CN115089681A

CN115089681A - Application of herbal composition in preparation of benign prostatic hyperplasia acupoint medicine

Info

Publication number: CN115089681A
Application number: CN202210858467.4A
Authority: CN
Inventors: 唐铭浩; 徐静; 唐吉宁
Original assignee: Hunan Guose Biotechnology Co ltd
Current assignee: Hunan Guose Biotechnology Co ltd
Priority date: 2022-07-21
Filing date: 2022-07-21
Publication date: 2022-09-23

Abstract

The invention discloses an application of a medicinal herb composition in preparing a medicine for acupuncture points for benign prostatic hyperplasia. The extraction method of the active ingredients of the medicinal herb composition is simple and safe, has no toxic or side effect, has good effect, has high process feasibility for preparing the acupoint medicine, and has the potential of large-scale production.

Description

Application of herbal composition in preparation of benign prostatic hyperplasia acupoint medicine

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to application of a medicinal herb composition in preparation of a benign prostatic hyperplasia acupoint medicine.

Background

Benign Prostatic Hyperplasia (BPH), also known as prostatic hypertrophy, is a chronic Hyperplasia of the Prostate that develops in men after age 50. Since the male urethra passes through the prostate, BPH may block or irritate the urethra, resulting in obstruction of the bladder outlet, causing symptoms including lower abdominal distention, frequent urination, dysuria and pain, secondary sexual dysfunction and male infertility may occur, resulting in urinary retention, bladder infection and renal failure in severe cases, greatly affecting the quality of life and psychological mood of the patient.

Modern medicine is the first choice for clinical diagnosis and treatment of BPH, and western medicines and traditional Chinese medicines are respectively superior. Western medicine divided into alpha ₁ Receptor blockers (relax pressure on the prostate and bladder neck) and 5-alpha reductase inhibitors (block the proliferative effects of dihydrotestosterone on the prostate); the traditional Chinese medicine is subjected to dialectical treatment according to basic syndrome types, mainly takes oral decoction as a main part, and occasionally adopts rectal suppository or lotion for auxiliary treatment. The difficulty of treating BPH comes from several aspects: (1) the cognition of the patient, BPH is considered as a natural process of human organ aging and does not belong to the category of diseases, and the patient is superposed with possible avoidance of hospitalizing by middle-aged and elderly people and has a light view on cognition; (2) patient compliance, concerns from hepatorenal toxicity of oral drugs, mental stress from long-term dosing, difficult to adhere to dosing regimens, etc.; (3) social public opinion, under a specific language environment, similar to the expression of 'frequent micturition and urgent micturition', can associate with male sexual dysfunction, and the metaphor is unacceptable to many men and is easy to generate the mind of resistance and escape; (4) the BPH progressive course, the prostatic hyperplasia is not formed in a day, but symptoms are shown in the early stage, and mild symptoms enable patients to be in a treatment option but not in a treatment option, and the treatment is delayed due to mild symptoms; (5) BPH can occur naturally, the etiology is complex, the symptoms are continuous, and the radical treatment is difficult. The factors lead middle-aged and elderly men to mainly tolerate the BPH in the early stage, and the symptoms can last for more than ten years from the first to serious or accidental hospitalization, so that the patients are in long and secret suffering.

The long-term circulation and application of acupoints in folks is an important component of traditional Chinese medicine. The acupoint application is guided by the theory of zang-fu organs and the theory of meridians, and the medicine is applied to the acupoints to exert the dual effects of the medicine and the acupoint effect. On one hand, reasonable acupoint stimulation can activate neuroendocrine regulation, activate the fascia network of the whole body and awaken the self-healing capability of the human body; on the other hand, in the dosage forms of decoction, pill, powder and the like of the traditional Chinese medicines, after entering the digestive tract, dregs of the medicines can not enter the channels and collaterals, and the dregs can enter the qi of the medicinal materials. The acupoint application can also cut the qi of the medicinal materials on the skin, take the effect of promoting skin, absorb the air and melt in the exudate, namely, the qi enters the lymphatic circulation to participate in metabolism through the transdermal effect. Compared with acupuncture and moxibustion and other acupuncture point therapies, acupoint application has no requirement on an operator, and the operation is simple and convenient; compared with oral medicines, acupoint application avoids the first pass effect of the medicines through the stomach and the liver, has lower toxic and side effects, has the same efficacy with the specific routes, and has the function of regulating the channels and collaterals. The acupoint application can make up the deficiency of medication and needle therapy, which is important for improving the compliance of patients, and is particularly suitable for relieving and treating BPH in the early stage of middle-aged and old people.

