CN115068383A - 一种漱口水及其制备方法 - Google Patents
一种漱口水及其制备方法 Download PDFInfo
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- CN115068383A CN115068383A CN202210784491.8A CN202210784491A CN115068383A CN 115068383 A CN115068383 A CN 115068383A CN 202210784491 A CN202210784491 A CN 202210784491A CN 115068383 A CN115068383 A CN 115068383A
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- extract
- mouthwash
- chinese medicine
- oral cavity
- traditional chinese
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
本申请提出了一种漱口水及其制备方法,涉及漱口水技术领域。一种漱口水,按重量百分比计,包括如下原料:西吡氯铵0.03‑0.05%、中药提取物0.1‑0.3%、口味调节剂0.05‑0.09%、润湿剂1‑2%、氯化钠1‑3%、防腐剂0.02‑0.04%、余量为臭氧水,所述臭氧浓度为1‑10mg/L。本申请通过添加有西吡氯铵具有广谱抗菌性,对革兰氏阳性菌具有快速的杀菌作用,尤其对酵母有较好的杀菌作用,能够抑制牙菌斑,对口腔念珠菌有较好的杀灭效果,可以保护口腔健康;中药提取物对于口腔的有害病菌有较好的抗菌作用,且其在口腔内时,能通过口腔内壁渗透,作用于人体,提高人体免疫力,避免口腔疾病;氯化钠在口腔中起到清洁作用和杀菌消炎的作用。
Description
技术领域
本申请涉及漱口水技术领域,具体而言,涉及一种漱口水及其制备方法。
背景技术
牙齿是口腔的门户,拥有一口健康洁白的好牙是健康的标志之一。随着生活水平的提高,人们对口腔保健的意识也大大增强。而口腔中多存在一些有害菌种,比如变异链球菌和幽门螺杆菌等等,会导致口腔疾病,甚至会导致胃病。因此,对口腔进行清洁,杀灭有害病菌,保持口腔健康十分重要。资料显示,常规刷牙只能清除牙面40%-50%的菌斑,对于清除口腔软组织表明的菌斑基本无能为力,而对于常见的口腔疾病如龋齿和口腔溃疡等,在治疗时会大量使用抗生素药物,导致口腔菌群失衡。
漱口水作为一种口腔护理产品,可深入口腔各部位辅助控制菌斑。目前,市售的漱口水大多采用精油或氯己定作为杀菌剂,含精油的漱口水虽然渗透性强,但是漱口水中含有酒精,对口腔有刺激作用,且现有的口腔漱口水对于口腔杀菌作用较差。
发明内容
本申请的目的在于提供一种漱口水,此漱口水具有对口腔杀菌效果好的优点。
本申请的另一目的在于提供一种漱口水的制备方法,以获得此漱口水。
本申请解决其技术问题是采用以下技术方案来实现的。
一方面,本申请实施例提供一种漱口水,按重量百分比计,包括如下原料:西吡氯铵0.03-0.05%、中药提取物0.1-0.3%、口味调节剂0.05-0.09%、润湿剂1-2%、氯化钠1-3%、防腐剂0.02-0.04%、余量为臭氧水,所述臭氧浓度为1-10mg/L。
另一方面,本申请实施例提供一种漱口水的制备方法,包括如下步骤:
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,搅拌后,得到漱口水成品。
相对于现有技术,本申请的实施例至少具有如下优点或有益效果:
