WO2022018765A1

WO2022018765A1 - Synergistic agrochemical mixture for soil application

Info

Publication number: WO2022018765A1
Application number: PCT/IN2021/050716
Authority: WO
Inventors: Dipakkumar Patel; Kenal V. Shah; Kawarlal DABHODIA; Bhavesh V. Shah
Original assignee: Rajdhani Petrochemicals Private Limited
Priority date: 2020-07-24
Filing date: 2021-07-22
Publication date: 2022-01-27

Abstract

The present invention more particularly relates to the synergistic agrochemical insecticidal composition comprising of bioactive amount of at least one insecticide selected from class of Nereistoxin compound; at least one insecticide from various groups or mixture thereof; and at least one plant growth regulator or mixture thereof. The present invention further relates to process for preparing the said compositions in specific ratio. The present invention further relates to the process for preparing the said composition along with at least one inactive excipient; and formulations thereof. The present invention further relates to the synergistic agrochemical compositions, wherein active ingredient present in fixed ratio shows synergy in an insecticidal activity.

Description

Title- SYNERGISTIC AGROCHEMICAL MIXTURE FOR SOIL APPLICATION

FIELD OF THE INVENTION:

The present invention relates to synergistic agrochemical compositions for soil application comprising bioactive amounts of (A) at least one insecticide selected from class of Nereistoxin compound; (B) at least one insecticide from various groups or mixture thereof; and (C) at least one plant growth regulator (PGR) or mixture thereof. The present invention further relates to process of preparing said composition with fixed ratio along with at least one inactive excipients and formulation thereof.

BACKGROUND OF THE INVENTION:

Agriculture crop cultivation is labor intensive and cost intensive field. Moreover plant pesticides and herbicides are very expensive. Additionally surface run-off of pesticides is a major issue. Hence, soil applied granules are the best possible solution. These granules reduce the surface run-off of pesticides and protect the crops from insect pests and nematode infestation.

Combination of Nereistoxin, insecticides and Plant growth regulator is used to broaden the spectrum of control of insects and nematodes, reduce dosage and decrease the chances of development of resistance. The combination of Nereistoxin, insecticide and PGR demonstrate an additive or synergistic effect that results in an improved control on the pests and overall crop health and plant vigour in field condition.

Damage to plants from insect pests and nematodes is another major concern for agriculturalist. There are various insects and nematodes that infect the plant and consequently reduce the overall yield of the crop. Applying insecticides and Nereistoxin to the soil in the form of granules help reduce damage to the crop from soil borne pest and nematodes. Moreover, these granules have the ability of controlled release. Hence the effect of insecticide and Nereistoxin in the soil is retained for a longer period of time. Additionally, the mixture also comprises a PGR which is advantageous for plant propagation, improved plant health and increased overall yield.

There are many mixtures of Nereistoxin, Insecticide and Plant growth regulator known in the prior art for the control of soil borne pests and nematodes. For example CN102388892B relates to a pesticide composition taking chlorantraniliprole and thiocyclam as active ingredient. The composition has a remarkable synergized action in poisoning insects, has the characteristics of wide insecticidal spectrum, high efficiency, high speed of action, durative efficacy, low toxicity, low pesticide consumption and agricultural cost, no cross resistance among the agents, and the like, and overcomes and suspends pesticide resistance of pests.

EP2744790B1 relates to an insecticidal and fungicidal mixture using Chlorantraniliprole and Thiocyclam to provide compounds having improved activity and/or a broader activity spectrum against phytopathogenic harmful fungi.

US8153560B2 discloses an insecticidal mixture of Thiocyclam and Chlorantraniliprole to prevent insects, arachnids or nematodes in and on plants, and for protecting such plants being infested with pests, especially also for protecting seeds.

There is however a need for improvement of these combinations. Single active combination used over a long period of time has resulted in resistance. With the onset of resistance to certain pests, there is a need in the art for a combination of actives that decreases chances of resistance and improves the spectrum of pest control.

Therefore one object of the present invention is to provide improved combinations of insecticide and Nereistoxin along with plant growth regulators for the control of soil borne pest. Another object of the present invention is to provide a method and a composition for controlling insect pests and parasitic nematodes in and on the plants.

Yet another object of the present invention is to provide improved combinations of Nereistoxin, insecticide and Plant growth regulators to promote plant health and increasing plant vigour in field condition.

Embodiment of the present invention can ameliorate one or more of the above mentioned problems.

Inventors of the present invention have surprisingly found that the synergistic mixture for soil application comprising of a Nereistoxin; one or more insecticide; and one or more Plant growth regulator as described herein can provide solution to the above mentioned problems.

SUMMARY OF THE INVENTION

Therefore an aspect of the present invention provides an agrochemical mixture for soil application comprising (A) Nereistoxin; (B) one or more insecticides; (C) a Plant Growth Regulator (PGR). More particularly an aspect of the present invention provides an agrochemical mixture for soil application comprising (A) Nereistoxin such as bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride or thiosultap sodium; (B) one or more insecticides such as phenylpyrazole, neonicotinoids, sulfoximines, butenolides, mesoionics, chordotonal organ modulators, diamides, metadiamide, isoxazolines and compounds with unknown class or unknown mode of action; (C) one or more Plant Growth Regulators like auxin, cytokinin, ethylene modulators, gibberellins, growth inhibitors, growth retardants, growth stimulators, unclassified growth regulators, micronutrients or plant health additives or mixture thereof.Accordingly, in a further aspect, the present invention provides a method of protecting plant, plant parts and or plant organs that grow at a later point in time against nematode damage or pest damage by applying granules comprising a mixture of said agrochemical composition defined in the first aspect.