Disclosure of Invention

In view of the above, the invention provides an application of a herbal composition for preparing a medicine for acupuncture points of benign prostatic hyperplasia, which has the advantages of good curative effect, small side effect, long-term storage and simple use.

One of the objectives of the present invention is to provide the application of a herbal composition in the preparation of a medicine for acupuncture points with benign prostatic hyperplasia.

The second objective of the present invention is to provide a method for preparing active ingredients of a herbal composition for the preparation of a medicine for acupuncture points with benign prostatic hyperplasia.

The invention also aims to provide a preparation method of the gel applied to the preparation of the medicine for benign prostatic hyperplasia acupoints by the medicinal herb composition.

The fourth purpose of the invention is to provide a preparation method of a plaster applied to the preparation of a medicine for acupuncture points of benign prostatic hyperplasia.

In order to achieve the above objects, the present invention provides an application of a herbal composition in the preparation of a medicine for benign prostatic hyperplasia acupoints, wherein the herbal composition comprises the following raw materials: 8-16 parts of wormwood, 2-8 parts of Hangzhou angelica root, 10-32 parts of black ginger, 4-8 parts of roman chamomile, 5-9 parts of verbena, 7-11 parts of ginseng, 14-18 parts of fructus cnidii, 1-4 parts of narcissus root, 4-8 parts of Chinese gall, 4-8 parts of fructus evodiae, 5-7 parts of asarum and 3-5 parts of cananga odorata.

In a preferred embodiment, the application of a herbal composition in preparing a medicine for treating benign prostatic hyperplasia acupoints is disclosed, wherein the herbal composition is prepared from the following raw materials in parts by weight: 12 parts of wormwood, 4 parts of Hangzhou angelica root, 18 parts of black ginger, 6 parts of Roman chamomile, 7 parts of verbena, 9 parts of ginseng, 16 parts of common cnidium fruit, 4 parts of narcissus root, 5 parts of Chinese gall, 5 parts of fructus evodiae, 6 parts of asarum and 4 parts of cananga odorata.

The invention provides application of a medicinal herb composition in preparing benign prostatic hyperplasia acupoint medicaments, wherein the active components of the medicinal herb composition are prepared by the following steps:

s1 weighing folium Artemisiae Argyi, radix Angelicae Dahuricae, rhizoma Zingiberis recens, Roman flos Matricariae Chamomillae, herba Verbenae, radix Ginseng, fructus Cnidii, radix narcissi chinensis, Galla chinensis, fructus evodiae, herba asari, and cananga odorata;

s2, placing the medicinal herbs weighed in the step S1 into a nylon filter bag, then putting the filter bag into an ultrasonic reaction kettle, filling purified water which is 8-15 times of the weight of the medicinal herbs in the kettle in advance, adding disodium edetate with the weight of 0.005% (w/w) of the purified water, carrying out ultrasonic washing for 20 min, washing away silt, chelating heavy metal ions, and removing washing liquid;

s3 ultrasonically rinsing with 8-15 times of purified water for 2 times, 15 min each time, and discarding the washing liquid;

s4 taking out the nylon filter bag, putting the washed medicinal herbs into a constant temperature drying box, and drying at 45 ℃ for 12 hours;

s5 pulverizing the dried medicinal herbs to below 40 meshes, and drying at 45 deg.C for 6 hr;

s6 supercritical extracting the powder of S5 with carbon dioxide at 45 deg.C under 38 MPa, and extracting with CO in extraction kettle ₂ The gas flow is 50L/h, and the extraction time is 2.5 h;

the analysis conditions of the S7 analysis kettle are 45 deg.C and 4.8 MPa, and the extract is precipitated to obtain active components of the medicinal composition.