本申请通过添加有西吡氯铵具有广谱抗菌性,对革兰氏阳性菌具有快速的杀菌作用,尤其对酵母有较好的杀菌作用,能够抑制牙菌斑,减少牙周炎的发生概率,且对口腔念珠菌有较好的杀灭效果,可以保护口腔健康;同时,中药提取物对于口腔的有害病菌有较好的抗菌作用,且其在口腔内时,能够通过口腔内壁渗透,作用于人体,提高人体免疫力,避免口腔疾病;再通过添加有口味调节剂,能够提高本漱口水的使用舒服度;氯化钠还可以在口腔中起到清洁作用和杀菌消炎的作用。以西吡氯铵、中药提取物和氯化钠共同作用,杀灭口腔内的有害病菌,维持口腔环境健康;臭氧能够清除口腔内部的异味和细菌,且长期使用能够减少牙痛的发生。
本申请的制备方法简单便捷,能够快捷批量化的生产。
具体实施方式
为使本申请实施例的目的、技术方案和优点更加清楚,下面将对本申请实施例中的技术方案进行清楚、完整地描述。实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者,均为可以通过市售购买获得的常规产品。
需要说明的是,在不冲突的情况下,本申请中的实施例及实施例中的特征可以相互组合。下面将参考具体实施例来详细说明本申请。
本实施例提供一种漱口水,按重量百分比计,包括如下原料:西吡氯铵0.03-0.05%、中药提取物0.1-0.3%、口味调节剂0.05-0.09%、润湿剂1-2%、氯化钠1-3%、防腐剂0.02-0.04%、余量为臭氧水,所述臭氧浓度为1-10mg/L。
本申请通过添加有西吡氯铵具有广谱抗菌性,对革兰氏阳性菌具有快速的杀菌作用,尤其对酵母有较好的杀菌作用,能够抑制牙菌斑,减少牙周炎的发生概率,且对口腔念珠菌有较好的杀灭效果,可以保护口腔健康;同时,中药提取物对于口腔的有害病菌有较好的抗菌作用,且其在口腔内时,能够通过口腔内壁渗透,作用于人体,提高人体免疫力,避免口腔疾病;再通过添加有口味调节剂,能够提高本漱口水的使用舒服度;氯化钠还可以在口腔中起到清洁作用和杀菌消炎的作用。以西吡氯铵、中药提取物和氯化钠共同作用,杀灭口腔内的有害病菌,维持口腔环境健康;臭氧能够清除口腔内部的异味和细菌,且长期使用能够减少牙痛的发生。
在本申请的一些实施例中,上述中药提取物包括重量比为(2-4):1:(1-2):1:1:(1-2)的兰香草提取物、金银花提取物、板蓝根提取物、连翘提取物、甘草提取物和百里香提取物。
在本申请的一些实施例中,上述臭氧水通过将臭氧注入水中获得。
兰香草味辛,性温。疏风解表,祛痰止咳,散淤止痛。用于上呼吸道感染,百日咳,支气管炎,风湿关节痛,胃肠炎,跌打肿痛,产后淤血腹痛;外用治毒蛇咬伤,湿疹,皮肤搔痒。对于金黄色葡萄球菌和白喉杆菌有明显的抑制作用,对伤寒,甲型和乙型副伤寒、绿脓和大肠,痢疾(弗氏)等杆菌以及溶血性链球菌也有-定作用;较高浓度为杀菌,较低浓度为抑菌。
金银花味甘,性寒。清热解毒,凉散风热。用于痈肿疔疮,喉痹,丹毒,热毒血痢,风热感冒,温病发热。具有广谱抗菌作用,对金黄色葡萄球菌和痢疾杆菌等致病菌有较强的抑制作用,对钩端螺旋体、流感病毒及致病霉菌等多种病原微生物亦有抑制作用;金银花煎剂能促进白细胞的吞噬作用;有明显的抗炎及解热作用。
板蓝根味苦,性寒。清热解毒,凉血利咽。用于温毒发斑,舌绛紫暗,痄腮,喉痹,烂喉丹痧,大头瘟疫,丹毒,痈肿。对多种革兰阳性菌、革兰阴性菌、流感病毒、虫媒病毒和腮腺病毒均有抑制作用;可增强免疫功能;有明显的解热效果。
连翘味苦,性微寒。清热解毒,消肿散结。用于痈疽,瘰疠,乳痈,丹毒,风热感冒,温病初起,温热入营,高热烦渴,神昏发斑,热淋尿闭。有广谱抗菌作用,抗菌主要成分为连翘酚及挥发油,对金黄色葡萄球菌和痢疾杆菌有很强的抑制作用,对其他致病菌和流感病毒以及钩端螺旋体也均有一定的抑制作用;本品有抗炎、解热作用。所含齐墩果酸有强心、利尿及降血压作用;所含维生素P可降低血管通透性及脆性,防止溶血。
甘草味甘,性平。补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。甘草醇提取物及甘草次酸钠在体外对金黄色葡萄球菌、结核杆菌、大肠杆菌、阿米巴原虫及滴虫均有抑制作用,但在有血浆存在的情况下,其抑制和杀阿米巴原虫的作用有所减弱。甘草多糖对水泡性口炎病毒、腺病毒Ⅲ型、单纯疱疹病毒Ⅰ型和牛痘病毒均有明显抑制作用。还有抗消化性溃疡的作用。
