CN115177560B

CN115177560B - Multi-effect oil control composition, essence preparation, and preparation methods and applications thereof

Info

Publication number: CN115177560B
Application number: CN202210835984.XA
Authority: CN
Inventors: 李冰; 周翊; 鄢浩然; 李月
Original assignee: Shanghai Pibao Biotechnology Development Co ltd
Current assignee: Shanghai Pibao Biotechnology Development Co ltd
Priority date: 2022-07-15
Filing date: 2022-07-15
Publication date: 2023-08-18
Anticipated expiration: 2042-07-15
Also published as: CN115177560A

Abstract

The invention relates to the technical field of A61K8/00, in particular to a multi-effect oil control composition, an essence preparation, a preparation method and application thereof. A multiple-effect oil control composition is prepared from radix Ardisiae Crenatae seed extract, flos Nelumbinis extract, nymphaeae flower extract, mandarin orange fruit extract, fructus Canarii albi extract, and semen Lini extract. According to the multi-effect oil control composition provided by the invention, the raw materials are compounded, so that the targeting effect of each component is clear, the composition has the obvious synergistic effect of synergistic compounding, the effects of inhibiting the activity of sebaceous glands of skin, inhibiting the proliferation of propionibacterium acnes, limiting the proliferation of malassezia, relieving skin and the like can be achieved through synergistic compounding, the effects of controlling excessive secretion of skin grease and side effects thereof are achieved, the effects of controlling oil, cleaning skin, preventing acne and seborrheic dermatitis can be comprehensively solved, the sources of raw materials are safe, and the application prospect is good.

Description

Multi-effect oil control composition, essence preparation, and preparation methods and applications thereof

Technical Field

The invention relates to the technical field of A61K8/00, in particular to a multi-effect oil control composition, an essence preparation, a preparation method and application thereof.

Background

With the development of social economy, consumers pay attention to their own mental and external images, so that skin care products with various effects are also required in life. The oil control products are concerned by consumers, and the sebum ingredients in the skin are relatively complex, mainly contain triglyceride and free fatty acid wax, and are mixed with phospholipid and cholesterol ester generated after epithelial cell metabolism. Sebum is oily, has moistening effect on skin, and can prevent skin dryness and chapping; the fatty acid in sebum can kill bacteria and resist mold and virus, and is called as a natural barrier of skin; however, acne, pimple, seborrheic dermatitis, dandruff, etc. may be formed when sebum excessively overflows. In general, facial seborrhea actually means that the skin is subjected to IGF-1 signal increase, sebaceous gland secretion function is high, so that skin microecological confusion and skin internal inflammation outbreak are caused, and further the problems of inflammatory acne, closed mouth, large pores and the like are caused, and severe cases even develop into seborrheic dermatitis.

The Chinese patent with the patent application number of CN201811596142.3 discloses an oil control pore-shrinking essence, which adopts Hamamelis virginiana extract, red clover flower extract and yarrow extract to be matched for solving the problems of controlling oil secretion and shrinking pores, has the function of controlling oil secretion, but has different adopted extracts and the invention conception of solving the problems, and also has no verification of antibacterial effect.

The present invention considers that skin problems such as acne, pore enlargement, seborrheic dermatitis and the like caused by seborrhea are the results of multiple aspects of compound actions, and single-point breakthrough is insufficient to solve the problems. Therefore, providing an oil control product that can combine the mechanism of facial grease spillover and the various skin problems that result, and that is a multi-target combined solution, is a major technical problem that needs to be addressed at present.

Disclosure of Invention

In order to solve the above problems, the first aspect of the present invention provides a multi-effect oil control composition, which is prepared from the raw materials including a cranberry seed extract, a lotus flower extract, a blue water lily flower extract, a citrus fruit extract, an olive fruit extract, and a linseed extract.

In one embodiment of the present invention, the method for preparing the multi-effect oil control composition comprises the steps of: uniformly mixing the Baimai root seed extract, the lotus flower extract, the Egyptian blue water lily flower extract, the citrus fruit extract, the olive fruit extract and the linseed extract to obtain the multi-effect oil control composition.

The Latin chemical name of the Baimaigen is: lotus corniculatus Linn.

In one embodiment of the present invention, the manufacturer of the Baimai root seed extract is Shanghai Jia Kai Biotechnology Co., ltd., model number of Jiayanjing (Smopenre LC).

The Latin chemical name of the lotus flower is Nelumbo nucifera Gaertn.

The pull Ding Xueming of the Egypt blue-sleeper lotus is Nymphaea caerulea Savigny.

In one embodiment of the invention, the mass ratio of the lotus extract to the blue water lily flower extract in the lotus extract and the Egypt blue water lily flower extract is 1:1, and the lotus extract and the Egypt blue water lily flower extract are mixed together to be used as a purchase raw material sample, wherein the purchase manufacturer is PROVITAL, S.A.U, and the model is NELUPURETM.

The Latin theory of the citrus fruit extract is Citrus reticulata Blanco.

In one embodiment of the present invention, the citrus fruit extract is purchased from Shanghai Kai Biotechnology Inc. under the model of Xiyuanning (Caldnerv CR).

The Latin theory of olive is Olea europaea.

In one embodiment of the present invention, the olive fruit extract is purchased from INDENA SAS, model OLIVE POLYPHENOLIC DRY EXTRACT

The Latin chemical name of the flaxseed is Linum usitatissimum

In one embodiment of the invention, the flaxseed extract is purchased from Ashland LLC, model Lipipine ^TM biofunctional。

The inventor finds in experiments that the multi-effect oil control composition is prepared by adding the extract of the baimai root seeds, the extract of lotus flowers, the extract of the Egyptian blue water lily flowers, the extract of citrus fruits, the extract of olive fruits and the extract of flaxseed, and the effects of controlling oil, cleaning skin, preventing acnes and seborrheic dermatitis can be achieved by controlling the excessive secretion of skin grease and the occurrence of side reactions through the effects of controlling the skin sebaceous gland activity, inhibiting the proliferation of propionibacterium acnes, limiting the proliferation of malassezia, relieving skin and the like through the multi-component synergistic effect by limiting the proportioning usage amount of the extracts.

