CN107753582B - Composition for treating acne, external gel and preparation method thereof - Google Patents
Composition for treating acne, external gel and preparation method thereof Download PDFInfo
- Publication number
- CN107753582B CN107753582B CN201711175234.XA CN201711175234A CN107753582B CN 107753582 B CN107753582 B CN 107753582B CN 201711175234 A CN201711175234 A CN 201711175234A CN 107753582 B CN107753582 B CN 107753582B
- Authority
- CN
- China
- Prior art keywords
- composition
- polysaccharide
- treating acne
- gel
- bletilla striata
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composition for treating acne, which comprises the following components in percentage by mass: 29-33% of peony seed oil, 48-54% of bletilla striata polysaccharide and 15-19% of aloe polysaccharide, wherein the sum of the mass percentages of the components is 100%. The invention also discloses an external gel of the composition and a preparation method thereof. The invention is based on the compatibility theory of traditional Chinese medicine, selects peony seed oil, bletilla striata polysaccharide and aloe polysaccharide as raw materials, obtains the composition capable of treating acne, obtains the preparation thereof, namely the nanoemulsion gel which has the characteristics of high transdermal efficiency and delayed release, solves the defects of skin irritation and drug resistance existing in the existing local administration of acne, and has the characteristics of safety and good non-toxic effect; meanwhile, the comprehensive utilization of oil peony, bletilla striata and aloe resources is improved, the industrial chain is prolonged, and certain social benefits are generated.
Description
Technical Field
The invention belongs to the technical field of medicines, relates to a composition for treating acne, and also relates to an external gel of the composition and a preparation method of the external gel.
Background
Acne, commonly known as whelk and comedo, is a common disease in dermatology, and about 85% of people in the adolescence suffer from acne with different degrees, which affects the appearance of patients on one hand and even seriously affects the psychology on the other hand. Modern research has shown that acne is caused by a variety of causes including sex hormone secretion, microbial infection, inflammatory lesions, and immune disorders. The treatment scheme mainly adopts oral administration and local administration, wherein the local administration mainly adopts tretinoin medicaments and antibacterial medicaments, and although the skin injury of a patient is obviously reduced, the problems of skin irritation and drug resistance exist.
The natural components from the traditional Chinese medicine have the dual advantages of both efficacy and safety. The peony seed oil is vegetable oil obtained by processing oil peony seeds, the oil yield is 27-32%, the proportion of unsaturated fatty acid in the total oil is 82.81-93.23%, the content of alpha-linolenic acid (32-67%) is obviously higher than that of other common edible vegetable oil, and in addition, the peony seed oil contains active ingredients such as oleanolic acid, trans-resveratrol, paeoniflorin, vitamin E and the like, is a natural vegetable oil resource and is approved by the state as a new resource food. Modern researches show that the peony seed oil has the effects of sun screening, whitening, radiation resistance, oxidation resistance and inflammation resistance besides unique nutrition and health care functions, and the physiological activity of the peony seed oil provides a basis for the research and development of external preparations of the peony seed oil. The bletilla striata polysaccharide is a water-soluble high-molecular polysaccharide extracted, separated and purified from bletilla striata, has pharmacological activities such as anti-inflammation, tissue repair and the like, is safe and non-toxic, and has good biological adhesiveness. It has been used in the fields of medicine and cosmetics because of its pharmacological activity and adjuvant properties. Aloe polysaccharide is the main active component of aloe, and has physiological activities of resisting bacteria, inflammation, oxidation and radiation, whitening and moisturizing, etc., and has been widely used in the cosmetic industry due to its unique moisturizing property. Based on the research, the peony seed oil, the bletilla striata polysaccharide and the bletilla striata polysaccharide are selected to be compatible for use, and on one hand, the three components have synergistic effect in whitening, anti-inflammation and antioxidation aspects; on the other hand, the three have the property of auxiliary materials in preparation of the ring joint.
The nano-emulsion gel is a transparent and stable colloid with a reticular structure formed by mixing the medicament, proper oil, emulsifier assistant emulsifier and water according to a certain proportion to prepare nano-emulsion and then adding water-soluble high polymer materials such as carbomer and the like. The nano-emulsion and the gel have the advantages of both nano-emulsion and gel, have the characteristics of high transdermal efficiency and delayed release, are suitable for topical treatment of skin, and can be used as a novel transdermal drug delivery carrier of drugs.
