CN115103835B - Il-17a调节剂及其用途 - Google Patents
Il-17a调节剂及其用途 Download PDFInfo
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- CN115103835B CN115103835B CN202080079537.5A CN202080079537A CN115103835B CN 115103835 B CN115103835 B CN 115103835B CN 202080079537 A CN202080079537 A CN 202080079537A CN 115103835 B CN115103835 B CN 115103835B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- Nitrogen Condensed Heterocyclic Rings (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962901249P | 2019-09-16 | 2019-09-16 | |
| US62/901,249 | 2019-09-16 | ||
| US16/783,268 | 2020-02-06 | ||
| PCT/US2020/016925 WO2020163554A1 (en) | 2019-02-06 | 2020-02-06 | Il-17a modulators and uses thereof |
| USPCT/US2020/016925 | 2020-02-06 | ||
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| JP7566889B2 (ja) | 2019-09-16 | 2024-10-15 | ダイス・アルファ・インコーポレイテッド | Il-17aモジュレーターおよびその使用 |
| MX2024000504A (es) * | 2021-07-09 | 2024-04-05 | Dice Alpha Inc | Moduladores de il-17a basados en fenilacetamida y usos de los mismos. |
| WO2023025783A1 (en) | 2021-08-23 | 2023-03-02 | Leo Pharma A/S | Small molecule modulators of il-17 |
| CN113896712B (zh) * | 2021-11-12 | 2024-04-09 | 华东理工大学 | 含环类氨基酸的二酰胺类化合物 |
| WO2023111181A1 (en) | 2021-12-16 | 2023-06-22 | Leo Pharma A/S | Small molecule modulators of il-17 |
| AU2023223283A1 (en) | 2022-02-25 | 2024-08-29 | Dice Alpha, Inc. | Di-cyclopropyl based il-17a modulators and uses thereof |
| WO2023166172A1 (en) | 2022-03-04 | 2023-09-07 | Leo Pharma A/S | Small molecule modulators of il-17 |
| WO2024115662A1 (en) | 2022-12-02 | 2024-06-06 | Leo Pharma A/S | Small molecule modulators of il-17 |
| WO2024208228A1 (en) * | 2023-04-03 | 2024-10-10 | Nuphase Therapeutics (Hangzhou) Limited., Co. | Novel compounds, compositions comprising the same and uses thereof |
| CN121079298A (zh) * | 2023-05-12 | 2025-12-05 | 上海翰森生物医药科技有限公司 | 噻唑类衍生物抑制剂、其制备方法和应用 |
| TW202506666A (zh) * | 2023-05-18 | 2025-02-16 | 中國大陸商歌禮生物科技(杭州)有限公司 | Il-17a的小分子調節劑、其製備方法和使用方法 |
| WO2025077732A1 (en) * | 2023-10-09 | 2025-04-17 | Shenzhen Ionova Life Science Co., Ltd. | Novel interleukin-17 inhibtors |
| WO2025080986A1 (en) * | 2023-10-13 | 2025-04-17 | Quantx Biosciences Us, Inc. | Amide compounds |
| WO2025131062A1 (zh) * | 2023-12-21 | 2025-06-26 | 江苏恒瑞医药股份有限公司 | 烯烃类化合物、其制备方法及其在医药上的应用 |
| WO2025201532A1 (en) * | 2024-03-28 | 2025-10-02 | Nuphase Therapeutics (Shanghai) Limited., Co. | Novel pegylation compounds, compositions comprising the same and uses thereof |
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| WO2025209397A1 (en) * | 2024-04-03 | 2025-10-09 | Innocare Pharma Inc. | Il-17 modulators and used thereof |
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