WO2017195734A1

WO2017195734A1 - Method for controlling pests, pharmaceutical composition for controlling pests, and pest control agent set

Info

Publication number: WO2017195734A1
Application number: PCT/JP2017/017400
Authority: WO
Inventors: 昌宏川口
Original assignee: 日本曹達株式会社; 日産化学工業株式会社
Priority date: 2016-05-11
Filing date: 2017-05-08
Publication date: 2017-11-16
Also published as: JP2019131469A

Abstract

Provided are: a method by which various pests can be controlled even at low dosage with no problems in safety; and a pharmaceutical composition for controlling pests and a pest control agent set, which are suitable for use in said method. This method comprises applying 3-endo-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridyloxy]-9-azabicyclo[3.3.1]nonane or a salt thereof, along with (Z)-4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[(methoxyimino)methyl]-2-methylbenzamide or a salt thereof, to a subject, and controls pests.

Description

Pest control method, pest control pharmaceutical composition and pest control agent set

The present invention relates to a pest control method, a pest control pharmaceutical composition, and a pest control agent set. More specifically, the present invention relates to a method capable of controlling various pests with no safety problem and a low dosage, and a pest control pharmaceutical composition suitable for use in the method and a harmful composition. The present invention relates to a biocontrol agent set.
This application claims priority to Japanese Patent Application No. 2016-95067 filed on May 11, 2016, the contents of which are incorporated herein by reference.

Conventionally, many compounds having insecticidal / miticidal activity have been proposed. However, most of the proposed compounds have insufficient efficacy, their use is limited due to drug resistance problems, cause phytotoxicity and contamination of plants, and are toxic to livestock and fish. However, it was not always satisfactory. Under such circumstances, Patent Document 1 discloses that a cyclic amine compound having a specific structure has excellent insecticidal / miticidal activity. Patent Document 2 discloses that an isoxazoline-substituted benzamide compound having a specific structure is useful as an insecticide / acaricide.

WO 2011/078081 A1 WO 2007/026965 A1

An object of the present invention is to provide a method capable of controlling various pests with no safety problem and a low dosage, and a pest control pharmaceutical composition and pest control suitable for use in the method. It is to provide a set of agents.

As a result of earnest research to solve the above problems, the present invention including the following modes has been completed.

That is, the present invention includes the following forms.
[1] 3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane Or a salt thereof, (Z) -4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyimino) methyl] -A method for controlling pests, which comprises applying to 2-objects together with 2-methylbenzamide or a salt thereof.
[2] The pest control method according to [1], wherein the pest is an insect or a tick.

[3] 3-Endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane Or a salt thereof and (Z) -4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyimino) methyl] -A pest control pharmaceutical composition containing 2-methylbenzamide or a salt thereof.
[4] The pest control pharmaceutical composition according to [3], wherein the pest is an insect or a tick.

[5] 3-Endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane Or a pharmaceutical composition containing the salt thereof, and (Z) -4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N- [ (Methoxyimino) methyl] -2-methylbenzamide or a pharmaceutical composition containing a salt thereof is combined with a pharmaceutical composition containing a pest control agent.
[6] The pest control agent set according to [5], wherein the pest is an insect or a tick.

According to the pest control method of the present invention, pests such as insects and mites can be controlled more safely with a smaller dose. The pest control pharmaceutical composition and the pest control agent set of the present invention can be suitably used in the pest control method of the present invention. In particular, the pest control agent of the present invention can be suitably used as an agricultural / horticultural insecticide / acaricide composition.

The pest control method of the present invention includes applying Compound A together with Compound B to an object.

Compound A is obtained from 3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1]. Nonane (hereinafter sometimes referred to as compound (I)) or a salt of compound (I). Compound (I) is a compound represented by formula (I) (CAS No .: 1332838-17-1, generic name: acynonapyr). Compound (I) can be produced by the method described in Patent Document 1 and the like.

The salt of compound (I) is not particularly limited as long as it is an agro-horticulturally acceptable salt. For example, salts of inorganic acids such as hydrochloric acid and sulfuric acid; salts of organic acids such as acetic acid and lactic acid; salts of alkali metals such as lithium, sodium and potassium; salts of alkaline earth metals such as calcium and magnesium; iron and copper Transition metal salts; organic base salts such as triethylamine, tributylamine, pyridine, hydrazine; and ammonia salts. The salt of compound (I) can be produced from compound (I) by a known method.

Compound B is (Z) -4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyimino) methyl]- 2-methylbenzamide (hereinafter sometimes referred to as compound (II)) or a salt of compound (II). Compound (II) is a compound represented by formula (II) (CAS No .: 928783-29-3, general name: fluxametamide). Compound (II) can be produced by the method described in Patent Document 2 and the like.

The salt of compound (II) is not particularly limited as long as it is an agro-horticulturally acceptable salt. For example, salts of inorganic acids such as hydrochloric acid and sulfuric acid; salts of organic acids such as acetic acid and lactic acid; salts of alkali metals such as lithium, sodium and potassium; salts of alkaline earth metals such as calcium and magnesium; iron and copper Transition metal salts; organic base salts such as triethylamine, tributylamine, pyridine, hydrazine; and ammonia salts. The salt of compound (II) can be produced from compound (II) by a known method.

The mass ratio of compound A to compound B used in the method of the present invention (compound A / compound B) is not particularly limited, but is preferably 1,000 / 1 to 1/1000, more preferably 100/1 to 1/100, more preferably 10/1 to 1/10, and particularly preferably 1/1 to 10/1.

In the method of the present invention, the active ingredient of Compound A or Compound B can be used as it is, however, a pharmaceutical composition containing Compound A, a pharmaceutical composition containing Compound B, or a pharmaceutical composition containing Compound A and Compound B. (Hereinafter, these three may be collectively referred to as a “pharmaceutical composition.” A pharmaceutical composition containing Compound A and Compound B may also be referred to as “a pest control pharmaceutical composition”.) It is preferable to use it. The pharmaceutical composition may be formulated into a known form. Possible forms of general agricultural chemicals or veterinary drugs by formulation, for example, wettable powder, granules, powders, tablets, emulsions, aqueous solvents, suspensions, wettable granules, flowable, microcapsules, aerosols, sprays Agent, spray agent, haze agent, heat transpiration agent, smoke agent, bait agent and the like. Moreover, what impregnated compound A and / or compound B to base materials, such as a porous ceramic board, a nonwoven fabric, and paper, may be used.

The total amount of Compound A and Compound B contained in the pharmaceutical composition varies slightly depending on the dosage form, but is usually 0.1 to 80% by mass with respect to the pharmaceutical composition.
In dosage forms such as emulsions, solutions, wettable powders (eg, granular wettable powders), aqueous suspension formulations or microemulsions. The total content of Compound A and Compound B is preferably 1 to 80% by mass, more preferably 10 to 50% by mass, based on the pharmaceutical composition.
In dosage forms such as oils and powders, the total content of Compound A and Compound B is preferably about 0.1 to 50% by weight, more preferably about 0.1 to 20% by weight, based on the pharmaceutical composition. is there.
In dosage forms such as granules, tablets, jumbo and the like, the total content of compound A and compound B is preferably 0.5 to 50% by mass, more preferably 0.5 to 0.5%, based on the pharmaceutical composition. 10% by mass.

