CN115252507B - Antibacterial facial cleanser with peony flowers - Google Patents
Antibacterial facial cleanser with peony flowers Download PDFInfo
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- CN115252507B CN115252507B CN202211109109.XA CN202211109109A CN115252507B CN 115252507 B CN115252507 B CN 115252507B CN 202211109109 A CN202211109109 A CN 202211109109A CN 115252507 B CN115252507 B CN 115252507B
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- hydrogel
- peony
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- 241000736199 Paeonia Species 0.000 title claims abstract description 67
- 235000006484 Paeonia officinalis Nutrition 0.000 title claims abstract description 61
- 230000001815 facial effect Effects 0.000 title claims abstract description 43
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 22
- 239000000017 hydrogel Substances 0.000 claims abstract description 85
- 239000000843 powder Substances 0.000 claims abstract description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000000284 extract Substances 0.000 claims abstract description 47
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000007788 liquid Substances 0.000 claims abstract description 33
- 229920001661 Chitosan Polymers 0.000 claims abstract description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000011248 coating agent Substances 0.000 claims abstract description 19
- 238000000576 coating method Methods 0.000 claims abstract description 19
- 239000000839 emulsion Substances 0.000 claims abstract description 17
- 229960002152 chlorhexidine acetate Drugs 0.000 claims abstract description 16
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims abstract description 16
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 11
- -1 alkyl glycoside Chemical class 0.000 claims abstract description 11
- 150000001412 amines Chemical class 0.000 claims abstract description 11
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims abstract description 11
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims abstract description 11
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 11
- 229930182470 glycoside Natural products 0.000 claims abstract description 11
- 238000000605 extraction Methods 0.000 claims abstract description 10
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims abstract description 6
- 239000000686 essence Substances 0.000 claims abstract description 3
- GOJYXPWOUJYXJC-UHFFFAOYSA-M sodium;2-[1-(2-hydroxyethyl)-2-undecyl-4,5-dihydroimidazol-1-ium-1-yl]acetate;hydroxide Chemical compound [OH-].[Na+].CCCCCCCCCCCC1=NCC[N+]1(CCO)CC([O-])=O GOJYXPWOUJYXJC-UHFFFAOYSA-M 0.000 claims abstract description 3
- 238000003756 stirring Methods 0.000 claims description 31
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 28
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 25
- 239000008367 deionised water Substances 0.000 claims description 22
- 229910021641 deionized water Inorganic materials 0.000 claims description 22
- 238000001291 vacuum drying Methods 0.000 claims description 20
- 244000236658 Paeonia lactiflora Species 0.000 claims description 17
- 235000008598 Paeonia lactiflora Nutrition 0.000 claims description 17
- 238000002791 soaking Methods 0.000 claims description 16
- 239000007921 spray Substances 0.000 claims description 15
- 229960000583 acetic acid Drugs 0.000 claims description 14
- 239000012362 glacial acetic acid Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 12
- 239000001913 cellulose Substances 0.000 claims description 11
- 229920002678 cellulose Polymers 0.000 claims description 11
- 239000002121 nanofiber Substances 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 10
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 9
- 239000000661 sodium alginate Substances 0.000 claims description 9
- 235000010413 sodium alginate Nutrition 0.000 claims description 9
- 229940005550 sodium alginate Drugs 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 238000007598 dipping method Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 230000003385 bacteriostatic effect Effects 0.000 claims description 6
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 6
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 6
- 229960002216 methylparaben Drugs 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 238000000889 atomisation Methods 0.000 claims description 5
- 238000009924 canning Methods 0.000 claims description 5
- 239000000919 ceramic Substances 0.000 claims description 5
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- 238000005520 cutting process Methods 0.000 claims description 5
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- 239000000499 gel Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 238000001132 ultrasonic dispersion Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 229940045110 chitosan Drugs 0.000 claims description 2
- 229960000587 glutaral Drugs 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 9
- 229960004106 citric acid Drugs 0.000 claims 1
- 238000007654 immersion Methods 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 24
- 241000894006 Bacteria Species 0.000 abstract description 13
- 239000003755 preservative agent Substances 0.000 abstract description 8
- 230000002335 preservative effect Effects 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 5
- 239000002253 acid Substances 0.000 abstract description 4
- 241001391944 Commicarpus scandens Species 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 9
- 238000005470 impregnation Methods 0.000 description 8
- 206010061218 Inflammation Diseases 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 6
- 210000003780 hair follicle Anatomy 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 244000304217 Brassica oleracea var. gongylodes Species 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 238000007865 diluting Methods 0.000 description 3
- 238000011010 flushing procedure Methods 0.000 description 3
- 238000004898 kneading Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 238000009740 moulding (composite fabrication) Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
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- 229920001817 Agar Polymers 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
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- 238000004132 cross linking Methods 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
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- 238000009210 therapy by ultrasound Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention discloses a peony antibacterial type face cleaning emulsion which comprises water, chlorhexidine acetate, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauroamphoacetate, glycerol, essence, preservative, dipotassium glycyrrhizinate, citric acid and peony extract essence. When the face cleaning emulsion is used, the chitosan coating material on the surface of the peony extraction essence is easy to break under the rubbing action of external force, so that the external acid liquid is in contact with hydrogel powder, and the grid holes in the hydrogel are increased, so that part of the peony extraction essence can flow out quickly to remove facial bacteria.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a peony antibacterial type facial cleanser.
