CN115053910B - Pesticide composition and application thereof - Google Patents

Pesticide composition and application thereof Download PDF

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CN115053910B
CN115053910B CN202210777400.8A CN202210777400A CN115053910B CN 115053910 B CN115053910 B CN 115053910B CN 202210777400 A CN202210777400 A CN 202210777400A CN 115053910 B CN115053910 B CN 115053910B
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pesticide composition
set forth
pesticide
flonicamid
composition
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CN115053910A (en
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余思策
刘润峰
李光亮
陶代雨
张磊
熊利鹏
赵悬豪
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Jiangsu Mingde Lida Crop Technology Co ltd
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Jiangsu Mingde Lida Crop Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A01P7/04—Insecticides

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  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Insects & Arthropods (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The embodiment of the invention relates to a pesticide composition and application thereof, and relates to the field of pesticides, wherein the effective components comprise the cyproconazole and the flonicamid, and the weight ratio of the cyproconazole to the flonicamid is 1 (0.1-28). The compound pesticide of the ipflubendiamide and the flonicamid has a synergistic effect, and compared with the single pesticide of the ipflubendiamide or the flonicamid, the compound pesticide of the ipflubendiamide and the flonicamid has a remarkably improved pest control effect.

Description

Pesticide composition and application thereof
Technical Field
The invention relates to the field of pesticides, in particular to a pesticide composition and application thereof.
Background
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.
Cycloprid, english generic name cyproflanilide, test code CAC-I-785.IUPAC name: 3'- [ ({ 2-bromo-4- [1, 2-tetrafluoro-1- (trifluoromethyl) ethyl ] -6- (trifluoromethyl) phenyl } amino) carbonyl ] -N- (cyclopropylmethyl) -2', 4-difluorobenzanilide; CAS name: n- [3- [ [ [ 2-bromo-4- [1, 2-tetrafluoro-1- (trifluoromethyl) ethyl ] -6- (trifluoromethyl) phenyl ] amino ] carbonyl ] -2-fluorophenyl ] -N- (cyclopropylmethyl) -4-fluorobenzamide. CAS accession number: 2375110-88-4; the molecular formula: c 28H17BrF12N2O2. The structural formula is shown in formula 1:
the cypress-flubendiamide is a meta-bisamide pesticide created by Taihe group by taking bisamide pesticide as a lead compound, has novel chemical structure and unique action mechanism, and has the effects of stomach toxicity, contact killing, systemic and the like. The clothianidin is an insecticide with a novel action mechanism: GABA-gated chloride channel allosteric modulators. It can cause hyperexcitation and convulsions in the insect. The cypress fipronil is classified into group 30 by the pesticide resistance action committee (IRAC), has no mutual resistance with the existing pesticide, and has good control effect on the pests such as chilo suppressalis, cnaphalocrocis medinalis, plutella xylostella, spodoptera exigua, flea beetle, thrips, aphid and the like on various crops such as rice, corn, cotton, soybean, fruit trees, vegetables and the like. And the composite material has good environmental compatibility and high safety to aquatic organisms such as people, livestock, beneficial insects, fishes, shrimps, algae and the like.
The flonicamid is a novel low-toxicity pyridine amide insect growth regulating pesticide developed by the Kappyo Co., ltd, and has the effects of contact killing, stomach toxicity, systemic absorption and rapid antifeedant. The flonicamid has the advantages of high neurotoxicity and fast antifeedant effect, unique action mechanism and different efficient pesticides such as neonicotinoids, pymetrozine and the like. It has the characteristics of low dosage, high activity, strong systemic conductivity, rain wash resistance and the like. When the insect ingests the plant juice with flonicamid, the insect is quickly prevented from eating. Can be used for preventing and controlling aphid, thrips, whitefly and other piercing-sucking mouthparts pests on wide crops, and can also be used for preventing and controlling pests with resistance to other pesticides. Has good safety to crops, people, livestock and environment and good development prospect.
The long-term use of pesticides containing a single active ingredient for pest control can cause poor drug effect and environmental pollution caused by drug resistance of targets, and meanwhile, different pesticides are needed for different pests, so that a great deal of manpower, financial resources and other problems are wasted. The compound with different action mechanisms and different active components is reasonably compounded, so that the effects of expanding the insecticidal spectrum, delaying the duration of action, reducing the dosage and the dosage cost and reducing the environmental pollution can be achieved.
In view of this, the present invention has been made.