The pharmaceutical composition may contain various additives or carriers. The carrier can be appropriately selected from a solid carrier, a liquid carrier, and a gas carrier according to the dosage form.

Additives and carriers used in solid formulations include vegetable powders such as soybean flour, wheat flour, mineral fine powders such as diatomaceous earth, apatite, gypsum, talc, bentonite, pyrophyllite, clay, sodium benzoate, Examples thereof include organic and inorganic compounds such as urea and mirabilite.

Solvents used in liquid formulations include petroleum aromatic hydrocarbons such as kerosene and xylene, cyclohexane, cyclohexanone, dimethylformamide, dimethyl sulfoxide, alcohol, acetone, trichloroethylene, methyl isobutyl ketone, mineral oil, vegetable oil, water And so on.

Examples of the gas carrier used when formulating into a propellant include butane gas, LPG, dimethyl ether, carbon dioxide gas and the like.

Substrates for poisonous baits include food ingredients such as cereal flour, vegetable oil, sugar and crystalline cellulose; antioxidants such as dibutylhydroxytoluene and nordihydroguaiaretic acid; preservatives such as dehydroacetic acid; children such as pepper Anti-fouling agents by pets; pest-attracting perfumes such as cheese flavors and onion flavors.

In order to take a uniform and stable form in the pharmaceutical composition, a surfactant can be added as necessary. The surfactant that can be added is not particularly limited. For example, alkyl phenyl ether added with polyoxyethylene, alkyl ether added with polyoxyethylene, higher fatty acid ester added with polyoxyethylene, sorbitan higher fatty acid ester added with polyoxyethylene, tristyryl added with polyoxyethylene Nonionic surfactants such as phenyl ether, sulfates of alkylphenyl ethers added with polyoxyethylene, alkylbenzene sulfonates, sulfates of higher alcohols, alkylnaphthalene sulfonates, polycarboxylates, lignin sulfones Acid salt, formaldehyde condensate of alkyl naphthalene sulfonate, and isobutylene-maleic anhydride copolymer.

As long as the pharmaceutical composition does not impair the object of the present invention, it is used as necessary, bactericides, insecticides / acaricides, nematicides, plant regulators, synergists, fertilizers, soil improvers, animal use. It may contain feed.

Specific examples of insecticide / acaricide, nematicide, soil insecticide and anthelmintic are shown below.

(1) Acetylcholinesterase inhibitor:
(A) Carbamate series: Alanicarb, Aldicarb, Bengiocarb, Benfuracarb, Butcarboxyme, Butoxycarboxyme, Carbaryl, Carbofuran, Carbosulfuran, Ethiophenecarb, Fenobucarb, Formethanate, Furatiocarb, Isoprocarb, Methiocarb, Mesomil, Oxamyl, Pirimicarb, Propoxycarb Thiodicarb, thiophanox, triazamate, trimetacarb, XMC, xylylcarb; phenothiocarb, MIPC, MPMC, MTMC, aldoxicarb, alixicarb, aminocarb, bufencarb, cloetocarb, metam sodium, promecarb;

(B) Organophosphorus: Acephate, azamethiphos, azinephos-ethyl, azinephos-methyl, kazusafos, chlorethoxyphos, chlorfenvinphos, chlormefos, chlorpyrifos, chlorpyrifos-methyl, coumaphos, cyanophos, dimethone-S-methyl, diazinon, Dichlorvos / DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethione, etoprophos, famfur, phenamiphos, fenitrothion, fenthion, phostiazet, heptenophos, imisiaphos, isofenphos, isocarbophos, isoxathione, malathione, methalmethione, mecarbamethione Monocrotophos, nared, ometoate, oxydimethone-methyl, parathion, parathion-methyl, fento Ate, folate, hosalon, phosmet, phosphamidone, phoxime, pyrimiphos-methyl, propenophos, propetamphos, prothiophos, pyracrofos, pyridafenthion, quinalphos, sulfotep, tebupyrine phos, temefos, terbufos, tetrachlorbinphos, thiomethone, triazophos, trichlorfos, bamidthione;・ Ethyl, BRP, carbophenothion, cyanophenphos, CYAP, dimeton-S-methylsulfone, diariphos, diclofenthion, dioxabenzophos, etrimphos, fensulfothion, flupyrazophos, phonofos, formotethione, phosmethylan, isazophos, iodofenphos, methacliphos , Pyrimifos-ethyl, phosphocarb, propaphos, protoate, sulprophos.

(2) GABA-agonist chloride channel antagonists: chlordane, endosulfan, ethiprole, fipronil, pyrafluprole, pyriprole; camfechlor, heptachlor, dienochlor.
(3) Sodium channel modulators: Acrinatrin, d-cis-trans allethrin, d-transarethrin, bifenthrin, bioareslin, bioareslin isomers, violesmethrin, cycloprotorin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda- Cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, ciphenothrin [(1R) -trans isomer], deltamethrin, enpentrin [(EZ)-( 1R) -isomers], esfenvalerate, etofenprox, fenpropatoline, fenvalerate, flucitrinate, flumethrin, tau-fulvalinate, halfenprox, imiprito , Cadreslin, permethrin, phenothrin [(1R) -trans isomer], praretrin, pyrethram, resmethrin, silafluophene, tefluthrin, tetramethrin, tetramethrin [(1R) -isomer], tralomethrin, transfluthrin; allethrin, pyrethrin, pyrethrin I, pyrethrin II, profluthrin, dimefluthrin, bioethanomethrin, biopermethrin, transpermethrin, fenfluthrin, fenpyritrin, fulbrocitrinate, flufenprox, methfluthrin, protofenbuto, pyrethmethrin, terraretrin.

(4) Nicotinic acetylcholine receptor agonists: acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam, sulfoxafurol, nicotine, flupiradiflon.
(5) Nicotinic acetylcholine receptor allosteric modulator: spinetoram, spinosad.
(6) Chloride channel activator: Abamectin, emamectin benzoate, lepimectin, milbemectin; ivermectin, selamectin, doramectin, eprinomectin, moxidectin, milbemycin, milbemycin oxime.
(7) Juvenile hormone-like substances: hydroprene, quinoprene, mesoprene, phenoxycarb, pyriproxyfen; geofenolan, epofenanane, triprene.
(8) Other non-specific inhibitors: methyl bromide, chloropicrin, sulfuryl fluoride, borax, and tartar.
(9) Homoptera selective feeding inhibitor: flonicamid, pymetrozine, pyrifluquinazone.

(10) Tick growth inhibitor: clofentezin, diflovidazine, hexythiazox, etoxazole.
(11) Microbial-derived insect midgut mesentery: Bacillus thuringiensis subsp. Isla elensis, Bacillus sphaericus, Bacillus thuringiensis subsp. Aisawai, Bacillus thuringiensis subsp. Kurstaki, Bacillus thuringiensis subsp. Tenebrionis, Bt Crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / Cry35Ab1.
(12) Mitochondrial ATP biosynthetic enzyme inhibitors: diafenthiuron, azocyclotin, cyhexatin, fenbutasine oxide, propargite, tetradiphone.
(13) Oxidative phosphorylation uncouplers: chlorfenapyr, sulframide, DNOC; binapacryl, dinobutone, dinocup.
(14) Nicotinic acetylcholine receptor channel blocker: bensultap, cartap hydrochloride; nereistoxin; thiosultap monosodium salt, thiocyclam.
(15) Chitin synthesis inhibitor: bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novallon, nobiflumuron, teflubenzuron, triflumuron, buprofezin, fluazuron.
(16) Diptera molting agent: cyromazine.
(17) Molting hormone receptor agonists: Chromafenozide, halofenozide, methoxyphenozide, tebufenozide.
(18) Octopamine receptor agonist: amitraz, demiditraz, chlordimeform.
(19) Mitochondrial electron transport system complex III inhibitor: acequinosyl, fluacrylpyrim, hydramethylnon.
(20) Mitochondrial electron transport complex I inhibitor: phenazaquin, fenproxymate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, rotenone.