The invention provides application of a medicinal herb composition in preparing a medicine for acupoints on benign prostatic hyperplasia, which is characterized in that the dosage form of the medicine for the acupoints is gel and emplastrum.

In particular, the invention provides an application of a herbal composition in preparing a medicine for benign prostatic hyperplasia acupoints, which is characterized in that the gel is prepared by the following steps:

the analysis conditions of the S7 resolving kettle are 45 deg.C and 4.8 MPa, and the extract is separated out to form active components of the medicinal composition;

s8, adding 6 parts of carbomer into 790 parts of water, fully dissolving, and adjusting the pH of the material body to 5.5-6.5 by using triethanolamine to prepare a gel matrix;

s9 adding 9 parts of Tween 80, 3 parts of span 80 and 90 parts of glycerol into 90 parts of the extract obtained in the step S7, and fully mixing and emulsifying;

s10, adding the emulsified extract obtained in the step S9 into the gel matrix obtained in the step S8, and uniformly stirring to obtain the gel.

In particular, the invention provides an application of the herbal composition in preparing a medicine for acupuncture points with benign prostatic hyperplasia, which is characterized in that the emplastrum is prepared by the following steps:

s3 ultrasonically rinsing with 8-15 times of purified water for 2 times, each time for 15 min, and discarding the washing liquid;

s8 adding 2 parts of vaseline and 2.5 parts of lanolin into 18 parts of the medicinal herb extract prepared in the step S7, and fully stirring and uniformly mixing for later use;

s9, putting 40 parts of the rubber which is milled in the open mill into a kneader, adding 3 parts of an anti-aging agent, and starting the kneader to knead for 1 hour;

s10, adding 13 parts of rosin, the thick paste obtained in the step S8, 7 parts of zinc oxide and 32.5 parts of lithopone into a kneader one by one, and kneading for 15 min each batch to obtain a sizing material;

s11, filtering the rubber material through a screw extrusion filter;

s12, coating the sizing material obtained in the step S11 according to a hot-press coating machine, punching, slicing and packaging to obtain the emplastrum.

The medicinal herb composition consists of ten Chinese medicinal materials of wormwood, radix angelicae dahuricae, black ginger, verbena, ginseng, fructus cnidii, narcissus root, gallnut, fructus evodiae and asarum, and two Chinese medicinal herbs of roman chamomile and cananga odorata. In the formula, the Heixiangyang has the effects of expelling wind and removing dampness, and relieving swelling and pain, and the narcissus root has the effects of clearing heat and removing toxicity, eliminating stagnation and relieving swelling, and the two medicinal materials are monarch drugs together and have the effects of relieving swelling and pain. In the formula, the ginseng can greatly tonify primordial qi, recover pulse and relieve depletion, the fructus cnidii can warm kidney and strengthen yang, eliminate dampness and dispel wind, the two medicinal materials are used as ministerial medicines together, the ministerial medicines can warm and tonify kidney yang, and nourish primordial qi and consolidate the base, thereby providing the effects of promoting qi circulation and assisting in benefiting for the detumescence and stagnation elimination of monarch medicine. In the formula, the wormwood dispels cold and relieves pain, the channels are warmed and the bleeding is stopped, the dahurian angelica root dispels wind and removes dampness, the orifices are communicated and the pain is relieved, the verbena has the functions of promoting blood circulation and removing blood stasis, inducing diuresis and reducing edema, the Chinese gall has the functions of astringing the lung and reducing fire, relieving diarrhea with astringents, the evodia has the functions of dispelling cold and relieving pain, and calming the adverse-rising energy and arresting vomiting, the five medicinal materials are used as adjuvant medicines together, have the effects of promoting blood circulation and removing blood stasis and relieving diarrhea with astringents, and have the effects of relieving swelling and pain by assisting the adjuvant medicines and distributing the ministerial medicines. In the formula, the asarum has the effects of inducing resuscitation and relieving pain, warming lung and relieving fluid retention, the Roman chamomile has the effects of relieving emotion and soothing emotion, the cananga odorata has the effects of resisting depression and rejuvenating spirit, and the three medicinal herbs are used as the guiding medicaments, so that the dispersing and hair growing effects of the lung can be enhanced, the monarch medicament and the guiding medicaments are distributed on the whole body, and the blood circulation is promoted and the collateral is dredged; has effects of tranquilizing mind, and invigorating qi. The monarch, the minister, the assistant and the guide are mutually compatible and respectively play the role of the principal and the subordinate, and the effects of reducing swelling, relieving pain, promoting blood circulation and removing blood stasis are achieved together. The medicinal herb composition is used for preparing the acupoint application medicament, has exact and reasonable curative effect and no toxic or side effect.

