CN115067325A - Preparation method of anhydrous dinotefuran suspending agent - Google Patents
Preparation method of anhydrous dinotefuran suspending agent Download PDFInfo
- Publication number
- CN115067325A CN115067325A CN202210673804.2A CN202210673804A CN115067325A CN 115067325 A CN115067325 A CN 115067325A CN 202210673804 A CN202210673804 A CN 202210673804A CN 115067325 A CN115067325 A CN 115067325A
- Authority
- CN
- China
- Prior art keywords
- dinotefuran
- suspending agent
- anhydrous
- agent
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- YKBZOVFACRVRJN-UHFFFAOYSA-N dinotefuran Chemical compound [O-][N+](=O)\N=C(/NC)NCC1CCOC1 YKBZOVFACRVRJN-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 239000000375 suspending agent Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000945 filler Substances 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 239000002270 dispersing agent Substances 0.000 claims abstract description 10
- 239000003755 preservative agent Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 239000002562 thickening agent Substances 0.000 claims abstract description 10
- 239000000080 wetting agent Substances 0.000 claims abstract description 10
- 239000000575 pesticide Substances 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 238000010008 shearing Methods 0.000 claims abstract description 6
- 238000005303 weighing Methods 0.000 claims abstract description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 14
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 14
- 235000019441 ethanol Nutrition 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 229940043264 dodecyl sulfate Drugs 0.000 claims description 7
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 claims description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 5
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 5
- NHFDKKSSQWCEES-UHFFFAOYSA-N dihydrogen phosphate;tris(2-hydroxyethyl)azanium Chemical compound OP(O)(O)=O.OCCN(CCO)CCO NHFDKKSSQWCEES-UHFFFAOYSA-N 0.000 claims description 5
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 5
- 229920002866 paraformaldehyde Polymers 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- 235000010356 sorbitol Nutrition 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 229920000142 Sodium polycarboxylate Polymers 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- LDMOEFOXLIZJOW-UHFFFAOYSA-N 1-dodecanesulfonic acid Chemical compound CCCCCCCCCCCCS(O)(=O)=O LDMOEFOXLIZJOW-UHFFFAOYSA-N 0.000 claims description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- BWDBEAQIHAEVLV-UHFFFAOYSA-N 6-methylheptan-1-ol Chemical compound CC(C)CCCCCO BWDBEAQIHAEVLV-UHFFFAOYSA-N 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- BOLQUPOXTWHXIX-UHFFFAOYSA-N OC1=CC=CC=C1.C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 Chemical compound OC1=CC=CC=C1.C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 BOLQUPOXTWHXIX-UHFFFAOYSA-N 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 239000000783 alginic acid Substances 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229960001126 alginic acid Drugs 0.000 claims description 2
- 150000004781 alginic acids Chemical class 0.000 claims description 2
- 229960000892 attapulgite Drugs 0.000 claims description 2
- 235000012216 bentonite Nutrition 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 229960004365 benzoic acid Drugs 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229910052625 palygorskite Inorganic materials 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 229960003885 sodium benzoate Drugs 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 14
- 230000000857 drug effect Effects 0.000 abstract description 5
- 230000035699 permeability Effects 0.000 abstract description 3
- 238000005507 spraying Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 8
- 239000004562 water dispersible granule Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- GUUULVAMQJLDSY-UHFFFAOYSA-N 4,5-dihydro-1,2-thiazole Chemical compound C1CC=NS1 GUUULVAMQJLDSY-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 241000209094 Oryza Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 241000125167 Rhopalosiphum padi Species 0.000 description 3
- 229920006243 acrylic copolymer Polymers 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 150000002191 fatty alcohols Chemical class 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- -1 polyoxyethylene Polymers 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- TVFWYUWNQVRQRG-UHFFFAOYSA-N 2,3,4-tris(2-phenylethenyl)phenol Chemical compound C=1C=CC=CC=1C=CC1=C(C=CC=2C=CC=CC=2)C(O)=CC=C1C=CC1=CC=CC=C1 TVFWYUWNQVRQRG-UHFFFAOYSA-N 0.000 description 2
- 241001498622 Cixius wagneri Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 description 2
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 description 2
- 206010033799 Paralysis Diseases 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 239000004557 technical material Substances 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 241001466042 Fulgoromorpha Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- JSPKFLGISILEDM-UHFFFAOYSA-N phenol;styrene Chemical compound OC1=CC=CC=C1.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 JSPKFLGISILEDM-UHFFFAOYSA-N 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a preparation method of an anhydrous dinotefuran suspending agent, which comprises a dinotefuran raw pesticide, a dispersing agent, a wetting agent, a thickening agent, a preservative and an alcohol filler, wherein the dinotefuran raw pesticide accounts for 1-50 wt% of the suspending agent, 3-5 wt% of the dispersing agent, 3-5 wt% of the wetting agent, 0.15-0.3 wt% of the thickening agent, 0.3-1 wt% of the preservative and the balance of the alcohol filler, and all the components are added according to mass percentage; the anhydrous dinotefuran suspending agent is obtained by mixing, shearing, sanding, filtering, weighing and detecting the components. The anhydrous suspending agent provided by the invention has the advantages of being capable of being uniformly mixed and dispersed with water in any proportion, good in fluidity, capable of improving the drug effect, free from the influence of water quality and water temperature, convenient to use, not easy to pollute the environment, and capable of spraying after being diluted; the invention greatly improves the adhesion and the permeability of the product by adding the special alcohol mixture as the filler, thereby improving the drug effect.