In one embodiment of the invention, the weight ratio of the extract of the seed of the cranberry, the extract of the lotus flower and the extract of the blue water lily flower is (1-5): 1:1.

in order to achieve the effects of comprehensively inhibiting excessive sebum secretion of sebaceous glands and reducing sebum synthesis, the inventor finds that when the weight ratio of the extract of the centella asiatica seeds to the extract of lotus flower to the extract of the Egyptian blue water lily flower is (1-5): 1:1, the effect of comprehensively inhibiting the excessive secretion of sebum by sebaceous glands can be achieved, probably because 5-O-rhamnosyluridine and quercetin contained in the extract of the seeds of the centella asiatica can inhibit the differentiation of 3T3-L1 cells of preadipocytes and inhibit the lipid synthesis induced by dihydrotestosterone DHT, and ellagic acid and polyphenol contained in the extract of lotus flower and the extract of Nymphaea caerulea flower selected by the invention can reduce the expression of leptin receptors in sebaceous gland cells, thereby reducing the synthesis of sebum.

In one embodiment of the invention, the weight ratio of citrus fruit extract to olive fruit extract is (1-10): 1.

in one embodiment of the invention, the weight ratio of citrus fruit extract to flaxseed extract is (1.5-4.5): 1.

the inventor finds in experiments that when the raw materials for preparing the multi-effect oil control composition contain citrus fruit extract, olive fruit extract and flaxseed extract, the weight ratio of the citrus fruit extract to the olive fruit extract is (1-10): the ability of inhibiting sebaceous gland cells from secreting grease after being matched with the extract of the cranberry seeds, the lotus flower extract and the Egyptian blue water lily flower extract is improved, and the inventor discovers that the weight ratio of the citrus fruit extract to the olive fruit extract is (1-5): 1 or the weight ratio of the citrus fruit extract to the flaxseed extract is (1.5-4.5): 1, the ability of inhibiting the secretion of grease by sebaceous gland cells after being matched with the extract of the roots and seeds of the Baimai, the extract of the lotus flower and the extract of the Egyptian blue water lily flower is obviously improved.

When sebum is excessively secreted by a human body, propionibacterium acnes and malassezia are greatly planted in the skin, the skin micro-ecological environment is broken, and skin inflammation is induced; skin diseases that develop inflammatory acne and seborrheic dermatitis further develop after inducing skin inflammation. The inventor found in experiments that when the citrus fruit extract and the olive fruit extract are contained in the raw materials for preparing the multi-effect oil control composition, the weight ratio of the citrus fruit extract to the olive fruit extract is (1-10): 1, can effectively inhibit the excessive proliferation of propionibacterium acnes and can also limit the proliferation of harmful bacteria such as malassezia, probably because the citrus fruit extract contains a certain amount of active ingredients such as flavone and alkaloid, can inhibit TRPV1 activation and reduce calcium ion inflow, has the effects of relieving acne, relieving redness and swelling caused by seborrhea, relieving pain and the like, and the citrus fruit extract and the olive fruit extract are prepared according to the following formula (1-10): after the weight ratio of 1 is matched, the inventor finds that the active ingredients such as oleuropein, acteoside and the like contained in the olive fruit extract can further reduce the oxidation pressure of skin grease, and can achieve the effects of regulating the inflammatory environment in the skin together and reducing inflammatory reaction and allergic discomfort; when the olive fruit extract or the citrus fruit extract is not used in the preparation raw materials, or when the mixing amount of the olive fruit extract or the citrus fruit extract is too large or too small, the effective antibacterial effect cannot be achieved, and particularly the effect of inhibiting propionibacterium acnes is poor.

The second aspect of the invention provides an essence preparation, which comprises the following preparation raw materials, by mass, 0.5-11% of a multi-effect oil control composition, a component A and a component B; the A component comprises a thickener and a humectant, and the B component comprises a skin conditioning agent.

In one embodiment of the invention, the preparation raw materials of the multi-effect oil control composition comprise, by the total mass of the essence preparation, 0.01-3% of a Baimai root seed extract, 0.0001-2% of a lotus flower extract, 0.0001-2% of a Nymphaea caerulea flower extract, 0.01-2% of a citrus fruit extract, 0.01-1% of an olive fruit extract and 0.0001-1% of a linseed extract.

In a preferred embodiment of the invention, the preparation raw materials of the multi-effect oil control composition comprise, by the total mass of the essence preparation, 0.01-2% of a Baimai root seed extract, 0.0001-1% of a lotus flower extract, 0.0001-1% of a blue water lily flower extract, 0.01-1% of a citrus fruit extract, 0.01-0.8% of an olive fruit extract and 0.0001-0.8% of a linseed extract.

In one embodiment of the invention, the thickener comprises one or more of carbomers, sodium polyacrylate, acrylic acid (esters) of C10-30 alkanol acrylate cross-linked polymers, hydroxyethylcellulose, xanthan gum, sphingomonas fermentation product extract, polyacrylate cross-linked polymer-6.

In one embodiment of the application, the weight ratio of the Sphingomonas fermentation product extract, xanthan gum and polyacrylate crosslinked polymer-6 is 1: (1-3): (2-4).

In a preferred embodiment of the present application, the sphingomonas fermentation product extract, xanthan gum, polyacrylate crosslinked polymer-6 are present in a weight ratio of 1:2:3.5.

in one embodiment of the application, the Sphingomonas fermentation product extract is purchased from commercial manufacturer Lubrizol Advanced Materials, inc.