The preparation process of the active ingredients of the herbal composition in the technical scheme of the invention is simple and feasible, is safe to operate, can be developed in a conventional purification workshop, and is easy for large-scale production and implementation.

Drawings

FIG. 1 is a flow chart of the process for extracting the active ingredients of the herbal composition of the present invention.

Figure 2 is a scoring criteria for multiple complete skin irritation experiments.

FIG. 3 is the results of multiple complete skin irritation experiments with the gel of example 3.

FIG. 4 is the results of multiple complete skin irritation experiments for the patch of example 4.

Detailed Description

The efficacy brief introduction of each raw material medicine of the medicinal herb composition for relieving benign prostatic hyperplasia provided by the invention is as follows.

And (3) moxa: pungent, bitter and warm in nature. Enter spleen, liver and kidney meridians. Dispel cold to alleviate pain, warm meridians to stop bleeding, regulate qi and blood, dispel cold-dampness, and treat various diseases through moxibustion.

Hangzhou dahurian angelica root: pungent and warm in nature and flavor. It enters stomach, large intestine and lung meridians. Dispel wind and dampness, induce resuscitation and alleviate pain, resolve swelling and expel pus.

Ginger with black heart: bitter, pungent and warm in nature. Dispelling wind and removing dampness; relieving swelling and pain.

Verbena: bitter in nature and cool. It enters liver and spleen meridians. Promoting blood circulation, removing blood stasis, clearing away heat and toxic material, inducing diuresis to alleviate edema.

Ginseng: sweet in nature and taste, slightly bitter and mild. It enters spleen, lung and heart meridians. Tonify primordial qi, recover pulse to stop collapse, tonify spleen and nourish lung.

Fructus cnidii: pungent, bitter and warm in nature. It enters kidney meridian. Warming kidney and strengthening yang, drying dampness and dispelling wind.

Narcissus root: slightly pungent in flavor, cold in nature, toxic when taken orally. Clear heat and remove toxicity, dissipate nodulation and relieve swelling.

Gallnut: sour, astringent and cold in nature and taste. It enters lung, large intestine and kidney meridians. Astringe lung to reduce fire, astringe intestine to check diarrhea, astringe sweat to stop bleeding, astringe dampness to heal wound.

Evodia fruit: pungent, bitter and hot in nature. It enters liver, spleen, stomach and kidney meridians. Dispel cold and alleviate pain, check adverse rise of qi and arrest vomiting, strengthen yang and check diarrhea.

Asarum: pungent and warm in nature and flavor. It enters heart, lung and kidney meridians. Dispel wind and cold, induce resuscitation and alleviate pain, warm lung and resolve retained fluid.

Roman chamomile: the herbal medicines in the aromatherapy relieve anxiety, soothe mood, promote blood circulation to remove blood stasis and have fragrance.

Cananga odorata: the herbs in the aromatherapy have the functions of resisting depression and rejuvenating spirit and have fragrance.