Disclosure of Invention
Object of the Invention
The invention aims to provide a pesticide composition and application thereof, and the compound pesticide of the cypress-flubendiamide and the flonicamid has a synergistic effect, and compared with the single pesticide of the cypress-flubendiamide or the flonicamid, the compound pesticide of the cypress-flubendiamide and the flonicamid has obviously improved pest control effect.
Solution scheme
In order to achieve the aim of the invention, the embodiment of the invention provides a pesticide composition, the effective components comprise the cyclopropane flubendiamide and the flonicamid, the weight ratio of the cyclopropane flubendiamide to the flonicamid is 1 (0.1-28), optionally 1 (0.1-25), optionally 1 (0.3-20), optionally 1 (1-15), optionally 1 (1-7), optionally 1 (1-5), optionally 1 (1-3), optionally 1:1, or 1:3, or 1:7.
Further, the active ingredient accounts for 1 to 99 percent of the total weight of the composition, alternatively 25 to 50 percent, alternatively 40 to 42 percent.
Further, the composition also comprises an auxiliary agent, wherein the weight ratio of the active ingredient to the auxiliary agent is 1 (1-90).
Further, the auxiliary agent is one or more selected from dispersing agents, wetting agents, emulsifying agents, solvents, cosolvents, thickening agents, stabilizing agents, defoamers, antifreezing agents, preservatives, binders, wall materials, acid-regulating mediums, alkali-regulating mediums, water, disintegrating agents and solid inert carriers;
Alternatively, the dispersant comprises one or more of alkyl naphthalene sulfonate, bis (alkyl) naphthalene sulfonate formaldehyde condensate, aryl phenol polyoxyethylene succinate sulfonate, octyl phenol polyoxyethylene ether sulfate, polycarboxylate, lignin sulfonate sodium salt, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene sulfonate calcium salt, naphthalene sulfonate formaldehyde condensate sodium salt, polyoxyethylene polyoxypropylene block copolymer, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester and ester polyoxyethylene ether;
Optionally, the wetting agent comprises one or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, pesticide emulsion 2000# series, sodium laurylsulfate, wetting penetrating agent F, wetting agent T, fructus Gleditsiae Abnormalis powder, tea cake, faeces Bombycis and soapberry powder;
optionally, the solvent or co-solvent comprises one or more of methanol, ethanol, isopropanol, propylene glycol, glycerol, N-butanol, aromatic hydrocarbon solvent oil, cyclohexanone, dimethyl sulfoxide, sec-butyl acetate, N-methylpyrrolidone and methyl oleate;
Optionally, the antifreeze agent comprises one or more of ethylene glycol, 1, 2-propanediol, glycerol, and urea;
optionally, the binder comprises one or more of starch, gypsum, glucose, sucrose, polyvinyl alcohol, gum arabic, and dextrin;
Optionally, the thickener comprises one or more of magnesium aluminum silicate, xanthan gum, polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, and phenolic resin;
optionally, the solid inert carrier comprises one or more of clay, silica, diatomaceous earth, kaolin, attapulgite, montmorillonite, bentonite, talc, and light calcium carbonate;
Optionally, the defoamer is selected from one or more of silicone, C8-10 fatty alcohol, C10-20 saturated fatty acid (such as capric acid), amide and organosilicon;
Optionally, the wall material comprises one or more of polyureas, polyurethanes, melamine resins and mixed polyureas/polyamides, gelatin/acacia, polyamides, urea/formaldehyde, nylon (Nylon), polyethylene/paraffin;
optionally, the acid regulating medium comprises one or more of ammonium chloride, hydrochloric acid, citric acid, phosphoric acid, ammonium sulfate, ammonium nitrate and acetic acid;
Optionally, the alkali regulating medium comprises one or more of sodium hydroxide, triethanolamine, triethylamine, ammonia water, sodium ethoxide and urea;
optionally, the preservative comprises sodium benzoate.
Further, the pesticide composition is one or more of water suspending agent, seed treatment suspending agent, emulsifiable concentrate, soluble agent, microcapsule suspending agent, aqueous emulsion, microemulsion, dispersible oil suspending agent, wettable powder or water dispersible granule.