Background
The facial cleanser is also called facial cleanser, is a cleaning product for cleaning facial dirt such as sweat, dust, makeup and the like, has smaller stimulation to skin than the use of soap for cleaning the face, is easier to wash, and can clean even the concave-convex position of the face. Generally, a cleanser is a liquid product composed of oil phase matters, water phase matters, surfactants, moisturizers, nutrients and the like, and the surfactants in the cleanser have five functions of wetting, dispersing, foaming, decontamination and emulsification, and are main active matters of the cleanser. Moreover, as environmental pollution increases and the pressure of people's work and life increases, sebaceous gland secretion increases, sebum is decomposed by bacteria present in hair follicles to produce fatty acids, which stimulate the hair follicles to cause inflammation, so that the hair follicle wall is damaged and ruptured, and hair follicle contents enter dermis, thereby causing inflammatory reactions of varying degrees around hair follicles. Therefore, the facial cleanser is required to not only meet the effect of removing facial dirt, but also have a certain antibacterial effect.
For example, the invention patent with publication number CN105853296a discloses a cleansing cosmetic containing kohlrabi extract and a preparation method thereof, comprising kohlrabi extract, minerals, facial cleansing surfactant, anti-inflammatory and antiallergic agent, whitening agent, moisturizer, potassium hydroxide, thickener, emulsifier, preservative and deionized water; kohlrabi extract in the patent is used as a plant extract, has small side effect, and can effectively remove bacteria growing on the face by utilizing the antibacterial effect of the kohlrabi extract; however, the facial cleansing cosmetic can only effectively remove bacteria which are bred on the face, people often wash the face with clear water after using the facial cleansing cosmetic, foam of the facial cleansing cosmetic is washed, at the moment, the kohlrabi extract is washed away along with the foam by water flow, so that the washed face does not contain antibacterial substances, the breeding of bacteria at the later stage can not be inhibited, and inflammatory reactions with different degrees still exist around hair follicles of the face after washing the face.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the peony antibacterial facial cleanser, when the peony antibacterial facial cleanser is used, under the kneading of external force, chitosan coating materials on the surfaces of peony extract essence are easy to crack, so that external acid liquid is in contact with hydrogel powder, mesh pores in the hydrogel are increased, part of peony extract can flow out rapidly to remove facial bacteria, and meanwhile, after the peony antibacterial facial cleanser is used, part of peony extract can be attached to facial skin for a long time, and the residual peony extract is slowly released, so that the bacteria on the face can be inhibited from growing for a long time, long-time facial cleaning can be realized after people wash the face, long-time protection is realized on the skin, and the generation of facial inflammation can be better prevented.
In order to achieve the above purpose, the present invention provides the following technical solutions:
A peony antibacterial type facial cleanser comprises the following components in parts by weight: 680-730 parts of water, 0.2-0.8 part of chlorhexidine acetate, 0.05-0.08 part of cetylpyridinium chloride, 12-17 parts of amine oxide, 5-10 parts of cocoamidopropyl betaine, 1-3 parts of alkyl glycoside, 2-5 parts of sodium lauryl amphoacetate, 2-5 parts of glycerin, 0.1-0.2 part of essence, 0.2-0.4 part of preservative, 0.03-0.08 part of dipotassium glycyrrhizinate, 0.2-0.5 part of citric acid and 0.01-0.05 part of paeonia lactiflora extraction essence.