(21) Voltage-gated sodium channel blocker: indoxacarb, metaflumizone.
(22) Acetyl CoA carboxylase inhibitor: spirodiclofen, spiromesifen, spirotetramat.
(23) Mitochondrial electron transport complex IV inhibitor: Aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, cyanide.
(24) Mitochondrial electron transport system complex II inhibitor: Sienopyrafen, cyflumetofene, piflummid.
(25) Ryanodine receptor modulator: chlorantraniliprole, cyantraniprole, fulvendiamide, cyclaniliprol, tetraniprolol.
(26) Mixed function oxidase inhibitor compound: Piperonyl butoxide.
(27) Latrophilin receptor agonist: depsipeptide, cyclic depsipeptide, 24-membered cyclic depsipeptide, emodepside.
(28) Other agents (unknown mechanism of action): azadirachtin, benzoxymate, biphenazate, bromopropyrate, quinomethionate, cryolite, dicofol, pyridalyl; bencrothiaz, sulfur, amidoflumet, 1,3-dichloropropene, DCIP , Phenisobromolate, benzomate, metaldehyde, chlorbenzilate, clothiazoben, dicyclanyl, phenoxacrime, fentriphanyl, flubenzimine, fluphenazine, gossip lure, japonyla, methoxadiazone, petroleum, potassium oleate, tetrasul, trialacene; afidopyropen), flometokin, flufiprole, fluenesulfone, meperfluthrin, tetramethylfluthrin, tralopyril, dimefluthrin, me Luneodecanamide; fluralanel, afoxolanel, floxamethamide, 5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2- (1H-1,2, , 4-Triazol-1-yl) benzonitrile (CAS: 943137-49-3), brofuranilide, and other metadiamides.

(29) Anthelmintic:
(A) benzimidazole series: fenbendazole, albendazole, triclabendazole, oxybendazole, mebendazole, oxfendazole, perbendazole, fulbendazole; fevantel, netobimine, thiophanate; thiabendazole, canbendazole;
(B) salicylanilide series: closantel, oxyclozanide, rafoxanide, niclosamide;
(C) substituted phenols: nitroxinyl, nitroskanate;
(D) Pyrimidine series: Pirantel, Morantel;
(E) imidazothiazole series: levamisole, tetramisol;
(F) Tetrahydropyrimidine series: praziquantel, epsiprantel;
(G) Other anthelmintic drugs: cyclodiene, riania, chlorthrone, metronidazole, demiditraz; piperazine, diethylcarbamazine, dichlorophene, monepantel, tribendimidine, amidantel; thiacetalsamide, melolsamine, arsenamide.

Specific examples of the disinfectant are shown below.
(1) Nucleic acid biosynthesis inhibitors:
(A) RNA polymerase I inhibitor: benalaxyl, benalaxyl-M, furaxyl, metalaxyl, metalaxyl-M; oxadixil; cloziracone, off-race;
(B) adenosine deaminase inhibitor: bupilimate, dimethylylmol, ethylimol;
(C) DNA / RNA synthesis inhibitors: Himexazole, octirinone;
(D) DNA topoisomerase II inhibitor: Oxophosphate.

(2) Mitotic fission inhibitor and cell division inhibitor:
(A) β-tubulin polymerization inhibitors: benomyl, carbendazim, chlorphenazole, fuberidazole, thiabendazole; thiophanate, thiophanate-methyl; dietofencarb; zoxamide; ethaboxam;
(B) Cell division inhibitor: Penciclone;
(C) Delocalization inhibitor of spectrin-like protein: fluopicolide.

(3) Respiratory inhibitor:
(A) Complex I NADH oxidoreductase inhibitor: diflumetrim; tolfenpyrad;
(B) Complex II succinate dehydrogenase inhibitors: benodanyl, flutolanil, mepronil; isophetamide; fluopyram; fenfram, flumeciclos; carboxin, oxycarboxyl; tifluzamide; benzovindiflupyr, bixafen, floxapyroxad , Furametopyr, isopyrazam, penflufen, penthiopyrad, sedaxane; boscalid;
(C) Complex III ubiquinol oxidase Qo inhibitor: azoxystrobin, cumoxystrobin, cumethoxystrobin, enoxastrobin, fluphenoxystrobin, picoxystrobin, pyroxystrobin; Piramethostrobin, triclopyricarb; Cresoxime-methyl, trifloxystrobin; Dimoxystrobin, Phenaminestrobin, Metominostrobin, Orisastrobin; Famoxadone; Fluoxastrobin; Fenamidon; Pyribencarb;
(D) Complex III ubiquinol reductase Qi inhibitor: cyazofamide; amisulbrom;
(E) Uncoupler of oxidative phosphorylation: Binapacryl, meptyldinocup, dinocup; fluazinam; ferrimzone;
(F) Oxidative phosphorylation inhibitor (inhibitor of ATP synthase): fentin acetate, fentin chloride, fentin hydroxide;
(G) ATP production inhibitor: silthiofam;
(H) Complex III: Cyclochrome Qx (unknown) inhibitor of bc1 (ubiquinone reductase): Amethoctrazine.

(4) Amino acid and protein synthesis inhibitors (a) Methionine biosynthesis inhibitors: Andoprim, cyprodinil, mepanipyrim, pyrimethanil;
(B) Protein synthesis inhibitor: blasticidin-S; kasugamycin, kasugamycin hydrochloride; streptomycin; oxytetracycline.

(5) Signaling inhibitor:
(A) Signaling inhibitor: quinoxyphene, proquinazide;
(B) MAP / histidine kinase inhibitor in osmotic signal transduction: fenpiclonil, fludioxonil; clozolimate, iprodione, procymidone, vinclozolin.

(6) Lipid and cell membrane synthesis inhibitors:
(A) Phospholipid biosynthesis, methyltransferase-inhibitors: edifenphos, iprobenphos, pyrazophos; isoprothiolane;
(B) lipid peroxidants: biphenyl, chloroneb, dichlorane, kinden, technazene, tolcrofosmethyl; etridiazole;
(C) Agents that act on cell membranes: iodocarb, propamocarb, propamocarb hydrochloride, propamocarbfocetylate, prothiocarb;
(D) Microorganisms that disturb the cell membrane of pathogenic bacteria: Bacillus subtilis, Bacillus subtilis QST713 strain, Bacillus subtilis FZB24 strain, Bacillus subtilis MBI600 strain, Bacillus subtilis D747 strain;
(E) Agent that disturbs the cell membrane: An extract of Goseika Yupte (Tea Tree).