Accordingly, in yet another aspect the agrochemical mixture for soil application comprising (A) a Nereistoxin; (B) one or more insecticide; (C) one or more Plant Growth Regulators wherein the formulations are selected from Powder for dry soil application (DS), , Granule/ soil applied (GR), Controlled (Slow or Fast) release granules (CR), Jambo balls or bags (bags in water soluble pouch), Water soluble granule (SG), Water dispersible granule (WG or WDG),

Accordingly, in a first aspect, the present invention provides an agrochemical mixture comprising (A) Nereistoxin; (B) one or more insecticides; (C) one or more Plant Growth Regulator shows synergistic activity.

DETAILED DESCRIPTION OF THE INVENTION:

The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased. Noteworthy, the health of a plant when applying the method according to the invention, is increased independently of the pesticidal properties of the active ingredients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which result for example in an activation of the plant's own natural defense system. As a result, the health of a plant is increased even in the absence of pest pressure. Accordingly, in an especially preferred embodiment of the method according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. The above identified indicators for the health condition of a plant may be interdependent or they may result from each other. An increase in plant vigor may for example result in an increased yield and/or tolerance to abiotic or biotic stress. One indicator for the condition of the plant is the yield. "Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and/or processed after harvesting.

In an especially preferred embodiment of the invention, the yield of the treated plant is increased.

In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.

According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention.

Increased yield can be characterized, among others, by the following improved proper-ties of the plant: increased plant, weight, increased plant height, increased biomass such as higher overall fresh weight (FW), increased number of flowers per plant, higher grain yield, more tillers or side shoots (branches), larger leaves, increased shoot growth, increased protein content, increased oil content, increased starch content, increased pigment content, increased leaf are index.

A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance. In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention, is increased synergistically. Improved plant vigor can be characterized, among others, by the following improved properties of the plant: improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less plant verse/lodging), improved emergence, enhanced root growth and/or more developed root system, enhanced nodulation, in particular rhizobial nodulation, bigger leaf blade, bigger size, increased plant weight, increased plant height, increased tiller number, increased number of side shoots, increased number of flowers per plant, increased shoot growth, increased root growth (extensive root system), increased yield when grown on poor soils or unfavorable climate, enhanced photosynthetic activity (e.g. based on increased stomatal conductance and/or increased C02 assimilation rate), increased stomatal conductance, increased C02 assimilation rate, enhanced pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, earlier and improved germination, earlier grain maturity, improved self-defense mechanisms, improved stress tolerance and resistance of the plants against biotic and abiotic stress factors such as fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and/or salt stress, less non-productive tillers, less dead basal leaves, less input needed (such as fertilizers or water), greener leaves, complete maturation under shortened vegetation periods, less fertilizers needed, less seeds needed, easier harvesting, faster and more uniform ripening, longer shelf-life, longer panicles, delay of senescence, stronger and/or more productive tillers, better extractability of ingredients, improved quality of seeds (for being seeded in the following seasons for seed production), better nitrogen uptake, improved reproduction, reduced production of ethylene and/or the inhibition of its reception by the plant.

The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components).

Another indicator for the condition of the plant is the "quality" of a plant and/or its products.

In an especially preferred embodiment of the invention, the quality of the treated plant is increased.

In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.

According to the present invention, enhanced quality means that certain plant characteristics such as the content or composition of certain ingredients are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the application of the mixtures of the present invention. Enhanced quality can be characterized, among others, by following improved properties of the plant or its product: increased nutrient content, increased protein content, increased content of fatty acids, increased metabolite content, increased carotenoid content, increased sugar content, increased amount of essential amino acids, improved nutrient composition, improved protein composition, improved composition of fatty acids, improved metabolite composition, improved carotenoid composition, improved sugar composition, improved amino acids composition, improved or optimal fruit color, improved leaf color, higher storage capacity, higher processability of the harvested products.

Another indicator for the condition of the plant is the plant's tolerance or resistance to biotic and/or abiotic stress factors. Biotic and abiotic stress, especially over longer terms, can have harmful effects on plants. Biotic stress is caused by living organisms while abiotic stress is caused for example by environmental extremes. According to the present invention, "enhanced tolerance or resistance to biotic and/or abiotic stress factors" means (1.) that certain negative factors caused by biotic and/or abiotic stress are diminished in a measurable or noticeable amount as compared to plants exposed to the same conditions, but without being treated with a mixture according to the invention and (2.) that the negative effects are not diminished by a direct action of the mixture according to the invention on the stress factors, e.g. by its fungicidal or insecticidal action which directly destroys the microorganisms or pests, but rather by a stimulation of the plants' own defensive reactions against said stress factors.

The present invention provides a synergistic mixture for soil application comprising (A) a Nereistoxin; (B) one or more insecticides; (C) one or more Plant growth regulators;

More preferably the present invention provides a synergistic agrochemical mixture comprising (A) a Nereistoxin selected from bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride or thiosultap sodium; (B) one or more Insecticides selected from the class of phenylpyrazole, neonicotinoids, sulfoximines, butenolides, mesoionics, chordotonal organ modulators, diamides, metadiamide, isoxazolines and compounds with unknown class or unknown mode of action; (C) one or more Plant growth regulator selected from the class of auxin, cytokinin, ethylene modulators, gibberellins, growth inhibitors, growth retardants, growth stimulators, unclassified growth regulators, micronutrients or plant health additives or mixture thereof.

In an embodiment of the present invention, one or more insecticide may be selected from the class of Phenylpyrazole such as fipronil, nicofluprole.

In a further embodiment of the present invention, one or more insecticide may be selected from the class of Neonicotinoids such as acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr and cycloxylidin.

In a further embodiment of the present invention, one or more insecticide may be selected from the class of Sulfoximines such as sulfoxaflor. In a further embodiment of the present invention, one or more insecticide may be selected from the class of Butenolides such as flupyradifurone.