The invention provides application of a herbal composition in preparation of a medicine for acupuncture points of benign prostatic hyperplasia, wherein the medicine for acupuncture points is a medicine which is applied to acupuncture points of a human body to exert curative effects and acupuncture point effects. The acupoint medicine has wide application range, and can be used for acupoints which are not available for acupuncture, moxibustion and massage because the acupoints are sensitive and special and are easy to cause embarrassment of patients. The following are the points with obvious effects after practice, and the points and the application method do not constitute the present invention, and are listed for better explanation.

Guanyuan acupoint: three cuns below the umbilicus, the small intestine, three yin of foot taiyin, shaoyin and jueyin, and the conception vessel. The subordinate, the guanyuan. It is indicated for pain under umbilicus, dark urine, enuresis, and pain in urination.

Zhongji point: also called Yuquan and Qi Yuan. One cun below guanyuan, recruitment of the bladder and the three yin and conception vessels of foot. It is indicated for five kinds of stranguria, dark urine, loss of essence, umbilicus nodule like cup covering, yang qi exhaustion, hernia, edema, cardiac arrest by cardiac dolphin, or even stranguria.

Shenshu points: two cun are placed below the fourteen segments of the spine and on each side. It is used to treat lumbago such as fracture, hematochezia, spermatorrhea, pudendal pain, fever, deafness, knee spasm, and cold foot.

The perineum acupoint: also called as nebula, lower extreme and lower yin differentiation. In the perineum, the male is the midpoint of the line connecting the scrotum root and anus. It can be used for treating drowning asphyxia, coma, mania, proctoptosis, hemorrhoid, hernia, urinary obstruction, leukorrhagia, menoxenia, and pudendal pruritus.

Yongquan acupoint: and (4) performing alias ground rushing. On the bottom of the foot, the forefoot is depressed when curling the foot. Can be used for treating syncope, headache, vertigo, pharyngitis, epistaxis, infantile convulsion, epilepsy, plantar heat, shock, sunstroke, neurasthenia, hypertension, and schizophrenia. The kidney comes from the spring, the foot center of the spring is also called the "Nei Jing Yun".

The medicinal herb composition in the technical scheme of the invention consists of ten Chinese medicinal materials of wormwood, Hangzhou angelica root, black ginger, verbena, ginseng, common cnidium fruit, narcissus root, Chinese gall, evodia, asarum and two Chinese medicinal herbs of Roman chamomile and cananga odorata. Wherein, monarch drugs (ginger and narcissus root) can reduce swelling and relieve pain, minister drugs (ginseng and common cnidium fruit) can warm and tonify kidney yang, adjuvant drugs (wormwood, verbena, dahurian angelica root, Chinese gall and evodia rutaecarpa) can promote blood circulation and remove blood stasis, and conductant drugs (asarum, roman chamomile and cananga odorata) can guide and center, and the monarch drugs, the minister drugs, the adjuvant drugs and the conductant drugs are mutually compatible, and can play the roles of reducing swelling and relieving pain, and promoting blood circulation and removing blood stasis. The medicinal herb composition is used for preparing acupoint application medicines, and can be used for relieving and treating BPH of middle-aged and elderly men in early stage.

The invention is further illustrated by the following examples.

Example 1

An application of a herbal composition in preparing a medicine for benign prostatic hyperplasia acupoints is disclosed, wherein the active ingredients of the herbal composition are prepared by the following steps:

s1, weighing 12 parts of wormwood, 4 parts of Hangzhou angelica root, 18 parts of black ginger, 6 parts of Roman chamomile, 7 parts of verbena, 9 parts of ginseng, 16 parts of fructus cnidii, 4 parts of narcissus root, 5 parts of Chinese gall, 5 parts of fructus evodiae, 6 parts of asarum and 4 parts of cananga odorata according to parts by weight;