(7) Cell membrane sterol biosynthesis inhibitors:
(A) Demethylation inhibitor at C14 position in sterol biosynthesis: Triphorine; Pyrifenox, Pyriisoxazole; Phenarimol, Flurprimidol, Nuarimol; Imazalyl, Imazaryl Sulfate, Oxpoconazole, Pefrazoate, Prochloraz, Triflumizole, biniconazole;
Azaconazole, viteltanol, bromconazole, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriazole, fluconazole, fluconazole-cis , Hexaconazole, imibenconazole, ipconazole, metconazole, microbutanyl, penconazole, propiconazole, quinconazole, cimeconazole, tebuconazole, tetraconazole, triadimethone, triadimenol, triticonazole; prothioconazole, voriconazole;
(B) Inhibitors of Δ14 reductase and Δ8 → Δ7-isomerase in sterol biosynthesis:
Aldimorph, dodemorph, dodemorph acetate, fenpropimorph, tridemorph; fenpropidin, piperalin; spiroxamine;
(C) 3-keto reductase inhibitor in C4-demethylation of sterol biosynthesis system: phenhexamide; fenpyrazamine;
(D) Sterol biosynthetic squalene epoxidase inhibitors: Pyributicarb; Naftifen, Terbinafine.

(8) Cell wall synthesis inhibitor (a) Trehalase inhibitor: Validamycin;
(B) chitin synthase inhibitor: polyoxin, polyoxolim;
(C) Cellulose synthase inhibitor: dimethomorph, furmorph, pyrimorph; benavalicarb, iprovaricarb, toluprocarb, varifenalate; mandipropamide.

(9) Melanin biosynthesis inhibitor (a) Reductase inhibitor of melanin biosynthesis: Fusaride; Pyroxylone; Tricyclazole;
(B) Dehydrase inhibitor of melanin biosynthesis: carpropamide; diclocimet; phenoxanyl.

(10) Host plant resistance inducer:
(A) Agents acting on the salicylic acid synthesis pathway: Acibenzoral-S-methyl;
(B) Other: Probenazole; thiazinyl; isotianil; laminarin;

(11) Agents with unknown activity: Simoxanyl, fosetylaluminum, phosphoric acid (phosphate), teclophthalam, triazoxide, fursulfamide, dichromedin, metasulfocarb, cyflufenamide, metolaphenone, pyriophenone, dodin, dodin free base, fluthianyl.

(12) Agents having multiple action points: copper (copper salt), Bordeaux liquid, copper hydroxide, copper naphthalate, copper oxide, copper oxychloride, copper sulfate, sulfur, sulfur products, calcium polysulfide; farbum, mancozeb, maneb, Mankappa, methylam, polycarbamate, propineb, thiram, dineb, ziram; captan, captahol, phorpet; chlorothalonil; diclofluuride, tolylfluanid; guazatine, iminotadine acetate, iminoctadine albecate; anilazine; dithianone; Fluorimide.

(13) Other agents: DBEDC, fluorophorpet, guazatine acetate, bis (8-quinolinolato) copper (II), propamidine, chloropicrin, ciprofuram, Agrobacterium, betoxazine, diphenylamine, methyl isothiocyanate (MITC) ), Mildeomycin, Capsaicin, Cufraneb, Cyprosulfamide, Dazomet, Debacarb, Dichlorophen, Diphenzoquat, Diphenzoquat methylsulfonate, Flumetober, Focetyl calcium, Focetyl sodium, Irumamycin, Natamycin, Nitrotal isopropyl , Oxamocarb, sodium propamosine, pyrrolnitrin, tebufloquine, torniphanide, zaliramide, Algophase, amicalhiazole (Amicarthiazol), oxachi Pipurorin (Oxathiapiprolin), metiram zinc, benches azole, trichlamide, uniconazole, mill Deo mycin, oxyphencyclimine Ji-in (Oxyfenthiin), Pical -but Ratho box (picarbutrazox).

Specific examples of plant regulators are shown below.
Abscisic acid, kinetin, benzylaminopurine, 1,3-diphenylurea, forchlorfenuron, thidiazuron, chlorfenuron, dihydrozeatin, gibberellin A, gibberellin A4, gibberellin A7, gibberellin A3, 1-methylcyclopropane, N-acetyl Aminoethoxyvinylglycine (also known as abiglycine), aminooxyacetic acid, silver nitrate, cobalt chloride, IAA, 4-CPA, cloprop, 2,4-D, MCPB, indole-3-butyric acid, dichloroprop, phenothiol, 1 -Naphtylacetamide, Ethiclozate, Cloxiphonac, Maleic acid hydrazide, 2,3,5-Triiodobenzoic acid, Salicylic acid, Methyl salicylate, (-)-Jasmonic acid, Methyl jasmonate, (+)-Strigol, (+) -Deoxyst Goal, (+) - Orobankoru, (+) - Sorugorakuton, 4-oxo-4- (2-phenylethyl) amino acid; ethephon, chlormequat, mepiquat chloride, benzyl adenine, 5-aminolevulinic acid.

As an embodiment of the method of the present invention, for example, a pharmaceutical composition containing Compound A and a pharmaceutical composition containing Compound B are prepared, respectively, and they are placed on the object at the same time or before and after opening little time. Applying; preparing a pharmaceutical composition containing Compound A and a pharmaceutical composition containing Compound B, mixing them, and applying the resulting mixture to the target; Compound A and Compound B Preparation of a pharmaceutical composition containing, and applying it to an object.

The pest control agent set of the present invention is a combination of a pharmaceutical composition containing Compound A and a pharmaceutical composition containing Compound B, without mixing them. The pest control agent set of the present invention makes it easy to obtain a ratio of compound A and compound B suitable for controlling the target pest, and contains a pharmaceutical composition containing compound A and compound B. It is possible to save the trouble of preparing each of the pharmaceutical compositions separately. In the pest control agent set of the present invention, in addition to the pharmaceutical composition containing Compound A and the pharmaceutical composition containing Compound B, other agents suitable for controlling the target pest, for example, bactericides , Insecticide / acaricide, nematicide, plant regulator, synergist, fertilizer, soil improver, animal feed, etc. It is preferable that they are collected together. Furthermore, the pest control agent set of the present invention may include a measuring cup or dropper, a mixing tank, a glove, a mask, or the like.
There are no particular restrictions on the form of grouping. For example, each pharmaceutical composition can be separately stored in a bag, box, bottle, can, etc., and stored together in a container such as a bag or box.

The pharmaceutical composition for controlling pests of the present invention contains Compound A and Compound B. In the pharmaceutical composition for controlling pests of the present invention, compound A and compound B are mixed at a predetermined ratio, so that the pharmaceutical composition containing compound A and the pharmaceutical composition containing compound B are measured, It is possible to save the trouble of mixing. The pharmaceutical composition for controlling pests of the present invention can be stored or transported by bagging, bottled, boxed, canned or the like depending on the dosage form.