Further, the pesticide composition is in the form of an aqueous suspension, and the aqueous suspension comprises the following raw materials in parts by weight: 26 to 50 percent of pesticide active ingredient, 1 to 10 percent of dispersing agent, 0.1 to 8 percent of thickening agent, 0.1 to 0.3 percent of defoaming agent, 0.1 to 0.5 percent of preservative, 2 to 8 percent of antifreezing agent and 40 to 70 percent of water;
Optionally, the dispersing agent is selected from one or more of polycarboxylate, sodium lignin sulfonate and polyoxyethylene polyoxypropylene block copolymer;
optionally, the thickener is selected from one or more of magnesium aluminum silicate and xanthan gum;
Optionally, the defoamer is selected from silicone defoamers;
Optionally, the antifreeze agent comprises one or more of ethylene glycol, 1, 2-propanediol, glycerol, and urea;
Among the adjuvants required for the pesticide composition of the present invention, stabilizers and preservatives are commonly used in the art, which are well known to those skilled in the art, and are not described in detail herein, and the preservatives may include sodium benzoate;
Optionally, the water suspending agent comprises the following raw materials in parts by weight: 40 to 50 percent of pesticide active ingredient, 1 to 3 percent of sodium lignin sulfonate, 1 to 3 percent of polyoxyethylene polyoxypropylene segmented copolymer, 2 to 4 percent of polycarboxylate, 0.1 to 0.15 percent of xanthan gum, 0.4 to 0.6 percent of magnesium aluminum silicate, 0.2 to 0.5 percent of organosilicon defoamer, 0.1 to 0.5 percent of sodium benzoate, 3 to 8 percent of glycol and the balance of water;
optionally, the water suspending agent comprises the following raw materials in parts by weight: 40% -50% of pesticide active ingredient, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.12% of xanthan gum, 0.5% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
Further, the pesticide composition is characterized in that the formulation of the pesticide composition is water dispersible granules, and the water dispersible granules comprise the following raw materials in parts by weight: 26-50% of pesticide effective ingredient, 5-10% of dispersing agent, 1-8% of wetting agent, 1-8% of binder and 24-77% of acid regulating medium;
Optionally, the water dispersible granule comprises the following raw materials in parts by weight: 40-50% of pesticide effective ingredient, 6-9% of dispersing agent, 1-8% of wetting agent, 4-8% of binder and 25-49% of acid regulating medium;
optionally, the dispersant is selected from sodium lignin sulfonate;
Optionally, the wetting agent is selected from sodium dodecyl sulfate;
optionally, the binder is selected from sucrose;
optionally, the acid modulating medium is selected from ammonium sulfate;
Optionally, the water dispersible granule comprises the following raw materials in parts by weight: 40-50% of pesticide active ingredient, 6-7% of lignin sulfonate sodium salt, 2-4% of sodium dodecyl sulfate, 4-8% of sucrose and 31-49% of ammonium sulfate;
Optionally, the water dispersible granule comprises the following raw materials in parts by weight: 40-50% of pesticide active ingredient, 7% of sodium lignin sulfonate, 3% of sodium dodecyl sulfate, 5% of sucrose and 35-45% of ammonium sulfate.
In another aspect, there is provided the use of the pesticidal composition for controlling plant pests; optionally, the plant pest includes one or more of chilo suppressalis, cnaphalocrocis medinalis, plutella xylostella, asparagus caterpillar, spodoptera frugiperda, flea beetle, thrips and aphid.
Optionally, the crop comprises one or more of rice, corn, cotton, soybean, fruit tree, and vegetables.
In still another aspect, the present invention provides a method for using the pesticidal composition, wherein the amount of the active ingredient applied is 0.5-20 g/mu, optionally 1-5 g/mu.
Advantageous effects
(1) The compound pesticide of the ipflubendiamide and the flonicamid has a synergistic effect, and compared with the single pesticide of the ipflubendiamide or the flonicamid, the compound pesticide of the ipflubendiamide and the flonicamid has a remarkably improved pest control effect.
(2) The compound pesticide of the invention can prevent and treat a plurality of pests which occur simultaneously or sequentially at one time, reduce the using amount of pesticides, reduce the using cost and delay the improvement of pest resistance.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention. Throughout the specification and claims, unless explicitly stated otherwise, the term "comprise" or variations thereof such as "comprises" or "comprising", etc. will be understood to include the stated element or component without excluding other elements or components.
In addition, numerous specific details are set forth in the following description in order to provide a better illustration of the invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In some embodiments, materials, elements, methods, means, etc. well known to those skilled in the art are not described in detail in order to highlight the gist of the present invention.
In the following examples, the raw materials were commercially available. Wherein the cyflufenamid is purchased from the chemical company of Nantoon He; flonicamid is purchased from mibezoar chemical technology limited.