Disclosure of Invention
The invention aims to provide a composition for treating acne, which solves the problems of skin irritation and drug resistance existing in local administration in an acne treatment scheme.
Another object of the present invention is to provide a gel for external use of the above composition.
The third purpose of the invention is to provide a preparation method of the external gel of the composition.
The invention adopts the technical scheme that a composition for treating acne comprises the following components in percentage by mass: 29-33% of peony seed oil, 48-54% of bletilla striata polysaccharide and 15-19% of aloe polysaccharide, wherein the sum of the mass percentages of the components is 100%.
The invention adopts another technical scheme that the external gel of the composition for treating acne consists of the following components in percentage by mass: 47-49% of a composition for treating acne, 29-31% of PEG-40 hydrogenated castor oil, 4-6% of polyethylene glycol 400and 15-17% of carbomer, wherein the sum of the mass percentages of the components is 100%.
The third technical scheme adopted by the invention is that the preparation method of the external gel of the composition for treating acne is implemented according to the following steps:
and 4, adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, heating for reaction, stirring and dripping into the nanoemulsion obtained in the step 3, and then homogenizing under high pressure to obtain the nanoemulsion gel.
The present invention is also characterized in that,
the stirring speed is 25-35 r/min.
The mass-to-volume ratio of the mixture of the peony seed oil and the purified water in the step 2 is 1: 30-36 g/ml.
In the high-speed shearing emulsification process in the step 3, the rotating speed is 9000-10000 r/min, and the emulsification time is 25-35 min; homogenizing for 3-6 times under the high-pressure homogenizing pressure of 800-900 bar; the ultrasonic treatment power is 250-350W, and the time is 15-25 min.
In the step 4, the mass-to-volume ratio of the bletilla striata polysaccharide, the aloe polysaccharide, the carbomer and the purified water is 1: 90-110 g/ml.
The heating reaction in the step 4 specifically comprises the following steps: adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, and heating and reacting for 4-6 hours at the temperature of 75-85 ℃.
And 4, after the heating reaction in the step 4, adjusting the pH value of the reactant to 7.2-7.6 by using 18-22% triethanolamine.
And 4, homogenizing for 2-4 times at a high-pressure homogenizing pressure of 400-600 bar.
The invention has the beneficial effects that on the basis of the compatibility theory of traditional Chinese medicines, the peony seed oil, the bletilla striata polysaccharide and the aloe polysaccharide are selected as raw materials to obtain the composition capable of treating acne, and the preparation, namely the nanoemulsion gel integrating the characteristics of high transdermal efficiency and delayed release, is obtained, overcomes the defects of skin irritation and drug resistance existing in the existing local administration of acne, and has the characteristics of safety and good non-toxic effect; meanwhile, the comprehensive utilization of oil peony, bletilla striata and aloe resources is improved, the industrial chain is prolonged, and certain social benefits are generated.
Drawings
FIG. 1 is a micrograph of the nanoemulsion obtained in step 7;
FIG. 2 is a graph of the particle size of the nanoemulsion obtained in step 7;
FIG. 3 is a potential diagram of the nanoemulsion obtained in step 7;
FIG. 4 is a UV absorption spectrum of the nanoemulsion gel prepared by the present invention.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.
The invention provides a composition for treating acne, which comprises the following components in percentage by mass: 29-33% of peony seed oil, 48-54% of bletilla striata polysaccharide and 15-19% of aloe polysaccharide, wherein the sum of the mass percentages of the components is 100%.
The bletilla striata polysaccharide and the aloe polysaccharide are commercially available finished products and are produced by Xian Haoyuan biotechnology limited company.
A topical gel of composition for treating acne comprises the following components by mass percent: 47-49% of a composition for treating acne, 29-31% of PEG-40 hydrogenated castor oil, 4-6% of polyethylene glycol 400and 15-17% of carbomer, wherein the sum of the mass percentages of the components is 100%.
The preparation method of the external gel of the composition for treating acne is specifically implemented according to the following steps:
And 2, uniformly mixing the PEG-40 hydrogenated castor oil and the polyethylene glycol 400 in a constant-temperature magnetic stirrer at the rotating speed of 25-35 r/min for 3-6 min, and marking as a material I.
And 3, dropwise adding the peony seed oil into the material I, and recording as a material II when the rotating speed of the constant-temperature magnetic stirrer is 25-35 r/min.
