CN115103673A - 组合 - Google Patents

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Publication number
CN115103673A
CN115103673A CN202080095319.0A CN202080095319A CN115103673A CN 115103673 A CN115103673 A CN 115103673A CN 202080095319 A CN202080095319 A CN 202080095319A CN 115103673 A CN115103673 A CN 115103673A
Authority
CN
China
Prior art keywords
cancer
optionally substituted
compound
group
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080095319.0A
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English (en)
Chinese (zh)
Inventor
艾哈迈德·阿布迪·萨玛塔
马健会
李佳莉
黄琴华
萨伊·盖亚南·海格
凯文·杜安·邦克
费尔南多·多纳特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ricoram Ip Holding Co ltd
Original Assignee
Ricoram Ip Holding Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ricoram Ip Holding Co ltd filed Critical Ricoram Ip Holding Co ltd
Publication of CN115103673A publication Critical patent/CN115103673A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Steroid Compounds (AREA)
  • Glass Compositions (AREA)
CN202080095319.0A 2019-12-20 2020-12-16 组合 Pending CN115103673A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962952042P 2019-12-20 2019-12-20
US62/952,042 2019-12-20
US202063009754P 2020-04-14 2020-04-14
US63/009,754 2020-04-14
PCT/US2020/065411 WO2021127046A1 (en) 2019-12-20 2020-12-16 Combinations

Publications (1)

Publication Number Publication Date
CN115103673A true CN115103673A (zh) 2022-09-23

Family

ID=76478099

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080095319.0A Pending CN115103673A (zh) 2019-12-20 2020-12-16 组合

Country Status (12)

Country Link
US (1) US20230042653A1 (enExample)
EP (1) EP4069224A4 (enExample)
JP (1) JP2023507799A (enExample)
KR (1) KR20220119428A (enExample)
CN (1) CN115103673A (enExample)
AU (1) AU2020408698A1 (enExample)
BR (1) BR112022012286A2 (enExample)
CA (1) CA3165477A1 (enExample)
IL (1) IL294084A (enExample)
MX (1) MX2022007624A (enExample)
TW (1) TW202135810A (enExample)
WO (1) WO2021127046A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202543650A (zh) 2024-03-08 2025-11-16 美商海爾達醫療運營公司 異雙官能化合物及其在治療疾病中之用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101970440A (zh) * 2007-11-28 2011-02-09 先灵公司 作为蛋白激酶抑制剂的2-氟吡唑并[1，5-a]嘧啶类
US20160008361A1 (en) * 2012-11-28 2016-01-14 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
CN109311870A (zh) * 2016-04-01 2019-02-05 芝诺罗耶尔蒂里程碑有限责任公司 雌激素受体调节剂
US20190084985A1 (en) * 2015-11-01 2019-03-21 The Regents Of The University Of Colorado, A Body Corporate Wee1 kinase inhibitors and methods of making and using the same
WO2019085933A1 (zh) * 2017-11-01 2019-05-09 南京明德新药研发股份有限公司 作为Wee1抑制剂的大环类化合物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5411847B2 (ja) * 2007-04-25 2014-02-12 Ｍｓｄ株式会社 Ｗｅｅｌキナーゼインヒビターとしてのジヒドロピラゾロピリミジノン誘導体の多形
EP2477628B1 (en) * 2009-09-15 2014-08-20 Merck Sharp & Dohme Corp. Preparation of crystalline hemihydrate forms of dihydropyrazolopyrimidinone
WO2016146591A1 (en) * 2015-03-16 2016-09-22 Astrazeneca Ab Combination treatment
US11932650B2 (en) * 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
KR20220044528A (ko) * 2019-08-06 2022-04-08 리커리엄 아이피 홀딩스, 엘엘씨 돌연변이체를 치료하기 위한 에스트로겐 수용체 조절제

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101970440A (zh) * 2007-11-28 2011-02-09 先灵公司 作为蛋白激酶抑制剂的2-氟吡唑并[1，5-a]嘧啶类
US20160008361A1 (en) * 2012-11-28 2016-01-14 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
US20190084985A1 (en) * 2015-11-01 2019-03-21 The Regents Of The University Of Colorado, A Body Corporate Wee1 kinase inhibitors and methods of making and using the same
CN109311870A (zh) * 2016-04-01 2019-02-05 芝诺罗耶尔蒂里程碑有限责任公司 雌激素受体调节剂
WO2019085933A1 (zh) * 2017-11-01 2019-05-09 南京明德新药研发股份有限公司 作为Wee1抑制剂的大环类化合物及其应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COLIN O\'DOWD ET AL: "Abstract 4423: Antitumor activity of the novel oral highly selective Wee1 inhibitor Debio 0123", 《CANCER RES》, vol. 79, no. 13, 1 July 2019 (2019-07-01), pages 1 - 2 *

Also Published As

Publication number Publication date
AU2020408698A1 (en) 2022-07-14
BR112022012286A2 (pt) 2022-08-30
KR20220119428A (ko) 2022-08-29
WO2021127046A1 (en) 2021-06-24
US20230042653A1 (en) 2023-02-09
TW202135810A (zh) 2021-10-01
CA3165477A1 (en) 2021-06-24
MX2022007624A (es) 2022-08-16
IL294084A (en) 2022-08-01
EP4069224A1 (en) 2022-10-12
EP4069224A4 (en) 2023-12-20
JP2023507799A (ja) 2023-02-27

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Application publication date: 20220923