CA3154608A1 - Il-17a modulators and uses thereof - Google Patents

Il-17a modulators and uses thereof Download PDF

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Publication number
CA3154608A1
CA3154608A1 CA3154608A CA3154608A CA3154608A1 CA 3154608 A1 CA3154608 A1 CA 3154608A1 CA 3154608 A CA3154608 A CA 3154608A CA 3154608 A CA3154608 A CA 3154608A CA 3154608 A1 CA3154608 A1 CA 3154608A1
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Prior art keywords
optionally substituted
compound
salt
halogen
alkyl
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English (en)
French (fr)
Inventor
Paul R. Fatheree
Martin S. Linsell
John R. Jacobsen
Wouter A. VAN DER LINDEN
Timothy J. Church
Claudio Aquino
Margot G. Paulick
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Dice Alpha Inc
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Dice Alpha Inc
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Priority claimed from PCT/US2020/016925 external-priority patent/WO2020163554A1/en
Application filed by Dice Alpha Inc filed Critical Dice Alpha Inc
Publication of CA3154608A1 publication Critical patent/CA3154608A1/en
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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US16/783,268 US11447468B2 (en) 2019-02-06 2020-02-06 IL-17 ligands and uses thereof
US16/783,268 2020-02-06
US202063061719P 2020-08-05 2020-08-05
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CN115103835B (zh) 2024-12-10
JP2025013344A (ja) 2025-01-24
JP2022547617A (ja) 2022-11-14
BR112022004802A2 (pt) 2022-08-23
US11274094B2 (en) 2022-03-15
IL291345B1 (en) 2023-12-01
US20220235038A1 (en) 2022-07-28
US12421212B2 (en) 2025-09-23
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AU2020348685A1 (en) 2022-04-14
US20230141212A1 (en) 2023-05-11
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