And 4, dropwise adding the purified water into the material II according to the mass-volume ratio of 1: 30-36 g/mL of the material II to the purified water, and marking as a material III.
And 5, emulsifying the material III in a high-shear homogenizing and emulsifying machine for 25-35 min at the rotating speed of 9000-10000 r/min, and marking as a material IV.
And 6, homogenizing the material IV for 3-6 times by a high-pressure homogenizer at the homogenizing pressure of 800-900 bar, and marking as a material V.
And 7, carrying out ultrasonic treatment on the material V for 15-25 min, wherein the ultrasonic power is 250-350W, and marking as a material VI.
And 8, adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, heating to 75-85 ℃ to react for 4-6 h, and then adjusting the pH to 7.2-7.6 by using 18-22% triethanolamine to obtain a material VII, wherein the mass volume ratio of the bletilla striata polysaccharide to the aloe polysaccharide to the carbomer to the purified water is 1: 90-110 g/ml.
And 9, slowly dripping the material VI into the material VII, homogenizing for 2-4 times by a high-pressure homogenizer at the homogenizing pressure of 400-600 bar by using a constant-temperature magnetic stirrer at the rotating speed of 25-35 r/min to obtain the nanoemulsion gel.
According to the invention, safe, effective and nontoxic natural active sites are searched from traditional Chinese medicines, and peony seed oil, bletilla striata polysaccharide and aloe polysaccharide which are similar in pharmacological activity and different in action mechanism are selected as a medicinal composition for treating acne on the basis of the compatibility theory of traditional Chinese medicines, wherein the peony seed oil has the effects of resisting inflammation, resisting oxidation, whitening and preventing sunburn; the bletilla striata polysaccharide has anti-inflammatory and tissue repair effects; the aloe polysaccharide has the functions of resisting inflammation, whitening and moisturizing, and the compatibility of the three components has the synergistic effect on the treatment of the acne. Meanwhile, the nano-emulsion gel is prepared by the raw materials through a two-phase alternative dropping method-high-speed shearing emulsification method-high-pressure homogenization combined technology, has the characteristics of high transdermal efficiency and delayed release, and is suitable for topical skin treatment. The invention provides a new idea for selecting the medicine in the external acne treatment preparation.
In addition, the invention provides technical support for comprehensive utilization of oil peony, bletilla striata and aloe resources, and prolongs the industrial chain of the oil peony, bletilla striata and aloe resources.
The material VI obtained in the step 7 is nano-emulsion, the appearance of the nano-emulsion is in a semitransparent state, and the nano-emulsion shows light blue opalescence. Observed by an inverted microscope, as shown in figure 1, the emulsion droplets are uniform in size, circular in shape and free of obvious adhesion phenomenon, and various indexes of appearance inspection meet requirements.
The particle size, Zeta potential and PDI of the nano-emulsion were measured by a Malvern instrument, the particle size distribution is shown in FIG. 2, and the potential distribution is shown in FIG. 3. The average particle diameter is 88.44 + -1.74 nm, the Zeta potential is-18.6 + -2.8 mV, and the PDI is 0.538 + -0.084. The results show that: the particle size distribution of the nano-emulsion meets the quality requirement, and the potential is more than 15mV, which indicates that the system meets the stability requirement.
The stability of the nanoemulsion is inspected: after being stored for 15 days at room temperature (25 ℃), the appearance is still semitransparent, and the product is blue opalescent without instability phenomena such as layering and the like; after being stored for 24 hours at high temperature (60 ℃), the appearance is relatively transparent, and blue opalescence is realized, and unstable phenomena such as layering and emulsion breaking are avoided, but unstable phenomena such as layering occur after 15 days; after being stored for 24 hours at low temperature (-4 ℃), the appearance is in a semitransparent state and shows blue opalescence, and unstable phenomena such as layering and emulsion breaking are avoided, but after 15 days, the appearance becomes slightly turbid, the blue opalescence is not obvious, and the unstable phenomena such as slight layering are caused; after being centrifuged for 2.0h under the condition of high-speed centrifugation (3500r/min, 30min), the appearance still presents a semitransparent state, and presents blue opalescence, and unstable phenomena such as demulsification and delamination are avoided. The above results show that: the nanoemulsion is suitable for being stored at the temperature of-4 ℃ as a preparation intermediate.