As a further preferable embodiment of the present invention, the preservative is at least one selected from the group consisting of methylparaben and propylparaben.
As a further preferable scheme of the invention, the preparation method of the paeonia lactiflora extraction essence comprises the following steps:
1) Adding deionized water and glacial acetic acid into a container, adding sodium alginate and chitosan, stirring uniformly, adding glutaraldehyde solution, stirring at 80-130r/min for 23-28h at room temperature, performing vacuum drying after gel forming, cutting, soaking with deionized water for 20-30h, and performing vacuum drying at room temperature to constant weight to obtain a hydrogel block;
2) Immersing the hydrogel blocks in the peony extracting solution in a vacuum immersing tank, immersing the hydrogel blocks in the peony extracting solution at 0-3 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel blocks, vacuum drying the hydrogel blocks to constant weight at room temperature, grinding the hydrogel blocks to obtain hydrogel powder, and then coating the hydrogel powder to obtain the required peony extracting essence.
As a further preferable scheme of the invention, the dosage proportion of the deionized water, glacial acetic acid, sodium alginate, chitosan and glutaraldehyde solution is (20-30) mL: (5-8) mL: (0.2-0.6) g: (0.3-0.5) g: (1.0-1.3) mL;
the concentration of the glutaraldehyde solution is 23-28g/L;
In the process of soaking in deionized water, water needs to be replaced every 10-12 hours.
As a further preferable scheme of the invention, the peony extract is obtained by adding peony into a ceramic purple marmite, adding 6-10 times of water, and extracting with strong fire for 12-20min and then with slow fire for 65-90 min.
As a further preferable aspect of the present invention, the dipping is performed in a negative-positive alternating manner, comprising the steps of:
Placing the hydrogel block in a vacuum soaking tank, vacuumizing the soaking tank to 10-60Pa, injecting radix Paeoniae extract, pressurizing the soaking tank to 0.5-1.0MPa after the radix Paeoniae extract completely covers the hydrogel block, maintaining for 10-30min, intermittently starting ultrasonic wave with frequency of 25-30KHz and power of 100-150W in the pressurizing process, starting for 1-5min, closing for 3-10min, and repeating the above operation for 1-3 times.
As a further preferable mode of the invention, the method for coating the hydrogel powder comprises the following steps:
1) Adding glacial acetic acid into deionized water, stirring uniformly, adding chitosan powder, stirring until the chitosan powder is completely dissolved, adding glutaraldehyde solution, continuously stirring until the glutaraldehyde solution is uniformly dispersed, adding cellulose nanofibers, performing ultrasonic dispersion for 5-15min, and standing at room temperature for 20-25h to obtain film forming liquid for later use;
2) Adding the film forming liquid into an atomizer for atomization to obtain film forming liquid spray, spraying hydrogel powder and the film forming liquid spray into a container at the same time, carrying out countercurrent contact mixing, controlling the temperature to be 60-70 ℃, and carrying out vacuum drying on the obtained product to constant weight.
Further, in the step 1), the dosage ratio of the glacial acetic acid, the deionized water, the chitosan powder, the glutaraldehyde solution and the cellulose nano fibers is (1-5) mL: (100-300) mL: (2-5) g: (0.1-0.3) mL: (0.2-0.5) g;
The concentration of the glutaraldehyde solution is 23-28g/L.
Further, in the step 2), the flow rate of the film forming liquid spray is 10-15m/s;
The powder feeding rate of the hydrogel powder is 60-80kg/h.
A peony flower antibacterial facial cleanser comprises the following production processes:
Weighing the components according to the parts by weight, fully dissolving chlorhexidine acetate with warm water at 52-56 ℃, and then fully stirring the dissolved chlorhexidine acetate, water, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauroamphoacetate, glycerol, essence, preservative, dipotassium glycyrrhizinate, citric acid and peony extract essence in a stainless steel homogenizing reaction kettle, and then filtering, canning and packaging the mixture to obtain the required facial cleaning emulsion.