The method of the present invention is not particularly limited. For example, a wettable powder, an emulsion, a flowable powder, an aqueous solvent and a granular wettable powder are diluted with water to a predetermined concentration to obtain a solution, suspension or emulsion. It can be applied by spraying on plants or soil. Powders and granules can be applied by spreading on plants or soil. Formulations such as poison baits and mite-proof sheets can be applied by placing them in desired places or hanging them. Gas preparations such as aerosols and aerosols can be applied using a device such as a spray. Furthermore, it can be applied by known veterinary techniques (topical, oral, parenteral or subcutaneous administration). Veterinary methods include oral administration to animals by mixing tablets, capsules, feed, etc .; administration to animals by immersion, suppository, injection (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.) A method of locally administering an oily or aqueous liquid agent by spraying, pour-on, spot-on, etc .; kneading an ectoparasite control agent into the resin, shaping the kneaded product into an appropriate shape such as a collar or ear tag; And the like, and is administered locally to an animal.

The above-described fungicides, insecticides / acaricides, nematicides, plant regulators, synergists, fertilizers, soil conditioners, as described above, with or without application at the same time. Animal feed or the like may be applied to the object.

The application amount to the target is not particularly limited, and can be set as appropriate according to the type of control target, the control time, and the like. For example, in order to control mites parasitizing domestic animals such as cattle and pigs, and pet animals such as dogs and cats, for example, the total amount of Compound A and Compound B is 0 with respect to 1 kg of the host animal. It can be applied in a ratio of 0.01 to 1000 mg.

Examples of objects to be applied include cereals; vegetables; root vegetables; potatoes; trees such as fruit trees, tea, coffee, cacao; pastures; turf; flowers; foliage plants; be able to. Plants as application objects are not limited by original species, varieties, improved varieties, cultivars, mutants, hybrids, genetically modified organisms (GMO), and the like. In the method of the present invention, it may be applied to the whole plant, or applied to a part of the plant such as leaves, stems, stems, flowers, persimmons, fruits, seeds, sprout, roots, tubers, tuberous roots, shoots and cuttings. May be. In order to control various agricultural pests and mites, seed treatment, foliage application, soil application, water application, and the like can be performed.

In addition, the target of application can be a host animal of ectoparasites; pets such as dogs and cats; pets; livestock such as cattle, horses, pigs and sheep; warm-blooded animals such as poultry; Insects such as stag beetles and beetles can be mentioned.

The pests that can be controlled by the method of the present invention are not particularly limited. Examples include sanitary pests, storage pests, clothing pests, house pests, parasites, and crop pests. These include mites and can be used as insecticidal and acaricidal methods.
The method of the present invention can be carried out at all stages of development of pests to be controlled. For example, the method of the present invention can be performed on eggs, nymphs, larvae, pupae and adults.

Examples of pests to be controlled are shown below.
(1) Lepidoptera butterfly or moth, for example
(1-a) Arctiidae moths such as Hyphantria cunea and Lemyra imparilis;
(1-b) buds of the family Bucculatricidae such as Bucculatrix pyrivorella;
(1-c) moths of Carposinidae such as Carposina sasakii;
(1-d) Diaphania spp., Such as cotton pear (Diaphania indica), Diaphania nitidalis; Ostrinia furnacalis; Ostrinia spp. such as scapulalis; and Chilo suppressalis, Cnaphalocrocis medinalis, Conogethes punctiferalis, Southwestern conborator (Diatraea grandiosella), lys pho des Crambadae moths of other genera such as Hellula undalis and Parapediasiateterrella;
(1-e) moths of the eleganidae (Gelechiidae) such as Helcystogramma triannulella, cotton beetle (Pectinophora gossypiella), potato moth (Phthorimaea operculella), Sitotroga cerealella;
(1-f) Geometridae moths such as Ascotis selenaria;
(1-g) moths of the family Gracoillariidae such as Caloptilia theivora, citrus leafworm (Phyllocnistis citrella), and king-butterfly moth (Phyllonorycter ringoniella);
(1-h) Hesperiidae butterflies, for example Parsara guttata;
(1-i) Lasiocampidae moths, for example, Malocasoma neustria;
(1-j) Lymantriidae moths, for example, Lymantria spp., Lymantria dispar, Nonmanmai monacha;
Other genus species, Euproctis pseudoconspersa, Orgyia thyellina;

(1-k) moths of the family Lyonetiidae, for example, Lyonetia clerkella, Lyonetia prunifoliella malinella, from the genus Lyonetia spp .;
(1-l) Noctuidae moths, for example, Spodoptera depravata, Southern army worm (Spodoptera eridania), Spodoptera exigua, Spodoptera exigua, Spodoptera exigua Spodoptera frugiperda), African Spodoptera littoralis, Spodoptera litura;
From the genus Autographa spp., Autographa gamma, Autographa nigrisigna;
Agrotis spp., Agrotis ipsilon, Agrotis segetum;
Helicoverpa spp., Helicoverpa armigera, Tobacco moth (Helicoverpaassulta), Cotton ball worm (Helicoverpa zea);
Heliothis armigera, Heliothis virescens of the genus Heliothis spp .;
Other genus species such as Aedia leucomelas, Ctenoplusia agnata, Eudocima tyrannus, Mamestra brassicae, Mythimna separata, Naranga aisen, Nideta manayaga (Peridroma saucia), soy bean looper (Pseudoplusia includens), nettle gulp (Trichoplusia ni);
(1-m) Nolidae moths, for example, Misiaoringa (Earias insulana);
(1-n) Pieridae butterflies, for example, Pieris brassicae, Pieris rapae crucivora from the genus Pieris spp .;
(1-o) Plutellidae moths, for example, Acrolepiopsis sapporensis, Acrolepiopsis suzukiella of Acrolepiopsis spp.
Other genus species, Plutella xylostella;
(1-p) moths of the family Pyralidae, for example, Cadra cautella, Elasmopalpus lignosellus, Etiella zinckenella, Galleria mellonella;
(1-q) moths of the family Sphingidae, for example, Manduca spp., Tomato horn worm (Manduca quinquemaculata), tobacco horn worm (Manduca sexta);

(1-r) moths of the family Stahmopodidae, for example, Stahmopoda masinissa;
(1-s) Tineidae moths, for example, tiger (Tinea translucens);
(1-t) Tortricidae moths, for example, Adoxophyes honmai, Adoxophyes orana from Adoxophyes spp .;
From the genus Archips spp., Archips breviplicanus, Archips fuscocupreanus;
Other genus species: Choristoneura fumiferana, Cydia pomonella, Eupoecilia ambiguella, Grapholitha molesta, Homona magnanima, Legorella tranquilt ), Bean sprout (Matsumuraeses phaseoli), Pandemis heparana, Sparganothis pilleriana;
(1-u) Yponomeutidae, for example, Argyresthia conjugella.

(2) Thysanoptera pests (2-a) from the Phlaeothripidae, for example, Ponticulothrips diospyrosi;
(2-b) From the Thripidae family, for example, Frankliniella intonsa, Frankliniella occidentalis, of the genus Francliniella spp .;
Thrips spp., Thrips palmi, Thrips tabaci;
Other genus species such as Croton thrips (Heliothrips haemorrhoidalis) and Chano thrips (Scirtothrips dorsalis).

(3) Hemiptera pests (3-A) Ceratozodia (Archaeorrhyncha)
(3-Aa) From the Delphacidae family, for example, the green planthopper (Laodelphax striatella), the green planthopper (Nilaparvata lugens), the black planthopper (Perkinsiella saccharicida), and the white planthopper (Sogatella furcifera).