In a further embodiment of the present invention, one or more insecticide may be selected from the class of Mesoionics such as triflumezopyrim, and dichloromezotiaz.

In a further embodiment of the present invention, one or more insecticide may be selected from the class of Chordotonal organs modulators such as flonicamid, pyridine azomethine like pymetrozine, pyrifluquinazon and pyropenes like afidopyropen.

In a further embodiment of the present invention, one or more insecticide may be selected from the class of Diamides such as chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, cyproflanilide, flubendiamide, tetraniliprole, tetrachlorantraniliprole and tyclopyrazoflor.

In a further embodiment of the present invention, one or more insecticide may be selected from the class of Metadiamide such as broflanilide.

In a further embodiment of the present invention, one or more insecticide may be selected from the class of Isoxazolines such as Fluxametamide and Isocycloseram,.

In a further embodiment of the present invention, one or more insecticide may be selected from the class of compounds of unknown or uncertain mode of action such as azadirechtin, benzpyrimoxan, pyridalyl, oxazosulfyl, dimpropyridaz, nematicidal compounds such as cyclobutrifluram, fluazaindolizine and tioxazafen.

In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Auxins such as Indole acetic acid, Indole butyric acid, alpha-naphthyl acetic acid.

In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Cytokinins such as kinetin, zeatin, 6-benzylaminopurine, dipheylurea, thidiazuron.

In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Ethylene modulators such as aviglycine, 1-MCP, prohexadione, prohexadione calcium, trinexapac, trinexapac-ethyl, aminoethoxyvinylglycine (AVG).

In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Gibberellins such as gibberelline, gibberellic acid, GA3. In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Growth inhibitors such as abscisic acid, chlorpropham, flumetralin, jasmonic acid, maleic hydrazide, mepiquat, mepiquat chloride, mepiquat pentaborate.

In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Growth retardants such as chlormequat, chlormequat chloride, paclobutrazol, uniconazole-P.

In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Growth stimulators such as brassinolide, forchlorfenuron, triacontanol, silicic acid, silicyclic acid, Nitrophenolate (sodium para-nitrophenolate, ortho-nitrophenolate, sodium- 5 -nitroguaiacolate) , nitrobenzene .

In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Micronutrients such as Zinc (zinc sulphate heptahydrate ZnS047H20, zinc sulphate mono hydrate ZnS04.H20, chelated zinc as Zn-EDTA, zinc oxide, Zinc Lactate Gluconate, Zinc Polyflavonoid); Boron (borax-sodium tetraborate, boric acid (H3B03), di sodium octa borate tetra hydrate (Na2B8013.4H20), di-sodium tetra borate penta hydrate, anhydrous borax, ); Manganese (manganese sulphate); Copper (copper sulphate); Iron (ferrous sulphate, chelated iron as Fe-EDTA); Molybdenum (ammonium molybdate); Magnesium (Magnesium sulphate); or Sulphur (elemental sulphur, boronated sulphur).

In a further embodiment of the present invention, one or more Plant growth regulators may be selected from the class of Plant health additives such as Acids like humic acid, potassium humate, fulvic acid, potassium fulvic acid, humic substances, fatty acids/lipids, amino acid, carboxylic acid, protein hydrolysates; Extracts chitosan, chitin, seaweed extract (Ascophyllum nodosum), polyamines, peptides, polysaccharides, botanicals; Microbials (bacteria, fungus, alagae etc.), microalgae polysaccharides, octadeconoic acid, amylopectin, hydrogen 1 -octadecenyl butanedioate, ascorbyl palmitate, lactic acid, cellulose acetate, fumaric acid, octanoic acid, myristic acid, oleic acid, carbonic acid, sorbic acid, citric acid, D-glucitol, L-ascorbic acid and mixture thereof.

NEREIS TOXIN:

Thiocyclam hydrogen oxalate:

Thiocyclam has been used as a contact and feeding poison that blocks the nicotinic acetylcholine receptors in the nervous system of insects. The insecticide is effective against various types of insects and is also toxic to bees, fish and other aquatic organisms. Thiocyclam is rapidly degraded in the environment - with a half-life in the soil of one to four days.

Thiocyclam is used to protect against Lepidoptera, Coleoptera, some Diptera and Thysanoptera. It is used to control Colorado beetle in potatoes, Lepidoptera and Coleoptera pest complexes in rape, stem borers in irrigated rice, com borers and Tanymecus in maize, weevils and other Coleoptera in sugar beet, stem borers in sugar cane, Lepidoptera in fruit trees and leaf miners in vegetables. Thiocyclam is a propesticide of the natural product nereistoxin which is a potent insect neurotoxin isolated from the annelid Lumbviconeveis hetevopoda. Thiocyclam is rapidly converted into nereistoxin in biological media, the latter being relatively stable.

INSECTICIDES:

Clothianidin:

Clothianidin acts on the central nervous system of insects as an agonist of acetylcholine, the neurotransmitter that stimulates nAChR, targeting the same receptor site (AChR) and activating post-synaptic acetylcholine receptors but not inhibiting AChE. Clothianidin and other neonicotinoids were developed to last longer than nicotine, which is more toxic and which breaks down too quickly in the environment.

Clothianidin is an alternative to organophosphate, carbamate, and pyrethroid pesticides. It poses lower risks to mammals, including humans, when compared to organophosphates and carbamates. It has helped prevent insect pests build up resistance to organophosphate and pyrethroid pesticides.

Thiamethoxam:

Thiamethoxam is a systemic insecticide in the class of neonicotinoids. It has a broad spectrum of activity against many types of insects.