Compared with the prior art, the invention has the beneficial effects that:
According to the invention, glutaraldehyde solution is used as a cross-linking agent, chitosan is used as a polycation component, sodium alginate is used as a polyanion component, hydrogel is prepared through cross-linking, and as chitosan has good water absorption performance, and chitosan and sodium alginate are cross-linked to form a large number of cross-linked grids, through a negative pressure-positive pressure impregnation mode and matching with ultrasonic treatment, the permeability can be improved, the penetration of the peony extract into the grid holes of the hydrogel is accelerated, so that the peony extract is loaded, on one hand, the stability of the peony extract is improved, the peony extract is not easy to oxidize and deteriorate, and meanwhile, citric acid is contained in the face cleaning emulsion to be acidic, under the acidic condition, the-NH 2 in the hydrogel exists in the form of-NH + 3, and as a result of electrostatic repulsive force, the grid holes in the hydrogel are increased, the channels are unblocked, so that the loaded peony extract is easy to flow out, the slow release effect of the peony extract is realized, the utilization rate of the peony extract is improved, and meanwhile, the interface emulsion can play a long-term antibacterial role in face protection after being used.
In order to prevent the peony extracting solution loaded on the hydrogel from flowing out during storage, only the peony extracting solution is slowly released during use, the hydrogel loaded with the peony extracting solution is subjected to coating treatment, glutaraldehyde solution is used as a cross-linking agent, cellulose nanofiber is used as an additive, a cross-linked chitosan coating material is prepared, and the hydrogel powder is in countercurrent contact with the film forming solution, so that the film forming solution is covered on the hydrogel powder to form a protective film, the effect of isolating the hydrogel powder from the external acidic environment is achieved, and the peony extracting solution loaded in the hydrogel powder cannot flow out during storage of the face cleaning emulsion; when people use the facial cleanser, under the kneading of external force, the chitosan coating material on the surface of the paeonia lactiflora extraction essence breaks, so that external acid liquid is contacted with hydrogel powder, mesh pores in the hydrogel are increased, and the paeonia lactiflora extraction liquid flows out more easily, so that bacteria on the face can be inhibited and killed; moreover, the cellulose nanofiber added in the film forming liquid forms a reticular structure through cross-linking, so that the strength of the chitosan film is improved, the chitosan film is not damaged in normal stirring and shaking, the inside hydrogel powder can be better protected, meanwhile, when the film forming liquid is solidified and formed on the surface of the hydrogel powder to form a film, part of the cellulose nanofiber can be exposed on the surface of the film, a large number of nanometer 'tentacles' are formed on the surface of the film, the contact area between the paeonia extract and the skin is increased, the bonding strength between the paeonia extract and the skin is improved, after people use the facial cleaning emulsion, part of the paeonia extract is adhered to the skin of the face, and bacteria on the face can be restrained from growing for a long time in a slow release manner of the paeonia extract, so that people can clean the face for a long time after washing the face.
When the face cleaning emulsion is used, under the kneading of external force, the chitosan coating material on the surface of the peony extract essence is easy to break, so that external acid liquid is in contact with hydrogel powder, grid holes in the hydrogel are increased, part of the peony extract can flow out quickly to remove facial bacteria, meanwhile, after the face cleaning emulsion is used, part of the peony extract essence can be attached to facial skin for a long time, and the residual peony extract is slowly released, so that the bacteria breeding on the face can be inhibited for a long time, long-time facial cleaning can be realized after people wash the face, long-time protection to the skin can be realized, and the generation of facial inflammation can be better prevented.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The peony antibacterial type facial cleanser comprises the following components in parts by weight: 680 parts of water, 0.2 part of chlorhexidine acetate, 0.05 part of cetylpyridinium chloride, 12 parts of amine oxide, 5 parts of cocamidopropyl betaine, 1 part of alkyl glycoside, 2 parts of sodium lauryl amphoacetate, 2 parts of glycerin, 0.1 part of essence, 0.2 part of methylparaben, 0.03 part of dipotassium glycyrrhizinate, 0.2 part of citric acid and 0.01 part of paeonia lactiflora extract;
the production process of the facial cleanser comprises the following steps:
Weighing the components according to the parts by weight, fully dissolving chlorhexidine acetate with warm water at 52 ℃, and then placing the dissolved chlorhexidine acetate, water, cetylpyridinium chloride, amine oxide, cocoamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerin, essence, preservative, dipotassium glycyrrhizinate, citric acid and paeonia lactiflora extract into a stainless steel homogenizing reaction kettle, fully stirring, filtering, canning and packaging to obtain the required face cleaning emulsion.