Example 1 (weight ratio of Cycloproflumilast to flonicamid 1:25)
Preparation of 1% cyclopropane flubendiamide 25% flonicamid SC
The composition comprises, by mass, 1% of cypress-flubendiamide, 25% of flonicamid, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.2% of xanthan gum, 1% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
Example 2 (weight ratio of Cycloproflumilast to flonicamid 1:20)
Preparation of 2% of cypress-flubendiamide-40% of flonicamid WDG
The pesticide composition of the embodiment is prepared from the following components in percentage by mass, namely 2% of cypress-flubendiamide, 40% of flonicamid, 7% of sodium lignin sulfonate, 3% of sodium dodecyl sulfate, 5% of sucrose and ammonium sulfate, and the components are complemented by weight, uniformly mixed, crushed, granulated, sieved and dried.
Example 3 (weight ratio of Cycloproflumilast to flonicamid 1:15)
Preparation of 2% of cyclopropane flubendiamide-30% of flonicamid OD
The weight percentage of each component is 10 percent of the cyclopropane flubendiamide, 30 percent of the flonicamid, 8 percent of the calcium dodecyl benzene sulfonate, 8 percent of the castor oil polyoxyethylene ether, 1 percent of the organic bentonite and the balance of the components is complemented by the methyl oleate.
Example 4 (weight ratio of Cycloproflumilast to flonicamid 1:7)
Preparation of 5% cyclopropane flubendiamide 35% flonicamid SC
The composition comprises, by mass, 5% of cypress-flubendiamide, 35% of flonicamid, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.12% of xanthan gum, 0.5% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
Example 5 (weight ratio of Cycloproflumilast to flonicamid 1:3)
Preparation of 10% of cypress-flubendiamide-30% of flonicamid SC
The composition comprises, by mass, 10% of cypress-flubendiamide, 30% of flonicamid, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.12% of xanthan gum, 0.5% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
Example 6 (weight ratio of Cycloproflumilast to flonicamid 1:1)
Preparation of 20% of cyclopropane flubendiamide-20% of flonicamid SC
The composition comprises, by mass, 20% of cypress-flubendiamide, 20% of flonicamid, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.12% of xanthan gum, 0.5% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
Example 7 (weight ratio of Cycloproflumilast to flonicamid is 3:1)
Preparation of 30% of cyclopropane flubendiamide 10% of flonicamid SC
The composition comprises, by mass, 30% of cypress-flubendiamide, 10% of flonicamid, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.12% of xanthan gum, 0.5% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
Example 8 (weight ratio of Cycloproflumilast to flonicamid 7:1)
Preparation of 35% of cyclopropane flubendiamide-5% of flonicamid SC
The composition comprises, by mass, 35% of cypress-flubendiamide, 5% of flonicamid, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.12% of xanthan gum, 0.5% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
Example 9 (weight ratio of Cycloproflumilast to flonicamid 10:1)
Preparation of 40% cyclopropane flubendiamide 4% flonicamid WP
The components are 40% of cypress flubendiamide, 4% of flonicamid, 8% of sodium lignin sulfonate, 2% of sodium dodecyl sulfate and kaolin which are complemented by mass percent, and the components are uniformly mixed and crushed.
Comparative example 1
40% Cycloproflumilast SC
The weight percentages of the components are 40% of cypress-flubendiamide, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene segmented copolymer, 3% of polycarboxylate, 0.12% of xanthan gum, 0.5% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate and 4% of ethylene glycol, and the balance is complemented by water.
Comparative example 2
40% Flonicamid SC
The weight percentage of each component is 40 percent of flonicamid, 2 percent of sodium lignin sulfonate, 2 percent of polyoxyethylene polyoxypropylene segmented copolymer, 3 percent of polycarboxylate, 0.12 percent of xanthan gum, 0.5 percent of magnesium aluminum silicate, 0.3 percent of organosilicon defoamer, 0.2 percent of sodium benzoate, 4 percent of glycol and the balance of water.
