CN104663701A - Dinotefuran synergistic suspending agent and preparation method thereof - Google Patents
Dinotefuran synergistic suspending agent and preparation method thereof Download PDFInfo
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- CN104663701A CN104663701A CN201510034620.1A CN201510034620A CN104663701A CN 104663701 A CN104663701 A CN 104663701A CN 201510034620 A CN201510034620 A CN 201510034620A CN 104663701 A CN104663701 A CN 104663701A
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Abstract
The invention relates to a dinotefuran synergistic suspending agent which is prepared from the following components in percentage by weight: 20-50% of dinotefuran, 2-5% of a dissolution inhibitor, 5-8% of a wetting dispersing agent, 0.1-1% of a thickener, 0.1% of a preservative, 3-5% of an anti-freezing agent, 0.1% of an antifoaming agent, 2-5% of a synergist and the balance being water. The preparation method comprises the following steps: premixing and shearing the dinotefuran, the dissolution inhibitor, the wetting dispersing agent, the thickener, the preservative, the antifreezing agent, the antifoaming agent, the synergist and water; and carrying out secondary sanding to form the product. The dinotefuran synergistic suspending agent provided by the invention is low in surface tension, high in pesticide effect, and adopts a simple preparation technology and simple application method; and a field test proves that the dinotefuran synergistic suspending agent provided by the invention has significant insecticidal efficacy.
Description
Technical field
The invention belongs to pesticide production technology field, be specifically related to a kind of MTI-446 synergy suspending agent and preparation method thereof.
Background technology
The third generation nicotinic insecticide that MTI-446 (dinotefuran) is developed for Mitsui chemical company.This medicament has remarkable interior suction osmosis, and namely shows very high insecticidal activity at very low dosage.This medicine insecticidal spectrum is wide, can prevent the various insects such as various Semiptera, Lepidoptera, diptera, orthoptera, Hymenoptera, beetle order.This medicament is fool proof to mammal, birds and aquatile, to crop without poisoning, can be used for numerous crops such as paddy rice, fruit tree, vegetables.
Modern change is very fast, just towards the future development of environmental type, suspending agent (SC) is being exactly wherein a kind of, and agricultural chemicals suspension agent is that in pesticidal preparations, developing history is short, very fast a kind of formulation, many weed killer herbicides, insecticidal bactericide can be processed into this formulation.Agricultural chemicals suspension agent take water as dispersion medium, insoluble or be slightly soluble in water the former medicine of solid through grinding, and by the effect of surfactant and other auxiliary agent, make it dispersed, the more stable liquid-solid state system that form the tiny higher suspension of a kind of particle, can flow, compared with missible oil, can avoid using a large amount of organic solvents; Compared with wettable powder, then to disperse drift without dust; To the toxicity of people and animals and excitant all lower; And the poisoning that can alleviate crop; Also can not burn in storage transportation because of organic solvent, safety is higher; Quite low degree is reduced to the danger that user and whole environment cause.Further, agricultural chemicals suspension agent excellent performance, good dispersion, suspensibility is high, puts forth effort with adhesion strength all stronger, resistance of rainwater washing against in the exhibition on plant corpus surface, and drug effect significantly and also more lasting.Insecticides adjuvant domestic is not at present also very flourishing, also has no small gap compared with developed countries, the problem that the suspending agent be made into existing auxiliary agent existence more or less in physical stability is certain.