The preparation method of the paeonia lactiflora extraction essence comprises the following steps:
1) Adding 20mL of deionized water and 5mL of glacial acetic acid into a container, adding 0.2g of sodium alginate and 0.3g of chitosan, uniformly stirring, adding 1.0mL of glutaraldehyde solution with the concentration of 23g/L, stirring at the room temperature for 23h at 80r/min, performing vacuum drying after gel forming, cutting, soaking with deionized water for 20h, changing water every 10h, and performing vacuum drying at the room temperature to constant weight to obtain a hydrogel block;
2) Immersing the hydrogel blocks in the peony extracting solution in a vacuum immersing tank, immersing the hydrogel blocks in the peony extracting solution at 0 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel blocks, vacuum drying the hydrogel blocks to constant weight at room temperature, grinding the hydrogel blocks to obtain hydrogel powder, and performing coating treatment on the hydrogel powder to obtain the required peony extracting essence;
wherein, the dipping is carried out in a negative pressure-positive pressure alternating mode, which comprises the following steps:
Placing the hydrogel block in a vacuum soaking tank, vacuumizing the soaking tank to 10Pa, injecting radix Paeoniae extractive solution, pressurizing the soaking tank to 0.5MPa after the radix Paeoniae extractive solution completely covers the hydrogel block, maintaining for 10min, intermittently starting ultrasonic wave with frequency of 25KHz and power of 100W in the pressurizing process, starting for 1min, closing for 3min, and repeating the above operation for 1 time.
The radix Paeoniae extract is obtained by adding radix Paeoniae into ceramic purple marmite, adding 6 times of water, and extracting with strong fire for 12min and low fire for 65 min.
The method for coating the hydrogel powder comprises the following steps:
1) Adding 1mL of glacial acetic acid into 100mL of deionized water, stirring uniformly, adding 2g of chitosan powder, stirring until the chitosan powder is completely dissolved, adding 0.1mL of glutaraldehyde solution with the concentration of 23g/L, continuously stirring until the glutaraldehyde solution is uniformly dispersed, adding 0.2g of cellulose nanofiber, performing ultrasonic dispersion for 5min at 100W, and standing for 20h at room temperature to obtain film forming liquid for later use;
2) Adding the film forming liquid into an atomizer for atomization to obtain film forming liquid spray, spraying hydrogel powder and the film forming liquid spray into a container at the same time, carrying out countercurrent contact mixing, controlling the temperature to be 60 ℃, wherein the flow rate of the film forming liquid spray is 10m/s, the powder feeding rate of the hydrogel powder is 60kg/h, and carrying out vacuum drying on the obtained product to constant weight.
Example 2
The peony antibacterial type facial cleanser comprises the following components in parts by weight: 700 parts of water, 0.5 part of chlorhexidine acetate, 0.07 part of cetylpyridinium chloride, 15 parts of amine oxide, 7 parts of cocamidopropyl betaine, 2 parts of alkyl glycoside, 3 parts of sodium lauryl amphoacetate, 3 parts of glycerin, 0.1 part of essence, 0.3 part of methylparaben, 0.05 part of dipotassium glycyrrhizinate, 0.3 part of citric acid and 0.03 part of paeonia lactiflora extract;
the production process of the facial cleanser comprises the following steps:
Weighing the components according to the parts by weight, fully dissolving chlorhexidine acetate with warm water at 54 ℃, and then placing the dissolved chlorhexidine acetate, water, cetylpyridinium chloride, amine oxide, cocoamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerin, essence, preservative, dipotassium glycyrrhizinate, citric acid and paeonia lactiflora extract into a stainless steel homogenizing reaction kettle, fully stirring, filtering, canning and packaging to obtain the required face cleaning emulsion.
The preparation method of the paeonia lactiflora extraction essence comprises the following steps:
1) Adding 25mL of deionized water and 7mL of glacial acetic acid into a container, adding 0.5g of sodium alginate and 0.4g of chitosan, uniformly stirring, adding 1.2mL of glutaraldehyde solution with the concentration of 25g/L, stirring at room temperature for 25h at 100r/min, performing vacuum drying after gel formation, cutting, soaking in deionized water for 25h, changing water every 11h, and performing vacuum drying at room temperature to constant weight to obtain a hydrogel block;
2) Immersing the hydrogel blocks in the peony extracting solution in a vacuum immersing tank, immersing the hydrogel blocks in the peony extracting solution at the temperature of 1 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel blocks, vacuum drying the hydrogel blocks to constant weight at room temperature, grinding the hydrogel blocks to obtain hydrogel powder, and then coating the hydrogel powder to obtain the required peony extracting essence;
wherein, the dipping is carried out in a negative pressure-positive pressure alternating mode, which comprises the following steps:
Placing the hydrogel block in a vacuum impregnation tank, vacuumizing the impregnation tank to 40Pa, injecting the peony extracting solution, pressurizing the impregnation tank to 0.7MPa after the peony extracting solution completely covers the hydrogel block, keeping for 20min, intermittently starting ultrasonic waves with the frequency of 30KHz and the power of 120W in the pressurizing process, starting for 2min, closing for 5min, and repeating the operation for 2 times.