Comparative example 3 (weight ratio of Cycloproflumilast to flonicamid 1:30)
Preparation of 1% cyclopropane flubendiamide 30% flonicamid SC
The composition comprises, by mass, 1% of cypress-flubendiamide, 30% of flonicamid, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.15% of xanthan gum, 1% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
Comparative example 4 (weight ratio of Cycloproflumilast to flonicamid 30:1)
Preparation of 30% cyclopropane flubendiamide 2% flonicamid SC
The composition comprises, by mass, 30% of cypress-flubendiamide, 2% of flonicamid, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.15% of xanthan gum, 1% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
The inventor carries out synergistic research of mutual compounding by using the insecticidal composition of the clothianidin and the flonicamid. The test adopts frankliniella occidentalis as a test object, and the following proportions (including percentages) are weight ratios unless otherwise specified, and the specific method is as follows:
test example 1 indoor toxicity test
1.1 Test method:
Indoor toxicity determination reference pesticide part 14, guidelines for pesticide indoor bioassay test: leaf dipping (NY/T1154.14-2008). The measurement steps are as follows: immersing fresh kidney beans in the liquid medicine for 5s, taking out, sucking the excessive liquid medicine by using absorbent paper, naturally airing, placing in a culture dish with the diameter of 7cm, accessing about 20 frankliniella occidentalis to initially eclose adults, sealing with a preservative film (a plurality of insect needle holes), and repeating each medicament concentration treatment and contrast treatment for 4 times. After the treatment, each dish was placed in an insect-breeding chamber at a temperature of (25.+ -. 1) ℃ and a relative humidity of (60.+ -. 10)%, and irradiated with light L: D=14 h: 10 h.
1.2 Data statistics and analysis:
The test insects were checked for mortality at 48h post-treatment and mortality was calculated (with no voluntary response of the needle-punched test insects as a criterion for judging mortality of the test insects) and total and dead insects were recorded.
From the survey data, corrected mortality for each treatment was calculated. And the co-toxicity coefficient (CTC value) of the mixture was calculated by the grand cloud Peel method with reference to NY/T1154.7-2006.
The corrected mortality is calculated according to the formulas (1) and (2), the unit is percentage (%), and the calculated result keeps two bits after decimal point:
Wherein:
p1- - -mortality;
K, the number of dead insects;
N- -total number of insects.
Wherein:
p2- - -correct mortality;
pt— mortality in treatment;
P0- - -blank mortality.
If the control mortality is less than 5%, the correction is not carried out; the control mortality is between 5% and 20%, and correction is carried out according to a formula (2); control mortality was > 20% and the test was reworked.
The logarithmic value of the concentration (mg/L) of the medicament is taken as an independent variable X, the probability value of the corrected mortality is taken as a dependent variable Y, virulence regression equations are respectively established, LC 50 of single medicament and each mixed medicament and the mixed medicament co-toxicity coefficient thereof are calculated by adopting DPS software, and the synergistic condition is compared. Calculation LC 50 co-toxicity coefficient (CTC) was calculated according to the grand cloud protocol. The co-toxicity coefficient CTC is calculated as follows:
(with the standard medicament of the clotrimide A, the toxicity index of the clotrimide A is 100, and the clotrimide B is flonicamid): statistical analysis was performed using DPS statistical analysis software, LC 50 was calculated for each agent, and co-toxicity coefficients (CTC values) for the blends were calculated according to the grand cloud Peel method.
The measured virulence index (ATI) = (standard agent LC 50/test agent LC 50) ×100.
Theoretical Toxicity Index (TTI) =a agent toxicity index x percentage of agent toxicity index in mixture + B agent toxicity index x percentage of agent toxicity in mixture.
Co-toxicity coefficient (CTC) = [ actual drug susceptibility index (ATI)/theoretical drug susceptibility index (TTI) ] x 100.
The classification standard is based on the combination effect of NY/T11547.7-2006 pesticides: the co-toxicity coefficient (CTC) is more than or equal to 120, and the synergistic effect is achieved; the cotoxicity coefficient (CTC) is less than or equal to 80 and shows antagonism; a co-toxicity coefficient (CTC) of 80 < 120 shows additive effect. The results are shown in Table 1.
TABLE 1 indoor Combined toxicity determination of Cycloproflumilast and flonicamid against Frankliniella occidentalis
As can be seen from table 1, the mixing ratio of the cyflufenapyr and the flonicamid is 1: 50-15: when the compound is carried out within the range of 1 (mass ratio), the co-toxicity coefficient (CTC) is 106.17-172.36, and the compound shows additive or synergistic effect on frankliniella occidentalis; the mixing proportion is 1: 25-10: at 1, the compound shows a synergistic effect on frankliniella occidentalis, and at 1:1 to 1: the effect is most obvious in the 3-time period, so that the reasonability and feasibility of the combination of the cyproconazole and the flonicamid are seen.