In one embodiment of the present application, the xanthan gum is commercially available from CP Kelco, model numberCG-SFT。

In one embodiment of the present application, the polyacrylate crosslinked polymer-6 is commercially available from SEPPIC, model number SEPIMAX ZEN ^TM 。

The multi-effect oil control composition contains ionic components, and the vegetable flavone or other active components contained in the used vegetable extract have the problem of poor water solubility. In order to improve the oil control and anti-seborrheic property, antibacterial property and good moisturizing effect of the essence preparation, the inventor generally adds PCA zinc, but the PCA zinc releases zinc ions, so that the conventional thickener can generate destructive effects such as precipitation and flocculation, and serious consequences such as precipitation, composition precipitation and layering can be directly generated on the essence preparation containing the multi-effect oil control composition, so that the normal stability of the essence preparation is affected. The general conventional thickener is used singly and compounded, and can not meet the requirement of the stability of the multi-effect oil control composition, but can not meet the requirement of the essence preparation of the application on the compatibility of PCA zinc, so that the stability of the multi-effect oil control composition in the essence preparation system needs to be met, and the good compatibility of the multi-effect oil control composition on the PCA zinc becomes a technical problem in the industry.

In order to solve the technical problems that the multi-effect oil control composition has good stability in an essence preparation system and provides good compatibility for PCA zinc, in particular to improve the low-temperature stability of an essence preparation, the inventor finds that the stability requirement of the multi-effect oil control composition in the essence preparation system can be improved by singly or compositely adopting carbomer, sodium polyacrylate, acrylic acid (ester) or C10-30 alkanol acrylate crosslinked polymer, hydroxyethyl cellulose and xanthan gum, but the problem that the compatibility of PCA zinc in the essence preparation system is poor can not be solved, and the inventor particularly finds that the combination of the carbomer fermentation product extract, the xanthan gum and the polyacrylate crosslinked polymer-6 is adopted in experiments, wherein the weight ratio of the carbomer fermentation product extract to the xanthan gum to the polyacrylate crosslinked polymer-6 is 1: (1-3): (2-4), in particular, the weight ratio of the Sphingomonas fermentation product extract, the xanthan gum and the polyacrylate crosslinked polymer-6 is 1:2:3.5, the problem that the multi-effect oil control composition has good stability in an essence preparation system and the compatibility of PCA zinc in the essence preparation system is poor can be solved, and particularly the low-temperature stability of the essence preparation can be improved, and the possible reasons are that the polyacrylate crosslinked polymer-6 and xanthan gum adopted in the essence preparation system have a chain segment structure with a certain length, and after the polyacrylate crosslinked polymer-6 and the xanthan gum are matched with a Sphingomonas fermentation product extract, an interactive network structure can be formed, the multi-effect oil control composition can be stabilized in the interactive network structure, and zinc ions released by PCA zinc and PCA zinc can be wrapped, so that the stability of the essence preparation system is enhanced, and the problems of precipitation, composition precipitation and layering can not occur.

In one embodiment of the invention, the weight ratio of the A component to the B component is (18-46): 1.

In one embodiment of the invention, the a component comprises one or more of water, glycerol polyether-26, poloxamer 407, butylene glycol, 1, 2-pentanediol, glycerol, 1, 2-hexanediol, phytosphingosine, polydimethylsiloxane, caprylic/capric triglyceride, sphingomonas fermentation product extract, polyacrylate cross-linked polymer-6, xanthan gum, p-hydroxyacetophenone, sodium citrate, carbomer, sodium polyacrylate, acrylic acid (esters) type/C10-30 alkanol acrylate cross-linked polymer, hydroxyethyl cellulose.

In a preferred embodiment of the present invention, the A-component comprises, in mass percent, one or more of 50.0-86.0% water, 1.0-5.0% glycerol polyether-26, 0.1-1.0% poloxamer 407, 1.0-5.0% butylene glycol, 1.0-3.0%1, 2-pentanediol, 1.0-5.0% glycerol, 0.1-1.0%1, 2-hexanediol, 0.01-0.2% phytosphingosine, 1.0-5.0% polydimethylsiloxane, 1.0-5.0% caprylic/capric triglyceride, 0.01-1.0% Sphingomonas fermentation product extract, 0.1-1.0% polyacrylate crosslinked polymer-6, 0.1-0.5% xanthan gum, 0.1-0.5% p-hydroxyacetophenone, 0.01-0.2% sodium citrate.

In one embodiment of the application, the B component comprises a combination of one or more of zinc PCA, panthenol, acetylglucosamine, bisabolol, eucalyptus globulus oil, allantoin.

In a preferred embodiment of the present application, the B component comprises, in mass percent, one or more of zinc PCA 0.1-1.0%, panthenol 0.1-3.0%, acetylglucosamine 0.1-1%, salicylic acid 0.05-1%, bisabolol 0.1-0.2%, eucalyptus oil 0.01-0.2%, and allantoin 0.1-0.2%.

The inventor finds that precipitation, composition precipitation and layering of the essence preparation can occur at low temperature in experiments, and in order to improve the low-temperature stability of the essence preparation, the inventor finds that the low-temperature stability of the essence preparation can be improved by matching the component A with the component B, wherein the weight ratio of the component A to the component B is (18-46): 1, the low-temperature resistance of a raw material system of the essence preparation is poor when the component A and the component B are not used in a specific dosage, and the precipitation problem can occur at low temperature, and the possible reason is that the raw material system of the essence preparation is changed due to the fact that the different dosage of the component A and the component B is needed in the application, so that the stability of the multi-effect oil control composition in the essence preparation system is affected.

The third aspect of the invention provides a preparation method of an essence preparation, comprising the following steps:

s1, adding the raw materials in the component A into a batching device for homogenizing and dispersing uniformly, stirring and heating to 75-95 ℃, preserving heat and stirring for 10 minutes, and then cooling to 40-45 ℃;

s2, adding the raw materials in the component B into a batching device, and uniformly stirring and mixing to obtain a mixture a;

s3, cooling the mixture a to 35-40 ℃, adding the multi-effect oil control composition, homogenizing for 1-10 minutes, stirring for 10-30 minutes, screening, and discharging to obtain the essence preparation.

In a preferred embodiment of the present invention, the preparation method of the essence preparation comprises the following steps:

s1, adding the raw materials in the component A into a batching device for homogenizing and dispersing uniformly, stirring and heating to 75-85 ℃, preserving heat and stirring for 10 minutes, and then cooling to 40-45 ℃;

s3, cooling the mixture a to 35-40 ℃, adding the multi-effect oil control composition, homogenizing for 5 minutes, stirring for 20 minutes, screening, and discharging to obtain the essence preparation.