The radix Paeoniae extract is obtained by adding radix Paeoniae into ceramic dark-red enameled pottery, adding 8 times of water, and extracting with strong fire for 15min and slow fire for 70 min.
The method for coating the hydrogel powder comprises the following steps:
1) Adding 3mL of glacial acetic acid into 200mL of deionized water, stirring uniformly, adding 3g of chitosan powder, stirring until the chitosan powder is completely dissolved, adding 0.2mL of glutaraldehyde solution with the concentration of 25g/L, continuously stirring until the glutaraldehyde solution is uniformly dispersed, adding 0.3g of cellulose nanofiber, performing ultrasonic dispersion for 10min at 150W, and standing at room temperature for 23h to obtain film forming liquid for later use;
2) Adding the film forming liquid into an atomizer for atomization to obtain film forming liquid spray, spraying hydrogel powder and the film forming liquid spray into a container at the same time, carrying out countercurrent contact mixing, controlling the temperature to be 65 ℃, wherein the flow rate of the film forming liquid spray is 12m/s, the powder feeding rate of the hydrogel powder is 70kg/h, and carrying out vacuum drying on the obtained product to constant weight.
Example 3
The peony antibacterial type facial cleanser comprises the following components in parts by weight: 730 parts of water, 0.8 part of chlorhexidine acetate, 0.08 part of cetylpyridinium chloride, 17 parts of amine oxide, 10 parts of cocamidopropyl betaine, 3 parts of alkyl glycoside, 5 parts of sodium lauryl amphoacetate, 5 parts of glycerin, 0.2 part of essence, 0.4 part of methylparaben, 0.08 part of dipotassium glycyrrhizinate, 0.5 part of citric acid and 0.05 part of paeonia lactiflora extract;
the production process of the facial cleanser comprises the following steps:
Weighing the components according to the parts by weight, fully dissolving chlorhexidine acetate with warm water at 56 ℃, and then placing the dissolved chlorhexidine acetate, water, cetylpyridinium chloride, amine oxide, cocoamidopropyl betaine, alkyl glycoside, sodium lauryl amphoacetate, glycerin, essence, preservative, dipotassium glycyrrhizinate, citric acid and paeonia lactiflora extract into a stainless steel homogenizing reaction kettle, fully stirring, filtering, canning and packaging to obtain the required face cleaning emulsion.
The preparation method of the paeonia lactiflora extraction essence comprises the following steps:
1) Adding 30mL of deionized water and 8mL of glacial acetic acid into a container, adding 0.6g of sodium alginate and 0.5g of chitosan, uniformly stirring, adding 1.3mL of glutaraldehyde solution with the concentration of 28g/L, stirring at the room temperature for 28h at 130r/min, performing vacuum drying after gel forming, cutting, soaking in deionized water for 30h, changing water every 12h, and performing vacuum drying at the room temperature to constant weight to obtain a hydrogel block;
2) Immersing the hydrogel blocks in the peony extracting solution in a vacuum immersing tank, immersing the hydrogel blocks in the peony extracting solution at 3 ℃ in a negative pressure-positive pressure alternating mode, taking out the hydrogel blocks, vacuum drying the hydrogel blocks to constant weight at room temperature, grinding the hydrogel blocks to obtain hydrogel powder, and performing coating treatment on the hydrogel powder to obtain the required peony extracting essence;
wherein, the dipping is carried out in a negative pressure-positive pressure alternating mode, which comprises the following steps:
placing the hydrogel block in a vacuum impregnation tank, vacuumizing the impregnation tank to 60Pa, injecting the peony extracting solution, pressurizing the impregnation tank to 1.0MPa after the peony extracting solution completely covers the hydrogel block, maintaining for 30min, intermittently starting ultrasonic waves with the frequency of 30KHz and the power of 150W in the pressurizing process, starting for 5min, closing for 10min, and repeating the operation for 3 times.