Chinese invention patent CN12239829A is open, and " water complements to 100% for a kind of MTI-446 suspending agent and preparation method thereof: a kind of dinotefuran aqueous suspension agent of this disclosure of the invention; by weight percentage; comprise following component: the former medicine 5% ~ 40% of MTI-446; suspension aid 0 ~ 6%, surfactant 2% ~ 20%, thickener 0 ~ 1%; defoamer 0 ~ 1%; preservative 0 ~ 1%, antifreezing agent 0.5% ~ 5%; Described suspension aid is white carbon, bentonite, Magnesiumaluminumsilicate or kaolin; Described surfactant is NP, 500#, polycarboxylate, TWEEN, 600P, any mixing of 1 ~ 5 kind in thermally coupled distillation columns salt; Described thickener is xanthans, carboxymethyl cellulose, polyacrylamide or polyvinyl alcohol; Described defoamer is silicone defoaming agent, tributyl phosphate or butanols; Described preservative is formaldehyde, benzoic acid, Kathon CG or methenamine; Described antifreezing agent is ethylene glycol, glycerine, urea, isopropyl alcohol or propane diols ".This patent preparation process does not add synergist, can only play the general effect of preparation, and this invention does not add resistance solvent and cannot prepare high-load MTI-446 suspending agent in addition.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of MTI-446 synergy suspending agent and preparation method thereof, solve a preparation difficult problem for high-load MTI-446 suspending agent, improve the control efficiency of MTI-446 suspending agent by adding synergist, there is economy and environment double benefit.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of MTI-446 synergy suspending agent, be made up of following component by weight percentage: MTI-446 20%-50%, resistance solvent 2%-5%, dispersion moisture agent 5%-8%, thickener 0.1%-1%, preservative 0.1%, antifreezing agent 3%-5%, defoamer 0.1%, synergist 2%-5%, Yu Weishui.
Further, described resistance solvent is 5# white oil; Described dispersion moisture agent is modified polycarboxylic acid salt: acrylic acid-acrylic ester-co-polymer of sulfonate, its molecular weight 30,000, and each monomer mole ratio is acrylic acid: acrylate: sulfonic acid=1:3.2:0.8; Described thickener is that xanthans and Magnesiumaluminumsilicate are with the mixture of arbitrary proportion; Described antifreezing agent is ethylene glycol or propane diols; Described defoamer is silicone defoaming agent dimethicone, polyethers or n-octyl alcohol; Described preservative sodium benzoate; Described synergist is Cocoamidopropyl betaine.
Further, the preparation process of MTI-446 synergy suspending agent is: in the container stirred, add amount of preparation water and resistance solvent, stir, then the former medicine of dispersion moisture agent, thickener, preservative, antifreezing agent, defoamer, synergist and MTI-446 is added successively, mix, 12000 revs/min are carried out high speed shear 20-50 minute; Feed liquid after high speed shear carries out secondary sand milling, can obtain synergy MTI-446 suspending agent.
The beneficial effect adopting technique scheme to produce is: the present invention compares the MTI-446 suspending agent not adding synergist surface tension by adding synergist reduces by 8 ~ 22 mN/m.After showing to add synergist by field experiment, insecticidal effect significantly improves.The solvability of the former medicine of MTI-446 in water is large, only can make by commonsense method the aqueous suspension agent that weight content is 10% in industry, not easily make more high-load aqueous suspension agent, and the present invention is by adding resistance solvent 5# white oil, the solvability of the former medicine of MTI-446 in water is reduced greatly, solve the problem not easily preparing high-load dinotefuran aqueous suspension agent, greatly reduce the manufacturing, artificial, packaging material, cost of transportation, improve production efficiency.MTI-446 suspending agent broad-spectrum high efficacy of the present invention, safety low-poison, the crop pests such as rice fulgorid, cotten aphid and trialeurodes vaporariorum are efficient.
Embodiment
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
Add water 647 grams and 5# white oil 20 grams in the reactor having heating jacket, stir, then add dispersion moisture agent modified polycarboxylic acid salt 50 grams, thickener xanthans 2 grams, aluminium-magnesium silicate 8 grams, antifreeze glycol 50 grams, defoamer polyethers 1 gram, preservative sodium benzoate 1 gram, synergist Cocoamidopropyl betaine 20 grams and the former medicine of MTI-446 200 grams successively to mix, 12000 revs/min are carried out high speed shear 20 minutes; Then carry out secondary sand milling, can obtain 20% synergy MTI-446 suspending agent is sample one.