The rotation speed of stirring in the step S3 is 20-80 rpm.

The screening in the step S3 is carried out through a 200-mesh screen.

The fourth aspect of the invention provides a multi-effect oil control composition applied to the technical field of facial masks, creams, emulsions, essences and aqueous cosmetics.

Advantageous effects

1. The multi-effect oil control composition provided by the invention comprises a hundred vein root seed extract, a lotus flower extract, a Egyptian blue water lily flower extract, a citrus fruit extract, an olive fruit extract and a flaxseed extract, and has the obvious synergistic effect of synergistic combination through compounding the raw materials except the targeting effect of the components, so that the effects of inhibiting the activity of sebaceous glands of the skin, inhibiting the proliferation of propionibacterium acnes, limiting the proliferation of malassezia, relieving the skin and the like can be achieved through synergistic combination, the excessive secretion of skin grease and the occurrence of side reactions of the skin can be controlled, the effects of controlling oil, purifying skin, preventing vaccinia and seborrheic dermatitis can be achieved, the problem of facial sebum overflow can be comprehensively solved, the sources of the raw materials are safe, and the application prospect is good.

2. The multi-effect oil control composition provided by the invention can achieve the effects of comprehensively inhibiting excessive sebum secretion of sebaceous glands and reducing sebum synthesis by limiting the proportion of the extracts of the Baimai root seeds, the lotus flower and the Egyptian blue water lily flower.

3. According to the multi-effect oil control composition provided by the invention, the weight ratio of the citrus fruit extract to the olive fruit extract is limited, so that the capacity of inhibiting sebaceous gland cells from secreting grease after the composition is matched with the cranberry seed extract, the lotus flower extract and the Egyptian blue water lily flower extract to be used can be remarkably increased, and an effective antibacterial effect can be achieved, in particular to inhibiting Propionibacterium acnes.

4. According to the invention, the type and the proportion of the thickening agent are limited by adding the specific thickening agent into the essence preparation, and particularly, a thickening system which is used by matching with the Sphingomonas fermentation product extract, xanthan gum and polyacrylate crosslinked polymer-6 can simultaneously meet the stability and compatibility problems of the multi-effect oil control composition and PCA zinc, so that a basic technical support is provided for the application of the composition in multi-effect repair of the essence preparation.

5. The invention can improve the problems of precipitation, composition precipitation and layering of the essence preparation at low temperature by limiting the types of raw materials and the use proportion of the component A and the component B in the essence preparation.

Drawings

FIG. 1 is a graph showing the results of lipid drop test experiments on the essence preparations prepared in examples 1 to 4.

Fig. 2 is a graph of the test effect of examples 1-3 relative to example 4.

FIG. 3 is a graph of human consumer testing results.

Detailed Description

Example 1

The embodiment provides a multi-effect oil control composition, which is prepared from the following raw materials of a hundred-vein root seed extract, a lotus flower extract, a blue water lily flower extract, a citrus fruit extract, an olive fruit extract and a flaxseed extract.

The weight ratio of the Baimai root seed extract to the lotus flower extract to the Egyptian blue water lily flower extract is 4:1:1.

the weight ratio of the citrus fruit extract to the olive fruit extract is 4:1.

the preparation method of the multi-effect oil control composition comprises the following steps: uniformly mixing the Baimai root seed extract, the lotus flower extract, the Egyptian blue water lily flower extract, the citrus fruit extract, the olive fruit extract and the linseed extract to obtain the multi-effect oil control composition.

In a second aspect of the present embodiment, a essence preparation is provided, which comprises, by mass, 2.27% of a multi-effect oil control composition, 94.79% of a component a, and 2.94% of a component b.

The preparation raw materials of the multi-effect oil control composition comprise 1.0% of a Baimaigen seed extract, 0.5% of a lotus flower extract, a Egyptian blue water lily flower extract, 0.52% of a citrus fruit extract, 0.13% of an olive fruit extract and 0.12% of a linseed extract according to 2.27% of the total mass of an essence preparation.

The preparation raw materials of the component A comprise, by weight, 94.79% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.1% of sphingomonas fermentation product extract, 0.35% of polyacrylate crosslinked polymer-6, 0.2% of xanthan gum, 0.2% of p-hydroxyacetophenone, and 0.18% of sodium citrate and the balance of water.

The preparation raw materials of the component B comprise, by weight, 2.94% of total mass of the essence preparation, 0.25% of zinc PCA, 2.0% of panthenol, 0.2% of chitosan, 0.2% of salicylic acid, 0.12% of bisabolol, 0.03% of eucalyptus oil and 0.14% of allantoin.

A third aspect of the present embodiment provides a method for preparing an essence preparation, including the following steps:

s1, adding phytosphingosine in the component A into a proportioning device after the phytosphingosine in the component A is completely dissolved in advance by adopting caprylic/capric triglyceride, stirring and heating to 80 ℃, homogenizing and dispersing uniformly, keeping the temperature and stirring for 10 minutes, and then cooling to 40 ℃;

S3, cooling the mixture a to 35 ℃, adding the multi-effect oil control composition, homogenizing for 5 minutes, stirring for 20 minutes, screening, and discharging to obtain the essence preparation.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The fourth aspect of the present embodiment provides a multi-effect oil control composition applied to the technical field of facial masks, creams, emulsions, essences and aqueous cosmetics.

The manufacturer of the Baimai root seed extract is Shanghai Jia Kai biotechnology Co., ltd, and the model is Jiayanjing (Smopore LC).

The mass ratio of the lotus extract to the blue water lily flower extract in the lotus extract and the Egypt blue water lily flower extract is 1:1, the lotus extract and the Egypt blue water lily flower extract are mixed together to be used as a purchase raw material sample, and the purchase manufacturer is PROVITAL, S.A. U, and the model is NELUPURETM.