The radix Paeoniae extract is obtained by adding radix Paeoniae into ceramic dark-red enameled pottery, adding 10 times of water, and extracting with strong fire for 20min and slow fire for 90 min.
The method for coating the hydrogel powder comprises the following steps:
1) Adding 5mL of glacial acetic acid into 300mL of deionized water, stirring uniformly, adding 5g of chitosan powder, stirring until the chitosan powder is completely dissolved, adding 0.3mL of glutaraldehyde solution with the concentration of 28g/L, continuously stirring until the glutaraldehyde solution is uniformly dispersed, adding 0.5g of cellulose nanofiber, performing ultrasonic dispersion for 15min at 200W, and standing at room temperature for 25h to obtain film forming liquid for later use;
2) Adding the film forming liquid into an atomizer for atomization to obtain film forming liquid spray, spraying hydrogel powder and the film forming liquid spray into a container at the same time, carrying out countercurrent contact mixing, controlling the temperature to be 70 ℃, wherein the flow rate of the film forming liquid spray is 15m/s, the powder feeding rate of the hydrogel powder is 80kg/h, and carrying out vacuum drying on the obtained product to constant weight.
Comparative example 1: this comparative example is basically the same as example 1, except that the paeonia extract is directly replaced with paeonia extract.
Comparative example 2: this comparative example is substantially the same as example 1, except that the conventional direct dipping instead of the alternate negative-positive pressure dipping method is used in the preparation of paeonia lactiflora extract.
Comparative example 3: this comparative example is basically the same as example 1, except that the ultrasonic assistance is omitted during the preparation of paeonia lactiflora extract essence and during the alternate negative-positive pressure impregnation.
Comparative example 4: this comparative example is substantially the same as example 1 except that the hydrogel powder was subjected to the coating treatment without adding cellulose nanofibers.
Bacteriostasis test:
Test strain: staphylococcus aureus (ATCC 6538), seventh generation, escherichia coli (8099), eighth generation, candida albicans (ATCC 10231), sixth generation, were all purchased from north na alliance biotechnology limited, su.
Resuscitating the strains, culturing to logarithmic phase, diluting to 100-101CFU/mL with culture medium, and uniformly coating diluted bacterial liquid on nutrient agar culture medium with a coater.
Performing a test on the face, sampling according to the requirement of determining the total number of bacteria before cleaning the face, recording the colony number as S1, cleaning the face by using a face cleaning emulsion according to a general face cleaning method for 40S-60S, finally flushing under flowing water, sampling after cleaning, diluting the collected sample, mixing the diluted sample with a liquefied agar culture medium, culturing at 37 ℃ for 24 hours, and calculating the total number of bacteria in the sample as S2 according to the colony number on the culture medium; after normal activity for 12 hours after cleaning, directly flushing with flowing water, sampling after flushing, diluting the collected sample, mixing with liquefied agar culture medium, culturing at 37 ℃ for 24 hours, calculating total bacterial count S3 in the sample according to the bacterial colony number on the culture medium, and then calculating the continuous antibacterial efficiency of the face cleaning emulsion after cleaning the face;
the calculation formula is as follows: continuous bacteriostatic efficiency% = (S3-S2)/s1×100%.
The calculation results are shown in Table 1.
TABLE 1
| Example 1 | Example 2 | Example 3 | |
| Continuous bacteriostatic efficiency% | 94.5 | 95.7 | 95.1 |
| Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Continuous bacteriostatic efficiency% | 52.6 | 75.8 | 82.9 |
| Comparative example 4 | |||
| Continuous bacteriostatic efficiency% | 61.6 |
As can be seen from Table 1, the cleansing emulsion of the present invention has a high and durable bactericidal effect, and can achieve long-term facial cleansing and long-term protection of the skin, thereby better preventing facial inflammation.
The preferred embodiments of the invention disclosed above are intended only to assist in the explanation of the invention. The preferred embodiments are not exhaustive or to limit the invention to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention. The invention is limited only by the claims and the full scope and equivalents thereof.