(3-B) Clypeorrhyncha
(3-Ba) From the family of Cicadellidae, for example, from the Empoasca spp., The Empoasca fabae, the Empoasca nipponica, the Empoasca onukii, the mackerel Empoasca sakaii;
Other genus species are Arboridia apicalis, Balclutha saltuella, Epiacanthus stramineus, Macrosteles striifrons, Nephotettix cinctinceps.

(3-C) Stink bug (Heteroptera)
(3-Ca) of the family Alydidae, for example, Riptortus clavatus;
(3-Cb) from the family Coridae, for example, Cletus punctiger, Leptocorisa chinensis;
(3-Cc) from the family Lygaeidae, for example, the American leaf beetle (Blissus leucopterus), the leaf beetle (Cavelerius saccharivorus), the leaf beetle (Togo hemipterus);
(3-Cd) members of the family Miridae, for example, Black-headed turtle (Halticus insularis), Sabiiroka-sika turtle (Lygus lineolaris), Cotton-free hopper (Psuedatomoscelis seriatus), Nugget-headed turtle (Stenodema sibiricum) Stenotus rubrovittatus), Trigonotylus caelestialium;

(3-Ce) from the Pentatomidae family, for example, Nezara antennata, Nezara viridula, from the genus Nezara spp .;
From the genus Eysarcoris spp., Eysarcoris aeneus, Eysarcoris lewisi, Eysarcoris ventralis;
Other genus species: Dolycoris baccarum, Eurydema rugosum, Glaucias subpunctatus, Halyomorpha halys, Piezodorus hybneri, (Scotinophora lurida);
(3-Cf) from the family Pyrrhocoridae, for example, Dysdercus cingulatus;
(3-Cg) from the family Rhopalidae, for example, Rhopalus msculatus;
(3-Ch) from the family Scutelleridae, for example, Eurygaster integriceps;
(3-Ci) From the family Tingidae, for example, Stephanitis nashi.

(3-D) Sternorrhyncha
(3-Da) from the family Adelgidae, for example, Adelges laricis;
(3-Db) Aleyrodidae, for example, Bemisia spp., Silver leaf whitefly (Bemisia argentifolii), Tobacco whitefly (Bemisia tabaci);
Other species, Aleurocanthus spiniferus, Dialeurodes citri, Trialeurodes vaporariorum;

(3-Dc) Aphididae, for example, Aphis spp., Bean aphids (Aphis craccivora), bean aphids (Aphis fabae), strawberry aphids (Aphis forbesi), cotton aphids (Aphis) gossypii), European apple aphids (Aphis pomi), elder-core aphids (Aphis sambuci), yellow-spotted aphids (Aphis spiraecola);
Rhopalosiphum spp., Corn aphids (Rhopalosiphum maidis), wheat beetle (Rhopalosiphum padi);
Of the genus Dysaphis spp., Dysaphis plantaginea, Dysaphis radicola;
Macrosiphum spp., Macrosiphum avenae, Tulip beetle (Macrosiphum euphorbiae);
From the genus Myzus spp., Myzus cerasi, Myzus persicae, Myzus varians;
Other genus species: Acyrthosiphon pisum, potato beetle aphid (Aulacorthum solani), wheat aphid (Brachycaudus helichrysi), radish aphid (Brevicoryne brassicae), strawberry aphid pruni), Hyperomyzus lactucae, Lipaphis erysimi, broad bean aphid (Megoura viciae), Metopolophium dirhodum, lettuce aphid (Nashumous rib aphid) ), Wheat beetle (Schizaphis graminum), wheat aphid (Sitobion avenae), rice aphid (Toxoptera aurantii);

(3-Dd) from the family Coccidae, for example, Ceroplastes ceriferus, Ceroplastes rubens, from the genus Ceroplastes spp.
(3-De) Pseudaulacaspis pentagona, Pseudaulacaspis prunicola, of the genus Pseudaulacaspis spp. From the family Diaspididae;
From the Unaspis spp. Species, Unaspis euonymi, Unaspis yanonensis;
Other genus species, Aonidiella aurantii, Pseudaonidia paeoniae, Comstockaspis perniciosa, Fiorinia theae, Pseudaonidia paeoniae;
(3-Df) from the order of the Margarodidae, for example, Drosicha corpulenta, Icerya purchasi;
(3-Dg) from the family Phylloxeridae, for example, grape aphids (Viteus vitifolii);
(3-Dh) from the family Pseudococcidae, for example, Planococcus spp., Planococcus citri, Planococcus kuraunhiae;
Other species, Phenacoccus solani, Pseudococcus comstocki;
(3-Di) from the family Psyllidae, for example, Psylla mali, Psylla mali, Psylla pyrisuga;
Other genus species, Diaphorina citri.

(4) Coleoptera pests (4-a) from the family Anobiidae, for example, the tobacco beetle (Lasioderma serricorne);
(4-b) from the Attelabidae family, for example, Byctiscus betulae, Rhynchites heros;
(4-c) from the family Bostrichidae, for example, Lyctus brunneus;
(4-d) from the family Brentidae, for example, Cylas formicarius;
(4-e) from the Buprestidae family, for example, Agrilus sinuatus;
(4-f) From the Cerambycidae family, for example, Anoplophora malasiaca, Monochamus alternatus, Psacothea hilaris, Xylotrechus pyrrhoder;
(4-g) From the Chrysomelidae family, for example, Bruchus spp., Pea weevil (Bruchus pisorum), broad beetle (Bruchus rufimanus);
Diabrotica spp., Northern corn rootworm (Diabrotica barberi), Southern corn rootworm (Diabrotica undecimpunctata), Western corn rootworm (Diabrotica virgifera);
From the Phyllotreta spp. Species, Phyllotreta nemorum, Phyllotreta striolata;
Other genus species: Aulacophora femoralis, Adzuki beetle (Callosobruchuschinensis), Tortoise beetle (Cassida nebulosa), Tentobi beetle (Chaetocnemaconcinna), Colorado potato beetle (Leptinotarsa decemlineata), Nekubihoso yzae (Oulema or yzae) Potato beetle (Psylliodes angusticollis);

(4-h) from the Coccinellidae family, for example, Epilachna varivestis, Epilachna vigintioctopunctata, from the genus Epilachna spp .;
(4-i) from the Curculionidae, for example, Anthonomus spp., Anthonomus grandis, Anthonomus pomorum;
Sitophilus sp. abietis), alfalfa weevil (Hypera postica), rice weevil (Lissohoptrus oryzophilus), horned beetle weevil (Otiorhynchus sulcatus), red weevil (Sitona lineatus), sphenophora weevil (tus);
(4-j) from the Elateridae family, for example, Melanotus fortnumi, Melanonotus tamsuyensis, from the genus Melanotus spp .;
(4-k) from the family Nitidulidae, for example, Epuraea domina;
(4-l) From the family Scarabaeidae, for example, Anomala spp., Anomala cuprea, Anomala rufocuprea; Other species, Cetonia aurata, Coreo Clams (Gametis jucunda), Heptophylla picea, Melonlontha melolontha, Popillia japonica;
(4-m) from the Scolytidae family, for example, Ips typographus;
(4-n) from the family Staphylinidae, for example, Paederusfuscipes;
(4-o) from the Tenebrionidae family, for example, Tenebrio molitor, Tribolium castaneum;
(4-p) from the Trogossitidae family, for example, Tenebroides mauritanicus.

(5) Flies (Diptera) pests (5-A) Flies (Brachycera)
(5-Aa) from the family Agromyzidae, for example, Liriomyza bryoniae, Liriomyza bryoniae, Liriomyza chinensis, Liriomyza sativae, Liriomyza sativae, Trifolia myr );
Of other genus species, Chromatomyia horticola, Agromyza oryzae;
(5-Ab) from the family Anthomyiidae, for example, Delia spp., Delia platura, Cabbage (Delia radicum); from other species, Pegomya cunicularia );
(5-Ac) Drosophilidae, for example, Drosophila melanogaster, Drosophila suzukii of Drosophila spp .;
(5-Ad) from the Ephydridae family, for example, Hydrellia griseola;
(5-Ae) from the family Psilidae, for example, Psila rosae;
(5-Af) from the family Tephritidae, for example, Bactrocera cucurbitae, Bactrocera dorsalis of Bactrocera spp .;
Rhagoletis cerasi, Rhagoletis pomonella, from Rhagoletis spp .;
Other species, Ceratitis capitata and Olive fruit fly (Dacus oleae).

(5-B) Nematocera
(5-Ba) From the family Cecidomyiidae, for example, the soybean fly (Asphondylia yushimai), the sorghum fly (Contarinia sorghicola), the fly fly (Mayetiola destructor), the squirrel fly fly (Sitodiplosis mosellana).

(6) Grasshopper (Orthoptera) pests (6-a) Acrididae, for example, Schistocerca spp., Schistocerca americana, Schistocerca gregaria;
Other genus species: Australian flying grasshopper (Chortoicetes terminifera), Moroccan locust (Dociostaurus maroccanus), Tosama locust (Locusta migratoria), Brown locust (Locustana pardalina), Red-footed grasshopper (Nomadacris septemfasciata), Cobaneigo (Oxya zo)
(6-b) from the family Gryllidae, for example, European cricket (Acheta domestica), Teleogryllus emma;
(6-c) from the family Gryllotalpidae, for example, Gryllotalpa orientalis;
(6-d) From the Tettigoniidae family, for example, Tachycines asynamorus.

(7) Tick (Acari)
(7-A) Astigmata (Acaridida)
(7-Aa) Acaridae mites, for example, Rhizoglyphus echinopus, Rhizoglyphus robini from Rhizoglyphus spp .;
From the genus Tyrophagus spp., Tyrophagus neiswanderi, Tyrophagus perniciosus, Tyrophagusputrescentiae, Tyrophagus putrescentiae, Tyrophagus similis;
Other species, Acarus siro, Aleuroglyphus ovatus, Mycetoglyphus fungivorus;

(7-B) Prostigmata mites (Actinedida)
(7-Ba) Tetranychidae mites, for example, Bryobia spp., Clover spider mite (Bryobia praetiosa), Fake spider mite (Bryobia rubrioculus);
Eotetranychus spp., Eotetranychus asiaticus, Eotetranychus boreus, Eotetranychus celtis, Tetranychus geniculatus, Kitachus , Eotetranychus shii, Eotetranychus smithi, Eotetranychus suginamensis, Eotetranychus uncatus;
Oligonychus spp., Oligonychus hondoensis, Omitonychus ilicis, Oligonychus karamatus, Oligonychus mangiferus, Oligonychus mangiferus, Oius , Oligonychus pustulosus, Oligonychus shinkajii, Oligonychus ununguis;
Panonychus spp. From the genus Panonychus spp., Panonychus citri, Panonychus mori, Apple tick (Panonychus ulmi);
Tetranychus sp Spider mite (Tetranychus viennensis);
Aponicchus spp., Aponychus corpuzae, Aponychus firmianae;
From the genus Sasanychus spp., Sasanychus akitanus, Sasanychus pusillus;
From the genus Shizotetranychus spp., Shizotetranychus celarius, Shizotetranychus longus, Shizotetranychusmiscanthi, Shizotetranychuschiny
Other genus species, Tetranychina harti, Tuckerella pavoniformis, Yezonychus sapporensis;

(7-Bb) Tenuipalpidae mites, for example, Brevipalpus spp., Brevipalpus lewisi, Brevipalpus obovatus, Brevipalpus phoenicis, Cactus (Brevipalpus russulus), Onshitsuma spider mite (brevipalpus californicus);
Tenuipalpus spp., Tenuipalpus pacificus, Tenuipalpus zhizhilashviliae;
From other genus species, Dolichotetranychus floridanus;
(7-Bc) Eriophyidae mites, for example, Aceria spos., Aceria diospyri, Aceria ficus, Aceria japonica, Aceria kuko , Carnation spider mite (Aceria paradianthi), black spider mite (Aceria tiyingi), tulip spider mite (Aceriatulipae), Shiba Hamakifushi mite (Aceria zoysiea);
From Eriophyes spp., Eriophyes chibaensis, Eriophyes emarginatae;
Aculops spp., Tomato Scarlet (Aculops lycopersici), Acarops pelekassi;
Aculus fockeui, Aculus schlechtendali from Aculus spp.
Other genus species: Acaphylla theavagrans, Calacarus carinatus, Grape-spotted mite (Colomerus vitis), Grape-spotted tick (Calepitrimerus vitis), Epitrimerus pyri, Parametoptus kikus (Paraphytoptus kikus) podocarpi), Phyllocotruta citri;
(7-Bd) mites of the family Miteidae (Transonemidae), for example, Tarsonemus spp., Tarsonemus bilobatus, Tarsonemus waitei;
Other species of cyclamen dust mite (Phytonemus pallidus), chano mite mite (Polyphagotarsonemus latus);
(7-Be) Mites from the family Penthaleidae, for example, Penthaleus erythrocephalus, Penthaleus major, from the Penthaleusspp species.

The ectoparasites that are subject to control include those that inhabit the back, underarms, lower abdomen, and inner crotch of the host animal and obtain nutrients such as blood and dandruff from the animal, and the back of the host animal. Including those that come to the buttocks and inhabit by obtaining nutrients such as blood and dandruff from animals. Examples of ectoparasites include ticks, lices, fleas, mosquitoes, flies, and flyflies. Specific examples of ectoparasites are shown below.
(1) Tick (Acari)
Dermanyssidae ticks, Macronyssidae ticks, Laelapidae ticks, Varroidae ticks, Argasidae ticks, Ixodidae ticks, cucumber genus mite Psoroptidae mites, Sarcoptidae mites, Knemidokoptidae mites, Demodixidae mites, Trombiculidae mites.
(2) Phythiraptera
Haematopinidae lice, Linognathidae lice, Mennoponidae lice, Philopteridae lice, Trichodectidae lice
(3) Flea eyes (Siphonaptera)
Pulicidae fleas, for example, Ctenocephalides canis, Ctenocephalides felis of Ctenocephalides spp .;
Fleas from the family Tungidae, fleas from the Ceratophyllidae family, and fleas from the Leptopsyllidae family.
(4) Hemiptera
Insects of Cimicidae, Insects of Reduviidae, Insects of Triatominae
(5) Diptera mosquitoes from Culicidae, Simuliidae mosquitoes, Ceratopogonidae mosquitoes, Tabanidae abu, Muscidae flies, Glossinidae, Frostaceae, Flies of Hippoboscidae, Flies of Calliphoridae, Oestridae flies.

