CN115120558A - 稳定的亲脂生物活性化合物组合物 - Google Patents

稳定的亲脂生物活性化合物组合物 Download PDF

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Publication number
CN115120558A
CN115120558A CN202210164448.1A CN202210164448A CN115120558A CN 115120558 A CN115120558 A CN 115120558A CN 202210164448 A CN202210164448 A CN 202210164448A CN 115120558 A CN115120558 A CN 115120558A
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CN
China
Prior art keywords
aqueous
corresponds
alkoxylated solvent
temperature
solvent
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Pending
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CN202210164448.1A
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English (en)
Chinese (zh)
Inventor
伊尔莎·克内勒
托马斯·佐维克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Somic Biotechnology Co ltd
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Somic Biotechnology Co ltd
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Publication date
Application filed by Somic Biotechnology Co ltd filed Critical Somic Biotechnology Co ltd
Publication of CN115120558A publication Critical patent/CN115120558A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202210164448.1A 2017-07-07 2018-07-06 稳定的亲脂生物活性化合物组合物 Pending CN115120558A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17180380.2 2017-07-07
EP17180380.2A EP3424493A1 (en) 2017-07-07 2017-07-07 Stable cannabinoid compositions
PCT/EP2018/068452 WO2019008179A1 (en) 2017-07-07 2018-07-06 STABLE CANNABINOID COMPOSITIONS
CN201880057928.XA CN111246844A (zh) 2017-07-07 2018-07-06 稳定的大麻素组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880057928.XA Division CN111246844A (zh) 2017-07-07 2018-07-06 稳定的大麻素组合物

Publications (1)

Publication Number Publication Date
CN115120558A true CN115120558A (zh) 2022-09-30

Family

ID=59315425

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202210164448.1A Pending CN115120558A (zh) 2017-07-07 2018-07-06 稳定的亲脂生物活性化合物组合物
CN201880057928.XA Pending CN111246844A (zh) 2017-07-07 2018-07-06 稳定的大麻素组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880057928.XA Pending CN111246844A (zh) 2017-07-07 2018-07-06 稳定的大麻素组合物

Country Status (10)

Country Link
US (1) US11752126B2 (enExample)
EP (2) EP3424493A1 (enExample)
JP (1) JP7186222B2 (enExample)
KR (1) KR102680507B1 (enExample)
CN (2) CN115120558A (enExample)
AU (1) AU2018296679B2 (enExample)
CA (1) CA3076750A1 (enExample)
EA (1) EA202090177A1 (enExample)
IL (1) IL271892B2 (enExample)
WO (1) WO2019008179A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112915121A (zh) * 2019-12-06 2021-06-08 汉义生物科技（北京）有限公司 一种大麻素纳米胶束制剂及其制备方法
EP4275694A1 (de) 2022-05-13 2023-11-15 Solmic Biotech GmbH Verwendung von solubilisaten in erzeugnissen zur topischen anwendung
DE202022000150U1 (de) 2022-01-20 2022-07-07 Solmic Bio Tech Gmbh Maske für medizinische oder kosmetische Zwecke mit mizellierten Extrakten
WO2023139105A1 (de) 2022-01-20 2023-07-27 Solmic Biotech GmbH Topisch anwendbare zusammensetzung enthaltend solubilisate lipophiler wirkstoffe
CN117986017B (zh) * 2023-11-27 2025-11-21 陕西师范大学 一种（Sm2-aYa）Ba4CuBiO10纳米粉体及用其改善单畴SmBCO超导块材性能的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU696855B2 (en) 1994-03-18 1998-09-17 Shire Laboratories, Inc. Emulsified drug delivery systems
JP2003500368A (ja) * 1999-05-24 2003-01-07 ソーナス ファーマシューティカルス，インコーポレイテッド 溶解度が不十分な薬剤のためのエマルジョンビヒクル
US20030236236A1 (en) 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
IL163808A0 (en) * 2002-03-01 2005-12-18 Yissum Res Dev Co Self emulsifying drug delivery systems for poorly soluble drugs
US20080045559A1 (en) * 2003-10-29 2008-02-21 Sonus Pharmaceuticals, Inc. Tocopherol-modified therapeutic drug compounds
US7402325B2 (en) * 2005-07-28 2008-07-22 Phoenix Biotechnology, Inc. Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
WO2007016175A1 (en) 2005-07-28 2007-02-08 Guasch Michael N Fuel repellent compositions, fabrics and articles
TWI392507B (zh) * 2006-10-20 2013-04-11 Solvay Pharm Bv 包埋的膠束奈米顆粒
WO2008046905A1 (en) * 2006-10-20 2008-04-24 Solvay Pharmaceuticals B.V. Micellar nanoparticles of chemical substances
HUE032158T2 (en) * 2008-10-31 2017-09-28 Univ Mississippi Process for the preparation of delta9-THC amino acid esters
WO2012050978A1 (en) * 2010-09-29 2012-04-19 MyCell Holdings Limited Formulations of ubiquinol and resveratrol esters
WO2013009928A1 (en) * 2011-07-11 2013-01-17 Organic Medical Research Cannabinoid formulations
WO2014165672A1 (en) * 2013-04-06 2014-10-09 Igdrasol, Inc. Nanoparticle therapeutic agents, their formulations, and methods of their use
US9861611B2 (en) * 2014-09-18 2018-01-09 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same
US20170119660A1 (en) * 2015-10-29 2017-05-04 Solubest Ltd Pharmaceutical compositions for transmucosal delivery

Also Published As

Publication number Publication date
IL271892A (en) 2020-02-27
JP2020527170A (ja) 2020-09-03
EP3424493A1 (en) 2019-01-09
AU2018296679A1 (en) 2020-02-20
US11752126B2 (en) 2023-09-12
KR102680507B1 (ko) 2024-07-01
KR20200037247A (ko) 2020-04-08
JP7186222B2 (ja) 2022-12-08
WO2019008179A1 (en) 2019-01-10
CA3076750A1 (en) 2019-01-10
IL271892B1 (en) 2023-04-01
EP3675825A1 (en) 2020-07-08
EA202090177A1 (ru) 2020-06-05
IL271892B2 (en) 2023-08-01
AU2018296679B2 (en) 2024-07-25
CN111246844A (zh) 2020-06-05
US20200237713A1 (en) 2020-07-30

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