Example 2

An application of a medicinal herb composition in preparing a medicine for benign prostatic hyperplasia acupoints is disclosed, wherein active ingredients of the medicinal herb composition are prepared by the following steps:

s1 weighing 8 parts of wormwood, 3 parts of Hangzhou radix angelicae, 12 parts of black ginger, 4 parts of Roman chamomile, 5 parts of verbena, 7 parts of ginseng, 14 parts of fructus cnidii, 1 part of narcissus root, 4 parts of gallnut, 4 parts of fructus evodiae, 5 parts of asarum and 3 parts of cananga odorata according to parts by weight.

s4 taking out the nylon filter bag, putting the washed medicinal herbs into a constant temperature drying box, and drying for 12 hours at 45 ℃;

Example 3

An application of a herbal composition in preparing a medicine for acupuncture points of benign prostatic hyperplasia is disclosed, wherein the medicine gel for acupuncture points is prepared by the following steps:

s1, weighing 12 parts of wormwood, 4 parts of Hangzhou angelica root, 22 parts of black ginger, 6 parts of Roman chamomile, 7 parts of verbena, 9 parts of ginseng, 16 parts of fructus cnidii, 4 parts of narcissus root, 5 parts of Chinese gall, 5 parts of fructus evodiae, 6 parts of asarum and 4 parts of cananga odorata according to parts by weight;

s9, adding 9 parts of Tween 80, 3 parts of span 80 and 90 parts of glycerol into 90 parts of the extract obtained in the step S7, and fully mixing uniformly for emulsification;

Example 4

An application of a medicinal herb composition in preparing a medicine for acupuncture points with benign prostatic hyperplasia is disclosed, wherein the medicinal plaster for acupuncture points is prepared by the following steps:

s1 weighing 8 parts of wormwood, 3 parts of Hangzhou radix angelicae, 12 parts of black ginger, 4 parts of Roman chamomile, 5 parts of verbena, 7 parts of ginseng, 14 parts of fructus cnidii, 1 part of narcissus root, 4 parts of gallnut, 4 parts of fructus evodiae, 5 parts of asarum and 3 parts of cananga odorata in parts by weight;

s2, placing the medicinal herbs weighed in the step S1 into a nylon filter bag, then putting the filter bag into an ultrasonic reaction kettle, filling purified water which is 8-15 times of the weight of the medicinal herbs in the kettle in advance, adding disodium edetate which is 0.005% (w/w) of the weight of the purified water, carrying out ultrasonic washing for 20 min, washing away silt, chelating heavy metal ions, and discarding washing liquid;

s10, adding 13 parts of rosin, the thick paste obtained in the step S8, 7 parts of zinc oxide and 32.5 parts of lithopone into a kneader one by one, and kneading for 15 min in each batch to obtain a rubber material;

s11, filtering the rubber material through a screw extrusion filter;

s12, coating the sizing material obtained in the step S11 by a hot-press coater, punching, slicing and packaging to obtain the emplastrum.

Example 5

The gel prepared in example 3 and the patch prepared in example 4 were subjected to a number of complete skin irritation tests on New Zealand rabbits.

10 New Zealand male rabbits were purchased from the local laboratory animal company, raised for 3 days, and after the male rabbits were adapted to the new environment, the hair on both sides of the dorsal spine of the rabbits was removed by depilatory 24 hours before the test, with about 3 cm by 3 cm on each side, without damaging the skin.

The gel prepared in example 3 was tested in the first group, which was divided into 5 rabbits each. 0.5g of gel was applied to the dehaired area on the left side of the spine of the rabbit with gloved fingers until there was no greasy touch and no gel residue on the glove and the right side of the rabbit was left untreated as a blank. After 4 hours, the skin was gently wiped with warm water until no residue remained.

Second set of test examples 4 the patches prepared in example 4 were cut into 2.5 cm by 2.5 cm pieces, and the patches were peeled off and applied to the dehaired region on the left side of the spine of a rabbit, while the right side of the rabbit was left untreated as a blank control. After 4 h, the patch was gently torn off and the skin of the test was gently wiped with warm water until no residue remained.

After wiping the skin of the test for 10 hours each day, the skin condition was observed and recorded according to the figure 2 rating scale for a total of 14 days.