百里香味辛,性微温。祛风解表,行气止痛,止咳,降压。用于感冒,咳嗽,头痛,牙痛,消化不良,急性胃肠炎,高血压病。
兰香草、金银花、板蓝根、连翘、甘草和百里香共同配伍,能够增强对有害病菌的杀灭作用,且金银花与连翘配伍,可以增强清透疏表的效果,在口腔溃疡时,能够加速口腔恢复健康。增加板蓝根的配伍,对口腔溃疡、牙龈肿痛时,能够清热燥湿,促进口腔恢复,再加上金银花和甘草共同作用,可以增强清热解毒降火的功效,不仅能够杀菌消炎,还能够在口腔溃疡或口腔内红肿时,促进其恢复。再加上百里香共同作用,能够提高起到疏风散热、消痈散节和消解热毒的作用。
在本申请的一些实施例中,上述中药提取物通过如下方法制备:
将兰香草、金银花、板蓝根、连翘、甘草和百里香破碎后,加入乙醇,回流提取,提取2-3次,合并提取液后,减压浓缩干燥后,得到中药提取物。该提取方法简单,且能够充分提取出药材中的效用成分。
在本申请的一些实施例中,上述兰香草、金银花、板蓝根、连翘、甘草和百里香破碎到60-100目。充分破碎后,便于有益成分被提取出来。
在本申请的一些实施例中,上述乙醇与兰香草、金银花、板蓝根、连翘、甘草和百里香的重量比为(10-13):1,所述乙醇的体积浓度为65-70%,所述回流提取具体是在80℃下回流提取2h。
在本申请的一些实施例中,上述润湿剂包括透明质酸钠和/或甘油。透明质酸钠甘油具有优秀的保水能力,在使用后,能够为口腔保持湿润的环形,缓解口干。
在本申请的一些实施例中,上述口味调节剂包括重量比为(1-3):(1-2):(1-2):(2-3)的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷。水杨酸甲酯和薄荷酯能够使得漱口水具有一定的凉感,可以提高使用舒适度;薄荷酯不易挥发,且没有涩味,比较温和,且凉感持续时间久;甘露糖醇和甜菊糖苷甜味持久,且味道纯粹,多种味道综合到一起,能够使得漱口水的使用体验佳。
在本申请的一些实施例中,上述防腐剂包括辛二醇、山梨酸钾或苯甲酸钠。
本实施例还提供一种漱口水的制备方法,包括如下步骤:
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,搅拌后,得到漱口水成品。
在本申请的一些实施例中,上述搅拌时间为30-50min,搅拌具体是在密闭环境下进行,所述搅拌压力为6-10MPa。
以下结合实施例对本申请的特征和性能作进一步的详细描述。
实施例1
一种漱口水的制备方法,包括如下步骤:
原料:西吡氯铵0.03%、中药提取物(重量比为2:1:1:1:1:1的兰香草提取物、金银花提取物、板蓝根提取物、连翘提取物、甘草提取物和百里香提取物)0.1%、口味调节剂(重量比为1:1:1:2的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷)0.05%、润湿剂(透明质酸钠)1%、氯化钠1%、防腐剂(辛二醇)0.02%、余量为臭氧水(臭氧浓度1mg/L)。
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,在气压为6MPa、密闭条件下搅拌30min,得到漱口水成品。
中药提取物通过如下方法制备:
将兰香草、金银花、板蓝根、连翘、甘草和百里香破碎到60目,加入10重量倍、体积浓度为65%的乙醇,在80℃下回流提取2h,提取2次,合并提取液后,减压浓缩干燥后,得到中药提取物。
实施例2
一种漱口水的制备方法,包括如下步骤:
原料:西吡氯铵0.04%、中药提取物(重量比为3:1:2:1:1:1的兰香草提取物、金银花提取物、板蓝根提取物、连翘提取物、甘草提取物和百里香提取物)0.2%、口味调节剂(重量比为1:1:2:3的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷)0.07%、润湿剂(透明质酸钠)1.5%、氯化钠2%、防腐剂(辛二醇)0.03%、余量为臭氧水(臭氧浓度5mg/L)。