Claims (6)
1. The peony antibacterial type facial cleanser is characterized by comprising the following components in parts by weight: 680-730 parts of water, 0.2-0.8 part of chlorhexidine acetate, 0.05-0.08 part of cetylpyridinium chloride, 12-17 parts of amine oxide, 5-10 parts of cocoamidopropyl betaine, 1-3 parts of alkyl glycoside, 2-5 parts of sodium lauryl amphoacetate, 2-5 parts of glycerin, 0.1-0.2 part of essence, 0.2-0.4 part of methylparaben, 0.03-0.08 part of dipotassium glycyrrhizinate, 0.2-0.5 part of citric acid and 0.01-0.05 part of radix paeoniae alba extraction essence,
The preparation method of the peony extract essence comprises the following steps:
1) Adding deionized water and glacial acetic acid into a container, adding sodium alginate and chitosan, stirring uniformly, adding glutaraldehyde solution, stirring at 80-130r/min for 23-28h at room temperature, performing vacuum drying after gel forming, cutting, soaking with deionized water for 20-30h, and performing vacuum drying at room temperature to constant weight to obtain a hydrogel block;
2) Immersing the hydrogel block in radix Paeoniae extract in vacuum immersion tank, immersing at 0-3deg.C by negative pressure-positive pressure alternating method, taking out the hydrogel block, vacuum drying at room temperature to constant weight, grinding to obtain hydrogel powder, coating the hydrogel powder to obtain radix Paeoniae extract,
The negative pressure-positive pressure alternating mode is used for dipping, and the method comprises the following steps:
Placing the hydrogel block in a vacuum soaking tank, vacuumizing the soaking tank to 10-60Pa, injecting radix Paeoniae extractive solution, pressurizing the soaking tank to 0.5-1.0MPa after the radix Paeoniae extractive solution completely covers the hydrogel block, maintaining for 10-30min, intermittently starting ultrasonic wave with frequency of 25-30kHz and power of 100-150W during pressurizing, starting for 1-5min, closing for 3-10min, repeating the above operation for 1-3 times,
The method for coating the hydrogel powder comprises the following steps:
1) Adding glacial acetic acid into deionized water, stirring uniformly, adding chitosan powder, stirring until the chitosan powder is completely dissolved, adding glutaraldehyde solution, continuously stirring until the glutaraldehyde solution is uniformly dispersed, adding cellulose nanofibers, performing ultrasonic dispersion for 5-15min, and standing at room temperature for 20-25h to obtain film forming liquid for later use;
2) Adding the film forming liquid into an atomizer for atomization to obtain film forming liquid spray, spraying hydrogel powder and the film forming liquid spray into a container at the same time, carrying out countercurrent contact mixing, controlling the temperature to be 60-70 ℃, and carrying out vacuum drying on the obtained product to constant weight.
2. The peony antibacterial cleansing emulsion according to claim 1, wherein the deionized water, glacial acetic acid, sodium alginate, chitosan and glutaraldehyde solution are used in the following proportion (20-30) mL: (5-8) mL: (0.2-0.6) g: (0.3-0.5) g: (1.0-1.3) mL;
the concentration of the glutaraldehyde solution is 23-28g/L;
In the process of soaking in deionized water, water needs to be replaced every 10-12 hours.
3. The bacteriostatic facial cleanser for peony according to claim 1, wherein the peony extract is obtained by adding peony into a ceramic purple marmite, adding 6-10 times of water, and extracting with strong fire for 12-20min and then with slow fire for 65-90 min.
4. The peony antibacterial cleansing emulsion according to claim 1, wherein when the hydrogel powder is subjected to coating treatment, the dosage ratio of glacial acetic acid, deionized water, chitosan powder, glutaraldehyde solution and cellulose nanofibers is (1-5) mL: (100-300) mL: (2-5) g: (0.1-0.3) mL: (0.2-0.5) g;
The concentration of the glutaraldehyde solution is 23-28g/L.
5. The bacteriostatic facial cleanser for white peony according to claim 1, wherein the hydrogel powder is coated, and the flow rate of the film forming liquid spray is 10-15m/s;
The powder feeding rate of the hydrogel powder is 60-80kg/h.
6. The peony antibacterial facial cleanser according to claim 1, wherein the facial cleanser is produced by the following steps:
Weighing the components according to the parts by weight, fully dissolving chlorhexidine acetate with warm water at 52-56 ℃, and then fully stirring the dissolved chlorhexidine acetate, water, cetylpyridinium chloride, amine oxide, cocamidopropyl betaine, alkyl glycoside, sodium lauroamphoacetate, glycerol, essence, methylparaben, dipotassium glycyrrhizinate, citric acid and paeonia lactiflora extract in a stainless steel homogenizing reaction kettle, and filtering, canning and packaging the mixed solution to obtain the required facial cleanser.
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