And (3) test results: example 3 the gel group had a skin irritation index of 0, and no erythema or edema formed on the skin of the test male rabbits in the group; example 4 the patch group had a skin irritation index of 0.086 points, with 2 male rabbits having a barely visible edema formation at the beginning of the test, disappearance of the later stages, and no erythema formation. The gel obtained in example 3 and the patch obtained in example 4 were each determined to be non-irritating to the skin according to the rating scale.

Example 6

In Chuan, 59 years old, men often feel that the lower abdomen is pressed and swollen in flatday with radial dull pain in the abdomen, and the symptoms disappear after a few hours, but become worse when drinking wine, sitting and driving. Examination of prostate in vivo 4.6 cm by 3.6 cm is benign prostatic hyperplasia, and the rest indications are normal. After one month, the gel is tried out, and the call is returned. The medicine is administered every day or every other day, and is administered once when symptoms appear, and the acupoint is selected from Guanyuan acupoint, Zhongji acupoint and Shenshu acupoint. The symptoms are greatly improved, the frequency of falling and rising sensations is reduced, the falling and rising sensations can be eliminated quickly even if the falling and rising sensations appear, and no adverse reaction or side effect occurs in the period.

Example 7

Li Shi, 71 years old, male, frequent nocturia, incomplete urination, dribbling urination, urination time required more than 3 min, and no other symptoms were seen. The trial of the emplastrum of the invention advocates that the emplastrum does not feel suffocated and exerts force when people go to the toilet to avoid cardiovascular accidents, and the patient can return to the phone after two weeks. Since the medicine is used in the morning and before sleep every day, other treatment medicines are not used in the period, Guanyuan acupoint and Zhongji acupoint are selected as the acupoints, and Yongquan acupoint is pasted after the morning, the symptom is relieved, the mood is pleasant, the toileting time is shortened to be within 2 min, the urination is smooth compared with the prior art, the number of times of getting up to night is reduced by 1-2 times, no adverse reaction exists in the period, and no side effect exists.

The above are only embodiments of the present invention, and it should be noted that, for those skilled in the art, it can make several changes and modifications without departing from the structure of the present invention, and these should also be considered as the protection scope of the present invention, which will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be defined by the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.

Claims

1. The application of a medicinal herb composition in preparing benign prostatic hyperplasia acupoint medicines is characterized in that the medicinal herb composition is prepared from the following medicinal materials in parts by weight: 8-16 parts of wormwood, 2-8 parts of Hangzhou angelica root, 10-32 parts of black ginger, 4-8 parts of roman chamomile, 5-9 parts of verbena, 7-11 parts of ginseng, 14-18 parts of fructus cnidii, 1-4 parts of narcissus root, 4-8 parts of gallnut, 4-8 parts of fructus evodiae, 5-7 parts of asarum and 3-5 parts of cananga odorata.

2. The application of the composition as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 12 parts of wormwood, 4 parts of Hangzhou angelica root, 18 parts of black ginger, 6 parts of Roman chamomile, 7 parts of verbena, 9 parts of ginseng, 16 parts of common cnidium fruit, 4 parts of narcissus root, 5 parts of Chinese gall, 5 parts of fructus evodiae, 6 parts of asarum and 4 parts of cananga odorata.

3. The use according to claims 1 and 2, wherein the active ingredients of the herbal composition are prepared by the following steps:

4. The use of claims 1 and 2, wherein the herbal composition is in the form of a gel or patch.

5. The use according to claim 4, wherein the gelling agent is prepared by the steps of:

s8, adding 6 parts of carbomer into 790 parts of water, fully dissolving, adjusting the pH of the material to 5.5-6.5 by using triethanolamine, and preparing a gel matrix;

6. The use according to claim 4, wherein said patch is prepared by the steps of:

s9, putting 40 parts of rubber which is subjected to open milling into a kneader, adding 3 parts of anti-aging agent, and starting the kneader to knead for 1 hour;

s11, filtering the rubber material through a screw extrusion filter;