Description
Technical Field
The invention belongs to the technical field of plant pesticides, and particularly relates to a preparation method of an anhydrous dinotefuran suspending agent which has a good pesticidal effect and is stable in quality.
Background
Dinotefuran is mainly oriented to the market by soluble liquid, water dispersible granules and water suspending agent in China. The soluble agent uses a large amount of organic solvent in production, which wastes resources and pollutes the environment after being used. The water dispersible granules are easy to generate dust pollution during processing and use, and the existing flying prevention application is common, so that the spray head is easy to block due to poor dispersion of the water dispersible granules, and the operation efficiency is influenced. The water suspending agent can generate crystallization and large grain diameter due to the high solubility of the dinotefuran in water, which affects the quality of products, and liquid medicine can not be poured out and cleaned by farmers when in use.
The dinotefuran pure product is white crystal, has the melting point of 107.5 ℃, the solubility of 40 g/L water and is difficult to dissolve in organic solvents such as xylene, cyclohexane and the like. The action mechanism is as follows: dinotefuran mainly acts on insect nerve transmission systems, so that pests are paralyzed to play a role in killing insects. Also known as nicotinic acetylcholine receptor (nAChR) agonists, which causes the insect to die by abnormal excitation, general spasm, paralysis. It has not only contact poisoning and stomach poisoning action, but also excellent systemic and osmotic action, and can be quickly absorbed by root, stem and leaf of plant and upwards conducted. Belongs to the third generation of nicotine pesticide. Has the functions of contact killing and stomach toxicity, strong systemic property and long lasting period, has wider insecticidal spectrum and more convenient use compared with first and second generation insecticides, and can overcome the resistance risk brought by the first and second generation insecticides.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to provide an anhydrous dinotefuran suspending agent aiming at the defects of the prior art, wherein an alcohol product is used as a filler instead of water, so that the product quality is improved, and the product adhesiveness, permeability and moisture retention are improved to achieve a synergistic effect.
The technical scheme is as follows: the invention relates to a preparation method of an anhydrous dinotefuran suspending agent, which comprises a dinotefuran raw pesticide, a dispersing agent, a wetting agent, a thickening agent, a preservative and an alcohol filler, wherein the dinotefuran raw pesticide accounts for 1-50 wt% of the suspending agent, 3-5 wt% of the dispersing agent, 3-5 wt% of the wetting agent, 0.15-0.3 wt% of the thickening agent, 0.3-1 wt% of the preservative and the balance of the alcohol filler, and all the components are added according to mass percentage; the anhydrous dinotefuran suspending agent is obtained by mixing, shearing, sanding, filtering, weighing and detecting the components.
Further, as a preferred embodiment, the alcohol filler is one or a combination of ethanol, ethylene glycol, propylene glycol, glycerol, isooctanol, benzyl alcohol, sorbitol or xylitol.
Further, as a preferred embodiment, the dispersant is one or a mixture of more of triphenylethylene phenol polyoxyethylene ether phosphate triethanolamine, acrylic copolymer sodium polycarboxylate, alkylphenol polyoxyethylene ether and naphthalene sulfonate complex or alkylphenol polyoxyethylene ether and naphthalene sulfonate complex.
Further, as a preferred embodiment, the wetting agent is one or a mixture of several of fatty alcohol-polyoxyethylene ether, fatty alcohol-dodecyl sulfate, dodecyl sulfonate or dodecyl sulfate.
Further, as a preferred embodiment, the thickening agent is one or a mixture of more of xanthan gum, magnesium aluminum silicate, starch, attapulgite, organic bentonite, pectin, acacia, gelatin, methyl cellulose, carboxymethyl cellulose, polyvinyl alcohol, silicon dioxide and alginic acid.
Further, as a preferred embodiment, the preservative is one or a mixture of several of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, isothiazolinone, formaldehyde or paraformaldehyde.