And (3) observing the stability of the nanoemulsion gel obtained in the step 9: the nano-emulsion gel is stored for 24 hours at low temperature (-4 ℃) and high temperature (60 ℃), is taken out and is recovered to room temperature, the appearance is found to be uniform and fine, the instability phenomena such as layering oil-water separation and the like are avoided, the change of pH and viscosity is small, and the obtained nano-emulsion gel has good stability.
In addition, the ultraviolet spectrophotometry is adopted to carry out quantitative determination on the nanoemulsion gel, the absorption wavelength is shown in figure 4, and the result shows that: the content of the peony seed oil in the nano-emulsion gel is 5.23 +/-0.11 mg/g calculated by the peony seed oil, and the result provides data reference for establishing the quality standard of the preparation.
The encapsulation efficiency of the nano-emulsion gel is measured, and is 92.10 +/-0.53 percent based on the peony seed oil. The results show that: the encapsulation rate of the peony seed oil is higher than 80 percent of the common requirement, and the requirement is met. And simultaneously, the feasibility and the stability of the preparation process are further proved.
Clinical application conditions
1. Patient data
15 clinical cases were collected based on clinical manifestations of acne, inflammatory and papules, pustules, nodulocysts. 6 men and 9 women. The ages of the two are 15-18 years. According to the classification according to the nature of skin lesions in Chinese guidelines for treating acne, clinical cases are classified and classified, and the classification accords with 9 cases of mild cases (grade I) and 6 cases of moderate cases (grade II).
2. Method of treatment
Stage I: the external gel is used independently, and is applied externally in proper amount for 2 times per day for 15 days;
and II, stage: the external gel is used independently, and is applied externally in proper amount for 3 times per day for 15 days;
3. therapeutic effects
After 15 days of treatment, the external gel obviously improves the facial skin of 15 patients, the number of acnes and pimples is obviously reduced, and the patients do not reflect discomfort of the application part, so that the external gel has good treatment effect on the acnes and can obviously promote the recovery of the facial skin. And the active ingredients are plant extracts, so that the irritation of chemical drugs to the skin and drug resistance caused by long-term use are avoided.
Example 1
A composition for treating acne comprises the following components in percentage by mass: 29 percent of peony seed oil, 54 percent of bletilla striata polysaccharide and 17 percent of aloe polysaccharide, wherein the sum of the mass percentages of the components is 100 percent.
The external gel of the composition for treating acne consists of the following components in percentage by mass: 47% of composition for treating acne, 31% of PEG-40 hydrogenated castor oil, 4006% of polyethylene glycol and 16% of carbomer, wherein the sum of the mass percentages of the components is 100%.
The preparation method of the external gel of the composition for treating acne is specifically implemented according to the following steps:
And 2, uniformly mixing the PEG-40 hydrogenated castor oil and the polyethylene glycol 400 in a constant-temperature magnetic stirrer at the rotating speed of 35r/min for 6min, and marking as a material I.
And 3, dropwise adding the peony seed oil into the material I, wherein the rotating speed of the constant-temperature magnetic stirrer is 35r/min, and recording as a material II.
And 4, dropwise adding the purified water into the material II according to the mass-volume ratio of the material II to the purified water of 1:36g/mL, and adding the purified water into 55mL to obtain a material III.
And 5, emulsifying the material III in a high-shear homogenizing and emulsifying machine for 35min at the rotating speed of 10000r/min, and recording as a material IV.
And 6, homogenizing the material IV for 6 times by a high-pressure homogenizer at the homogenizing pressure of 900bar, and marking as a material V.
And 7, placing the material V in ultrasonic treatment for 25min, wherein the ultrasonic power is 350W, and marking as a material VI.
And 8, adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, heating to 85 ℃ to react for 6 hours, and then adjusting the pH to 7.6 by using 22% triethanolamine to obtain a material VII, wherein the mass volume ratio of the bletilla striata polysaccharide to the aloe polysaccharide to the carbomer to the purified water is 1:110 g/ml.
And 9, slowly dripping the material VI into the material VII, homogenizing for 4 times by a high-pressure homogenizer at the homogenizing pressure of 600bar after the rotating speed of the constant-temperature magnetic stirrer is 35r/min, and obtaining the nanoemulsion gel.
Example 2
A composition for treating acne comprises the following components in percentage by mass: 31% of peony seed oil, 50% of bletilla striata polysaccharide and 19% of aloe polysaccharide, wherein the sum of the mass percentages of the components is 100%.