Thiamethoxam is a broad- spectrum, systemic insecticide, which means it is absorbed quickly by plants and transported to all of its parts, including pollen, where it acts to deter insect feeding. An insect can absorb it in its stomach after feeding, or through direct contact, including through its tracheal system. The compound gets in the way of information transfer between nerve cells by interfering with nicotinic acetylcholine receptors in the central nervous system, and eventually paralyzes the muscles of the insects.

Chlorantraniliprole : Chlorantraniliprole is an insecticide of the ryanoid class. Chlorantraniliprole is a new class of selective insecticides featuring a novel mode of action to control a range of pests belonging to the order Lepidoptera and some other Coleoptera, Diptera and Isoptera species.

Chlorantraniliprole opens muscular calcium channels (in particular the ryanodine receptor), rapidly causing paralysis and ultimately death of sensitive species. The differential selectivity Chlorantraniliprole had towards insect ryanodine receptors explained the outstanding profile of low mammalian toxicity. Chlorantraniliprole is active on chewing pest insects primarily by ingestion and secondarily by contact.

Cyantraniliprole:

Cyantraniliprole is an insecticide of the ryanoid class. Because of its uncommon mechanism of action as a ryanoid, it has activity against pests such as Diaphorina citri that have developed resistance to other classes of insecticides. Cyantraniliprole is highly toxic to bees.

Tetraniliprole:

A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction. Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.

PLANT GROWTH REGULATOR:

Prohexadione calcium:

Prohexadione is a chemical compound from the group of carboxylic acids and a phytohormone. Prohexadione calcium inhibits certain steps in gibberellin biosynthesis and is used in fruit, wine, field and ornamental plant cultivation. Prohexadione is a plant growth regulator and also has a bactericidal effect.

Trinexapac-ethyl:

Trinexapac is a growth regulator from the carboxylic acid family. Trinexapac inhibits gibberellin biosynthesis. It acts as an internode shortener and is used as a straw stabilizer in cereals, rice and sunflowers.

At room temperature, trinexapac-ethyl is a white crystalline substance. The compound is moderately soluble in water and methanol, acetonitrile and cyclohexanone. Trinexapac-ethyl inhibits plant growth by inhibiting gibberellin biosynthesis. The compound also inhibits ethylene formation in plants because it is an inhibitor of the ACC oxidase enzyme .

Trinexapac-ethyl is used in agriculture to control plant growth. For example, it can be used to prevent cereals or rapeseed from growing too high. In addition, it is used on grasses.

Paclobutrazol:

Paclobutrazol (PBZ) is a plant growth retardant and triazole fungicide. It is a known antagonist of the plant hormone gibberellin. It acts by inhibiting gibberellin biosynthesis, reducing intemodal growth to give stouter stems, increasing root growth, causing early fruitset and increasing seedset in plants such as tomato and pepper. PBZ has also been shown to reduce frost sensitivity in plants. Moreover, paclobutrazol can be used as a chemical approach for reducing the risk of lodging in cereal crops. PBZ is used by arborists to reduce shoot growth and has been shown to have additional positive effects on trees and shrubs. Among those are improved resistance to drought stress, darker green leaves, higher resistance against fungi and bacteria, and enhanced development of roots. Cambial growth, as well as shoot growth, has been shown to be reduced in some tree species.

Uniconazole:

Uniconazole is a triazole chemical used as a plant growth retardant. It is active on a wide range of plants and acts by inhibiting the production of gibberellins. Uniconazole is applied to plants to restrain their growth. It is often used on perennials to maintain a marketable size and/or delay flowering. Leaves usually appear darker after application because uniconazole increases chlorophyll content.

Brassinolide:

Brassinolide is a plant hormone. The first isolated brassinosteroid, it was discovered when it was shown that pollen from rapeseed (Brassica napus) could promote stem elongation and cell division. The biologically active component was isolated and named brassinolide.

Triacontanol:

Triacontanol is a fatty alcohol of the general formula C30H62O, also known as melissyl alcohol or myricyl alcohol. It is found in plant cuticle waxes and in beeswax. Triacontanol has been reported to increase the growth of plants by enhancing the rates of photosynthesis, protein biosynthesis, the transport of nutrients in a plant and enzyme activity, reducing complex carbohydrates among many other purposes. The fatty alcohol appears to increase the physiological efficiency of plant cells and boost the potential of the cells responsible for the growth and maturity of a plant.

Salicyclic acid:

Salicylic acid is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid (BHA). It has the formula C7H603. This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone. It is derived from the metabolism of salicin.

Micronutrients:

Zinc: Zinc (Zn) is one of the eight essential micronutrients. It is needed by plants in small amounts, but yet crucial to plant development.

In plants, zinc is a key constituent of many enzymes and proteins. It plays an important role in a wide range of processes, such as growth hormone production and internode elongation.

Zinc deficiency is probably the most common micronutrient deficiency in crops worldwide, resulting in substantial losses in crop yields.

Boron:

Boron is a micronutrient necessary for plant growth. Without adequate boron in the soil, plants may appear healthy but will not flower or fruit. Water, organic matter and soil texture are all factors that affect boron in soil. The balance of too little or too much between plants and boron is a delicate one. Heavy boron soil concentration can be toxic to plants. Boron helps control the transport of sugars in plants. It is important to cell division and seed development. As a micronutrient, the amount of boron in soil is minute, but among micronutrients, boron deficiency in plants is the most common.

Plant Health Additives: Humic acid:

Humic acids are remarkable brown to black products of soil chemistry that are essential for healthy and productive soils. They are functionalized molecules that can act as photosensitizers, retain water, bind to clays, act as plant growth stimulants, and scavenge toxic pollutants. No synthetic material can match humic acid’s physical and chemical versatility. One obvious benefit of humus has been the aggregation of clay. This aggregation has made the clay more porous, soft, and aerobic, with better drainage, resulting in deeper root growth of all plants.