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,在气压为8MPa、密闭条件下搅拌40min,得到漱口水成品。
中药提取物通过如下方法制备:
将兰香草、金银花、板蓝根、连翘、甘草和百里香破碎到80目,加入12重量倍、体积浓度为68%的乙醇,在80℃下回流提取2h,提取2次,合并提取液后,减压浓缩干燥后,得到中药提取物。
实施例3
一种漱口水的制备方法,包括如下步骤:
原料:西吡氯铵0.05%、中药提取物(重量比为4:1:2:1:1:1的兰香草提取物、金银花提取物、板蓝根提取物、连翘提取物、甘草提取物和百里香提取物)0.3%、口味调节剂(重量比为3:2:2:3的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷)0.09%、润湿剂(透明质酸钠)1-2%、氯化钠3%、防腐剂(辛二醇)0.04%、臭氧水(臭氧浓度10mg/L)。
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,在气压为10MPa、密闭条件下搅拌50min,得到漱口水成品。
中药提取物通过如下方法制备:
将兰香草、金银花、板蓝根、连翘、甘草和百里香破碎到100目,加入13重量倍、体积浓度为70%的乙醇,在80℃下回流提取2h,提取3次,合并提取液后,减压浓缩干燥后,得到中药提取物。
实施例4
本实施例与实施例2基本相同,区别在于:润湿剂为甘油。
一种漱口水的制备方法,包括如下步骤:
原料:西吡氯铵0.04%、中药提取物(重量比为3:1:2:1:1:1的兰香草提取物、金银花提取物、板蓝根提取物、连翘提取物、甘草提取物和百里香提取物)0.2%、口味调节剂(重量比为1:1:2:3的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷)0.07%、润湿剂(甘油)1.5%、氯化钠2%、防腐剂(辛二醇)0.03%、臭氧水(臭氧浓度5mg/L)。
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,在气压为8MPa、密闭条件下搅拌40min得到漱口水成品。
中药提取物通过如下方法制备:
将兰香草、金银花、板蓝根、连翘、甘草和百里香破碎到80目,加入12重量倍、体积浓度为68%的乙醇,在80℃下回流提取2h,提取2次,合并提取液后,减压浓缩干燥后,得到中药提取物。
实施例5
本实施例与实施例2基本相同,区别在于:防腐剂为山梨酸钾。
一种漱口水的制备方法,包括如下步骤:
原料:西吡氯铵0.04%、中药提取物(重量比为3:1:2:1:1:1的兰香草提取物、金银花提取物、板蓝根提取物、连翘提取物、甘草提取物和百里香提取物)0.2%、口味调节剂(重量比为1:1:2:3的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷)0.07%、润湿剂(透明质酸钠)1.5%、氯化钠2%、防腐剂(山梨酸钾)0.03%、臭氧水(臭氧浓度5mg/L)。
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,在气压为8MPa、密闭条件下搅拌40min,得到漱口水成品。
中药提取物通过如下方法制备:
将兰香草、金银花、板蓝根、连翘、甘草和百里香破碎到80目,加入12重量倍、体积浓度为68%的乙醇,在80℃下回流提取2h,提取2次,合并提取液后,减压浓缩干燥后,得到中药提取物。
实施例6
本实施例与实施例2基本相同,区别在于:防腐剂为苯甲酸钠。
一种漱口水的制备方法,包括如下步骤:
原料:西吡氯铵0.04%、中药提取物(重量比为3:1:2:1:1:1的兰香草提取物、金银花提取物、板蓝根提取物、连翘提取物、甘草提取物和百里香提取物)0.2%、口味调节剂(重量比为1:1:2:3的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷)0.07%、润湿剂(透明质酸钠)1.5%、氯化钠2%、防腐剂(苯甲酸钠)0.03%、臭氧水(臭氧浓度5mg/L)。