The external gel of the composition for treating acne consists of the following components in percentage by mass: 49% of composition for treating acne, 29% of PEG-40 hydrogenated castor oil, 4005% of polyethylene glycol and 17% of carbomer, wherein the sum of the mass percentages of the components is 100%.
The preparation method of the external gel of the composition for treating acne is specifically implemented according to the following steps:
And 2, uniformly mixing the PEG-40 hydrogenated castor oil and the polyethylene glycol 400 in a constant-temperature magnetic stirrer at the rotating speed of 30r/min for 5min, and marking as a material I.
And 3, dropwise adding the peony seed oil into the material I, and recording as a material II when the rotating speed of the constant-temperature magnetic stirrer is 30 r/min.
And 4, dropwise adding the purified water into the material II according to the mass-volume ratio of the material II to the purified water of 1:33g/ml, and marking as a material III.
And 5, emulsifying the material III in a high-shear homogenizing and emulsifying machine for 30min at the rotating speed of 9500r/min, and recording as a material IV.
And 6, homogenizing the material IV for 4 times by a high-pressure homogenizer, wherein the homogenizing pressure is 850bar, and marking as a material V.
And 7, placing the material V in ultrasonic treatment for 20min, wherein the ultrasonic power is 300W, and marking as a material VI.
And 8, adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, heating to 80 ℃ to react for 5 hours, and then adjusting the pH to 7.4 by using 20% triethanolamine to obtain a material VII, wherein the mass volume ratio of the bletilla striata polysaccharide to the aloe polysaccharide to the carbomer to the purified water is 1:100 g/ml.
And 9, slowly dripping the material VI into the material VII, homogenizing for 3 times by a high-pressure homogenizer at the homogenizing pressure of 500bar after the rotating speed of the constant-temperature magnetic stirrer is 30r/min, and obtaining the nanoemulsion gel.
Example 3
A composition for treating acne comprises the following components in percentage by mass: 33% of peony seed oil, 48% of bletilla striata polysaccharide and 19% of aloe polysaccharide, wherein the sum of the mass percentages of the components is 100%.
The external gel of the composition for treating acne consists of the following components in percentage by mass: 47% of composition for treating acne, 31% of PEG-40 hydrogenated castor oil, 4005% of polyethylene glycol and 17% of carbomer, wherein the sum of the mass percentages of the components is 100%.
The preparation method of the external gel of the composition for treating acne is specifically implemented according to the following steps:
And 2, uniformly mixing the PEG-40 hydrogenated castor oil and the polyethylene glycol 400 in a constant-temperature magnetic stirrer at the rotating speed of 25r/min for 3min, and marking as a material I.
And 3, dropwise adding the peony seed oil into the material I, and recording as a material II when the rotating speed of the constant-temperature magnetic stirrer is 25 r/min.
And 4, dropwise adding the purified water into the material II according to the mass-volume ratio of the material II to the purified water of 1:30g/mL, and adding the purified water to 45mL to obtain a material III.
And 5, emulsifying the material III in a high-shear homogenizing and emulsifying machine for 25min at the rotating speed of 9000r/min, and marking as a material IV.
And 6, homogenizing the material IV for 3 times by a high-pressure homogenizer, wherein the homogenizing pressure is 800bar, and marking as a material V.
And 7, placing the material V in ultrasonic treatment for 15min, wherein the ultrasonic power is 250W, and marking as a material VI.
And 8, adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, heating to 75 ℃ to react for 4 hours, and then adjusting the pH to 7.2 by using 18% triethanolamine to obtain a material VII, wherein the mass volume ratio of the bletilla striata polysaccharide to the aloe polysaccharide to the carbomer to the purified water is 1:90 g/ml.
And 9, slowly dripping the material VI into the material VII, homogenizing for 2 times by a high-pressure homogenizer at the homogenizing pressure of 400bar after the rotating speed of the constant-temperature magnetic stirrer is 25r/min, and obtaining the nanoemulsion gel.
Example 4
A composition for treating acne comprises the following components in percentage by mass: 32% of peony seed oil, 53% of bletilla striata polysaccharide and 15% of aloe polysaccharide, wherein the sum of the mass percentages of the components is 100%.
The external gel of the composition for treating acne consists of the following components in percentage by mass: 49% of composition for treating acne, 30% of PEG-40 hydrogenated castor oil, 4006% of polyethylene glycol and 15% of carbomer, wherein the sum of the mass percentages of the components is 100%.