Fulvic acid:

Fulvic acid is a yellow-brown substances found in natural material such as shilajit, soil, peat, coal, and bodies of water such as streams or lakes. Fulvic acid is formed when plants and animals decompose.

Aggregation of soil plays an important role in plant growth. The soil aggregation is promoted by fulvic acid mediating iron and aluminum, one of the constituents of the soil particles, to bind the soil particles together.

Chitin:

Plants also have receptors that can cause a response to chitin, namely chitin elicitor receptor kinase 1 and chitin elicitor-binding protein. When the receptors are activated by chitin, genes related to plant defense are expressed, and jasmonate hormones are activated, which in turn activate systematic defenses.

Some pathogens produce chitin-binding proteins that mask the chitin they shed from these receptors. Zymoseptoria tritici is an example of a fungal pathogen that has such blocking proteins; it is a major pest in wheat crops.

Chitosan:

The agricultural and horticultural uses for chitosan, primarily for plant defense and yield increase, are based on how this glucosamine polymer influences the biochemistry and molecular biology of the plant cell. The cellular targets are the plasma membrane and nuclear chromatin. Subsequent changes occur in cell membranes, chromatin, DNA, calcium, MAP Kinase, oxidative burst, reactive oxygen species, callose pathogenesis-related (PR) genes and phytoalexins.

In agriculture, chitosan is typically used as a natural seed treatment and plant growth enhancer, and as an ecologically friendly biopesticide substance that boosts the innate ability of plants to defend themselves against fungal infections. It is one of the most abundant biodegradable materials in the world.

The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combination of the present invention allows for a broad spectrum of pest control and has surprisingly improved plant vigour and yield. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.

The synergistic agrochemical composition has very advantageous curative, preventive and systemic insecticidal properties for protecting cultivated plants. As has been mentioned, said active composition can be used to inhibitor destroy pest that occur on plants or parts of plants of different crops or useful plants. The synergistic agrochemical composition of specific active ingredient has the special advantage of being highly active against soil borne insect pests and nematodes.

The synergistic agrochemical composition of the present invention is used to protect the crops and plants from insect pest and nematodes. Examples of the crops on which the present compositions may be used include but are not limited to GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Beilis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).

The present invention can be applied to the soil of vegetables: solanaceous vegetables such as eggplant, tomato, pimento, pepper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous vegetables such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc, liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc, strawberry, sweet potato, Dioscorea japonica, colocasia, etc.

Moreover the present synergistic composition may be applied to flowers, foliage plants, turf grasses, fruits: pome fruits such apple, pear, quince, etc, stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such as orange, lemon, rime, grapefruit, etc., nuts such as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc. berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc. , trees other than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, Liquidambar formosana, plane tree, zelkova, Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, etc.

The mixtures according to the invention can be applied to any and all developmental stages of pests, such as egg, larva, pupa, and adult. The pests may be controlled by contacting the target pest, its food supply, habitat, breeding ground or its locus with a pesticidally effective amount of the inventive mixtures or of compositions comprising the mixtures.

The synergistic agrochemical mixture comprising of (A) Nereistoxin; (B) one or more Insecticide; (C) one or more Plant growth regulator; which is suitable for controlling many soil borne pests like The major insects pests are belongs to the order Hemiptera, for example, rice leafhopper Nephotettix nigropictus, rice brown plant hopper Nilaparvata lugen, rice white backed plant hopper, Apple Mealy bug Phenococcus aceris, bean aphid Aphis fabae, black citrus aphid Toxoptera aurantii, citrus black scale Saissetia oleae, cabbage aphid Brevicoryne brassicae, Lipaphis erysimi, citrus red scale Aonidiella aurantii, yellow scale Aonidiella citrine, citrus mealybug Planococcus citri, com leaf aphid Rhopalosiphum maidis, cotton aphid Aphis gossypii, cotton jassid Amrasca biguttula biguttla, cotton mealy bug Planococcus spp. And Pseudococcus spp., cotton Stainer Dysdercus suturellus, cotton whitefly Bemisia tabaci, cowpea aphid Aphis crassivora, grain aphid Sitobion avenae, golden glow aphid Uroleucon spp., grape mealybug Pseudococcus maritimus, green peach aphid Myzus persicae, greenhouse whitefly Trialeurodes vaporariorum, papaya mealy bug Pracoccus marginatus, pea aphid Acyrthosiphon pisum, sugarcane mealybug Saccharicoccus sacchari, potato aphid Myzus persicae, potato leaf hopper Empoasca fabae, cotton whitefly Bemisia tabaci, tarnished plant bug Lygus lineolaris, wooly apple aphid Eriosoma lanigemm, mango hopper Amritodus atkinsoni, Idioscopus spp. ; order Lepidoptera, army worm Mythimna unipuncta, asiatic rice borer Chilo suppressalis, bean pod borer Maruca vitrata, beet armyworm Spodoptera exigua, black cutworm Agrotis ipsilon, bollworm Helicoverpa armigera , cabbage looper Trichoplusia ni, codling moth Cydia pomonella, croton caterpillar Achea janata, diamond backmoth Plutella xylostella, cabbage worm Pieris rapae, pink bollworm Pectinophora gossypiella, sugarcane borer Diatraea saccharalis, tobacco budworm Heliothis virescens, tomato fmitworm Helicoverpa zea, velvet bean caterpillar Anticarsia gemmatalis, yellow stem borer Scirpophaga incertulas, spotted bollworm Earias vittella, rice leaffolder Cnaphalocrocis medinalis, pink stem borer Sesamia spp., tobacco leafeating caterpillar Spodoptera litura; brinjal fruit and shoot borer Leucinodes orbonalis, bean pod borer Maruca vitrata, Maruca testulalis, armyworm Mythimna separata, cotton pinkbollworm Pectinophora gossypiella, citrus leafminer Phyllocnistis citrella, cabbage butterfly Pieris bras-sicae, diamond backmoth Plutella xylostella, paddy stem borer Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, wheat stem borer Sesamia inferens, Sitotroga cerealella, Spilosoma obliqua, Spodoptera fmgiperda, Spodoptera littoralis, Spodoptera litura, Trichoplusia ni, Tryporyza novella, Tuta absoluta;from the order Coleoptera, for example, apple twig borer Amphicems spp., corn root worm Diabrotica virgifera, cucumber beetle diabrotica balteata, boll weevil Anthonomus grandis, grape flea beetle Altica chalybea, grape root worm Fidia viticola, grape trunk borer Clytoleptus albofasciatus, radish flea beetle Phyllotreta armoraciae, maize weevil Sitophilus zeamais, northern corn rootworm Diabrotica barberi, rice water weevil Lissorhoptrus oryzophilus, Anthonomus grandis, Bruchus lentis, Diabrotica semipunctata, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis, various species of white grubs are Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Leptinotarsa decemlineata, Phyllotreta chrysocephala, Popillia japonica etc; from the order Orthoptera, for example, Gryllotalpa spp., Locusta spp., and Schistocerca is spp.; from the order Thysanoptera, for example, Frankliniella spp., Thrips palmi, Thrips tabaci and Scirtothrips dorsalis; termites (Isoptera), e.g. Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis; from the order Heteroptera, for example, Dysdercus spp., Leptocorisa spp., from the order Hymenoptera, for example, Solenopsis spp. ; from the order Diptera, for example, Antherigona soccata, Dacus spp., Liriomyza spp., Melanagromyza spp., from the order Acarina, for example, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus, Oligonychus punicae, Panonychus citri, Panonychus ulmi, Polyphagotarsonemus latus, Tarsonemus spp., Tetranychus urticae, Tetranychus cinnabarinus.