Has the advantages that: (1) the anhydrous suspending agent provided by the invention has the advantages of being capable of being uniformly mixed and dispersed with water in any proportion, good in fluidity, capable of improving the drug effect, free from the influence of water quality and water temperature, convenient to use, not easy to pollute the environment, and capable of spraying after being diluted; (2) in the invention, a special alcohol mixture is added as a filler, so that the adhesion and the permeability of the product are greatly improved, and the drug effect is improved; (3) the anhydrous suspending agent provided by the invention is processed by a wet method, does not generate dust, replaces benzene organic solvent with naturally degraded alcohol mixture, meets the requirement of environmental protection, has finer particle size than water dispersible granules, uniform dispersion of active ingredients, high suspension rate and higher drug effect than the water dispersible granules, and is an ideal new environment-friendly formulation at present; (4) the anhydrous dinotefuran suspending agent is prepared by replacing water with alcohol mixture, the quality problems of crystallization and creaming are avoided, and the product quality is stable.
Detailed Description
The technical solution of the present invention is described in detail by the following examples, but the scope of the present invention is not limited to the examples.
Example 1: a preparation method of an anhydrous dinotefuran suspending agent comprises the following steps of: 2% of dinotefuran original drug, 2% of dispersant tristyrene phenol polyoxyethylene ether phosphate triethanolamine, 1% of compound of alkylphenol polyoxyethylene ether and naphthalenesulfonate, 2% of wetting agent deca fatty alcohol polyoxyethylene, 1% of lauryl sulfate, 0.25% of thickening agent xanthan gum, 0.1% of magnesium aluminum silicate, 0.3% of preservative isothiazoline, 0.2% of paraformaldehyde, 30% of filler sorbitol and 61.1% of ethylene glycol, mixing, shearing, sanding and filtering to prepare a sample 1.
Example 2: a preparation method of an anhydrous dinotefuran suspending agent comprises the following steps of: 20% of dinotefuran original drug, 2% of dispersant tristyrylphenol polyoxyethylene ether phosphate triethanolamine, 1% of acrylic copolymer sodium polycarboxylate, 1% of alkylphenol polyoxyethylene ether and naphthalenesulfonate complex, 2% of wetting agent fatty alcohol polyoxyethylene, 2% of lauryl sulfate, 0.15% of thickening agent xanthan gum, 0.05% of magnesium aluminum silicate, 0.3% of preservative isothiazoline, 0.2% of paraformaldehyde, 20% of filler sorbitol and 50.9% of ethylene glycol, and mixing, shearing, sanding and filtering to prepare a sample 2.
Example 3: a preparation method of an anhydrous dinotefuran suspending agent comprises the following steps of: 40% of dinotefuran original drug, 2% of dispersant tristyrylphenol polyoxyethylene ether phosphate triethanolamine, 2% of acrylic copolymer sodium polycarboxylate, 1% of alkylphenol polyoxyethylene ether and naphthalenesulfonate complex, 3% of wetting agent fatty alcohol polyoxyethylene, 2% of lauryl sulfate, 0.1% of thickening agent xanthan gum, 0.1% of magnesium aluminum silicate, 0.4% of preservative isothiazoline, 0.2% of paraformaldehyde, 10% of filler sorbitol and 38.4% of ethylene glycol, and mixing, shearing, sanding and filtering to prepare a sample 3.
Example 4: test and control data for samples prepared in examples 1-3
And (3) detecting the fineness, namely, respectively passing the products of examples 1 to 3 through three different screens of 200 meshes, 325 meshes and 500 meshes to measure the fineness of the products. The higher the fineness, the smaller the particle size of the product and the more stable the product quality, the results are shown in Table 1. The results show that the sample schemes 1-3 of the anhydrous dinotefuran suspending agent are superior to the commercial comparative sample 20% dinotefuran aqueous suspending agent.
TABLE 1 comparison of fineness measurements of samples from examples 1-3 with commercially available similar products
Wherein the dinotefuran technical material recorded in the examples 1-3 is purchased from: jingmen Jinxianda Biotech Co., Ltd;
the commercially available products of the same type in Table 1 are selected from: shandong province LvShi pesticide Co., Ltd, its name is Laifei.
The control effect test shows that the control effect is investigated on 7 days and 14 days after the application of the pesticide by diluting the schemes 1 to 3 with water by 1000 times and spraying the water to rice planthoppers and 1500 times to wheat aphids, and the control effect is shown in the attached table 2.
Test results show that the anhydrous dinotefuran suspending agent has remarkable control effect on rice planthopper and wheat aphid, the control effect on the rice planthopper and the wheat aphid in 4 days and 7 days is more than 85%, the control effect in 14 days is more than 75%, and the control effect is obviously higher than that of a comparative sample which is 20% of dinotefuran suspending agent.