The preparation method of the external gel of the composition for treating acne is specifically implemented according to the following steps:
And 2, uniformly mixing the PEG-40 hydrogenated castor oil and the polyethylene glycol 400 in a constant-temperature magnetic stirrer at the rotating speed of 27r/min for 4min, and marking as a material I.
And 3, dropwise adding the peony seed oil into the material I, and recording as a material II when the rotating speed of the constant-temperature magnetic stirrer is 27 r/min.
And 4, dropwise adding the purified water into the material II according to the mass volume ratio of the material II to the purified water of 1:35g/ml, and marking as a material III.
And 5, emulsifying the material III in a high-shear homogenizing and emulsifying machine for 27min at the rotating speed of 9700r/min, and recording as a material IV.
And 6, homogenizing the material IV for 5 times by a high-pressure homogenizer, wherein the homogenizing pressure is 830bar, and marking as a material V.
And 7, placing the material V in ultrasonic treatment for 22min, wherein the ultrasonic power is 270W, and marking as a material VI.
And 8, adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, heating to 82 ℃ to react for 4.5h, and then adjusting the pH to 7.5 by using 21% triethanolamine to obtain a material VII, wherein the mass volume ratio of the bletilla striata polysaccharide to the aloe polysaccharide to the carbomer to the purified water is 1:95 g/ml.
And 9, slowly dripping the material VI into the material VII, homogenizing for 3 times by a high-pressure homogenizer at the homogenizing pressure of 450bar after the rotating speed of the constant-temperature magnetic stirrer is 27r/min, and obtaining the nanoemulsion gel.
Claims (9)
1. The external gel of the composition for treating the acne is characterized by comprising the following components and purified water in percentage by mass: 47-49% of a composition for treating acne, 29-31% of PEG-40 hydrogenated castor oil, 4-6% of polyethylene glycol 4004 and 15-17% of carbomer, wherein the sum of the mass percentages of the composition for treating acne, the PEG-40 hydrogenated castor oil, the polyethylene glycol 400 and the carbomer is 100%;
the composition for treating acne comprises the following components in percentage by mass: 29-33% of peony seed oil, 48-54% of bletilla striata polysaccharide and 15-19% of aloe polysaccharide, wherein the sum of the mass percentages of the components is 100%.
2. The preparation method of the external gel of the composition for treating the acne according to claim 1 is characterized by comprising the following steps:
step 1, weighing peony seed oil, bletilla striata polysaccharide, aloe polysaccharide, hydrogenated castor oil, polyethylene glycol and carbomer for later use;
step 2, uniformly stirring and mixing hydrogenated castor oil and polyethylene glycol, then dropwise adding peony seed oil while stirring to form a material II, and dropwise adding purified water while stirring;
step 3, sequentially carrying out high-speed shearing emulsification and high-pressure homogenization on the mixed solution obtained in the step 2, and then carrying out ultrasonic treatment to obtain a nano-emulsion;
and 4, adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, heating for reaction, stirring and dripping into the nanoemulsion obtained in the step 3, and then homogenizing under high pressure to obtain the nanoemulsion gel.
3. The method for preparing the external gel of the composition for treating acne according to claim 2, wherein the stirring speed in step 2 is 25-35 r/min.
4. The preparation method of the external gel of the composition for treating acne according to claim 2, wherein the mass volume ratio of the material II added with the peony seed oil in the step 2 to the purified water is 1: 30-36 g/ml.
5. The method for preparing the external gel of the composition for treating acne according to claim 2, wherein in the high-speed shearing emulsification process in the step 3, the rotating speed is 9000-10000 r/min, and the emulsification time is 25-35 min; homogenizing for 3-6 times under the high-pressure homogenizing pressure of 800-900 bar; the ultrasonic treatment power is 250-350W, and the time is 15-25 min.
6. The preparation method of the external gel of the composition for treating acne according to claim 2, wherein the mass volume ratio of the bletilla striata polysaccharide, the aloe polysaccharide, the carbomer and the purified water in the step 4 is 1: 90-110 g/ml.
7. The method for preparing the external gel of the composition for treating the acne according to claim 2, wherein the heating reaction in the step 4 is specifically as follows: adding bletilla striata polysaccharide, aloe polysaccharide and carbomer into purified water, and heating and reacting for 4-6 hours at the temperature of 75-85 ℃.