Embodiment 2
532 grams of water and 5# white oil 30 grams is added in the reactor having heating jacket, stir, then add dispersion moisture agent modified polycarboxylic acid salt 60 grams, thickener xanthans 1 gram, aluminium-magnesium silicate 5 grams, antifreeze glycol 40 grams, defoamer n-octyl alcohol 1 gram, preservative sodium benzoate 1 gram, synergist Cocoamidopropyl betaine 30 grams and the former medicine of MTI-446 300 grams successively to mix, 12000 revs/min are carried out high speed shear 30 minutes; Then carry out secondary sand milling, can obtain 30% synergy MTI-446 suspending agent is sample two.
Embodiment 3:
307 grams of water and 5# white oil 50 grams is added in the reactor having heating jacket, stir, then add dispersion moisture agent modified polycarboxylic acid salt 60 grams, thickener aluminium-magnesium silicate 0.5 gram, xanthans 0.5g, antifreezing agent propane diols 30 grams, defoamer dimethicone 1 gram, preservative sodium benzoate 1 gram, synergist Cocoamidopropyl betaine 50 grams and the former medicine of MTI-446 500 grams successively to mix, 12000 revs/min are carried out high speed shear 50 minutes; Then carry out secondary sand milling, can obtain 50% synergy MTI-446 suspending agent is sample three.
Comparative example embodiment 1
687 grams of water are added in the reactor having heating jacket, open and stir, then add dispersion moisture agent modified polycarboxylic acid salt 50 grams successively, thickener xanthans 2 grams, aluminium-magnesium silicate 8 grams, antifreeze glycol 50 grams, defoamer polyethers 1 gram, preservative sodium benzoate 1 gram, the former medicine of MTI-446 200 grams mix, 12000 revs/min are carried out high speed shear 20 minutes; Then carry out secondary sand milling, can obtain 20% MTI-446 suspending agent is sample four.
Comparative example embodiment 2
562 grams of water are added in the reactor having heating jacket, open and stir, then add dispersion moisture agent modified polycarboxylic acid salt 60 grams successively, thickener xanthans 1 gram, aluminium-magnesium silicate 5 grams, antifreeze glycol 40 grams, defoamer n-octyl alcohol 1 gram, preservative sodium benzoate 1 gram, synergist water-based azone 30 grams, the former medicine of MTI-446 300 grams mix, 12000 revs/min are carried out high speed shear 30 minutes; Then carry out secondary sand milling, can obtain 30% MTI-446 suspending agent is sample five.
Comparative example embodiment 3
357 grams of water are added in the reactor having heating jacket, open and stir, then add dispersion moisture agent modified polycarboxylic acid salt 60 grams successively, thickener xanthans 0.5 gram, aluminium-magnesium silicate 0.5 gram, antifreezing agent propane diols 30 grams, defoamer dimethicone 1 gram, preservative sodium benzoate 1 gram, synergist water-based fatty alcohol 50 grams, the former medicine of MTI-446 500 grams mix, 12000 revs/min are carried out high speed shear 50 minutes; Then carry out secondary sand milling, can obtain 50% MTI-446 suspending agent is sample six.
Tensiometry Test
Surface tension size is the important indicator of preparation drug effect, and carry out Tensiometry Test to sample one ~ sample six that embodiment and comparative example embodiment configure, result of the test is as shown in table 1.
Table 1 sample one ~ sample six surface tension
| Title | Sample one | Sample two | Sample three | Sample four | Sample five | Sample six |
| Surface tension (mN/m) | 25.1 | 24.2 | 23.1 | 45.1 | 36.9 | 37.1 |
Table 1 shows, the surface tension that the MTI-446 suspending agent not adding synergist compared by the MTI-446 suspending agent adding Cocoamidopropyl betaine synergist reduces by 20 ~ 22 mN/m, adds Cocoamidopropyl betaine synergist and compares and add water-based azone and water-based fatty alcohol synergist better effects if in reduction MTI-446 suspending agent surface tension.