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,在气压为8MPa、密闭条件下搅拌40min,得到漱口水成品。
中药提取物通过如下方法制备:
将兰香草、金银花、板蓝根、连翘、甘草和百里香破碎到80目,加入12重量倍、体积浓度为68%的乙醇,在80℃下回流提取2h,提取2次,合并提取液后,减压浓缩干燥后,得到中药提取物。
对比例1
本对比例与实施例2基本相同,区别在于:未添加中药提取物。
一种漱口水的制备方法,包括如下步骤:
原料:西吡氯铵0.04%、口味调节剂(重量比为1:1:2:3的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷)0.07%、润湿剂(透明质酸钠)1.5%、氯化钠2%、防腐剂(辛二醇)0.03%、臭氧水(臭氧浓度5mg/L)。
向臭氧水中加入西吡氯铵、润湿剂、口味调节剂、氯化钠和防腐剂,在气压为8MPa、密闭条件下搅拌40min,得到漱口水成品。
实验例
(一)、抗菌性能实验
邀请实验组30人,年龄在22-43岁之间,随机分为3组,分别用实施例2、对比例1和清水进行漱口,具体是使用15ml漱口水/清水放入口腔内漱口,一分钟后吐出。在漱口前后用无菌棉签从舌背面进行取样,每次取样在舌背面来回滚动4次,取样完成的棉签放入含有1mL的PBS缓冲液中,再用PBS缓冲液稀释到10-4倍,再接种在琼脂培养基上,在36℃下培养48h,记录菌落数,得出抑菌率,结果如表1所示。抑菌率=(漱口前菌落数-漱口后菌落数)/漱口前菌落数
表1
分析表1,对比实施例2和清水可以看出本申请实施例2制备的漱口水杜宇口腔菌落的抑制效果好;对比实施例2和对比例2,可以看出是否添加有中药提取物,对于口腔抑菌效果影响比较大,在中药提取物和其余物质的配合下,才能达到99.76%以上的抑菌率。
(二)、依照QB/T2945-2012《口腔清洁护理液》对实施例1-实施例6制备的漱口水进行稳定性实验。
耐热稳定性:分别取实施例1-实施例6的漱口水25mL倒入具塞闭塞管内,在40℃下放置于恒温培育箱内24h后取出,恢复至室温,目视观察试样情况。
耐寒稳定性:分别取实施例1-实施例6的漱口水25mL倒入具塞闭塞管内,在4℃下放置于冰箱内24h后取出,恢复至室温,目视观察试样情况。
在耐热性测试和耐寒性测试过程中,实施例1-实施例6的漱口水均澄清,无肉眼可见的杂质或分层。这说明本申请制备的漱口水品质稳定。
综上所述,本申请通过添加有西吡氯铵具有广谱抗菌性,对革兰氏阳性菌具有快速的杀菌作用,尤其对酵母有较好的杀菌作用,能够抑制牙菌斑,减少牙周炎的发生概率,且对口腔念珠菌有较好的杀灭效果,可以保护口腔健康;同时,中药提取物对于口腔的有害病菌有较好的抗菌作用,且其在口腔内时,能够通过口腔内壁渗透,作用于人体,提高人体免疫力,避免口腔疾病;再通过添加有口味调节剂,能够提高本漱口水的使用舒服度;氯化钠还可以在口腔中起到清洁作用和杀菌消炎的作用。以西吡氯铵、中药提取物和氯化钠共同作用,杀灭口腔内的有害病菌,维持口腔环境健康;臭氧能够清除口腔内部的异味和细菌,且长期使用能够减少牙痛的发生。
本申请的制备方法简单便捷,能够快捷批量化的生产。
以上所描述的实施例是本申请一部分实施例,而不是全部的实施例。本申请的实施例的详细描述并非旨在限制要求保护的本申请的范围,而是仅仅表示本申请的选定实施例。基于本申请中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本申请保护的范围。
Claims (10)
1.一种漱口水,其特征在于,按重量百分比计,包括如下原料:西吡氯铵0.03-0.05%、中药提取物0.1-0.3%、口味调节剂0.05-0.09%、润湿剂1-2%、氯化钠1-3%、防腐剂0.02-0.04%、余量为臭氧水,所述臭氧浓度为1-10mg/L。