Test example 2 field efficacy test
The pesticide compositions of examples 1-9 and comparative examples 1-4 were tested for their control effect on frankliniella occidentalis on kidney beans in kidney bean planting fields, comprising the specific steps of: the pesticide compositions of examples 1 to 9 and comparative examples 1 to 4 were spray-applied in different planting areas at an effective ingredient application amount of 3 g/mu or 4 g/mu, and diluted with water to a spray amount of 30L per mu at the time of application. The kidney bean land is divided into 42 cells, each cell is 20m 2, a cell sprayed with water is set as a contrast, each treatment group is repeated 3 times, and the cells are isolated by an insect-proof net. The other planting conditions in the various planting areas are identical except that the insecticide is applied according to the above scheme. The control effect of each treatment agent on frankliniella occidentalis on kidney beans is investigated 15 days after the application of the pesticide, and the specific test method is carried out according to pesticide field efficacy test criterion. Each treatment area adopts random 5-point sampling, 5-strain kidney beans are taken at each point, the quantity of frankliniella occidentalis on each leaf at the upper part, the middle part and the lower part of each strain is investigated, the death rate is calculated according to a formula (3), the corrected death rate is calculated according to a formula (4), and the result is shown in a table 2:
TABLE 2 control effects of Cycloproflumilast and flonicamid on frankliniella occidentalis
As can be seen from the comparison of the data of examples 1-9 and comparative examples 1-4 in Table 2, the compound of the invention of the cyclopropyleaf flubendiamide and the flonicamid has good control effect on frankliniella occidentalis, and the control effect is over 85% compared with the compound of the single-component cyclopropyleaf flubendiamide and the flonicamid, or the pesticide of the compound of 1% of the cyclopropyleaf flubendiamide, 30% of the flonicamid and 30% of the cyclopropyleaf flubendiamide, and 2% of the flonicamid. The use proportion of the cyproconazole and the flonicamid has synergistic effect in a wider range, so that the dosage can be reduced, the cost can be reduced, and the pollution of pesticide residues to the environment can be reduced.
In conclusion, the invention adopts the compound composition with the two active ingredients of the cyproconazole and the flonicamid, and has a synergistic effect. Compared with single dose, the insecticidal composition has the advantages of unique action mechanism, small dosage, good quick action, long lasting period and environmental protection. Therefore, the invention has great social significance in research, development and popularization, and can generate great economic benefit.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims (47)

1. The pesticide composition is characterized in that the effective components consist of the cyproconazole and the flonicamid, and the weight ratio of the cyproconazole to the flonicamid is 1 (0.1-25).
2. The pesticide composition as set forth in claim 1, wherein the weight ratio of the ipflubendiamide to the flonicamid is 1 (0.3-20).
3. The pesticide composition as set forth in claim 1, wherein the weight ratio of the ipflubendiamide to the flonicamid is 1 (1-15).
4. The pesticide composition as set forth in claim 1, wherein the weight ratio of the ipflubendiamide to the flonicamid is 1 (1-7).
5. The pesticide composition as set forth in claim 1, wherein the weight ratio of the ipflubendiamide to the flonicamid is 1 (1-5).
6. The pesticide composition as set forth in claim 1, wherein the weight ratio of the ipflubendiamide to the flonicamid is 1 (1-3).
7. A pesticide composition as set forth in claim 1 wherein the weight ratio of the cyclopropflufenapyr to flonicamid is 1:1.
8. A pesticide composition as set forth in claim 1 wherein the weight ratio of the cyclopropflufenapyr to flonicamid is 1:3.
9. A pesticide composition as set forth in claim 1 wherein the weight ratio of the cyclopropflufenapyr to flonicamid is 1:7.
10. The pesticide composition as set forth in claim 1, wherein the active ingredient is 1 to 99% by weight based on the total weight of the composition.
11. The pesticide composition as set forth in claim 1, wherein the active ingredient is 25% -50% of the total weight of the composition.
12. The pesticide composition as set forth in claim 1, wherein the active ingredient is 40% -42% of the total weight of the composition.
13. The pesticide composition of claim 1, further comprising an auxiliary agent, wherein the weight ratio of the active ingredient to the auxiliary agent is 1 (1-90).
14. A pesticide composition as set forth in claim 13 wherein said adjuvant is selected from one or more of dispersants, wetting agents, emulsifiers, solvents, co-solvents, thickeners, stabilizers, defoamers, antifreeze agents, preservatives, binders, wall materials, acid adjusting media, alkali adjusting media, water, disintegrants and solid inert carriers.