Additionally, the said synergistic mixture is advantageous against plant parasitic nematodes such as root-knot nematodes, Meloidogyne incognita, Meloidogyne javanica and other Meloidogyne species; cyst nematodes, Globodera rostochiensis, Globodera pallida, Globodera tabacum and other Globodera species, Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species.

The formulation of the present synergistic mixture can be in any of the formulations selected from Powder for dry soil application (DS), Granule/ soil applied (GR), Controlled (Slow or Fast) release granules (CR), Jambo balls or bags (bags in water soluble pouch), Water soluble granule (SG), Water dispersible granule (WG or WDG), Soil Applied Granules (SAG)

Granular pesticide formulations are dry products similar to dust formulations except that granules are larger and heavier and cannot be applied with a duster. A fine granular pesticide pours like sugar or salt. The active insecticide is coated onto or absorbed into carrier particles made from an absorptive material such as clay, pieces of corn cobs or walnut shells.

In the structural pest control industry, granules are used mostly around plants to prevent insects such as crickets, cockroaches, ants and millipedes. They also can be broadcast on lawns to control fire ants, mole crickets, larval fleas, ticks and other pests. Some granules are applied to soil but act as systemic, meaning they are taken up by a plant into its leaves to kill pests feeding on the plant. Granules are an effective pest-control product because the particles drop into the soil where the insects are located.

Controlled release granules:

Controlled release formulations (CRFs) are intended to improve the delivery of pesticides and related biologically active substances. The consequent improvement in efficiency reduces losses in use and has many benefits, such as reduction in exposure to both workers and the environment, particularly in minimizing leaching and evaporation. As a consequence of this principle, reduced levels of pesticide delivered efficiently can be as efficacious as higher amounts of conventional formulations.

Dry spreadable granules are important commercial products because of their ability to eliminate undesirable vegetation in large areas of cultivated vegetation and because of their ease of application, either by hand or mechanical means. For example, a practical and labour-saving approach to selective herbicide delivery in areas such as golf courses, parks, lawns, gardens and woodlands has been broadcast application of granular insecticide products via rotary spreader.

Further (A) Nereistoxin; (B) one or more Insecticide; (C) one or more Plant growth regulators; which are bioactive ingredients for the present composition are present in specific fixed ratio. Compound A Nereistoxin is present in 0.1% to 40% w/w; Compound B Insecticide is present in 0.1% to 40% w/w; Compound C is present in 0.1% to 20% w/w.

The process of preparing the present synergistic composition can be modified by any person skilled in the art based on the knowledge of the manufacturing the formulation. However all such variation and modification is still covered by the scope of present invention.

The composition of the present invention in addition to bioactive amounts of active ingredients further comprises inactive excipients including but not limited to dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, antimicrobial agent, thickener, quick coating agent or sticking agents, filler, binders, anticaking agents, absorbents and buffering agent.

A dispersant is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Dispersants are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles re-disperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates and water-dispersible granules. Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to reaggregation of particles. The most commonly used surfactants are anionic, non ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lingo sulphonates. For suspension concentrates, very good adsorption and stabilization are obtained using poly electrolytes, such as sodium naphthalene sulphonate formaldehyde condensates. Tristyrylphenolethoxylate phosphate esters are also used. Nonionics such as alkyl aryl ethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersants for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersants or dispersing agent used herein include but not limited to alkylated naphthalene sulfonate, sodium salt, Sodium salt of naphthalene sulfonate condensate, Sodium Ligno sulfonate, Sodium ploycarboxylate,EO/PO based copolymer, Phenol sulfonate, Sodium Methyl Oleoyl Taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide, Copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly(oxypropylene) block polymer with poly(oxyethylene), ethoxylated tristyrene phenol is alpha-[2,4,6-tris[l- (phenyl)ethyl] phenyl] -omega-hydroxy poly(oxyethylene, poly(oxy-l,2-ethanediyl)-alpha-C10- 15alkyl-omega-hydroxy phosphate or sulphate and/or a C10-13alkylbenzenesulfonic acid, tristyrylphenols, nonylphenols, dinonylphenol and octylphenols, styrylphenol polyethoxyester phosphate, alkoxylated C14-20fatty amines, Naphthalenesulfonic acid, sodium salt condensated with formaldehyde, polyalcoxylated alkylphenol, naphthalenesulfonic acid formaldehyde condensate, methylnaphtaline-formaldehyde-condensate sodium salt, napthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt or mixture thereof.