TABLE 2 comparison of control effect test results of samples of examples 1-3 with similar products on the market
Wherein the dinotefuran technical material described in examples 1-3 is purchased from: jingmen Jinxianda Biotech Co., Ltd;
the commercially available products of the same type in Table 1 are selected from: shandong province LvShi pesticide Co., Ltd, its name is Laifei.
As noted above, while the present invention has been shown and described with reference to certain preferred embodiments, it is not to be construed as limited thereto. Various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (6)
1. A preparation method of an anhydrous dinotefuran suspending agent is characterized by comprising the following steps: the dinotefuran suspending agent comprises 1-50 wt% of dinotefuran raw pesticide, 3-5 wt% of dispersing agent, 3-5 wt% of wetting agent, 0.15-0.3 wt% of thickening agent, 0.3-1 wt% of preservative and the balance of alcohol filler, wherein the dinotefuran raw pesticide accounts for 1-50 wt% of suspending agent; the anhydrous dinotefuran suspending agent is obtained by mixing, shearing, sanding, filtering, weighing and detecting the components.
2. The method for preparing the anhydrous dinotefuran suspending agent according to claim 1, wherein the method comprises the following steps: the alcohol filler is one or a combination of ethanol, ethylene glycol, propylene glycol, glycerol, isooctanol, benzyl alcohol, sorbitol or xylitol.
3. The method for preparing the anhydrous dinotefuran suspending agent according to claim 2, wherein the method comprises the following steps: the dispersing agent is one or a mixture of more of triphenylethylene phenol polyoxyethylene ether phosphate triethanolamine, acrylic acid copolymer sodium polycarboxylate, alkylphenol polyoxyethylene ether and naphthalene sulfonate complex or alkylphenol polyoxyethylene ether and naphthalene sulfonate complex.
4. The method for preparing the anhydrous dinotefuran suspending agent according to claim 3, wherein the method comprises the following steps: the wetting agent is one or a mixture of fatty alcohol-polyoxyethylene ether, fatty alcohol-dodecyl-sulfate, dodecyl sulfonate or dodecyl sulfate.
5. The method for preparing the anhydrous dinotefuran suspending agent according to claim 4, wherein the method comprises the following steps: the thickening agent is one or more of xanthan gum, magnesium aluminum silicate, starch, attapulgite, organic bentonite, pectin, Arabic gum, gelatin, methyl cellulose, carboxymethyl cellulose, polyvinyl alcohol, silicon dioxide and alginic acid.
6. The method for preparing the anhydrous dinotefuran suspending agent according to claim 5, wherein the method comprises the following steps: the preservative is one or a mixture of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, isothiazolinone, formaldehyde or paraformaldehyde.
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| CN102239829A (en) * | 2011-07-13 | 2011-11-16 | 南京扬子鸿利源化学品有限责任公司 | Dinotefuran aqueous suspension agent and its preparation method |
| CN102239878A (en) * | 2011-07-05 | 2011-11-16 | 江苏丘陵地区镇江农业科学研究所 | Insecticide composite containing dinotefuran, preparation formulations and preparation method thereof |
| CN104663701A (en) * | 2015-01-23 | 2015-06-03 | 河北威远生化农药有限公司 | Dinotefuran synergistic suspending agent and preparation method thereof |
| CN110903810A (en) * | 2019-11-18 | 2020-03-24 | 宁波日晟新材料有限公司 | Hydrophilic non-oily anhydrous ceramic material suspending agent and preparation method and application thereof |
| CN115624032A (en) * | 2022-07-12 | 2023-01-20 | 江苏剑牌农化股份有限公司 | Preparation method of prochloraz-epoxiconazole water emulsion |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102239878A (en) * | 2011-07-05 | 2011-11-16 | 江苏丘陵地区镇江农业科学研究所 | Insecticide composite containing dinotefuran, preparation formulations and preparation method thereof |
| CN102239829A (en) * | 2011-07-13 | 2011-11-16 | 南京扬子鸿利源化学品有限责任公司 | Dinotefuran aqueous suspension agent and its preparation method |
| CN104663701A (en) * | 2015-01-23 | 2015-06-03 | 河北威远生化农药有限公司 | Dinotefuran synergistic suspending agent and preparation method thereof |
| CN110903810A (en) * | 2019-11-18 | 2020-03-24 | 宁波日晟新材料有限公司 | Hydrophilic non-oily anhydrous ceramic material suspending agent and preparation method and application thereof |
| CN115624032A (en) * | 2022-07-12 | 2023-01-20 | 江苏剑牌农化股份有限公司 | Preparation method of prochloraz-epoxiconazole water emulsion |
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