15. A pesticide composition as set forth in claim 14 wherein the dispersant is selected from one or more of alkyl naphthalene sulfonate, bis (alkyl) naphthalene sulfonate formaldehyde condensate, aryl phenol polyoxyethylene succinate sulfonate, octyl phenol polyoxyethylene ether sulfate, polycarboxylate, lignin sulfonate sodium salt, alkyl phenol polyoxyethylene ether formaldehyde condensate sulfate, alkyl benzene sulfonate calcium salt, naphthalene sulfonate formaldehyde condensate sodium salt, polyoxyethylene polyoxypropylene block copolymer, alkyl phenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester and ester polyoxyethylene ether.
16. A pesticide composition as set forth in claim 14 wherein the wetting agent is selected from one or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, agro-milk 2000 series, sodium lauryl sulfate, wetting penetrating agent F, wetting agent T, powdered fructus gleditsiae, tea seed cake, silkworm excrement and soapberry powder.
17. A pesticide composition as set forth in claim 14 wherein the solvent or co-solvent is selected from one or more of methanol, ethanol, isopropanol, propylene glycol, glycerol, N-butanol, aromatic hydrocarbon solvent oils, cyclohexanone, dimethyl sulfoxide, sec-butyl acetate, N-methylpyrrolidone, and methyl oleate.
18. A pesticide composition as set forth in claim 14 wherein the antifreeze is selected from one or more of ethylene glycol, 1, 2-propanediol, glycerol and urea.
19. A pesticide composition as set forth in claim 14 wherein the binder is selected from one or more of starch, gypsum, glucose, sucrose, polyvinyl alcohol, gum arabic and dextrin.
20. A pesticide composition as set forth in claim 14 wherein the thickener is selected from one or more of magnesium aluminum silicate, xanthan gum, polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, and phenolic resin.
21. A pesticide composition as set forth in claim 14 wherein the solid inert carrier is selected from one or more of clay, silica, diatomaceous earth, kaolin, attapulgite, montmorillonite, bentonite, talc and light calcium carbonate.
22. A pesticide composition as set forth in claim 14 wherein the defoamer is selected from one or more of silicones, C8-10 fatty alcohols, C10-20 saturated fatty acids and amides, silicones.
23. A pesticide composition as set forth in claim 14 wherein the wall material is selected from one or more of polyureas, polyurethanes, melamine resins and mixed polyureas/polyamides, gelatin/gum arabic, polyamides, urea/formaldehyde, nylon, polyethylene/paraffin waxes.
24. A pesticide composition as set forth in claim 14 wherein the acid modulating medium is selected from one or more of ammonium chloride, hydrochloric acid, citric acid, phosphoric acid, ammonium sulfate, ammonium nitrate, acetic acid.
25. A pesticide composition as set forth in claim 14 wherein the alkalinity adjusting medium is selected from one or more of sodium hydroxide, triethanolamine, triethylamine, ammonia, sodium ethoxide, urea.
26. A pesticide composition as set forth in claim 14 wherein the preservative is sodium benzoate.
27. A pesticide composition as set forth in any one of claims 1 to 26 in the form of one or more of an aqueous suspension, a seed treatment suspension, an emulsifiable concentrate, a soluble solution, a microcapsule suspension, an aqueous emulsion, a microemulsion, a dispersible oil suspension, a wettable powder or a water dispersible granule.
28. A pesticide composition as set forth in claim 27 in a dosage form of an aqueous suspension comprising the following materials in parts by weight: 26-50% of pesticide active ingredient, 1-10% of dispersing agent, 0.1-8% of thickening agent, 0.1-0.3% of defoaming agent, 0.1-0.5% of preservative, 2-8% of antifreezing agent and 40-70% of water.
29. A pesticide composition as set forth in claim 28 wherein the dispersant is selected from one or more of polycarboxylate, sodium lignin sulfonate, polyoxyethylene polyoxypropylene block copolymers.
30. A pesticide composition as set forth in claim 28 wherein the thickener is selected from one or more of magnesium aluminum silicate and xanthan gum.
31. A pesticidal composition according to claim 28, wherein the antifoaming agent is selected from silicone antifoaming agents.
32. A pesticidal composition according to claim 28, wherein the preservative is sodium benzoate.
33. A pesticide composition as set forth in claim 28 wherein the antifreeze is selected from one or more of ethylene glycol, 1, 2-propanediol, glycerol and urea.
34. The pesticide composition of claim 28 wherein the aqueous suspension comprises the following materials in parts by weight: 40% -50% of pesticide active ingredient, 1% -3% of sodium lignin sulfonate, 1% -3% of polyoxyethylene polyoxypropylene block copolymer, 2% -4% of polycarboxylate, 0.1% -0.15% of xanthan gum, 0.4% -0.6% of magnesium aluminum silicate, 0.2% -0.5% of organosilicon defoamer, 0.1% -0.5% of sodium benzoate, 3% -8% of glycol and the balance of water.