Anti-freezing agent as used herein can be selected from the group consisting of polyethylene glycols, methoxy polyethylene glycols, polypropylene glycols, polybutylene glycols, glycerin and ethylene glycol. Water-based formulations often cause foam during mixing operations in production. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of antifoam agents, namely silicones and non- silicones. Silicones are usually aqueous emulsions of dimethyl poly siloxane while the non-silicone anti-foam agents are water- insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules. Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations include but not limited to Mono C2-6alkyl ether of a polyC2-4alkylene oxide block copolymer , condensation product of castor oil and polyC2-4alkylene oxide, alkoxylated castor oil is available under the trade name Agnique CSO-36, a mono- or di-ester of a C12-24fatty acid and polyC2-4alkylene oxide, carboxylates, sulphates, sulphonates, alcohol ethoxylates, alkyl phenol ethoxylates, fatty acid ethoxylates, sorbitan esters, ethoxylated fats or oils, amine ethoxylates, phosphate esters, ethylene oxide - propylene oxide copolymers, fluorocarbons, alkyd-polyethylene glycol resin, polyalkylene glycol ether, apolyalkoxylated nonyl phenyl, alkoxylated primary alcohol, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, hydroxylated stearic acid polyalkylene glycol polymer, and their corresponding salts, alkyd- polyethylene glycol resin, polyalkylene glycol ether, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, tristyrylphenol phosphate potassium salt, dodecysulfate sodium salt or mixture thereof.

The quick coating agent can be a conventionally available sticker, for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinyl alcohol, vinyl acetate and vinyl pyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymers and mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly (methacrylate), poly(ethyl methacrylate), poly(methyl methacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinyl pyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(ortho esters), alkyd resins, and mixtures of two or more of these.

Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified com starch, poly capro lactone, poly(namylmethacrylate), wood rosin, poly anhydrides, poly vinyl alcohol, poly hydroxyl butyrate valerate, biodegradable aliphatic polyesters, and poly hydroxyl butyrate or mixtures thereof.

Diintegrating agent for the present formulation is selected from citric acid, succinic acid or the sodium bicarbonate.

Carrier for the present formulation is selected from diatomaceous earth, attapulgite or zeolites, dolomite, limestone, silica, fly ash, hydrated lime, wheat flour, wood flour, ground wheat straw, cellulose and soy flour, bentonite, kaolin, attapulgite, diatomaceous earth, calcium carbonate, talc, muscovite mica, fused sodium potassium, aluminum silicate , perlite, talc and muscovite mica, urea, sulfur-coated urea, isobutylidene diurea, ammonium nitrate, ammonium sulfate, ammonium phosphate, triple super phosphate, phosphoric acid, potassium sulfate, potassium nitrate, potassium metaphosphate, potassium chloride, dipotassium carbonate, potassium oxide and a combination of these, Calcium, magnesium, sulfur, iron, manganese, copper, zinc; oxides, humic acid, Wood floor, Calcium silicate, Cellulose granules, Magnesium stearate, China Clay, Silica, Lactose anhydrous, Ammonium sulfate, Sodium sulfate anhydrous, Corn starch, Urea, EDTA.

Colorant for the present formulation is selected from Crystal violet, Thalocyano dye chlorinated, Aerosol green FFB dye, Rodamine, Azo compound.

Preservative for the present formulation is selected from l,2-benzisothiazolin-3(2H)-one, sodium salt, Sodium benzoate, 2-bromo-2-nitropropane-l,3-diol, Formaldehyde, Sodium o- phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.

The solvent for the formulation of the present invention may include water, water soluble alcohols and dihydroxy alcohol ethers. The water-soluble alcohol which can be used in the present invention may be lower alcohols or water-soluble macromolecular alcohols. The term "lower alcohol", as used herein, represents an alcohol having 1-4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tertbutanol, etc. Macromolecular alcohol is not limited, as long as it may be dissolved in water in a suitable amount range, e.g., polyethylene glycol, sorbitol, glucitol, etc. The examples of suitable dihydroxy alcohol ethers used in the present invention may be dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, and the like. Any of the above mentioned solvent can be used either alone or in combination thereof.

The process for preparing the present novel synergistic composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However all such variation and modification is still covered by the scope of present invention.

The present invention highlights the synergistic effect of the combination of the at least one insecticide selected from class of a Nereistoxin or mixture thereof; at least one insecticide from phenylpyrazole, neonicotinoids, sulfoximines, butenolides, mesoionics, chordotonal organ modulators, diamides, metadiamide, isoxazolines and compounds with unknown class or unknown mode of action or mixture thereof; and one or more Plant Growth Regulators. Following the right use of the invented technology and the synergistic insecticidal composition of the invention with a formulations having a multi-pesticide components i.e. pesticide mixture, formulation prepared with an extra care of physical compatibility by purposefully specially selected solvents, dispersing agents, carriers and the surfactants, thickeners, stabilisers etc. exhibits better insect and pest management and boost plant health.