The citrus fruit extract is purchased from Shanghai Jia Kai Biotechnology Co., ltd, and is available in the form of Yueshenrv CR.

The olive fruit extract has a purchase manufacturer of INDENASAS and model OLIVE POLYPHENOLIC DRY EXTRACT

The flaxseed extract is purchased from Ashland LLC, and is of the type lipigenine ^TM biofunctional。

The Sphingomonas fermentation product extract is purchased from Lubrizol Advanced Materials, inc. model Diutan Gum.

The purchase manufacturer of the xanthan gum is CP Kelco, and the model isCG-SFT。

The polyacrylate crosslinked polymer-6 has a manufacturer of SEPPIC and a model of SEPIMAX ZEN ^TM 。

The glycerolyether-26 is purchased from Vantage Specialty Ingredients, inc. under the model LIPONIC EG-1.

The poloxamer 407 has the manufacturer of Basiff (China) Limited and the model of Plurace F127 NF Prill.

The phytosphingosine is purchased from Chongqing Zhi He biomedical Co., ltd.

The polydimethylsiloxane has a manufacturer of Wacker Chemicals Silicones (ZJG) and a model number ofDM 350。

The manufacturer of the caprylic/capric triglyceride is InterMed Esters Sdn.Bhd. Model is IMEX MCT60/40.

The manufacturer of the p-hydroxyacetophenone is Shanghai Zibang biomedical Co., ltd, and the model is BINPRES NYX.

The sodium citrate is purchased from Weifang Yingxuan Utility company, and the model is sodium citrate.

The manufacturer of the 1, 2-pentanediol is Lang Cheng Huaxue (China) limited company, and the model is Purolan PD-LO N.

The manufacturer of the 1, 2-hexanediol is OSAKA ORGANIC CHEMICAL INDUSTRY LTD, and the model is KMO-6.

The purchase manufacturer of the PCA zinc is Shanghai Huixin biotechnology Co., ltd, and the model is PCA Zn (pyrrolidone zinc carboxylate).

The manufacturer of the panthenol is Hangzhou Xinfu technology Co., ltd, and the model is D-panthenol (G).

The manufacturer of the chitosan amine is Jiangsu Jiushoutang biological product limited company, and the model is N-Acetyl-D-Glucosamine.

The manufacturer of the salicylic acid is Merck KGaA, and the model is RonaCare Salicylic Acid Extra pure.

The manufacturer of the Bisabolol is Atina Ind, stria e Com rcio de Ativos Naturais Ltda, and the model is (-) -Alpha-Bisabolol 85%.

The manufacturer of the eucalyptus oil is CETOLE BIO-TECH, and the model is Pure Eucalyptus oil% and 80% of the eucalyptus oil.

The manufacturer of allantoin is Ashland LLC, and the model is ALLANTOIN (ISP).

Example 2

the weight ratio of the citrus fruit extract to the olive fruit extract is 10:1.

The second aspect of the embodiment provides an essence preparation, which comprises, by mass, 2.15% of a multi-effect oil control composition, 94.91% of a component A and 2.94% of a component B.

The preparation raw materials of the multi-effect oil control composition comprise 1.0% of a Baimaigen seed extract, 0.5% of a lotus flower extract/Egyptian blue water lily flower extract, 0.5% of a citrus fruit extract, 0.05% of an olive fruit extract and 0.1% of a linseed extract according to 2.15% of the total mass of an essence preparation.

The preparation raw materials of the component A comprise 2.8% of glycerin polyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.1% of sphingomonas fermentation product extract, 0.35% of polyacrylate crosslinked polymer-6, 0.2% of xanthan gum, 0.2% of p-hydroxyacetophenone, 0.18% of sodium citrate and the balance of water according to the 94.91% of the total mass of the essence preparation.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Example 3

The embodiment provides a multi-effect oil control composition, which is prepared from the following raw materials of a hundred-vein root seed extract, a lotus flower extract, a blue water lily flower extract, a citrus fruit extract and a linseed extract.

The weight ratio of the Baimai root seed extract to the lotus flower extract to the Egyptian blue water lily flower extract is 3:1:1.

the preparation method of the multi-effect oil control composition comprises the following steps: uniformly mixing the Baimai root seed extract, the lotus flower extract, the Egyptian blue water lily flower extract, the citrus fruit extract and the linseed extract to obtain the multi-effect oil control composition.

The second aspect of the embodiment provides an essence preparation, which comprises, by mass, 2.8% of a multi-effect oil control composition, 94.26% of a component A and 2.94% of a component B.

The preparation raw materials of the multi-effect oil control composition comprise 1.5% of the extract of the Baimaigen seeds, 1% of the extract of lotus flower/Egypt blue water lily flowers, 0.2% of the extract of citrus fruits and 0.1% of the extract of flaxseed according to 2.8% of the total mass of the essence preparation.

The preparation raw materials of the component A comprise 2.8% of glycerin polyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.1% of sphingomonas fermentation product extract, 0.35% of polyacrylate crosslinked polymer-6, 0.2% of xanthan gum, 0.2% of p-hydroxyacetophenone, 0.18% of sodium citrate and the balance of water according to the 94.26% of the total mass of the essence preparation.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Example 4

The embodiment provides a multi-effect oil control composition, which is prepared from the following raw materials of a hundred-vein root seed extract, a lotus flower extract, a Egyptian blue water lily flower extract and an olive fruit extract.

the preparation method of the multi-effect oil control composition comprises the following steps: uniformly mixing the extract of the seed of the common macrocephala, the extract of the lotus flower, the extract of the flower of the Egyptian blue water lily and the extract of the olive fruit to obtain the multi-effect oil control composition.

The second aspect of the embodiment provides an essence preparation, which comprises, by mass, 1.6% of a multi-effect oil control composition, 95.46% of a component A and 2.94% of a component B.

The preparation raw materials of the multi-effect oil control composition comprise 1.0% of the extract of the seed of the common cranberry, 0.5% of the extract of lotus flower/Egypt blue water lily flower and 0.1% of the extract of olive fruits according to 1.6% of the total mass of the essence preparation.