35. The pesticide composition of claim 28 wherein the aqueous suspension comprises the following materials in parts by weight: 40% -50% of pesticide active ingredient, 2% of sodium lignin sulfonate, 2% of polyoxyethylene polyoxypropylene block copolymer, 3% of polycarboxylate, 0.12% of xanthan gum, 0.5% of magnesium aluminum silicate, 0.3% of organosilicon defoamer, 0.2% of sodium benzoate, 4% of ethylene glycol and the balance of water.
36. The pesticide composition of claim 27, wherein the pesticide composition is in the form of water dispersible granules, and the water dispersible granules are prepared from the following raw materials in parts by weight: 26-50% of pesticide active ingredient, 5-10% of dispersing agent, 1-8% of wetting agent, 1-8% of binder and 24-77% of acid regulating medium.
37. The pesticide composition of claim 36, wherein the water dispersible granule comprises the following raw materials in parts by weight: 40% -50% of pesticide active ingredient, 6% -9% of dispersing agent, 1% -8% of wetting agent, 4% -8% of binder and 25% -49% of acid regulating medium.
38. A pesticide composition as set forth in claim 36 wherein said dispersant is selected from sodium lignin sulfonate.
39. A pesticide composition as set forth in claim 36 wherein said wetting agent is selected from sodium lauryl sulfate.
40. A pesticide composition as set forth in claim 36 wherein said binder is selected from sucrose.
41. A pesticide composition as set forth in claim 36 wherein said acid modulating medium is selected from ammonium sulfate.
42. The pesticide composition of claim 36, wherein the water dispersible granule comprises the following raw materials in parts by weight: 40% -50% of pesticide active ingredient, 6% -7% of sodium lignin sulfonate, 2% -4% of sodium dodecyl sulfate, 4% -8% of sucrose and 31% -49% of ammonium sulfate.
43. The pesticide composition of claim 36, wherein the water dispersible granule comprises the following raw materials in parts by weight: 40% -50% of pesticide active ingredient, 7% of sodium lignin sulfonate, 3% of sodium dodecyl sulfate, 5% of sucrose and 35% -45% of ammonium sulfate.
44. Use of a pesticidal composition according to any one of claims 1 to 43 for controlling plant pests.
45. The use according to claim 44, wherein the plant pest is selected from one or more of chilo suppressalis, cnaphalocrocis medinalis, plutella xylostella, asparagus caterpillar, spodoptera frugiperda, flea beetle, thrips, and aphid.
46. A method of using the pesticidal composition of any one of claims 1 to 43, wherein the amount of the active ingredient applied of the pesticidal composition is 0.5 to 20 g/mu.
47. A method of using a pesticidal composition according to claim 46, wherein the amount of the active ingredient applied is 1 to 5 g/mu.
CN202210777400.8A 2022-07-04 2022-07-04 Pesticide composition and application thereof Active CN115053910B (en)

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WO2022018765A1 (en) * 2020-07-24 2022-01-27 Rajdhani Petrochemicals Private Limited Synergistic agrochemical mixture for soil application
WO2022018747A1 (en) * 2020-07-18 2022-01-27 Rajdhani Petrochemicals Private Limited Synergistic agrochemical composition comprising diamides and plant growth regulators
WO2022034611A1 (en) * 2020-08-10 2022-02-17 Rajdhani Petrochemicals Private Limited Synergistic pesticidal composition of insecticides and fungicides
CN114423748A (en) * 2019-07-23 2022-04-29 拜耳公司 Novel heteroaryl triazole compounds as pesticides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109497062A (en) * 2018-06-26 2019-03-22 上海泰禾国际贸易有限公司 One inter-species diamide compound and its preparation method and application
CN114423748A (en) * 2019-07-23 2022-04-29 拜耳公司 Novel heteroaryl triazole compounds as pesticides
WO2022018747A1 (en) * 2020-07-18 2022-01-27 Rajdhani Petrochemicals Private Limited Synergistic agrochemical composition comprising diamides and plant growth regulators
WO2022018765A1 (en) * 2020-07-24 2022-01-27 Rajdhani Petrochemicals Private Limited Synergistic agrochemical mixture for soil application
WO2022034611A1 (en) * 2020-08-10 2022-02-17 Rajdhani Petrochemicals Private Limited Synergistic pesticidal composition of insecticides and fungicides

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