In addition, pests that have poisonous needles and venom and cause damage to humans, pests that carry various pathogens and pathogens, and pests that cause discomfort to humans (toxic pests, sanitary pests, unpleasant pests, etc.) Is excellent.
The specific example is shown below.
(1) Hymenoptera pests, Argidae bees, Cynipidae bees, Diprionidae bees, Formicidae ants, Mutillidae bees, A wasp of the vespidae family (Vespidae).
(2) Other pest cockroaches (Blattodea), termites (termite), spiders (Araneae), centipedes (cetipede), millipedes (crustacea), paddybirds (Cimex lectularius).

Hereinafter, the formulation of the pharmaceutical composition for controlling pests according to the present invention will be shown slightly, but the additives and addition ratios are not limited to these examples, and can be varied in a wide range. The part in a formulation prescription shows a mass part.

Formulation 1 (wettable powder)
Compound A 20 parts, compound B 20 parts, diatomaceous earth 53 parts, higher alcohol sulfate 4 parts, and alkyl naphthalene sulfonate 3 parts are uniformly mixed and finely pulverized to obtain a wettable powder of 40% active ingredient.

Formulation 2 (Emulsion)
15 parts of Compound A, 15 parts of Compound B, 33 parts of xylene, 30 parts of dimethylformamide and 7 parts of polyoxyethylene alkylallyl ether are mixed and dissolved to obtain an emulsion containing 30% active ingredient.

Formulation 3 (Emulsion)
2.5 parts of Compound A, 2.5 parts of Compound B, 93.6 parts of dimethylformamide, and 1.4 parts of polyoxyethylene alkylaryl ether are mixed and dissolved to obtain an emulsion having a 5% active ingredient.

Formulation 6 (Granule)
2.5 parts of Compound A, 2.5 parts of Compound B, 40 parts of talc, 38 parts of clay, 10 parts of bentonite, and 7 parts of sodium alkylsulfate were uniformly mixed and then finely pulverized, and then granulated to give a diameter of 0. A granule of 5 to 1.0 mm and an active ingredient of 5% is obtained.

Formulation 7 (Granule)
2.5 parts of compound A, 2.5 parts of compound B, 73 parts of clay, 20 parts of bentonite, 1 part of dioctyl sulfosuccinate sodium salt and 1 part of potassium phosphate are thoroughly pulverized and mixed, and water is added to this and mixed well. Thereafter, granulation and drying are performed to obtain granules containing 5% of the active ingredient.

Formulation 8 (Suspension)
5 parts of compound A, 5 parts of compound B, 4 parts of polyoxyethylene alkyl allyl ether, 2 parts of polycarboxylic acid sodium salt, 10 parts of glycerin, 0.2 part of xanthan gum and 73.8 parts of water are mixed to obtain a particle size of 3 μm or less. To obtain a suspension of 10% active ingredient.

The formulation of the ectoparasite control agent is shown below.

Formulation 9 (Granule)
Dissolve 2.5 parts of Compound A and 2.5 parts of Compound B in an organic solvent to obtain a solution, spray the solution onto 94 parts of kaolin and 1 part of white carbon, and then evaporate the solvent under reduced pressure to obtain granules. . The granules can also be used in admixture with animal food.

Formulation 10 (Injection)
An injection is obtained by uniformly mixing 0.5 part of Compound A, 0.5 part of Compound B, and 99 parts of peanut oil, and then filter sterilizing with a sterilizing filter.

Formulation 11 (Pour-on agent)
2.5 parts of Compound A, 2.5 parts of Compound B, 10 parts of myristic acid ester, and 85 parts of isopropanol are uniformly mixed to obtain a pour-on agent.

Formulation 12 (Spot-on agent)
A spot-on agent is obtained by uniformly mixing 5 parts of Compound A, 5 parts of Compound B, 10 parts of palmitate and 80 parts of isopropanol.

Formulation 13 (Spray agent)
Compound A 0.5 part, compound B 0.5 part, propylene glycol 10 parts, and isopropanol 89 parts are uniformly mixed to obtain a spray.

Next, the function and effect of the pharmaceutical composition for controlling pests of the present invention will be described.

(Preparation of emulsion for evaluation test)
Compound A and / or Compound B (5 parts), dimethylformamide (93.6 parts), and polyoxyethylene alkylaryl ether (1.4 parts) were mixed and dissolved to prepare an emulsion (I) containing 5% active ingredient.
However, at the time of preparing the emulsion, the compounding ratio of the compound A and the compound B was 10/1 in the test 1 and 10/1 in the test example 2.

(Test 1) Efficacy test for chahamaki Emulsion (I) was diluted with water to obtain emulsion dilutions 1a to 3a having the concentrations shown in Table 1.
Tea leaves were immersed in the emulsion diluent for 10 seconds. Tea leaves were removed from the emulsion dilution and air-dried. After that, the tea leaves were transferred to a petri dish, and five Chahamaki larvae were released. The petri dish was placed in a constant temperature room at a temperature of 25 ° C. and a humidity of 65%. When 3 days had passed since the release, adults were examined for viability. The test was performed in duplicate.
Table 1 shows the results of the efficacy test on chahamaki for the emulsion diluents 1a to 3a. The theoretical insecticidal rate E was calculated based on Colby's formula and shown in Table 1.

Colby's formula:
E (%) = X + Y−X × Y / 100
X: Measured insecticidal rate (%) when treated with a chemical solution using Compound A alone
Y: Measured insecticidal rate (%) when treated with a chemical solution using Compound B alone
E: Theoretical insecticidal rate (%) when treated with a chemical solution comprising a combination of Compound A and Compound B

(Test 2) Efficacy test against citrus red mite Emulsion (I) was diluted with water to obtain emulsion dilutions 1b to 3b having the concentrations shown in Table 2.
Citrus leaves were placed in a petri dish, and 10 adult mandarin orange mites were inoculated on the leaves.
The emulsion dilution was sprayed on the citrus leaves using a rotary spray tower. The tangerine leaf was placed in a constant temperature room at a temperature of 25 ° C. and a humidity of 65%. One day after spraying, the life and death of adults were investigated. The test was performed in duplicate.
Table 2 shows the results of the efficacy test against citrus red mite on the emulsion dilutions 1a to 3a. The theoretical insecticidal rate E was calculated based on Colby's formula and shown in Table 2.

From the above results, it can be seen that the pest control method of the present invention synergistically increases the control effect inherent to Compound A or Compound B.

Claims

3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane or a salt thereof (Z) -4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyimino) methyl] -2- A method for controlling pests, which comprises applying to methylbenzamide or a salt thereof to an object.
The pest control method according to claim 1, wherein the pest is an insect or a tick.
3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane or a salt thereof (Z) -4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyimino) methyl] -2- A pharmaceutical composition for controlling pests comprising methylbenzamide or a salt thereof.
The pest control pharmaceutical composition according to claim 3, wherein the pest is an insect or a tick.
3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane or a salt thereof And (Z) -4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyimino ) Methyl] -2-methylbenzamide or a pharmaceutical composition containing a salt thereof, a pest control agent set which is combined together without mixing.
The pest control agent set according to claim 5, wherein the pest is an insect or a tick.