The preparation raw materials of the component A comprise, by weight, 95.46% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.1% of sphingomonas fermentation product extract, 0.35% of polyacrylate crosslinked polymer-6, 0.2% of xanthan gum, 0.2% of p-hydroxyacetophenone, and 0.18% of sodium citrate and the balance of water.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Example 5

The weight ratio of the Baimai root seed extract to the lotus flower extract to the Egyptian blue water lily flower extract is 2:1:1.

the weight ratio of the citrus fruit extract to the olive fruit extract is 2:1.

The second aspect of the embodiment provides an essence preparation, which comprises, by mass, 6% of a multi-effect oil control composition, 90% of an A component and 4%B components.

The preparation raw materials of the multi-effect oil control composition comprise, by weight, 6% of the total mass of the essence preparation, 2.0% of a Baimaigen seed extract, 2.0% of a lotus flower extract/Egypt blue water lily flower extract, 1.0% of a citrus fruit extract, 0.5% of an olive fruit extract and 0.5% of a linseed extract.

The preparation raw materials of the component A comprise, by 90% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.05% of Sphingomonas fermentation product extract, 0.20% of polyacrylate crosslinked polymer-6, 0.15% of xanthan gum, 0.2% of p-hydroxyacetophenone, and 0.20% of sodium citrate and the balance of water.

The preparation raw materials of the component B comprise, by weight, 4% of the total mass of the essence preparation, 0.5% of zinc PCA, 2.0% of panthenol, 0.5% of chitosan, 0.4% of salicylic acid, 0.2% of bisabolol, 0.2% of eucalyptus oil and 0.2% of allantoin.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Example 6

the weight ratio of the citrus fruit extract to the olive fruit extract is 4:1.

The second aspect of the embodiment provides an essence preparation, which comprises, by mass, 2.27% of a multi-effect oil control composition, 94.69% of a component A and 3.04% of a component B.

The preparation raw materials of the multi-effect oil control composition comprise 1.0% of a Baimaigen seed extract, 0.5% of a lotus flower extract/Egyptian blue water lily flower extract, 0.52% of a citrus fruit extract, 0.13% of an olive fruit extract and 0.12% of a linseed extract according to 2.27% of the total mass of an essence preparation.

The preparation raw materials of the component A comprise, by weight, 94.69% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.2% of xanthan gum, 0.2% of p-hydroxyacetophenone, 0.18% of sodium citrate and the balance of water.

The preparation raw materials of the component B comprise 2.35% of panthenol, 0.2% of chitosan amine, 0.2% of salicylic acid, 0.12% of bisabolol, 0.03% of eucalyptus oil and 0.14% of allantoin according to the total mass of the essence preparation.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Example 7

The weight ratio of the citrus fruit extract to the olive fruit extract is 4:1.

The preparation raw materials of the component A comprise, by weight, 94.79% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.3% of carbomer, 0.2% of xanthan gum, 0.2% of p-hydroxyacetophenone, 0.18% of sodium citrate and the balance of water.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

The carbomer has a manufacturer of Lubrizol Advanced Materials, inc. model numberUltrez 30Polymer。

Example 8

the weight ratio of the citrus fruit extract to the olive fruit extract is 4:1.

The preparation raw materials of the component A comprise, by weight, 94.79% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.3% of sodium polyacrylate, 0.2% of xanthan gum, 0.2% of p-hydroxyacetophenone, 0.18% of sodium citrate and the balance of water.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

The manufacturer of the sodium polyacrylate is Basoff and the model is Cosmedia SP.

Example 9

the weight ratio of the citrus fruit extract to the olive fruit extract is 4:1.

The preparation raw materials of the component A comprise, by weight, 94.79% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.3% of acrylic acid (esters) type/C10-30 alkanol acrylate crosslinked polymer, 0.3% of polyacrylate crosslinked polymer-6, 0.2% of p-hydroxyacetophenone, and 0.18% of sodium citrate and the balance of water.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

The acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer has a manufacturer of brizol Advanced Materials, inc. and a model of PEMULEN ^TM TR-1Polymer。

Example 10

the weight ratio of the citrus fruit extract to the olive fruit extract is 4:1.

The preparation raw materials of the component A comprise, by weight, 94.79% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.3% of hydroxyethyl cellulose, 0.2% of p-hydroxyacetophenone, 0.18% of sodium citrate and the balance of water.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Example 11

the weight ratio of the citrus fruit extract to the olive fruit extract is 4:1.

The preparation raw materials of the component A comprise, by weight, 94.79% of the total mass of the essence preparation, 2.8% of glycerolyether-26, 0.2% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 2.5% of polydimethylsiloxane, 1.5% of caprylic/capric triglyceride, 0.05% of sphingomonas fermentation product extract, 0.1% of polyacrylate crosslinked polymer-6, 0.5% of xanthan gum, 0.2% of p-hydroxyacetophenone, and 0.18% of sodium citrate and the balance of water.

The rotation speed of stirring in the step S3 is 40 revolutions per minute.

The screening in the step S3 is carried out through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Example 12

the weight ratio of the citrus fruit extract to the olive fruit extract is 4:1.

In a second aspect of the present embodiment, a essence preparation is provided, which comprises, by mass, 2.27% of a multi-effect oil control composition and 97.73% of a component.

The preparation raw materials of the component A comprise, by weight, 97.73% of the total mass of the essence preparation, 3.0% of glycerolyether-26, 0.5% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 3.5% of polydimethylsiloxane, 2.0% of caprylic/capric triglyceride, 0.1% of sphingomonas fermentation product extract, 0.35% of polyacrylate crosslinked polymer-6, 0.2% of xanthan gum, 0.4% of p-hydroxyacetophenone, and 0.05% of sodium citrate and the balance of water.

S2, adding the multi-effect oil control composition into a batching device, homogenizing for 5 minutes, stirring for 20 minutes, screening, and discharging to obtain the essence preparation.

The stirring speed in the step S2 is 40 revolutions per minute.