Land for growing field crops effect experiment one: land for growing field crops insecticidal test-cotton aphid
With sample one ~ sample six MTI-446 suspending agent in above-described embodiment 1 ~ 6, insecticidal test is carried out to Wei County, Hebei, by the drug effect of field experiment inspection MTI-446 synergy suspending agent.Specific experiment scheme is as follows:
Medication: each sample repeats twice
Extension rate: 20% MTI-446 SC 2000X 3000X other press content conversion multiple dilutions
Use apparatus: conventional backpack sprayer, directed spraying
Water consumption: every mu of 30 kg of water
Investigation method: adopt five point samplings
Control time: after medicine three, five, seven, 15 days
Revision insect recluced rate (%)=(before spray medicine, each sky remains borer population after insect population radix-spray medicine) * 100/ sprays insect population radix before medicine
Rectifying efficacies (%)=(treatment region Revision insect recluced rate-check plot Revision insect recluced rate) * 100/(100-check plot Revision insect recluced rate)
Result of the test is in table 2
Effect experiment result table 2
。
As known from Table 2, add the MTI-446 suspending agent of synergist apparently higher than not adding the MTI-446 suspending agent of synergist to cotton cotton aphid control effect, and the MTI-446 suspending agent ratio adding synergist Cocoamidopropyl betaine adds water-based azone and water-based fatty alcohol synergist control cotton cotten aphid successful strengthens.After medicine, the effect of 7 days is best
Land for growing field crops effect experiment two: land for growing field crops insecticidal test-trialeurodes vaporariorum
Trialeurodes vaporariorum on the Quzhou booth wild cabbage of Hebei creates drug resistance in various degree to most pharmaceutical agents.Insecticidal test is carried out, by the drug effect of land for growing field crops inspection MTI-446 suspending agent with above-mentioned sample one ~ sample six MTI-446 suspending agent.Specific experiment scheme is as follows:
Medication: each sample repeats twice use
Extension rate: 20% MTI-446 SC 2000X 3000X other press content conversion multiple dilutions
Use apparatus: conventional backpack sprayer, directed spraying
Water consumption: every mu of 30 kg of water
Investigation method: adopt five point samplings
Control time: after medicine three, five, seven, 15 days
Revision insect recluced rate (%)=(before spray medicine, each sky remains borer population after insect population radix-spray medicine) * 100/ sprays insect population radix before medicine
Rectifying efficacies (%)=(treatment region Revision insect recluced rate-check plot Revision insect recluced rate) * 100/(100-check plot Revision insect recluced rate)
Result of the test is as shown in table 3.
Effect experiment result table 3
。
As known from Table 3, add the MTI-446 suspending agent of synergist apparently higher than not adding the MTI-446 suspending agent of synergist to wild cabbage trialeurodes vaporariorum control efficiency, and the MTI-446 suspending agent ratio adding synergist Cocoamidopropyl betaine adds water-based azone and water-based fatty alcohol synergist control wild cabbage trialeurodes vaporariorum successful strengthens.
Land for growing field crops effect experiment three:
Carry out land for growing field crops insecticidal test with same method to Nanchang rice fulgorid, specific experiment scheme is as follows:
Medication: each sample repeats twice
Extension rate: 20% MTI-446 SC 2000X 3000X other press content conversion multiple dilutions
Use apparatus: conventional backpack sprayer, directed spraying
Water consumption: every mu of 30 kg of water
Investigation method: adopt five point samplings
Control time: after medicine three, five, seven, 15 days
Revision insect recluced rate (%)=(before spray medicine, each sky remains borer population after insect population radix-spray medicine) * 100/ sprays insect population radix before medicine
Rectifying efficacies (%)=(treatment region Revision insect recluced rate-check plot Revision insect recluced rate) * 100/(100-check plot Revision insect recluced rate)
Result of the test is as shown in table 4.
Effect experiment result table 4
。
As known from Table 4, add the MTI-446 suspending agent of synergist apparently higher than not adding the MTI-446 suspending agent of synergist to rice fulgorid control efficiency, and the MTI-446 suspending agent ratio adding synergist Cocoamidopropyl betaine adds water-based azone and water-based fatty alcohol synergist control rice fulgorid successful strengthens.