8. The method for preparing a topical gel of a composition for treating acne according to claim 2, wherein the pH of the reaction product is adjusted to 7.2-7.6 by 18-22% triethanolamine after the heating reaction in step 4.
9. The method for preparing the external gel of the composition for treating acne according to claim 2, wherein the high-pressure homogenizing pressure in step 4 is 400-600 bar, and the homogenizing is performed for 2-4 times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711175234.XA CN107753582B (en) | 2017-11-22 | 2017-11-22 | Composition for treating acne, external gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711175234.XA CN107753582B (en) | 2017-11-22 | 2017-11-22 | Composition for treating acne, external gel and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107753582A CN107753582A (en) | 2018-03-06 |
| CN107753582B true CN107753582B (en) | 2021-02-12 |
Family
ID=61280319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711175234.XA Active CN107753582B (en) | 2017-11-22 | 2017-11-22 | Composition for treating acne, external gel and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107753582B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110215428A (en) * | 2019-07-02 | 2019-09-10 | 北京神飞航天应用技术研究院 | A kind of skin nursing facial mask of aerospace grade |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622734A (en) * | 2014-12-17 | 2015-05-20 | 菏泽尧舜牡丹生物科技有限公司 | Skin-cleaning and acne-removing peony compound essential oil and preparation method thereof |
-
2017
- 2017-11-22 CN CN201711175234.XA patent/CN107753582B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622734A (en) * | 2014-12-17 | 2015-05-20 | 菏泽尧舜牡丹生物科技有限公司 | Skin-cleaning and acne-removing peony compound essential oil and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 白芨多糖胶皮肤毒理学安全性评价研究;张卫明等;《中国野生植物资源》;20031031;第22卷(第5期);第59-61页 * |
| 芦荟维生素E乳膏处方的筛选及稳定性考察;程万清等;《医药导报》;20060630;第25卷(第6期);第566-567页 * |
| 茶树油微乳凝胶的制备及其质量评价;卢秀霞等;《中草药》;20150731;第46卷(第13期);第1892-1900页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107753582A (en) | 2018-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0717847A (en) | Skin external preparation | |
| AU2021236518B2 (en) | A highly concentrated seawater mineral extract and uses thereof | |
| CN107753582B (en) | Composition for treating acne, external gel and preparation method thereof | |
| CN112315883B (en) | Skin care composition for controlling oil and removing acne and preparation and application thereof | |
| JP2001158728A (en) | Agent for promoting production of hyaluronic acid and skin preparation for external use | |
| CN115429738B (en) | Acne-removing, repairing and reviving essence and preparation method thereof | |
| CN113925907B (en) | Antibacterial, anti-inflammatory and antiallergic composition, and preparation method and application thereof | |
| JP2014091721A (en) | Ceramide production promoter | |
| CN101766558A (en) | Acne-removing cosmetic composite | |
| CN106726987A (en) | A kind of inhibiting bacteria and diminishing inflammation composition and its application | |
| CN106214622A (en) | Moisturizing maintenance cosmetic water and preparation method thereof | |
| KR100983076B1 (en) | Skin cream cosmetic composition | |
| KR20210042616A (en) | Wax-type cleanser | |
| KR20050031211A (en) | Cosmetic composition having anti-inflammatory, skin-protecting, skin-elastic effects which comprise mixed plants extract | |
| CN110237005A (en) | A kind of composition comprising the coptis, preparation method and application | |
| WO2020022991A2 (en) | Topical compositions for stretch marks on the skin | |
| CN115844767B (en) | Natural plant essential oil composition with multidimensional synergistic acne removal effect and preparation method thereof | |
| KR20170130159A (en) | Composition comprising water-soluble propolis composition for preventing or treating acne | |
| CN1647819A (en) | Use of active enzyme and composition in preventing and treating gastropathy and cosmetics fields | |
| CN1113773A (en) | Natural vigour beauty and skin-protecting cream and its preparing method | |
| KR102329748B1 (en) | Wax-type cleanser improving problematic skin | |
| Jacob et al. | Formulation and Evaluation of Anti-Microbial Cream by Using Cucurbita Pepo Seed Oil | |
| US20230220122A1 (en) | Method for production of functional polysaccharide and cosmetic composition | |
| RU2681545C1 (en) | Method of getting cream mask (options) | |
| Dua et al. | Preparation of Herbal Face Pack Cum Scrub using Papaya and Neem Extracts |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |