CN109964940A - A kind of application of miticide composition and its preparation, miticide composition and preparation - Google Patents
A kind of application of miticide composition and its preparation, miticide composition and preparation Download PDFInfo
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- CN109964940A CN109964940A CN201910219178.8A CN201910219178A CN109964940A CN 109964940 A CN109964940 A CN 109964940A CN 201910219178 A CN201910219178 A CN 201910219178A CN 109964940 A CN109964940 A CN 109964940A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
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Abstract
The invention belongs to technical field of pesticide, more particularly to the application of a kind of miticide composition and its preparation, miticide composition and preparation;The effective component of the miticide composition includes active components A and active constituent B;The active components A is Acynonapyr, and the active constituent B is one or more in pyridaben, etoxazole, Envidor and Fenpropathrin;The mass ratio of the active components A and active constituent B are 80:1~1:80, preferably 40:1~1:40, more preferably 20:1~1:20;By the total weight of the miticide composition for 100wt% in terms of, the sum of content of the active components A and active constituent B is 5~80wt%.Miticide composition of the invention or its preparation can enhance drug effect, reduce dosage, extend the lasting period and delay development of drug resistance.
Description
Technical field
The invention belongs to technical field of pesticide, more particularly to a kind of miticide composition and its preparation, miticide composition and
The application of preparation.
Background technique
Acynonapyr is the acaricide newly developed by Japanese Cao Da company, can be used for preventing and treating the pest mite of fruits and vegetables and tea tree
Class, and there is important dissemination without cross tolerance with other acaricides.The CAS chemistry of Acynonapyr is entitled (in 3-)-
3- [2- propoxyl group -4- (trifluoromethyl) phenoxy group] -9- [[5- (trifluoromethyl) -2- pyridyl group] oxygroup] -9- azabicyclo
[3.3.1] nonane (CAS:No.1332838-17-1), structural formula is as follows:
Currently, pyridaben, etoxazole, Envidor, Fenpropathrin are all common desinsection/acaricides, to having in agricultural
Harmful mite class has good control efficiency.
Pyridaben category pyridazine class broad spectrum acaricides, contact toxicity is stronger, has better effects to the entire growth period of mite class.And
And the medicament is not affected by temperature, and can obtain good result in spring and autumn.Its structural formula is as follows:
Etoxazole category diphenyloxazole derivative prevents and treats harmful mite class with stomach poison function by tagging.It mainly passes through
Inhibit the molting process of mite class and then drug effect is played to the mite class of ovum, nymph and pupa different phase.Its structural formula is as follows:
Envidor is broad spectrum acaricides, has contact toxicity;It mainly destroys the energy of acarid by inhibiting Fatty synthesis
Metabolic activity.Its structural formula is as follows:
Fenpropathrin is a kind of pyrethroid insecticidal/acaricidal agent, have tag, stomach poison function;It has Nervous toxicity
Property can cause pest to be overexcited, benumb and dead.Its structural formula is as follows:
Although above compound can be used as individual insecticide/miticide and use, what is prevented and treated pest
In the process, the development of pest resistance to insecticide is often inevitable.With being continuously increased for single pharmaceutical use and frequency, evil
The drug resistance of worm can also be accelerated therewith.How by the way that reasonably different pharmaceutical is compounded, play enhancing drug effect, reduce dosage,
Extend the lasting period and delay the effect of development of drug resistance, is present urgent problem.
Summary of the invention
It is an object of the present invention to there is drug resistance existing mite killing medicament, a kind of miticide composition is provided
And its preparation, the miticide composition or its preparation can enhance drug effect, reduce dosage, while can extend the lasting period and delay to resist
Pharmacological property development.
To achieve the goals above, the present invention provides a kind of miticide composition, the effective component packet of the miticide composition
Containing active components A and active constituent B;The active components A is Acynonapyr, and the active constituent B is selected from pyridaben, second mite
Azoles, Envidor or Fenpropathrin.
The mass ratio of the miticide composition provided according to the present invention, the active components A and active constituent B are 80:1~1:
80, preferably 40:1~1:40, more preferably 20:1~1:20.
The miticide composition provided according to the present invention, it is preferable that the mass ratio of the Acynonapyr and pyridaben is 15:
1~1:15, more preferably 10:1~1:15.
Preferably, the Acynonapyr and the mass ratio of etoxazole are 10:1~1:10, more preferably 5:1~1:5.
Preferably, the Acynonapyr and the mass ratio of Envidor are 10:1~1:10, more preferably 5:1~1:5.
Preferably, the mass ratio of the Acynonapyr and Fenpropathrin is 8:1~1:8, more preferably 6:1~1:6.
The miticide composition provided according to the present invention, it is preferable that the total weight with the miticide composition is 100wt%
Meter, the sum of the active components A and content of the active constituent B in miticide composition be 1~95wt%, more preferably 5~
80wt%, further preferably 10~50wt%.
Preferably, in terms of by the total weight of the miticide composition for 100wt%, the Acynonapyr and pyridaben are being killed
The sum of content in acaricidal composition is 20~50wt%.
Preferably, in terms of by the total weight of the miticide composition for 100wt%, the Acynonapyr and etoxazole are being killed
The sum of content in acaricidal composition is 20~40wt%.
Preferably, in terms of by the total weight of the miticide composition for 100wt%, the Acynonapyr and Envidor are being killed
The sum of content in acaricidal composition is 10~40wt%.
Preferably, in terms of by the total weight of the miticide composition for 100wt%, the Acynonapyr and Fenpropathrin exist
The sum of content in miticide composition is 10~40wt%.
The miticide composition provided according to the present invention, it is preferable that the miticide composition further includes adjuvant, the auxiliary
Agent is selected from wetting agent, dispersing agent, emulsifier, thickener, disintegrating agent, antifreezing agent, defoaming agent, solvent, preservative, stabilizer, increasing
Imitate one of agent and carrier or a variety of.
Preferably, the wetting agent is selected from alkylbenzene sulfonate, alkylnaphthalene sulfonate, lignosulfonates, dodecyl
Sodium sulphate, succinic acid dibutyl ester sodium sulfonate, alhpa olefin sulfonate, alkyl phenol polyoxyethylene ether (for example, NP-10), castor oil polyoxy
Vinethene, alkylphenol ethoxylate, alcohol ethoxylate (for example, penetrating agent JFC), fatty alcohol polyoxyethylene ether sulfuric acid
Sodium, silkworm excrement, spaonin powder, spaonin powder, SOPA (APES formaldehyde condensation product sulfonate), detergent, emulsifier
One of 2000 series and wet bleeding agent F are a variety of.
Preferably, the dispersing agent is selected from lignosulfonates, alkylnaphthalene sulfonate formaldehyde condensation products, naphthalene sulfonate, three
Styrylphenol ethoxylates phosphate, alcohol ethoxylate, alkyl phenol polyoxyethylene ether, alkylphenol-polyethenoxy
Ether methyl ether condensate sulfate, aliphatic amine polyoxyethylene ether, glycerol fatty acid ester polyoxyethylene ethe, polycarboxylic acid salt, polypropylene
One of acids, phosphoric acid salt, EO-PO block copolymer and EO-PO graft copolymer are a variety of.
Preferably, the emulsifier is selected from calcium dodecyl benzene sulfonate, alkyl phenol formaldehyde resin polyoxyethylene ether, phenethyl
Phenol polyoxyethylene poly-oxygen propylene aether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrylphenol polyoxyethylene ether,
One of castor oil polyoxyethylene base ether and alkyl phenol ether phosphate are a variety of.
Preferably, the thickener be selected from xanthan gum, organobentonite, gum arabic, sodium alginate, aluminium-magnesium silicate,
It is one or more in carboxymethyl cellulose and white carbon black.
Preferably, the disintegrating agent is selected from sodium sulphate, ammonium sulfate, aluminium chloride, sodium chloride, ammonium chloride, bentonite, grape
One of sugar, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid and tartaric acid are a variety of.
Preferably, the antifreezing agent is selected from one of alcohols, alcohol ethers, chlorinated hydrocarbon and inorganic salts or a variety of.
Preferably, the defoaming agent is selected from C10-C20Saturated fat acids compound, silicone oil, silicone compound, C8-C10
One of fatty alcohol is a variety of.
Preferably, the solvent is selected from benzene,toluene,xylene, durol, methanol, ethyl alcohol, isopropanol, n-butanol, two
In methyl sulfoxide, dimethylformamide, cyclohexanone, alkylene carbonate, diesel oil, solvent naphtha, vegetable oil, vegetable oil derivatives and water
It is one or more.
Preferably, the preservative is selected from propionic acid, propionic acid sodium salt, sorbic acid, sodium sorbate salt, sorbic acid sylvite, benzene first
In acid, benzoic acid sodium salt, P-hydroxybenzoic acid sodium salt, methyl p-hydroxybenzoate, Kathon CG and 1,2- benzisothiazole-3-ketone
It is one or more.
Preferably, the stabilizer is selected from disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2,6- di-t-butyl
Paracresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, white carbon black, talcum powder, montmorillonite
With one of starch or a variety of.
Preferably, the synergist is selected from Synergistic Phosphorus and/or Butacide.
Preferably, the carrier be selected from ammonium salt, grind natural minerals, grind artificial mineral, silicate, resin, wax,
One of solid fertilizer, water, organic solvent, mineral oil, vegetable oil and vegetable oil derivatives are a variety of.
The present invention also provides a kind of preparations of miticide composition, are prepared using miticide composition as described above.
The preparation provided according to the present invention, it is preferable that the dosage form of the preparation be selected from missible oil, aqueous emulsion, wettable powder,
Water dispersible granules, suspending agent or microcapsule formulations.
The present invention also provides a kind of miticide composition as described above, preparations as described above in preventing and treating harmful mite class
Using.
Detailed description of the invention
In some examples of the invention, the effective component of the miticide composition includes active components A and active constituent
B;The active components A is Acynonapyr, and the active constituent B is selected from pyridaben, etoxazole, Envidor or Fenpropathrin.
Wherein, the mass ratio of the active components A and active constituent B be 80:1~1:80, preferably 40:1~1:40, more
Preferably 20:1~1:20.
In some preferred embodiments, the mass ratio of the Acynonapyr and pyridaben is 15:1~1:15, preferably
For 10:1~1:15;Specifically, in miticide composition the mass ratio of Acynonapyr and pyridaben be 15:1,7:1,4:1,2:1,
1:1,1:2,1:4,1:7,1:15 or 1:8.
In some preferred embodiments, the mass ratio of the Acynonapyr and etoxazole is 10:1~1:10, preferably
For 5:1~1:5;Specifically, acynonapyr and the mass ratio of etoxazole are 10:1,5:1,4:1,3:1,2 in miticide composition:
1,1:1,1:2,1:3,1:4,1:5 or 1:10.
In some preferred embodiments, the mass ratio of the Acynonapyr and Envidor is 10:1~1:10, preferably
For 5:1~1:5;Specifically, Acynonapyr and the mass ratio of Envidor are 10:1,5:1,3:1,2:1,1 in miticide composition:
1,1:2,1:3,1:5,1:10 or 15:4.
In some preferred embodiments, the mass ratio of the Acynonapyr and Fenpropathrin is 8:1~1:8, preferably
For 6:1~1:6;Specifically, in miticide composition the mass ratio of Acynonapyr and Fenpropathrin be 8:1,6:1,5:1,3:1,
2:1,1:1,1:2,1:3,1:5 or 1:8.
In some instances, in terms of by the total weight of the miticide composition for 100wt%, the active components A and activity
The sum of content of ingredient B is 1~95wt%, preferably 5~80wt%, more preferably 10~50wt%.
In the preferred embodiment, the sum of content of the Acynonapyr and pyridaben is 20~50wt%, for example, institute
State the sum of content of Acynonapyr and pyridaben be 20wt%, 25wt%, 28wt%, 30wt%, 32wt%, 35wt%,
37wt%, 40wt%, 45wt%, 48wt% or 50wt%.
In the preferred embodiment, the sum of content of the Acynonapyr and etoxazole is 20~40wt%, for example, institute
State the sum of content of Acynonapyr and etoxazole be 20wt%, 22wt%, 25wt%, 28wt%, 30wt%, 35wt%,
38wt% or 40wt%.
In the preferred embodiment, the sum of content of the Acynonapyr and Envidor is 10~40wt%, for example, institute
State the sum of content of Acynonapyr and Envidor be 10wt%, 14wt%, 16wt%, 18wt%, 20wt%, 22wt%,
25wt%, 28wt%, 30wt%, 35wt%, 38wt% or 40wt%.
In the preferred embodiment, the sum of content of the Acynonapyr and Fenpropathrin is 10~40wt%, for example,
The sum of content of the Acynonapyr and Fenpropathrin be 10wt%, 12wt%, 15wt%, 18wt%, 20wt%,
25wt%, 28wt%, 30wt%, 35wt% or 40wt%.
The present invention makes its toxicity and residues reach preferable flat by the optimization to active constituent content in miticide composition
Weighing apparatus can enhance drug effect, reduce dosage, and cost is relatively low.
If Acynonapyr, pyridaben, etoxazole, Envidor or Fenpropathrin can be with alloisomerisms, optical siomerism
Or tautomeric form exists, then it should be understood that even if being not expressly mentioned in each example, under usable condition, such compound
It within a context further include corresponding isomeric form.
If Acynonapyr, pyridaben, etoxazole, Envidor or Fenpropathrin can be at salt, for example, forming acid with acid
Addition salts, the salt formed with alkali forming salt and ammonia or organic amine.Alternatively, being optionally formed corresponding inner salt.The acid can be selected from
Strong inorganic acid, strong organic carboxyl acid, organic sulfonic acid.The strong inorganic acid can be mineral acid (for example, can be selected from perchloric acid, sulfuric acid, nitre
Acid, nitrous acid, phosphoric acid or halogen acids);The strong organic carboxyl acid can be selected from unsubstituted or substituted C1-C4 alkane yl carboxylic acid (example
Such as, acetic acid), saturated or unsaturated dicarboxylic acids is (for example, oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid and O-phthalic
Acid), hydroxycarboxylic acid (for example, ascorbic acid, lactic acid, malic acid, tartaric acid and citric acid or benzoic acid);The organic sulfonic acid can
Selected from unsubstituted or substituted C1-C4 chain alkyl sulfonic acid or aryl sulfonic acid (for example, methanesulfonic acid or p-methyl benzenesulfonic acid).It is formed with alkali
When salt, the salt is metal salt, such as alkali metal salt or alkali salt (such as sodium salt, sylvite or magnesium salts).With ammonia or organic
When amine forming salt, ammonia or organic amine are rudimentary selected from morpholine, piperidines, pyrrolidines, single low-grade alkylamine, two-low-grade alkylamines or three-
Alkylamine (for example, ethamine, diethylamine, triethylamine or dimethyl propylamine) and monohydroxy-low-grade alkylamine, dihydroxy-are rudimentary
Alkylamine or trihydroxy-low-grade alkylamine (for example, monoethanolamine, diethanol amine or triethanolamine).In context of the invention
In, it is preferably formed as advantageous salt on agriculture chemistry.
In view of Acynonapyr, pyridaben, etoxazole, Envidor or Fenpropathrin free form and its salt form it
Between substantial connection, in situation advantageous and appropriate, in the context of the invention any place Acynonapyr referred to, mite of rattling away
Spirit, etoxazole, Envidor or Fenpropathrin or its salt are interpreted as respectively further comprising respective salt or Acynonapyr, rattle away
Mite spirit, etoxazole, Envidor, Fenpropathrin.Same situation is also applied for Acynonapyr, pyridaben, etoxazole, Envidor
Or stereoisomer, optical isomer or the tautomer and its salt of Fenpropathrin.
It will be understood by those skilled in the art that miticide composition of the present invention, removes and includes effective component
It Acynonapyr and is mentioned above outside the effective component B compounded therewith, usually also contains the common adjuvant of pesticide field.At this
In some examples of invention, the miticide composition further includes adjuvant;The adjuvant is selected from wetting agent, dispersing agent, emulsification
One of agent, thickener, disintegrating agent, antifreezing agent, defoaming agent, solvent, preservative, stabilizer, synergist and carrier are a variety of.
The adjuvant can be properly added according to the needs of preparation, can be varied according to different situations, be had no spy
It does not limit.Adjuvant is added in Pesticide formulation or use, for improving the auxiliary substance of medicament physicochemical property, auxiliary agent
Basic inactive itself, but control efficiency can be influenced.
Wetting agent is such substance, when being added into liquid, by reducing liquid and liquid spread on it
Interfacial tension between surface increases the spread or penetrating power of liquid.Wetting agent plays two kinds of masters in agrochemical formulations
It wants function: increasing the wetting rate of powder in water during processing and manufacture, thus the concentrate that preparation can dissolve in water
Or the mixture to suspend in water;When can also reduce the wetting of wettable powder before product and water are applied to aerosol can sprinkling
Between and improve water phase in the infiltration into dispersible particle.The wetting agent is selected from alkylbenzene sulfonate, alkylnaphthalene sulfonate, wood
Mahogany sulfonate, lauryl sodium sulfate (SDS), succinic acid dibutyl ester sodium sulfonate, alhpa olefin sulfonate, alkylphenol-polyethenoxy
Ether (APEO), castor oil polyoxyethylene ether, alkylphenol ethoxylate (APES), alcohol ethoxylate, fatty alcohol polyoxy
In ethylene ether sodium sulfate, silkworm excrement, spaonin powder, spaonin powder, SOPA, detergent, 2000 series of emulsifier and wet bleeding agent F
It is one or more.
The alkylbenzene sulfonate is selected from neopelex and/calcium dodecyl benzene sulfonate;The alkylnaphthalene sulphur
Hydrochlorate is selected from nekal and/isopropyl naphthalene sulfonate;The lignosulfonates be selected from sodium lignin sulfonate and/or
Calcium lignosulfonate;The alkyl phenol polyoxyethylene ether (APEO) be selected from nonylphenol polyoxyethylene ether, octyl phenol polyoxyethylene ether,
One of dodecane phenolic ether, dinonyl phenolic ether and mixing alkane phenolic ether are a variety of;The sodium sulfate of polyethenoxy ether of fatty alcohol choosing
From ethoxylated alkyl sulfate and/or AES.The Typical Representative of suitable wetting agent, such as SDS (lauryl sodium sulfate),OTB (dioctyl sulfosuccinate),EFW (alkylated naphthalene sulfonate),
BX (alkylated naphthalene sulfonate),1004 (alpha-alkene sulfonates).
Dispersing agent is such substance, is adsorbed on the surface of particle and helps to maintain the dispersity of particle and prevent
Tablet reassembles.Dispersing agent is added in agrochemical formulations to dispersion and suspension during facilitating manufacture, and is helped
In ensuring that particle is re-dispersed into water in aerosol can.They are widely used in wettable powder, suspending agent and water dispersible granules
In.Surfactant as dispersing agent, which has the ability being securely adsorbed on particle surface and provides confrontation particle, to reassemble
Electric double layer barrier or steric hindrance.Most common surfactant is anionic surfactant, non-ionic surface
The mixture of activating agent or both types.For wettable powder, the most common dispersing agent is sodium lignin sulfonate
(sodium lignosulphonate).For suspending agent, polyelectrolyte (polyelectrolyte) such as naphthalene sulfonic acids are used
Sodium formaldehyde condensation product (sodium naphthalene sulphonate formaldehyde condensate) can obtain very
Good absorption and stabilization.Also tristyrylphenol ethoxylates phosphate (tristyrylphenol is used
Ethoxylate phosphate ester), nonionic surface active agent such as alkylaryl ethylene oxide condensation product
(alkylarylethylene oxide condensate) and EO-PO block copolymer.Sometimes living using non-ionic surface
Property agent and anionic surfactant are in combination as the dispersing agent for suspending agent.In recent years, molecular weight has been developed
New type of the very high polymeric surfactant as dispersing agent.These dispersing agents have very long hydrophobicity " skeleton "
" tooth " of raw medicine is fixed using many ethylene oxide chains as it with formation " comb " type structure.These heavy polymers can be
Suspending agent provides extraordinary long-time stability, this is because hydrophobic skeleton has the multiple anchors being fixed on particle surface
Point.The dispersing agent is selected from lignosulfonates, alkylnaphthalene sulfonate formaldehyde condensation products, naphthalene sulfonate, triphenyl vinyl phenol
Ethoxylate phosphate esters, alcohol ethoxylate, alkyl phenol polyoxyethylene ether, alkyl phenol polyoxyethylene ether methyl ether condensation product
Sulfate, aliphatic amine polyoxyethylene ether, glycerol fatty acid ester polyoxyethylene ethe, polycarboxylic acid salt, polyacrylic, phosphate
One of class, EO-PO block copolymer and EO-PO graft copolymer are a variety of.The Typical Representative of suitable dispersing agent is such as Ufoxane NA、Morwet D425、Ethylan NS-
500LQ, GY-D07 or YUS-WG4.
Emulsifier is that a kind of liquid phase dropwise addition is made to improve its surface tension after another liquid phase, makes the object of its stabilized with mixture
Matter.In the case where no emulsifier, two kinds of liquid can be separated into two immiscible liquid phases.Most common emulsifier is to contain
There are alkyl phenol with 12 or more ethylene oxide units or fatty alcohol and the oil-soluble calcium salt of dodecyl benzene sulfonic acid
Blend.The emulsifier of 8 to 18 hydrophile-lipophile balance (" HLB ") value can usually provide good emulsion stability.Emulsion is steady
It is qualitative to be improved sometimes by the way that a small amount of EO-PO block copolymer surfactant is added.The emulsifier is selected from dodecane
Base benzene sulfonic acid calcium, alkyl phenol formaldehyde resin polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, fatty alcohol epoxy second
In alkane-epoxy propane copolymer, styrylphenol polyoxyethylene ether, castor oil polyoxyethylene base ether and alkyl phenol ether phosphate
It is one or more.The Typical Representative of suitable emulsifier, as agriculture breast 500#, agriculture breast 600#, Nongru-700 #, agriculture breast 1601# or
Ethylan 992。
Thickener (or gelling agent) is used primarily in the rheology for changing liquid in the types such as suspending agent, aqueous emulsion and suspoemulsion
Or mobility simultaneously prevent dispersed particle or small oil droplet from separation or sedimentation occurs.Thickener, gelling agent and antisettling agent are logical
Often it is divided into two classes, i.e. water-insoluble particle and water-soluble polymer.It is feasible that suspending agent is prepared using clay and silica.Water
The example of insoluble particle includes but is not limited to montmorillonite, such as bentonite;Aluminium-magnesium silicate and atlapulgite (attapulgite).
Water-soluble polymer such as water-soluble polysaccharide has been used as thickening-gelling agent for many years.Most common water-soluble polysaccharide is seed or seaweed
Natural extract or cellulose synthesis of derivatives, the example of the substance of these types includes but is not limited to guar gum, beans
Angle glue (locust beangum), carrageenan (carrageenam), alginates, methylcellulose, sodium carboxymethylcellulose
(SCMC), hydroxyethyl cellulose (HEC).Other types of antisettling agent such as converted starch, polyacrylate, polyvinyl alcohol and poly-
Ethylene oxide.Another good antisettling agent is xanthan gum.The thickener be selected from xanthan gum, organobentonite, I
It is one or more in uncle's natural gum, sodium alginate, aluminium-magnesium silicate, carboxymethyl cellulose and white carbon black.
The disintegrating agent be selected from sodium sulphate, ammonium sulfate, aluminium chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose,
One of starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid and tartaric acid are a variety of.
The antifreezing agent is selected from one of alcohols, alcohol ethers, chlorinated hydrocarbon, inorganic salts or a variety of.It is common antifreeze
Agent, for example, have methanol, ethyl alcohol, isopropanol, ethylene glycol, propylene glycol, glycerine, diethylene glycol (DEG), butyl glycol ether, propandiol butyl ether,
2-Butoxyethyl acetate, methylene chloride, 1,1- dichloroethanes, 1,2- dichloroethanes, dimethyl sulfoxide, formamide, calcium chloride,
Sodium acetate, magnesium chloride etc..
The application of surfactant normally results in aqua type preparation and generates foaming tendency in production and application.For
Reduction foaming tendency usually needs in the production phase or before being fitted into bottle that defoaming agent is added.In general, the class of defoaming agent
There are two types of types, i.e. siloxanes and non-silicone.Siloxanes belongs to organic silicon defoamer, and usually dimethyl silicone polymer is aqueous
Emulsion;Rather than silicone antifoam agent is water-insoluble oil, such as octanol and nonyl alcohol.In the defoaming agent situation using both types
Under, the function of defoaming agent is all that surfactant is replaced from air-water interface.The defoaming agent is selected from C10-C20Saturated fat
Acid compounds, silicone oil, silicone compound, C8-C10One of fatty alcohol is a variety of.
Solvent is that pesticide active ingredient can be made easy to process and used for dissolving and diluting pesticide active ingredient
Organic matter.It is sub- that the solvent is selected from benzene,toluene,xylene, durol, methanol, ethyl alcohol, isopropanol, n-butanol, dimethyl
One of sulfone, dimethylformamide, cyclohexanone, alkylene carbonate, diesel oil, solvent naphtha, vegetable oil, vegetable oil derivatives and water
Or it is a variety of.
Microorganism easily causes the corruption of prepared product, and therefore, preservative be used to eliminate or reduce this microorganism
Effect.The example of the preservative includes but is not limited to propionic acid, propionic acid sodium salt, sorbic acid, sodium sorbate salt, potassium sorbate
Salt, benzoic acid, benzoic acid sodium salt, P-hydroxybenzoic acid sodium salt, methyl p-hydroxybenzoate, Kathon CG (CIT/MIT) and 1,2- benzene
And one of isothiazoline -3- ketone (BIT) or a variety of.
Stabilizer is divided to two classes, and one kind can inhibit or slow down pesticide active ingredient decomposition, such as antioxidant, anti-light solution agent;
It is another kind of that preparation physical stability can be improved, such as anti-caking agent and antisettling agent.The stabilizer is selected from disodium hydrogen phosphate, grass
It is acid, succinic acid, adipic acid, borax, DBPC 2,6 ditertiary butyl p cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, swollen
Moisten one of soil, attapulgite, white carbon black, talcum powder, montmorillonite and starch or a variety of.
Synergist inactive itself, but the performance of active matter can be increased substantially, it, can be big when with certain combined use of pesticides
Amplitude improves pesticide virulence and drug effect.The synergist is selected from Synergistic Phosphorus and/or Butacide.
Carrier refers to natural or synthetic organic matter or inorganic matter, it is mixed or combined to have more with reactive compound
Good application, especially in the application on plant or plant part or seed.Carrier can be solid or liquid.The carrier
It is usually inert and should be suitable for used in agricultural.Suitable solid or liquid-carrier have: ammonium salt, the natural minerals ground
(for example, kaolin, clay, talcum, chalk, quartz, Attagel, montmorillonite or diatomite), the artificial mineral ground (for example,
Finely divided silica, aluminium oxide), natural or synthetic silicates, resin, wax, solid fertilizer, water, organic solvent (for example,
Alcohols, in particular butanol), mineral oil, one of vegetable oil and vegetable oil derivatives or a variety of.Solid suitable for granule
Carrier has: the natural minerals (for example, calcite, marble, float stone, sepiolite, dolomite) that crush and be classified, inorganic or organic
Powder manufactured particles and organic material (for example, sawdust, coconut husk, corncob or tobacco stem particle) one of or it is more
Kind.
It is gaseous liquid under environment temperature and atmospheric pressure that gaseous state filler or carrier after suitable liquefaction, which are those,
Body can be aerosol propellants (for example, butane, propane, nitrogen and carbon dioxide).
If filler used is water, also it can be used organic solvent as the secondary solvent in filler.Suitably
Secondary solvent can be selected from: aromatic compound (such as dimethylbenzene, toluene or alkylnaphthalene);Chlorinated aromatic compound and chloro fat
Race's hydrocarbon (for example, chlorobenzene, vinyl chloride or methylene chloride);Aliphatic hydrocarbon (such as hexamethylene or paraffin, mineral oil fractions, mineral oil and
Vegetable oil);Alcohol (for example, butanol or ethylene glycol) and its ether and ester;Ketone (such as acetone, methyl ethyl ketone, methyl iso-butyl ketone (MIBK) or
Cyclohexanone);And intensive polar solvent such as dimethylformamide and dimethyl sulfoxide.
If appropriate, other additional components, such as protective colloid, adhesive also may be present in the miticide composition
(binder), sticker (adhesive), thixotroping substance, bleeding agent, chelating agent, complexing forming agent, coloring agent etc..In general,
The effective component (reactive compound) can be in conjunction with any solid or liquid additive for being usually used in preparation preparation.
The present invention also provides a kind of preparations of miticide composition, are prepared using miticide composition as described above.It is logical
Often, miticide composition of the invention or preparation include the effective component of 0.05~99wt%;For example, 0.1wt%, 0.5wt%,
1wt%, 5wt%, 10wt%, 15wt%, 20wt%, 25wt%, 30wt%, 35wt%, 40wt%, 45wt%, 50wt%,
55wt%, 60wt%, 65wt%, 70wt%, 75wt%, 80wt%, 85wt% or 90wt%.
Term "comprising" is open language, that is, includes content specified by the present invention, but be not precluded otherwise
Content.
In miticide composition of the present invention or preparation, effective component includes active components A and active constituent B,
Middle active components A is Acynonapyr, and active constituent B is pyridaben, etoxazole, Envidor, any one in Fenpropathrin.
The mass ratio of active components A and active constituent B can change in relatively wide range, for example, it may be mass ratio is 1000:1
To 1:1000.The effective mass ratio of collaboration for being 100:1 to 1:100 with active components A and the range of active constituent B exists, excellent
Selecting mass ratio is 50:1 to 1:50, and further preferred mass ratio is 20:1 to 1:20, and even more preferably mass ratio is 10:1 to 1:
10.According to the present invention, other mass ratioes of workable active components A and active constituent B may is that 95:1 to 1:95,90:1
To 1:90,85:1 to 1:85,80:1 to 1:80,75:1 to 1:75,70:1 to 1:70,65:1 to 1:65,60:1 to 1:60,55:1
To 1:55,45:1 to 1:45,40:1 to 1:40,35:1 to 1:35,30:1 to 1:30,25:1 to 1:25,15:1 to 1:15,10:1
To 1:10,5:1 to 1:5,4:1 to 1:4,3:1 to 1:3,2:1 to 1:2,1:1.From can further improve the synergistic function side
Face considers, it is preferable that the mass ratio of Acynonapyr and pyridaben is 15:1~1:15;The matter of Acynonapyr and etoxazole
Amount is than being 10:1~1:10;Acynonapyr and the mass ratio of Envidor are 10:1~1:10;Acynonapyr and Fenpropathrin
Mass ratio be 8:1~1:8.
It is provided by the invention to be combined comprising Acynonapyr with the mite killing of pyridaben, etoxazole, Envidor or Fenpropathrin
Object can be used as it is or be made according to its each physical property or chemical property with its dosage form or use form prepared therefrom
With;For example, the molten pulvis of gas, microcapsule suspending agent, aerosol, microcapsulated granule, pulvis, suspension seed-coating agent, dust granule, missible oil, water and milk
Agent, microemulsion, effervescent, fine granule, oil loose powder, oil-suspending agent, finish, paste, at the coated seed of insecticide
Manage agent, suspension concentrating agents, suspoemulsion, suspension seed dressing, wettable powder, tablet, with reactive compound impregnate can wet-milling kind
Microcapsule formulations and ULV harl in the coating material of clothing agent, natural products and synthetic and polymeric material and seed
With hot atomization preparation.
Typical preparation formulation can be pulvis, wettable powder, microcapsule formulations, water dispersion granule, granule, suspension
Agent, missible oil, microemulsion, aqueous emulsion, ultra-low volume spray agent, seed coat agent.Preferably, the dosage form of the preparation is selected from missible oil, water
Emulsion, wettable powder, water dispersible granules, suspending agent or microcapsule formulations.
Pulvis (DP) is that a certain amount of inert dust is added in active material (effective component), such as clay, kaolin, talcum
Powder etc., then it is machined at powdered object;The powder diameter of powdered object is at 100 microns or less.
Wettable powder (WP) refer to by composition by a certain percentage with suitable surfactant and inert substance (example
Such as, kaolin powder) mixture.Wettable powder is the preparation for caning be uniformly dispersed Yu Shuizhong, wherein in addition to active material (has
Imitate ingredient) and inert substance (kaolin powder) other than, also contain a certain amount of anion or nonionic surface active agent (example
Such as, dispersing agent, wet benefit).
Microcapsule formulations (MC) be first active material (effective component) is coated in adhesive, film forming agent etc. formed it is small
Then cryptomere preparation is reprocessed into the dosage form of needs;Microcapsule formulations (MC) can be divided into micro-capsule suspension (Capsule
Suspensions, CS), microcapsules granula (Encapsulated Granule, CG), microcapsules dry suspending agent (Capsulated
Dry Flowable,CDF)。
Water dispersion () granula (WDG) refers to: by composition by a certain percentage with suitable surfactant and inert material
Mixture is formed after the mixing of matter (kaolin) powder, then by conventional method such as fluidized bed prilling, mist projection granulating, disk granulation
Method is granulated to obtain.Raw material in mixed process through air-flow crushing, so that particle size is reached requirement, and use double helical form
Repeatedly mixing keeps product mix uniform for mixing machine and coulter type mixer warp.
Granule (GR) refers to: by composition by a certain percentage with suitable surfactant, diluent and inert substance
(e.g., kaolin powder) is mixed to form mixture, then is granulated such as fluidized bed prilling method by pelletizer, is that powder is made to keep stream
Under dynamic state, spraying binder solution is allowed to the prilling process being aggregated.This method makes mixing, kneading, granulation, dry, classification etc.
Process in one apparatus, complete under air-tight state by the short time.
Aqua (AS) is to be dissolved in the water using certain raw medicines and Undec characteristic, is directly formulated with water
Liquid.
Suspending agent (SC) refer to composition is mixed with suitable surfactant, water or organic solvent by a certain percentage,
It is uniformly levigate through colloid mill, then grind 1 to 2 time through sand mill and be made to certain fineness.
Missible oil (EC), which refers to, to be dissolved composition in organic solvent by a certain percentage such as benzene,toluene,xylene, hexamethylene
Ketone, and being added in the mixture of a certain amount of anion or nonionic surface active agent (such as emulsifier) and preparing.
Microemulsion (ME) is generally made of liquid pesticide, surfactant (e.g., emulsifier), water, stabilizer etc.;Its feature
It is to be free of or using water as medium less containing organic solvent.Drop size in microemulsion is generally several nanometers to tens nanometers, is less than
The a quarter of visible wavelength.
Aqueous emulsion (EW) is insoluble in the raw medicine liquid of water or is dissolved in raw medicine and the organic solvent of the immiscible solution of water gained
A kind of formulations of pesticide that solution is dispersed in water.Aqueous emulsion is the liquid pesticidal raw medicine that will be mixed to prepare with organic solvent with 0.5-
The preparation that 1.5 microns of droplet is dispersed in water, appearance are milky milk shape liquid.
Ultra-low volume spray agent (ULV) refers to the medical fluid being sprayed on Target crops, with superfine droplet, extremely low dosage spray
It out, is a kind of dosage form applied for ultra-low volume spray.
Seed coat agent (SD) is mixed effective component and auxiliary agent are ground, can be coated on kind of a sublist directly or after dilution
Face forms the protective film with some strength and permeability.
Fumicants (FU) is also known as smoke agent, is to mix effective component and inflammable substance etc., is burnt, make pesticide
Smog grain or a kind of medicament directly pesticide dispersion at smog grain are condensed into after gasification.
About the meaning of various adjuvants, various preparation formulations, due to the difference in statement, the difference on understanding will cause
It is different.It should be understood that various adjuvants, preparation formulation disclosed in this field belong to the range that the present invention covers;Such as it can
With reference to " Pesticide formulation technology ", Luo Yanping, Song Weiwei, Chemical Industry Press, 2015;" pesticidal preparations ", Wang Kaiyun,
Chinese agriculture publishing house, 2009;" Preparation Forms of Modern Pesticide processing technology book series ", Liu Guangwen, Chemical Industry Press, 2018;" agriculture
Pharmaceutically dosage form and preparation and application method ", Tu Yuqin, Golden Shield publishing house, 2008;" Chinese pesticide ", Chinese pesticide industry association;Deng
Corresponding contents Deng described in.The preparation method of the preparation of various dosage forms includes but is not limited to described in the invention that
A bit.
Above-mentioned preparation can be prepared by per se known manner, for example, by by reactive compound or reactive compound
Conjugate is mixed at least one adjuvant.Suitable adjuvant is all conventional pharmaceutical adjuncts, such as organic solvent, filling
Agent, solvent or diluent, solid carrier and filler, surfactant (such as adjuvant, emulsifier, dispersing agent, protective colloid,
Wetting agent and tackifier), it is dispersing agent and/or adhesive or fixative, preservative, dyestuff and pigment, defoaming agent, inorganic and organic
Thickener, hydrophober.If appropriate, drier and UV stabilizer, gibberellin and water and other processing aids can also be added.?
In each case, according to preparation type to be prepared, it may be necessary to other procedure of processings, such as wet lapping, dry grinding or system
Grain.
" composition " referred in preparation type as above not only (can be used suitable device will comprising ready-to-use composition
It is applied to plant or seed), and include commercially available concentrate (must be diluted with water before use).
The present invention also provides the methods for controlling plant disease, and the method includes applying to the plant or plant part
With a effective amount of miticide composition comprising Acynonapyr and pyridaben, etoxazole, Envidor or Fenpropathrin or comprising
The preparation of Acynonapyr and pyridaben, etoxazole, Envidor or Fenpropathrin.
For the present invention, term " effective quantity ", which refers to, is enough to the total of the effective each active component of controlling plant diseases
Amount.This amount depend on pest, floristics, weather conditions and the present composition to be controlled in include compound and
Variation in wide scope.Term is " a variety of " to indicate two kinds and two or more.
The present invention also provides a kind of miticide composition as described above, preparations as described above in preventing and treating harmful mite class
Using.
According to the present invention, the miticide composition or the preparation obtained by it can handle all plant and plant part.
Plant refers to all plant and plant population, such as, it is desirable to and undesired wild plant, cultivar and plant variety are (no
By the protection whether weighed by Plant variety right or plant breeder).Cultivar and plant variety can be through Sterile culture and
Breeding method (is assisted or is supplemented by one or more biotechnology methods, such as by using dihaploid, protoplast
Fusion, random mutagenesis and directed mutagenesis, molecular labeling or genetic marker), or obtained by bioengineering and the method for genetic engineering
The plant obtained.Plant part refers to all grounds of plant, under ground portion and organ;For example, bud, leaf, needle, stem, branch, flower, son
Entity, fruit and seed and root, bulb and rhizome;Plant part may also include crop and asexual and case of propagation material;
For example, cutting, dividing bark of a cork tree and seed.
With the mite killing group provided by the invention comprising Acynonapyr with pyridaben, etoxazole, Envidor or Fenpropathrin
Closing the processing that object or preparation carry out plant and plant part conventional treatment method can be used directly to carry out or act on around it
Environment, habitat or storage ground;For example, by impregnating, spraying, be sprayed, irrigation, evaporation, dusting, atomizing, broadcast sowing, foam, smearing,
Coating watering (pouring), instils, and in the case of propagation materials, especially in the case of seed, can also pass through involucrum
(incrust), the modes such as one or more layers coating are coated with and handle seed, with powder-processed dry seeds, with solution with water soluble powder
Manage slurries in end.The miticide composition or preparation can be also injected into soil.
Main farming can be mentioned that in the plant that the miticide composition or preparation can act on through the invention
Object, such as corn and soybean, cotton, rape, rice, wheat, beet, sugarcane, oat, rye, barley, grain, triticale, flax, liana
Plant and various fruit and vegetables, gardening and forest crop from various plant classification groups;Ornamental plant;And these works
The homologue of the genetic modification of object.
The method that the present invention also includes the miticide composition or preparation processing seed.Miticide composition of the invention can be with
It directly applies, that is, do not include other components and without dilution.Generally, it is preferred to by the miticide composition with suitable preparation
Form is applied to seed.The suitable preparation and method for handling seed are that this field is conventional.Miticide composition of the invention can
Be converted into conventional Seed dressing formulations, for example, suspension seed-coating agent, suspension seed dressing, dry-powder seed coating agent, water and milk seed coat agent or other
Coating material and ULV preparation for seed.
According to plant species or plant cultivars, their position and growth conditions (soil, weather, trophophase, nutrition),
Superadditivity (" collaboration ") effect can also be brought using the processing that miticide composition of the present invention or preparation carry out.Thus, for example,
The following effect more than actual desired can be brought: can be used according to the invention comprising Acynonapyr and pyridaben, etoxazole,
The rate of application of the miticide composition of Envidor or Fenpropathrin reduces, activity profile is widened and activity increases, better plant is raw
It is long, improve the tolerance to high temperature or low temperature, improve the tolerance to arid or water or soil salt content, improve Flowering quality,
It is easier harvesting, hasting of maturity, higher harvesting yield, bigger fruit, higher plant height, greener leaf face
Color, make to bloom earlier, the quality of harvested products is higher and/or nutritive value is higher, the sugared concentration in fruit is higher, harvested products
Storage stability and/or processability it is more preferable.
Compared with the existing technology, the beneficial effect of technical solution of the present invention is following point or several points:
(1) present invention kills gained by compounding two kinds of effective components in miticide composition in the reasonable scope
The CTC (co-toxicity coefficient) of acaricidal composition 120 or more, has good synergistic function;
(2) present invention gained miticide composition expands prevention and treatment range, has widened use scope;
(3) gained miticide composition or its preparation for mite killing have good preventive effect, can delay drug resistance generation,
Pharmacological property is held in extension;
(4) in the case where the mite killing synergy of gained miticide composition or preparation improves, production can be reduced
Cost and use cost, to crop safety.
Specific embodiment
In order to technical characteristic and content of the invention is understood in detail, it is described in more detail below of the invention excellent
Select embodiment.Although describing the preferred embodiment of the present invention in embodiment, however, it is to be appreciated that can be in a variety of manners
Realize the present invention without that should be limited by the embodiments set forth herein.
<raw material sources>
The raw medicine of Acynonapyr is self-control, and preparation method can refer to patent document CN102770430A;
Pyridaben, etoxazole, Envidor, the raw medicine of Fenpropathrin are bought in Changshu Heng Rong commerce and trade Co., Ltd;Cinnabar
Tetranychid comes from field acquisition.
<test method>
The measurement of co-toxicity coefficient (CTC): using leaf disc spray measurement different agents to co-toxicity in Tetranychus cinnabarinus room.
According to the dose design of testing program, accurately weigh test sample (different agents) in beaker, use acetone as
Solvent is added in 1% ratio, and Tween 80 is added in 0.1% ratio and is added clear water as emulsifier, and test sample is diluted
To required concentration (20mg/l, 10mg/l, 5mg/l, 2.5mg/l, 1.25mg/l, 0.625mg/l);
It chooses and grows consistent cowpea blade, be made into leaf dish with punch, each culture dish is placed two leaf dish, cultivated
Wet sponge block is placed in ware, foliation dish on sponge, Jia Shui is flushed with leaf dish, spare;The tetranychid adult mite of indoor raising is inoculated into
On ready leaf dish, every dish puts 20 or more;Leaf dish with different agents before being handled, acarid radix recorded thereon;
Leaf dish is handled, the liquid of spray per treatment using potter spray tower (built-in prepared different agents)
Amount is 1ml.Blank control (containing only the aqueous solution of 1% acetone and 0.1% Tween 80) first is handled, then by prepared medicament
Aforesaid operations, no less than 3 repetitions per treatment are repeated by the sequence of test dose from low to high;Test material after chemicals treatment is set
The observation after observation ward, 48h is as a result, calculate the death rate of acarid;
Corresponding regression analysis is done according to composition concentration in each medicament and corresponding preventive effect, finds out composition in each medicament
LC50Value.
Using the co-toxicity coefficient calculation method of the abundant introduction of Sun Yun, the co-toxicity coefficient of mixture (miticide composition) is calculated
(CTC), the building performance of mixture is determined.
(LC is generally selected using single dose a certain in mixture as standard agent50Junior), it is calculated:
Single dose toxicity index=standard agent LC50/ certain single dose LC50×100;
Theoretical toxicity index (TTI)=A single dose toxicity index × A single dose proportion+B single dose in mixture virulence
Index × B single dose proportion in mixture;
Survey toxicity index (ATI)=standard single dose LC50Value/mixture LC50Value × 100;
Co-toxicity coefficient (CTC)=survey toxicity index/theoretical toxicity index × 100.
In measurement result, when CTC is greater than 120, mixture has synergetic, is antagonism when CTC is less than 80, and CTC exists
It is summation action between 80-120.
Experimental example
Test method as described above carries out toxicity test to the miticide composition of different ratio, and measurement result is shown in
Table 1, table 2, table 3 and table 4.
The toxicity test result of table 1:Acynonapyr and pyridaben different ratio to Tetranychus cinnabarinus
Medicament | LC50(mg/L) | ATI | TTI | CTC |
Acynonapyr | 4.167 | / | ||
Pyridaben | 0.173 | / | ||
Acynonapyr: pyridaben=30:1 | 2.920 | 142.71 | 174.47 | 81.79 |
Acynonapyr: pyridaben=15:1 | 1.367 | 304.83 | 244.29 | 124.78 |
Acynonapyr: pyridaben=7:1 | 0.813 | 512.55 | 388.58 | 131.90 |
Acynonapyr: pyridaben=4:1 | 0.406 | 1026.35 | 561.73 | 182.71 |
Acynonapyr: pyridaben=2:1 | 0.204 | 2042.65 | 869.56 | 199.91 |
Acynonapyr: pyridaben=1:1 | 0.165 | 2525.45 | 1254.34 | 201.34 |
Acynonapyr: pyridaben=1:2 | 0.119 | 3501.68 | 1639.11 | 213.63 |
Acynonapyr: pyridaben=1:4 | 0.091 | 4579.12 | 1946.94 | 235.20 |
Acynonapyr: pyridaben=1:7 | 0.079 | 5274.68 | 2120.09 | 248.80 |
Acynonapyr: pyridaben=1:15 | 0.065 | 6410.77 | 2264.38 | 283.11 |
Acynonapyr: pyridaben=1:30 | 0.153 | 2723.53 | 2334.20 | 116.68 |
As shown in Table 1, the proportion of Acynonapyr and pyridaben has association to the prevention and treatment of Tetranychus cinnabarinus in 15:1~1:15
Same synergistic effect.
The toxicity test result of table 2:Acynonapyr and etoxazole different ratio to Tetranychus cinnabarinus
Medicament | LC50(mg/L) | ATI | TTI | CTC |
Acynonapyr | 4.167 | / | ||
Etoxazole | 29.43 | / | ||
Acynonapyr: etoxazole=20:1 | 4.095 | 101.76 | 95.91 | 106.06 |
Acynonapyr: etoxazole=10:1 | 3.423 | 121.74 | 92.20 | 132.04 |
Acynonapyr: etoxazole=5:1 | 2.984 | 139.64 | 85.69 | 162.96 |
Acynonapyr: etoxazole=3:1 | 2.201 | 189.32 | 78.54 | 241.05 |
Acynonapyr: etoxazole=2:1 | 1.873 | 222.48 | 71.39 | 311.65 |
Acynonapyr: etoxazole=1:1 | 1.542 | 270.23 | 57.08 | 473.43 |
Acynonapyr: etoxazole=1:2 | 3.421 | 121.81 | 42.77 | 284.78 |
Acynonapyr: etoxazole=1:3 | 4.401 | 94.68 | 35.62 | 265.82 |
Acynonapyr: etoxazole=1:5 | 7.147 | 58.30 | 28.47 | 204.82 |
Acynonapyr: etoxazole=1:10 | 10.768 | 38.70 | 21.96 | 176.20 |
Acynonapyr: etoxazole=1:20 | 19.244 | 21.65 | 18.25 | 118.67 |
As shown in Table 2, the proportion of Acynonapyr and etoxazole has association to the prevention and treatment of Tetranychus cinnabarinus in 10:1~1:10
Same synergistic effect.
The toxicity test result of table 3:Acynonapyr and Envidor different ratio to Tetranychus cinnabarinus
As shown in Table 3, the proportion of Acynonapyr and Envidor has association to the prevention and treatment of Tetranychus cinnabarinus in 10:1~1:10
Same synergistic effect.
The toxicity test result of table 4:Acynonapyr and Fenpropathrin different ratio to Tetranychus cinnabarinus
Medicament | LC50(mg/L) | ATI | TTI | CTC |
Acynonapyr | 4.167 | / | ||
Fenpropathrin | 0.741 | / | ||
Acynonapyr: Fenpropathrin=10:1 | 0.751 | 152.36 | 142.03 | 107.27 |
Acynonapyr: Fenpropathrin=8:1 | 0.635 | 220.24 | 151.37 | 145.50 |
Acynonapyr: Fenpropathrin=5:1 | 0.601 | 315.44 | 177.06 | 178.16 |
Acynonapyr: Fenpropathrin=3:1 | 0.631 | 505.70 | 215.59 | 234.57 |
Acynonapyr: Fenpropathrin=2:1 | 0.569 | 677.56 | 254.12 | 266.63 |
Acynonapyr: Fenpropathrin=1:1 | 0.524 | 795.23 | 331.18 | 240.12 |
Acynonapyr: Fenpropathrin=1:2 | 0.615 | 732.34 | 408.23 | 179.39 |
Acynonapyr: Fenpropathrin=1:3 | 0.824 | 660.38 | 446.76 | 147.81 |
Acynonapyr: Fenpropathrin=1:5 | 1.321 | 693.34 | 485.29 | 142.87 |
Acynonapyr: Fenpropathrin=1:8 | 1.892 | 656.22 | 510.98 | 128.42 |
Acynonapyr: Fenpropathrin=1:10 | 2.735 | 554.86 | 520.32 | 106.64 |
As shown in Table 4, the proportion of Acynonapyr and Fenpropathrin has association to the prevention and treatment of Tetranychus cinnabarinus in 8:1~1:8
Same synergistic effect.
By the above indoor co-toxicity test result it is found that Acynonapyr and pyridaben, Acynonapyr and second mite
Azoles, Acynonapyr have obviously the prevention and treatment of Tetranychus cinnabarinus with Envidor and Acynonapyr with compounding for Fenpropathrin
Synergistic function.
The preparation example 1:45wt%Acynonapyr pyridaben wettable powder of miticide composition preparation
By Acynonapyr raw medicine 5g, pyridaben raw medicine 40g, alkylnaphthalene sulfonate formaldehyde condensation products (trade name: Morwet
D425, Akzo Nobel N.V.) 9g, lauryl sodium sulfate (Aladdin reagent) 3g, (the left native new material in Hangzhou has kaolin
Limit company) 100g is added to, first precomminution is uniformly mixed, then is crushed to through airslide disintegrating mill (the excellent nanogram Machinery Co., Ltd. in Kunshan)
Fineness meets the requirement that at least 98wt% passes through 45 μm of testing sieves, and the wettable powder that effective component mass content is 45wt% is made
Agent.
The preparation example 2:32wt%Acynonapyr pyridaben wettable powder of miticide composition preparation
By Acynonapyr raw medicine 2g, pyridaben raw medicine 30g, lignin sulfonic acid sodium salt (trade name: Ultrazine NA,
Bao Lige Industrial Co., Ltd) 10g, lauryl sodium sulfate (Aladdin reagent) 3g, (the left native new material in Hangzhou is limited for kaolin
Company) 100g is added to, first precomminution is uniformly mixed, then is crushed to carefully through airslide disintegrating mill (the excellent nanogram Machinery Co., Ltd. in Kunshan)
Degree meets the requirement that at least 98wt% passes through 45 μm of testing sieves, and the wettable powder that effective component mass content is 32wt% is made
Agent.
The preparation example 3:25wt%Acynonapyr pyridaben water dispersible granule of miticide composition preparation
By Acynonapyr raw medicine 20g, pyridaben raw medicine 5g, lignosulfonates (trade name: YUS-WG4, Japanese bamboo sheet
Grease Co., Ltd.) 6g, alpha-alkene sulfonate (trade name: TERWET 1004, Hensel step) 2g, urea (Aladdin reagent) 2g,
Bentonite (Hangzhou Zuo Tu new material Co., Ltd) adds to 100g, is first uniformly mixed, then through airslide disintegrating mill (the excellent nanogram machine in Kunshan
Tool Co., Ltd) 15 μm are crushed to hereinafter, be uniformly mixed with 15g water, it is granulated, is dried at 60 DEG C to containing by rotating pelletizer
Water≤1% selects the testing sieve of 20 mesh and 60 mesh to be sieved, and gives up the dust of top bulky grain and bottom filtering, is made
Effective component mass content is the water dispersible granules of 25wt%.
The preparation example 4:20wt%Acynonapyr Damanling suspension agent of miticide composition preparation
1. crushing the modulation of slurry: dispersing alkylnaphthalene sulfonate formaldehyde condensation products (trade name: Morwet in 53.5g water
D425, Akzo Nobel N.V.) 3g, EO-PO block copolymer (trade name: Ethylan NS-500LQ, Akzo Nobel
Company) 1g, lauryl sodium sulfate (Aladdin reagent) 2g and organic silicon defoamer (trade name: GY-X60, Beijing Guang Yuan benefit agriculture
Chemical Co., Ltd.) 0.5g, disperses Acynonapyr raw medicine 10g and pyridaben raw medicine 10g wherein, usesBead carries out case of wet attrition to the D90 (grain of 90% particle with sand mill (Shenyang Chemical Research Institute)
Diameter) 10 μm of <, it obtains and crushes slurry 80g.
2. the modulation of suspending agent: xanthan gum (Aladdin reagent) 0.2g, aluminium-magnesium silicate (Hangzhou is added toward slurry 80g is crushed
Zuo Tu new material Co., Ltd) 1.0g, ethylene glycol (Aladdin reagent) 5g, sodium benzoate (Aladdin reagent) 0.5g and mixing are
Even, benefit is filled with water to 100g, and the suspending agent that effective component mass content is 20wt% is uniformly made in high speed shear.
The preparation example 5:40wt%Acynonapyr etoxazole wettable powder of miticide composition preparation
By acynonapyr raw medicine 10g, etoxazole raw medicine 30g, lignin sulfonic acid sodium salt (trade name: Ultrazine NA,
Bao Lige Industrial Co., Ltd) 10g, Morwet EFW (Akzo Nobel N.V.) 2g, (the left native new material in Hangzhou has kaolin
Limit company) 100g is added to, first precomminution is uniformly mixed, then is crushed to through airslide disintegrating mill (the excellent nanogram Machinery Co., Ltd. in Kunshan)
Fineness meets the requirement that at least 98wt% passes through 45 μm of testing sieves, and the wettable powder that effective component mass content is 40wt% is made
Agent.
The preparation example 6:20wt%Acynonapyr etoxazole water dispersible granules of miticide composition preparation
By Acynonapyr raw medicine 10g, etoxazole raw medicine 10g, alkylnaphthalene sulfonate formaldehyde condensation products (trade name:
Morwet D425, Akzo Nobel N.V.) 8g, lauryl sodium sulfate (Aladdin reagent) 3g, ammonium sulfate (Aladdin examination
Agent) 2g, kaolin (Hangzhou Zuo Tu new material Co., Ltd) adds to 100g, it is first uniformly mixed, then (Kunshan is excellent through airslide disintegrating mill
Nanogram Machinery Co., Ltd.) 15 μm are crushed to hereinafter, be uniformly mixed with 15g water, it is granulated by rotating pelletizer, is done at 60 DEG C
It is dry to select the testing sieve of 20 mesh and 60 mesh to be sieved to water content≤1%, give up the powder of top bulky grain and bottom filtering
The water dispersible granules that effective component mass content is 20wt% are made in dirt.
The preparation example 7:20wt%Acynonapyr etoxazole suspending agent of miticide composition preparation
1. crushing the modulation of slurry: (trade name: GY-D07, Beijing are wide for dispersion polycarboxylic acid salt's dispersing agent in 54.8g water
Yuan Yi agriculture Chemical Co., Ltd.) 3g, Morwet EFW (Akzo Nobel N.V.) 2g and organic silicon defoamer (commodity
Name: GY-X60, Beijing Guangyuan Yinong Chemical Co., Ltd) 0.2g, disperses acynonapyr raw medicine 16g and second mite wherein
Azoles raw medicine 4g is usedBead carries out case of wet attrition to D90 with sand mill (Shenyang Chemical Research Institute)
10 μm of < of (partial size of 90% particle) obtains and crushes slurry 80g.
2. the modulation of suspending agent: xanthan gum (Aladdin reagent) 0.3g, organobentonite (Hangzhoupro is added toward slurry 80g is crushed
Zhou Zuotu new material Co., Ltd) it 0.4g, ethylene glycol (Aladdin reagent) 5g, sodium benzoate (Aladdin reagent) 0.5g and carries out
Mixing, benefit are filled with water to 100g, and the suspending agent that effective component mass content is 20wt% is uniformly made in high speed shear.
The preparation example 8:22wt%Acynonapyr etoxazole suspending agent of miticide composition preparation
1. crushing the modulation of slurry: dispersing alkylnaphthalene sulfonate formaldehyde condensation products (trade name: Morwet in 53.8g water
D425, Akzo Nobel N.V.) 2g, EO-PO block copolymer (trade name: Ethylan NS-500LQ, Akzo Nobel
Company) 2g and organic silicon defoamer (trade name: GY-X60, Beijing Guangyuan Yinong Chemical Co., Ltd) 0.2g, then at it
Middle dispersion Acynonapyr raw medicine 2g and etoxazole raw medicine 20g is usedBead, with sand mill (Shenyang
Work research institute) case of wet attrition is carried out to 10 μm of < of D90 (partial size of 90% particle), it obtains and crushes slurry 80g.
2. the modulation of suspending agent: being crushed toward 80g and xanthan gum (Aladdin reagent) 0.3g, organobentonite is added in slurry
(Hangzhou Zuo Tu new material Co., Ltd) 0.4g, ethylene glycol (Aladdin reagent) 5g, 0.5g is simultaneously for sodium benzoate (Aladdin reagent)
It is mixed, benefit is filled with water to 100g, and the suspending agent that effective component mass content is 22wt% is uniformly made in high speed shear.
The preparation example 9:38wt%Acynonapyr Envidor wettable powder of miticide composition preparation
By Acynonapyr raw medicine 30g, Envidor raw medicine 8g, lignin sulfonic acid sodium salt (trade name: Ultrazine NA,
Bao Lige Industrial Co., Ltd) 8g, Morwet EFW (Akzo Nobel N.V.) 4g, white carbon black (Aladdin reagent) 10g, height
Ridge soil (Hangzhou Zuo Tu new material Co., Ltd) adds to 100g, is uniformly mixed after first precomminution, then (Kunshan is excellent through airslide disintegrating mill
Nanogram Machinery Co., Ltd.) requirement for making the fineness satisfaction at least 98wt% of mixture pass through 45 μm of testing sieves is crushed, being made has
Imitate the wettable powder that composition quality content is 38wt%.
The preparation example 10:25wt%Acynonapyr Envidor suspending agent of miticide composition preparation
1. crushing the modulation of slurry: dispersing alkylnaphthalene sulfonate formaldehyde condensation products (trade name: Morwet in 49.8g water
D425, Akzo Nobel N.V.) 3g, EO-PO block copolymer (trade name: Ethylan NS-500LQ, Akzo Nobel
Company) 1g, Morwet EFW (Akzo Nobel N.V.) 1g and organic silicon defoamer (trade name: GY-X60, Beijing Guang Yuan benefit
Agriculture Chemical Co., Ltd.) 0.2g, then disperse Acynonapyr raw medicine 5g and Envidor raw medicine 20g wherein, it usesBead carries out case of wet attrition to the D90 (grain of 90% particle with sand mill (Shenyang Chemical Research Institute)
Diameter) 10 μm of <, it obtains and crushes slurry 80g.
2. the modulation of suspending agent: crushing slurry toward 80g and xanthan gum (Aladdin reagent) 0.2g, white carbon black (Aladdin is added
Reagent) it 0.5g, ethylene glycol (Aladdin reagent) 4g, sodium benzoate (Aladdin reagent) 0.5g and is mixed, benefit is filled with water to
The suspending agent that effective component mass content is 25wt% is uniformly made in 100g, high speed shear.
The preparation example 11:22wt%Acynonapyr Envidor suspending agent of miticide composition preparation
1. crush slurry modulation: in 52.8g water disperse polyacrylic graft copolymer dispersant (trade name:Hensel steps) 2g, EO-PO block copolymer (trade name: Ethylan NS-500LQ, Aksu
Nobel company) 2g, Morwet EFW (Akzo Nobel N.V.) 1g and organic silicon defoamer (trade name: GY-X60, Beijing
Guang Yuanyi agriculture Chemical Co., Ltd.) 0.2g, then disperse Acynonapyr raw medicine 20g and Envidor raw medicine 2g wherein, make
WithBead carries out case of wet attrition to the D90 (grain of 90% particle with sand mill (Shenyang Chemical Research Institute)
Diameter) 10 μm of <, it obtains and crushes slurry 80g.
2. the modulation of suspending agent: being crushed toward 80g and xanthan gum (Aladdin reagent) 0.2g, white carbon black (I are added in slurry
Fourth reagent) it 0.5g, ethylene glycol (Aladdin reagent) 5g, sodium benzoate (Aladdin reagent) 0.5g and is mixed, benefit is filled with water to
The suspending agent that effective component mass content is 22wt% is uniformly made in 100g, high speed shear.
The preparation example 12:14wt%Acynonapyr spirodiclofen water emulsion of miticide composition preparation
1, oil is mutually prepared: Acynonapyr raw medicine 7g and Envidor raw medicine 7g are dissolved in cyclohexanone (Aladdin reagent) 10g
With the complex solvent of 150# solvent naphtha (Yangzhou day reach at chemical industry) 15g composition, then with castor oil polyoxyethylene ether (trade name: BY-
110, the sincere chemical assistant of Xingtai City swallow) 3g, EO-PO block copolymer (trade name: Ethylan NS-500LQ, Aksu promise shellfish
Your company) 3g mixes well and oily phase is made.
2, prepared by water phase: by ethylene glycol (Aladdin reagent) 5g, organic silicon defoamer (trade name: GY-X60, Beijing Guang Yuan
Yi Nong Chemical Co., Ltd.) 0.2g be uniformly mixed with 49.8g water be made water phase.
3, emulsify: water phase is added dropwise to oily phase by (5000 revs/min) under high speed shear, continues shearing 10 minutes, is made
Effective component mass content is the aqueous emulsion of 14wt%.
The preparation example 13:30wt%Acynonapyr Fenpropathrin wettable powder of miticide composition preparation
By Acynonapyr raw medicine 20g, Fenpropathrin raw medicine 10g, lignin sulfonic acid sodium salt (trade name: Ultrazine
NA, Bao Lige Industrial Co., Ltd) 6g, Morwet EFW (Akzo Nobel N.V.) 2g, white carbon black (Aladdin reagent)
15g, bentonite (Hangzhou Zuo Tu new material Co., Ltd) add to 100g, are uniformly mixed after first precomminution, then through airslide disintegrating mill
(the excellent nanogram Machinery Co., Ltd. in Kunshan) is crushed to fineness and meets the requirement that at least 98wt% passes through 45 μm of testing sieves, is made effective
The wettable powder that composition quality content is 30%.
The preparation example 14:35wt%Acynonapyr Fenpropathrin water dispersible granules of miticide composition preparation
By Acynonapyr raw medicine 30g, Fenpropathrin raw medicine 5g, naphthalene sulfonate (trade name: YUS-TXC, Japanese this oil of bamboo
Rouge Co., Ltd.) 7g, lauryl sodium sulfate (Aladdin reagent) 2g, ammonium sulfate (Aladdin reagent) 2g, white carbon black (Aladdin
Reagent) 12g, kaolin (Hangzhou Zuo Tu new material Co., Ltd) adds to 100g, it is first uniformly mixed, then through airslide disintegrating mill (elder brother
Shan You nanogram Machinery Co., Ltd.) 15 μm are crushed to hereinafter, be uniformly mixed with 15g water, it is granulated by rotating pelletizer, in 60 DEG C
Lower drying selects the testing sieve of 20 mesh and 60 mesh to be sieved to water content≤1%, gives up top bulky grain and bottom filtering
The water dispersible granules that effective component mass content is 35wt% are made in dust.
The preparation example 15:18wt%Acynonapyr Fenpropathrin aqueous emulsion of miticide composition preparation
1, oil is mutually prepared: Acynonapyr raw medicine 2g and Fenpropathrin raw medicine 16g are dissolved in cyclohexanone (Aladdin reagent)
5g and dimethylbenzene (Aladdin reagent) 10g composition complex solvent in, then with castor oil polyoxyethylene ether (trade name: BY-
110, the sincere chemical assistant of Xingtai City swallow) 5g, agriculture breast 500# (the sincere chemical assistant of Xingtai City swallow) 2g and n-butanol (Aladdin reagent)
1g, which is mixed well, is made oily phase.
2, prepared by water phase: by ethylene glycol (Aladdin reagent) 2g, organic silicon defoamer (trade name: GY-X60, Beijing Guang Yuan
Yi Nong Chemical Co., Ltd.) 0.1g be uniformly mixed with 56.9g water be made water phase.
3, emulsify: water phase obtained is added dropwise to oily phase by (5000 revs/min) under high speed shear, continues 10 points of shearing
The aqueous emulsion that effective component mass content is 18wt% is made in clock.
The preparation example 16:12wt%Acynonapyr. Fenpropathrin aqueous emulsion of miticide composition preparation
1, oil is mutually prepared: Acynonapyr raw medicine 2g and Fenpropathrin raw medicine 10g are dissolved in cyclohexanone (Aladdin reagent)
8g and dimethylbenzene (Aladdin reagent) 8g composition complex solvent, then with castor oil polyoxyethylene ether (trade name: BY-110,
The sincere chemical assistant of Xingtai City swallow) (trade name: Ethylan NS-500LQ, Akzo Nobel are public for 4g, EO-PO block copolymer
Department) 1g mixes well and oily phase is made.
2, prepared by water phase: by ethylene glycol (Aladdin reagent) 3g, organic silicon defoamer (trade name: GY-X60, Beijing Guang Yuan
Yi Nong Chemical Co., Ltd.) 0.1g be uniformly mixed with 63.9g water be made water phase.
3, emulsify: water phase obtained is added dropwise to oily phase by (5000 revs/min) under high speed shear, continues 10 points of shearing
The aqueous emulsion that effective component mass content is 12wt% is made in clock.
Reference examples 1:20wt%Acynonapyr suspending agent
1. crushing the modulation of slurry: dispersing phosphoric acid salt dispersing agent (trade name: YUS-FS3000, Japan in 55.8g water
Zhu Ben's Oil Corporation) 3g, Morwet EFW (Akzo Nobel N.V.) 1g and organic silicon defoamer (trade name: GY-
X60, Beijing Guangyuan Yinong Chemical Co., Ltd) 0.2g, disperses Acynonapyr raw medicine 20g wherein, usesBead carries out case of wet attrition to the D90 (grain of 90% particle with sand mill (Shenyang Chemical Research Institute)
Diameter) 10 μm of <, it obtains and crushes slurry 80g.
2. the modulation of suspending agent: being crushed toward 80g and xanthan gum (Aladdin reagent) 0.3g, ethylene glycol (I are added in slurry
Fourth reagent) it 4g, sodium benzoate (Aladdin reagent) 0.5g and is mixed, benefit is filled with water to 100g, and high speed shear, which is uniformly made, to be had
Imitate the suspending agent that composition quality content is 20wt%.
Reference examples 2:45wt% pyridaben wettable powder
By pyridaben raw medicine 45g, alkylnaphthalene sulfonate formaldehyde condensation products (trade name: Morwet D425, Aksu promise shellfish
Your company) 9g, lauryl sodium sulfate (Aladdin reagent) 3g, kaolin (Hangzhou Zuo Tu new material Co., Ltd) adds to
100g, first precomminution be uniformly mixed, then through airslide disintegrating mill (the excellent nanogram Machinery Co., Ltd. in Kunshan) be crushed to fineness meet to
Few 98wt% passes through the requirement of 45 μm of testing sieves, and the wettable powder that effective component mass content is 45wt% is made.
Reference examples 3:20wt% etoxazole suspending agent
1. crushing the modulation of slurry: dispersing polycarboxylate (trade name: GY-D07, Beijing Guang Yuan benefit agrochemical in 55.8g water
Learn Co., Ltd) 2g, Morwet EFW (Akzo Nobel N.V.) 2g and organic silicon defoamer (trade name: GY-X60,
Beijing Guangyuan Yinong Chemical Co., Ltd) 0.2g, disperses etoxazole raw medicine 20g wherein, usesGlass
Glass pearl carries out case of wet attrition to 10 μm of < of D90 (partial size of 90% particle) with sand mill (Shenyang Chemical Research Institute), obtains powder
Pulping material 80g.
2. the modulation of suspending agent: being crushed toward 80g and xanthan gum (Aladdin reagent) 0.3g, organobentonite is added in slurry
(Hangzhou Zuo Tu new material Co., Ltd) 0.4g, ethylene glycol (Aladdin reagent) 4g, 0.5g is simultaneously for sodium benzoate (Aladdin reagent)
It is mixed, benefit is filled with water to 100g, and the suspending agent that effective component mass content is 20wt% is uniformly made in high speed shear.
Reference examples 4:25wt% Envidor suspending agent
1. crushing the modulation of slurry: dispersing alkylnaphthalene sulfonate formaldehyde condensation products (trade name: Morwet in 49.8g water
D425, Akzo Nobel N.V.) 3g, EO-PO block copolymer (trade name: Ethylan NS-500LQ, Akzo Nobel
Company) 1g, Morwet EFW (Akzo Nobel N.V.) 1g and organic silicon defoamer (trade name: GY-X60, Beijing Guang Yuan benefit
Agriculture Chemical Co., Ltd.) 0.2g, then disperse Envidor raw medicine 25g wherein, it usesBead uses sand
Grinding machine (Shenyang Chemical Research Institute) carries out case of wet attrition to 10 μm of < of D90 (partial size of 90% particle), obtains and crushes slurry
80g。
2. the modulation of suspending agent: being crushed toward 80g and xanthan gum (Aladdin reagent) 0.2g, white carbon black (I are added in slurry
Fourth reagent) it 0.5g, ethylene glycol (Aladdin reagent) 4g, sodium benzoate (Aladdin reagent) 0.5g and is mixed, benefit is filled with water to
The suspending agent that effective component mass content is 25wt% is uniformly made in 100g, high speed shear.
Reference examples 5:12wt% Fenpropathrin aqueous emulsion
1, oil is mutually prepared: Fenpropathrin raw medicine 12g is dissolved in cyclohexanone (Aladdin reagent) 5g and dimethylbenzene (Aladdin examination
Agent) 11g composition complex solvent in, then (trade name: BY-110, the sincere chemistry of Xingtai City swallow help with castor oil polyoxyethylene ether
Agent) 4g, EO-PO block copolymer (trade name: Ethylan NS-500LQ, Akzo Nobel N.V.) 1g mix well it is obtained
Oily phase.
2, prepared by water phase: by ethylene glycol (Aladdin reagent) 3g, organic silicon defoamer (trade name: GY-X60, Beijing Guang Yuan
Yi Nong Chemical Co., Ltd.) 0.1g be uniformly mixed with 63.9g water be made water phase.
3, emulsify: water phase obtained is added dropwise to oily phase by (5000 revs/min) under high speed shear, continues 10 points of shearing
The aqueous emulsion that effective component mass content is 12wt% is made in clock.
Field control effectiveness test:
The above preparation example of each miticide composition preparation and the field efficacy of reference examples: to Acynonapyr and active constituent
B and its compound carry out the pharmacodynamic test of prevention and treatment citrus red mite.
Reagent agent: preparation obtained by the preparation example 1~16 and reference examples 1~5 of miticide composition preparation.
By it is each be diluted with water for test preparation after carry out spraying treatment, in application before and application after 3d, 7d investigate insect density,
Calculate the preventive effect of medicament.Test result see the table below 5.
Table 5: preventive effect result of the reagent agent to citrus red mite
The preventive effect result of citrus red mite can be seen that by the different reagent agents of table 5, Acynonapyr and pyridaben,
Acynonapyr and etoxazole, Acynonapyr and Envidor and Acynonapyr compound gained mite killing group with Fenpropathrin
The effect that object is superior to single dose to the quick-acting and lasting effect of citrus red mite is closed, illustrates present invention compounding gained miticide composition
Or its preparation preventive effect is significant, better than single dose preventive effect in terms of delaying the generation of drug resistance, extension to hold pharmacological property.And in test not
It was found that compound drug generates phytotoxicity to crop, illustrate the case where the mite killing synergy of gained miticide composition or preparation improves
Under, production cost and use cost can be reduced, to crop safety.
Various embodiments of the present invention are described above, above description is exemplary, and non-exclusive, and
It is not limited to disclosed each embodiment.Without departing from the scope and spirit of illustrated each embodiment, for this skill
Many modifications and changes are obvious for the those of ordinary skill in art field.
Claims (10)
1. a kind of miticide composition, effective component includes active components A and active constituent B;It is characterized in that, it is described activity at
Dividing A is Acynonapyr, and the active constituent B is selected from pyridaben, etoxazole, Envidor or Fenpropathrin;
Wherein, the mass ratio of the active components A and active constituent B be 80:1~1:80, preferably 40:1~1:40, more preferably
For 20:1~1:20.
2. miticide composition according to claim 1, which is characterized in that the mass ratio of the Acynonapyr and pyridaben
For 15:1~1:15, preferably 10:1~1:15.
3. miticide composition according to claim 1, which is characterized in that the mass ratio of the Acynonapyr and etoxazole
For 10:1~1:10, preferably 5:1~1:5.
4. miticide composition according to claim 1, which is characterized in that the mass ratio of the Acynonapyr and Envidor
For 10:1~1:10, preferably 5:1~1:5.
5. miticide composition according to claim 1, which is characterized in that the quality of the Acynonapyr and Fenpropathrin
Than for 8:1~1:8, preferably 6:1~1:6.
6. miticide composition according to any one of claims 1-5, which is characterized in that with the total of the miticide composition
Weight is 100wt% meter, and the sum of the active components A and content of the active constituent B in miticide composition are 1~95wt%,
Preferably 5~80wt%, more preferably 10~50wt%;
Preferably, in terms of by the total weight of the miticide composition for 100wt%, the Acynonapyr and pyridaben are in mite killing group
Closing the sum of content in object is 20~50wt%;
Preferably, in terms of by the total weight of the miticide composition for 100wt%, the Acynonapyr and etoxazole are in mite killing group
Closing the sum of content in object is 20~40wt%;
Preferably, in terms of by the total weight of the miticide composition for 100wt%, the Acynonapyr and Envidor are in mite killing group
Closing the sum of content in object is 10~40wt%;
Preferably, in terms of by the total weight of the miticide composition for 100wt%, the Acynonapyr and Fenpropathrin are in mite killing
The sum of content in composition is 10~40wt%.
7. miticide composition described in -6 according to claim 1, which is characterized in that the miticide composition further includes adjuvant,
The adjuvant is selected from wetting agent, dispersing agent, emulsifier, thickener, disintegrating agent, antifreezing agent, defoaming agent, solvent, preservative, steady
Determine one of agent, synergist and carrier or a variety of;
Preferably, the wetting agent is selected from alkylbenzene sulfonate, alkylnaphthalene sulfonate, lignosulfonates, dodecyl sulphate
Sodium, succinic acid dibutyl ester sodium sulfonate, alhpa olefin sulfonate, alkyl phenol polyoxyethylene ether, castor oil polyoxyethylene ether, alkyl phenol second
It is oxygroup compound, alcohol ethoxylate, sodium sulfate of polyethenoxy ether of fatty alcohol, silkworm excrement, spaonin powder, spaonin powder, SOPA, net
One of lotion, 2000 series of emulsifier and wet bleeding agent F or a variety of;And/or
The dispersing agent is selected from lignosulfonates, alkylnaphthalene sulfonate formaldehyde condensation products, naphthalene sulfonate, triphenyl vinyl phenol
Ethoxylate phosphate esters, alcohol ethoxylate, alkyl phenol polyoxyethylene ether, alkyl phenol polyoxyethylene ether methyl ether condensation product
Sulfate, aliphatic amine polyoxyethylene ether, glycerol fatty acid ester polyoxyethylene ethe, polycarboxylic acid salt, polyacrylic, phosphate
One of class, EO-PO block copolymer and EO-PO graft copolymer are a variety of;And/or
The emulsifier is selected from calcium dodecyl benzene sulfonate, alkyl phenol formaldehyde resin polyoxyethylene ether, phenethyl phenol polyoxy second
Alkene polyethenoxy ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrylphenol polyoxyethylene ether, castor oil polyoxy
One of vinethene and alkyl phenol ether phosphate are a variety of;And/or
The thickener is selected from xanthan gum, organobentonite, gum arabic, sodium alginate, aluminium-magnesium silicate, carboxymethyl cellulose
With it is one or more in white carbon black;And/or
The disintegrating agent be selected from sodium sulphate, ammonium sulfate, aluminium chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch,
One of cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid and tartaric acid are a variety of;And/or
The antifreezing agent is selected from one of alcohols, alcohol ethers, chlorinated hydrocarbon and inorganic salts or a variety of;And/or
The defoaming agent is selected from C10-C20Saturated fat acids compound, silicone oil, silicone compound, C8-C10One in fatty alcohol
Kind is a variety of;And/or
The solvent is selected from benzene,toluene,xylene, durol, methanol, ethyl alcohol, isopropanol, n-butanol, dimethyl sulfoxide, two
One of methylformamide, cyclohexanone, alkylene carbonate, diesel oil, solvent naphtha, vegetable oil, vegetable oil derivatives and water are more
Kind;And/or
The preservative is selected from propionic acid, propionic acid sodium salt, sorbic acid, sodium sorbate salt, sorbic acid sylvite, benzoic acid, sodium benzoate
One of salt, P-hydroxybenzoic acid sodium salt, methyl p-hydroxybenzoate, Kathon CG and 1,2- benzisothiazole-3-ketone are more
Kind;And/or
The stabilizer is selected from disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, DBPC 2,6 ditertiary butyl p cresol, oleic acid
One in triethanolamine, epoxidized vegetable oil, kaolin, bentonite, attapulgite, white carbon black, talcum powder, montmorillonite and starch
Kind is a variety of;And/or
The synergist is selected from Synergistic Phosphorus and/or Butacide;And/or
The carrier be selected from ammonium salt, grind natural minerals, grind artificial mineral, silicate, resin, wax, solid fertilizer,
One of water, organic solvent, mineral oil, vegetable oil and vegetable oil derivatives are a variety of.
8. a kind of preparation of miticide composition, which is characterized in that combined using such as mite killing of any of claims 1-7
Object is prepared.
9. preparation according to claim 8, which is characterized in that the dosage form of the preparation is selected from missible oil, aqueous emulsion, wettable
Pulvis, water dispersible granules, suspending agent or microcapsule formulations.
10. as miticide composition of any of claims 1-7, preparation as claimed in claim 8 or 9 have in prevention and treatment
Application in harmful mite class.
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CN110663697A (en) * | 2019-10-11 | 2020-01-10 | 陕西上格之路生物科学有限公司 | Acaricidal composition containing Acynonapyr, preparation formulation and application thereof |
CN110679591A (en) * | 2019-10-28 | 2020-01-14 | 上海悦联生物科技有限公司 | Pesticide composition and preparation method thereof |
CN110896957A (en) * | 2019-12-25 | 2020-03-24 | 山东康乔生物科技有限公司 | Composition containing spiromesifen and Acynonapyr and application thereof |
CN111066805A (en) * | 2019-12-26 | 2020-04-28 | 山东康乔生物科技有限公司 | Acaricidal composition and application thereof |
CN112244027A (en) * | 2020-10-26 | 2021-01-22 | 侨昌现代农业有限公司 | Bactericidal composition, bactericide and application method thereof |
CN112314609A (en) * | 2020-11-18 | 2021-02-05 | 侨昌现代农业有限公司 | Bactericidal composition, bactericide and application thereof |
CN113016812A (en) * | 2019-12-24 | 2021-06-25 | 沈阳中化农药化工研发有限公司 | Insecticidal and acaricidal synergistic composition and application thereof |
CN115104616A (en) * | 2022-08-19 | 2022-09-27 | 陕西康禾立丰生物科技药业有限公司 | Acaricide containing acytonapryr and spirodiclofen |
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CN110663697A (en) * | 2019-10-11 | 2020-01-10 | 陕西上格之路生物科学有限公司 | Acaricidal composition containing Acynonapyr, preparation formulation and application thereof |
CN110679591A (en) * | 2019-10-28 | 2020-01-14 | 上海悦联生物科技有限公司 | Pesticide composition and preparation method thereof |
CN113016812A (en) * | 2019-12-24 | 2021-06-25 | 沈阳中化农药化工研发有限公司 | Insecticidal and acaricidal synergistic composition and application thereof |
CN113016812B (en) * | 2019-12-24 | 2022-02-11 | 沈阳中化农药化工研发有限公司 | Insecticidal and acaricidal synergistic composition and application thereof |
CN110896957A (en) * | 2019-12-25 | 2020-03-24 | 山东康乔生物科技有限公司 | Composition containing spiromesifen and Acynonapyr and application thereof |
CN111066805A (en) * | 2019-12-26 | 2020-04-28 | 山东康乔生物科技有限公司 | Acaricidal composition and application thereof |
CN112244027A (en) * | 2020-10-26 | 2021-01-22 | 侨昌现代农业有限公司 | Bactericidal composition, bactericide and application method thereof |
CN112244027B (en) * | 2020-10-26 | 2022-01-18 | 侨昌现代农业有限公司 | Bactericidal composition, bactericide and application method thereof |
CN112314609A (en) * | 2020-11-18 | 2021-02-05 | 侨昌现代农业有限公司 | Bactericidal composition, bactericide and application thereof |
CN112314609B (en) * | 2020-11-18 | 2022-01-18 | 侨昌现代农业有限公司 | Bactericidal composition, bactericide and application thereof |
CN115104616A (en) * | 2022-08-19 | 2022-09-27 | 陕西康禾立丰生物科技药业有限公司 | Acaricide containing acytonapryr and spirodiclofen |
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