Claims (3)
1. a MTI-446 synergy suspending agent, is characterized in that it is made up of following component by weight percentage: MTI-446 20%-50%, resistance solvent 2%-5%, dispersion moisture agent 5%-8%, thickener 0.1%-1%, preservative 0.1%, antifreezing agent 3%-5%, defoamer 0.1%, synergist 2%-5%, Yu Weishui.
2. MTI-446 synergy suspending agent according to claim 1, is characterized in that described resistance solvent is 5# white oil; Described dispersion moisture agent is modified polycarboxylic acid salt: acrylic acid-acrylic ester-co-polymer of sulfonate, its molecular weight 30,000, and each monomer mole ratio is acrylic acid: acrylate: sulfonic acid=1:3.2:0.8; Described thickener is that xanthans and Magnesiumaluminumsilicate mix with arbitrary proportion; Described antifreezing agent is ethylene glycol or propane diols; Described defoamer is dimethicone, polyethers or n-octyl alcohol; Described preservative is Sodium Benzoate; Described synergist is Cocoamidopropyl betaine.
3. the preparation method of the MTI-446 synergy suspending agent described in claim 1 or 2, it is characterized in that step is as follows: in the container stirred, add amount of preparation water and resistance solvent, stir, then the former medicine of described dispersion moisture agent, thickener, preservative, antifreezing agent, defoamer, synergist and MTI-446 is added successively, mix, 12000 revs/min are carried out high speed shear 20-50 minute; Feed liquid after high speed shear carries out secondary sand milling, can obtain described MTI-446 synergy suspending agent.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108513975A (en) * | 2018-05-23 | 2018-09-11 | 河北威远生物化工有限公司 | A kind of Fluoxastrobin suspending agent and preparation method thereof for flying to prevent |
| CN109221225A (en) * | 2018-09-28 | 2019-01-18 | 绩溪农华生物科技有限公司 | A kind of dinotefuran synergy suspending agent and preparation method thereof |
| CN109258632A (en) * | 2018-09-29 | 2019-01-25 | 绩溪农华生物科技有限公司 | A kind of nano pesticide composition and preparation method thereof |
| CN115067325A (en) * | 2022-06-14 | 2022-09-20 | 江苏剑牌农化股份有限公司 | Preparation method of anhydrous dinotefuran suspending agent |
| CN115104620A (en) * | 2021-08-13 | 2022-09-27 | 山东恒利达生物科技有限公司 | Furan nicotine insecticidal composition and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102239829A (en) * | 2011-07-13 | 2011-11-16 | 南京扬子鸿利源化学品有限责任公司 | Dinotefuran aqueous suspension agent and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102239829A (en) * | 2011-07-13 | 2011-11-16 | 南京扬子鸿利源化学品有限责任公司 | Dinotefuran aqueous suspension agent and its preparation method |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108513975A (en) * | 2018-05-23 | 2018-09-11 | 河北威远生物化工有限公司 | A kind of Fluoxastrobin suspending agent and preparation method thereof for flying to prevent |
| CN109221225A (en) * | 2018-09-28 | 2019-01-18 | 绩溪农华生物科技有限公司 | A kind of dinotefuran synergy suspending agent and preparation method thereof |
| CN109258632A (en) * | 2018-09-29 | 2019-01-25 | 绩溪农华生物科技有限公司 | A kind of nano pesticide composition and preparation method thereof |
| CN115104620A (en) * | 2021-08-13 | 2022-09-27 | 山东恒利达生物科技有限公司 | Furan nicotine insecticidal composition and application thereof |
| CN115104620B (en) * | 2021-08-13 | 2023-08-11 | 山东恒利达生物科技有限公司 | Furannicotine insecticidal composition and application thereof |
| CN115067325A (en) * | 2022-06-14 | 2022-09-20 | 江苏剑牌农化股份有限公司 | Preparation method of anhydrous dinotefuran suspending agent |
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Address after: 050031 Shijiazhuang chemical industry park in Hebei recycling Road No. 6 Patentee after: Hebei Weiyuan Biochemical Co., Ltd. Address before: 050031 Shijiazhuang chemical industry park in Hebei recycling Road No. 6 Patentee before: HEBEI VEYONG BIO-CHEMICAL CO., LTD. |