g: (0.1-0.3) mL: (0.2-0.5) g;
the concentration of the glutaraldehyde solution is 23-28g/L.
9. The facial cleanser with peony bacteria inhibiting effect of claim 7, wherein in step 2), the flow rate of spraying the deposition solution is 10-15m/s;
the powder feeding rate of the hydrogel powder is 60-80kg/h.
10. The peony antibacterial cleansing emulsion according to claim 1, wherein the production process of the cleansing emulsion comprises the following steps:
weighing the components in parts by weight, fully dissolving chlorhexidine acetate in warm water at 52-56 ℃, then putting the mixture, water, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerol, essence, preservative, dipotassium glycyrrhizinate, citric acid and peony extraction essence into a stainless steel homogenizing reaction kettle, fully stirring, filtering, canning and packaging to obtain the required face cleaning emulsion.
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