2.根据权利要求1所述的一种漱口水,其特征在于,所述中药提取物包括重量比为(2-4):1:(1-2):1:1:(1-2)的兰香草提取物、金银花提取物、板蓝根提取物、连翘提取物、甘草提取物和百里香提取物。
3.根据权利要求2所述的一种漱口水,其特征在于,所述中药提取物通过如下方法制备:
将兰香草、金银花、板蓝根、连翘、甘草和百里香破碎后,加入乙醇,回流提取,提取2-3次,合并提取液后,减压浓缩干燥后,得到中药提取物。
4.根据权利要求3所述的一种漱口水,其特征在于,所述兰香草、金银花、板蓝根、连翘、甘草和百里香破碎到60-100目。
5.根据权利要求3所述的一种漱口水,其特征在于,所述乙醇与兰香草、金银花、板蓝根、连翘、甘草和百里香的重量比为(10-13):1,所述乙醇的体积浓度为65-70%,所述回流提取具体是在80℃下回流提取2h。
6.根据权利要求1所述的一种漱口水,其特征在于,所述润湿剂包括透明质酸钠和/或甘油。
7.根据权利要求1所述的一种漱口水,其特征在于,所述口味调节剂包括重量比为(1-3):(1-2):(1-2):(2-3)的水杨酸甲酯、薄荷酯、甘露糖醇和甜菊糖苷。
8.根据权利要求1所述的一种漱口水,其特征在于,所述防腐剂包括辛二醇、山梨酸钾或苯甲酸钠。
9.如权利要求1-8任意一项所述的一种漱口水的制备方法,其特征在于,包括如下步骤:
向臭氧水中加入西吡氯铵、润湿剂、中药提取物、口味调节剂、氯化钠和防腐剂,搅拌后,得到漱口水成品。
10.根据权利要求9所述的一种漱口水的制备方法,其特征在于,所述搅拌时间为30-50min,所述搅拌具体是在密闭环境下进行,所述搅拌压力为6-10MPa。
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CN117530894A (zh) * | 2024-01-09 | 2024-02-09 | 北京洗得宝消毒制品有限公司 | 一种能够抑制幽门螺杆菌的漱口水及其制备方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108186441A (zh) * | 2018-02-10 | 2018-06-22 | 广州市九科精细化工有限公司 | 一种止血抗过敏的复合草本漱口水及其制备方法 |
-
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- 2022-07-05 CN CN202210784491.8A patent/CN115068383A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108186441A (zh) * | 2018-02-10 | 2018-06-22 | 广州市九科精细化工有限公司 | 一种止血抗过敏的复合草本漱口水及其制备方法 |
Non-Patent Citations (1)
Title |
---|
高学敏等: "《中药药理学》", 上海科学技术出版社, pages: 196 - 86 * |
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CN115554196A (zh) * | 2022-11-10 | 2023-01-03 | 武夷山元生泰生物科技有限公司 | 一种灵芝漱口液及其制备方法 |
CN117530894A (zh) * | 2024-01-09 | 2024-02-09 | 北京洗得宝消毒制品有限公司 | 一种能够抑制幽门螺杆菌的漱口水及其制备方法 |
CN117530894B (zh) * | 2024-01-09 | 2024-05-17 | 北京洗得宝消毒制品有限公司 | 一种能够抑制幽门螺杆菌的漱口水及其制备方法 |
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