The screening in S2 is carried out by screening through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Example 13

The weight ratio of the Baimai root seed extract to the lotus flower extract to the Egyptian blue water lily flower extract is 1:1:1.

the weight ratio of the citrus fruit extract to the olive fruit extract is 3:1.

In a second aspect, the embodiment provides an essence preparation, which comprises, by mass, 1.3% of a multi-effect oil control composition and 98.7% of a component.

The preparation raw materials of the multi-effect oil control composition comprise, by 1.3% of the total mass of the essence preparation, 0.5% of a Baimaigen seed extract, 0.25% of a lotus flower extract/Egypt blue water lily flower extract, 0.3% of a citrus fruit extract, 0.1% of an olive fruit extract and 0.15% of a linseed extract.

The preparation raw materials of the component A comprise, by weight, 98.7% of the total mass of the essence preparation, 3.0% of glycerolyether-26, 0.5% of poloxamer 407, 1.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.5% of 1, 2-hexanediol, 0.02% of phytosphingosine, 3.5% of polydimethylsiloxane, 2.0% of caprylic/capric triglyceride, 0.1% of sphingomonas fermentation product extract, 0.35% of polyacrylate crosslinked polymer-6, 0.2% of xanthan gum, 0.37% of p-hydroxyacetophenone, and 0.05% of sodium citrate and the balance of water.

The stirring speed in the step S2 is 40 revolutions per minute.

The screening in S2 is carried out by screening through a 200-mesh screen.

The raw materials were purchased from the same manufacturers as in example 1.

Performance testing

1. Centrifugal stability

The essence preparations prepared in examples 1 to 13 were tested for flocculation, sedimentation and color delamination of the plant composition by centrifugal acceleration test, and the test results are shown in Table 1.

TABLE 1

From the test results in table 1, it can be seen that the presence of zinc PCA can affect the stability of the multi-effect oil control composition, and by defining the specific thickener usage type and the usage ratio, the stability of the multi-effect oil control composition in the essence formulation can be improved, and the compatibility problem of the zinc PCA in the essence formulation can also be improved.

2. Temperature stability

The essence preparations prepared in examples 1 to 6 and examples 12 to 13 were subjected to a high and low temperature destructive test (30 days, 60 days and 90 days at-15 ℃ C., 42 ℃ C., respectively) to examine whether the composition was precipitated, and the test results are shown in Table 2.

TABLE 2

As can be seen from the test results in table 2, the low temperature stability of the multi-effect oil control composition in the essence formulation can be improved after the component a and the component B are used together according to the limited use ratio.

3. Lipid drop test experiment

Sebaceous cells synthesize large amounts of lipids and secrete them out of the cell in the form of lipid droplets, affecting cellular function.

The test method comprises the following steps: the essence preparation prepared in examples 1-4 was screened out by cytotoxicity test to a safe concentration of 0.000125%, an in vitro oil secretion model was established based on immortalized human sebaceous gland cell SZ95, and after lipid droplets were formed, the sebum secretion inhibition ability of the test compound was evaluated by analyzing the oil secretion amount after administration treatment using oil red O staining.

And (3) result judgment: the oil control effect of the essence preparation is verified by analyzing the significance of the relative IOD value before and after administration. Statistical analysis was performed in t-test, with significance expressed as x, P-value <0.05 as x, and P-value <0.01 as x, for the sample and blank groups. The inhibition ratios of examples 1, 2 and 3 relative to example 4 were evaluated by using example 4 as a standard, and the test results are shown in table 3, fig. 1 and fig. 2.

TABLE 3 Table 3

As can be seen from the results of Table 3 and FIG. 1, the in vitro ability of the present invention to inhibit secretion of oil from sebaceous gland cells is weaker, while the effects of examples 1 to 3 are more remarkable than those of example 4, showing a great difference, and having a good in vitro ability to inhibit secretion of oil from sebaceous gland cells. The results show that the scientific compounding of the citrus fruit extract, the olive fruit extract and the linseed extract in the multi-effect oil control composition can obviously increase the capacity of the lotus seed extract, the lotus extract/the Egypt blue water lily flower extract for inhibiting the secretion of grease by sebaceous gland cells.

As can be seen from fig. 2, examples 1 to 3 are different in the ability to inhibit the secretion of grease by sebaceous gland cells from example 4, and examples 1 and 3 are significantly stronger than example 2 by the difference in the ratio of citrus fruit extract, olive fruit extract, flaxseed extract, and the inhibition ability is significantly different from that of citrus fruit extract, olive fruit extract, flaxseed extract, and the inhibition ability is different from that of the amount of citrus fruit extract, olive fruit extract, flaxseed extract.

4. Propionibacterium acnes inhibition experiments

The test method comprises the following steps: the test uses a minimum inhibitory concentration test, a pre-added bacteria liquid pouring plate method and a punching method to measure the diameter of a bacteriostasis ring on a bacteria plate to evaluate the inhibition of the sample on acne Capacity of propionibacteria. Injecting activated bacterial liquid into solid culture medium cooled at about 60deg.C to obtain final concentration of 0.5-1.0X10 ⁷ CFU/ml, pour the plate after mixing well, horizontally rest. Punching holes on the prepared fungus flat plate by using a stainless steel round tube, 1-4 holes per dish, and carefully picking out small pieces of culture medium in the holes. After 100 μl of the sample to be tested was added to each well, the sample was allowed to diffuse at 4℃for 2 hours, and then anaerobic culture was carried out in an incubator at 37℃for 72 hours, the evaluation criteria are shown in Table 4, and the test results are shown in Table 5.

Test sample: the concentrate formulations prepared in examples 1-4 were tested at 100% concentration with at least 3 duplicate wells per concentrate example.

TABLE 4 Table 4

TABLE 5

From the results in table 5, it can be seen that example 1 and example 2 have inhibitory effects on propionibacterium acnes, both of which are similar in inhibitory ability and are moderately sensitive (++); examples 3 and 4 did not inhibit propionibacterium acnes, demonstrating that none of the essence formulations prepared when the multi-effect oil control composition of the present invention lacked olive fruit extract or citrus fruit extract achieved bacteriostatic effect; meanwhile, the implementation 3 also shows that even though the flaxseed extract has theoretical support for promoting antibacterial peptide, the flaxseed extract has no effect of actually inhibiting propionibacterium acnes; the multiple-effect oil control composition can achieve synergistic effect only when the components of the multiple-effect oil control composition are matched according to a specific proportion, and plays a role in inhibiting Propionibacterium acnes.

5. Test of the subject:

30 people with oily sensitivity and vigorous grease at forehead parts and easy acne on faces are selected as subjects, and the subjects directly use the essence preparation prepared in the example 1 in the morning and evening according to the use characteristics and the method noted by the cosmetic product labels. The user was observed for adverse reactions every week, and the subject self-evaluation roll was completed on days 3, 7, and 14, thereby obtaining the use effect of the essence preparation prepared in example 1 on the human body, and the test results are shown in fig. 3 and table 6.

And (3) result judgment: the following recognition degree result statistical method after the essence preparation is used: counting the number of people with identity degree of N being more than or equal to 4; statistical analysis using binomial distribution, with a satisfaction expectation set to 0.5 and a significance level of α=0.05, if the P value is less than 0.050, indicates significant differences.

TABLE 6

As can be seen from the experimental results shown in Table 6 and FIG. 3, 30 subjects with oily sensitivity and vigorous forehead portion fat, and face with easy acne and vaccinia have the effects of controlling and relieving after using the essence preparation prepared in example 1 for 14 days. In the aspect of oil control, compared with data of 3 days, 7 days and 14 days, the data of the oil control test effect show an ascending trend, and the data of 7 days and 14 days are obviously different from the set satisfactory expected value, and are presumed to be related to the conditioning effect of active substances such as lotus extract, egyptian water lily flower extract, citrus fruit extract, olive fruit extract and linseed extract containing the hundred-pulse root seed extract in the essence preparation in skin, wherein the conditioning is a progressive process. In terms of relief, the data obtained from the tests on 3 days, 7 days, and 14 days using the essence formulation were significantly different from the set satisfactory expected values, indicating that the essence formulation prepared in example 1 was excellent in terms of relief.

As can be seen from the test results, the subject was able to feel skin changes on the skin surface before and after using the essence preparation prepared in example 1; and the subjects who used for 7 days and 14 days can feel that the skin becomes fine and smooth and the facial gloss is reduced after the use, the skin is obviously different from the set satisfactory expected value, and the subjects do not have adverse reactions after the use for 14 days.

In conclusion, the multi-effect oil control composition provided by the application is reasonably prepared by using the extracts of the cranberry seeds, the lotus flower extract, the Egyptian blue water lily flower extract, the citrus fruit extract, the olive fruit extract and the flaxseed extract through multiple experimental researches, and plays a synergistic effect after the extracts of the cranberry seeds, the lotus flower extract, the Egyptian blue water lily flower extract, the citrus fruit extract, the olive fruit extract and the flaxseed extract are matched for use, and the prepared multi-effect oil control composition is applied as a skin care product, so that the skin care composition is safe and non-irritating, and the antibacterial and soothing effects of the skin care product are improved.

Claims

1. The multi-effect oil control composition is characterized in that the preparation raw materials comprise a hundred-vein root seed extract, a lotus flower extract, a blue water lily flower extract, a citrus fruit extract, an olive fruit extract and a linseed extract;

The weight ratio of the citrus fruit extract to the olive fruit extract is (1-10): 1, a step of;

the weight ratio of the citrus fruit extract to the flaxseed extract is (1.5-4.5): 1, a step of;

the type of the Baimai root seed extract is Jiayanjing;

the lotus extract and the Egyptian blue water lily flower extract are mixed together to be used as a purchase raw material sample, and the model is NELUPURETM;

the model of the olive fruit extract is OLIVE POLYPHENOLIC DRY EXTRACT OPEXTAN percent;

the flaxseed extract is lipigenine ™ biof actional;

the citrus fruit extract is skin-nourishing.

2. The multi-effect oil control composition of claim 1, wherein the ratio by weight of the extract of the seeds of the cranberry, the extract of the lotus flower, the extract of the gyptian blue water lily flower is (1-5): 1:1.

3. an essence preparation containing the multi-effect oil control composition described in 1 or 2, which is characterized in that the preparation raw materials comprise 0.5-11% of the multi-effect oil control composition, a component A and a component B in percentage by mass; the component A comprises a thickener and a humectant, and the component B comprises a skin conditioning agent; the weight ratio of the component A to the component B is (18-46) 1;

The component B comprises one or more of PCA zinc, panthenol, acetylglucosamine, bisabolol, eucalyptus oil and allantoin;

the thickener comprises a Sphingomonas fermentation product extract, xanthan gum and polyacrylate crosslinked polymer-6, wherein the weight ratio of the Sphingomonas fermentation product extract to the xanthan gum to the polyacrylate crosslinked polymer-6 is 1: (1-3): (2-4).

4. The concentrate formulation of claim 3, wherein the a component comprises one or more of water, glycerol polyether-26, poloxamer 407, butylene glycol, 1, 2-pentanediol, glycerol, 1, 2-hexanediol, phytosphingosine, polydimethylsiloxane, caprylic/capric triglyceride, sphingomonas fermentation product extract, polyacrylate crosslinked polymer-6, xanthan gum, p-hydroxyacetophenone, sodium citrate, carbomer, sodium polyacrylate, acrylic acid (ester) type/C10-30 alkanol acrylate crosslinked polymer, hydroxyethyl cellulose.

5. A process for the preparation of a concentrate formulation comprising a multi-effect oil control composition according to claim 3 or 4, comprising the steps of:

S1, adding the raw materials in the component A into a batching device for homogenizing and dispersing uniformly, stirring and heating to 75-95 ℃, preserving heat and stirring for 5-20 minutes, and cooling to 40-45 ℃;

6. The application of the multi-effect oil control composition according to claim 1 or 2 in the technical field of preparing face masks, creams, emulsions, essences and aqueous cosmetics.