While the foregoing written description of the invention enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention. The invention shall now be described with reference to the following specific examples. It should be noted that the example(s) appended below illustrate rather than limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the present invention.

These and other aspects of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.

EXAMPLE 1:

Granule-Slow release (GR-SL) formulation of Thiocyclam Hydrogen Oxalate 3.0 %+ Clothianidin 1.2%+ Humic Acid 0.8 %.

Procedure: Manufacturing process for the of Granules (GR) -Slow release Manufacturing process of Granules (GR) -Slow release

Storage Stability:

EXAMPLE 2:

Granule (GR) formulation of Thiocyclam Hydrogen Oxalate 2.0 %+Flupyrimin 1.0%+ Ortho Silicic acid 0.25%

Procedure: Manufacturing process of Granules (GR) Manufacturing process of Granules (GR)

Storage Stability:

EXAMPLE 3:

Granule (GR) formulation of Thiocyclam Hydrogen Oxalate 3%+Thiamethoxam 1.2%+Salicyclic acid 0.25%

Procedure: Manufacturing process as per Example 2 Storage Stability:

EXAMPLE 4:

Granule-Slow release (GR-SL) formulation of Thiocyclam Hydrogen Oxalate 2.0 %+Cyantraniliprole 0.5%+ Triacontanol 0.1%

Procedure: Manufacturing process as per Example 1 Storage Stability:

EXAMPLE 5:

Granule (GR) formulation of Thiocyclam Hydrogen Oxalate 2.0 %+Chlorantraniliprole 0.4%+ Zinc 2.0%

Procedure: Manufacturing process as per Example 2 Storage Stability:

EXAMPLE 6: Granule (GR) formulation of Cartap Hydrochloride 2% + Flubendiamide 0.5%+ Brassinolide 0.003%

Procedure: Manufacturing process as per Example 2 Storage Stability:

EXAMPLE 07:

Most Preferred formulations:

BIOLOGICAL EXAMPLES:

A synergistic effect exists wherever the action of a combination of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticidal activity than the sum of the pesticidal activities of the individual components.

In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two or three active components can be calculated as follows: Colby's formula for calculating synergism between three active ingredients

Colby’s formula for calculating synergism between two active ingredients

The synergistic insecticidal action of the inventive mixtures can be demonstrated by the experiments below.

FIELD BIO-EFFICACY STUDIES:

EXAMPLE 08:

Experiment 1: Control of insect-pests infesting paddy/rice Crop & Variety : Paddy

Location : Raipur, Chattishgarh

Plot size : 20 sq. mt. (5m x 4m)

Number of Treatments: 40

Application Time : 20 DATP (Days after transplanting) Method of Application: Broadcasting in to soil.

Observation Methods:

Leaf folder, stem borer control: The infestation by stem borer and leaf folder was observed as dead heart (DH), white ear (WE), and leaf folder damaged leaves (LFD) appeared during vegetative stage and reproductive stages from 10 hills per plot. The observation on per cent dead hearts at vegetative stage and the leaf damage as per cent damaged leaves were recorded at 30, 45 DATP (Days after transplanting) and white ear was recorded before harvest of the crop. The leaf was considered to be damaged by the leaf folder if at least 1/3 of its area showed symptoms.

The percentage of DH, WE and LFD in each individual plot was calculated by using formulae described below:

% BPH control:

Count the number of hoppers (BPH) per hill, observe 10 hills per plot at 75 DAT. Record the observations when moderate infestation noticed in untreated plot. Calculate the % Hoppers (BPH) control (observed value) as below formula.

The calculated value of % control was used to worked out the Colby’ s formula to judge the synergism.

Tiller count: Count the number of productive tillers per hill. Record observations from 10 hills per plot at the time of harvesting. Table 1: Treatment details for bio-efficacy against insect-pests infesting paddy crop

Treatment composition from 1 to 9 are innovative ready mix slow releasing granule (GR-SL). Treatment composition from 10 to 28 are prior arts. THO-Thiocyclam hydrogen oxalate, Cloth- Clothianidin WP-Wettable Powder, L-Liquid, GR-Granule, WDG-Water Dispersible Granule. Table 2: Synergistic control of insect-pests of paddy crop

All innovative ready-mix formulations (sr.no.1 to 9) shows synergistic activities in terms of control of leaf folder, stem borer and brown plant hopper compared to all prior art treatments (sr.no. 10 to 28). The one-time granular application in paddy crop provides season long control of key pests of paddy crop and thereby reducing the number of pesticidal applications and also reducing the risk of frequent pesticidal exposure. The innovative ready-mix formulations also yielded higher number of productive tillers contributing directly to the rice grain yield as compared to all prior art treatments.

Conclusion:

Very high level of synergism was observed in terms of key insect pest control of paddy crop i.e. leaf folder, stem borer and brown plant hopper.

Provides season long control of key insect pests of paddy crop.

Higher yield observed in the treatment of innovative ready-mix formulation

Other visual observations are excellent plant growth and vigor, dark green color leaves, large leaf blades, profuse root system.

EXAMPLE 09:

Experiment 2: Control of early shoot borer (ESB), Chilo infuscatellus infesting sugarcane crop

Crop & Variety: Sugarcane, Co-0118

Location : Dhanaula, Dist. Amroha, Uttar Pradesh

Treatments : 30

Plot size : 25 sq.m

Spacing : 90 cm row to row

Planting material: 3 budded setts, 4 setts per meter

Time of Application: At the time of planting.

Method of Application: In furrow application, over the setts and cover up with soil. The required dose was mixed up with sand to bulk out further and broadcasted over planted setts in open furrow and then cover up with soil.

Agronomic Practices: Fertilizer, irrigation, inter culturing, earthing up and weeding done as per the crop requirement.

Observation Methods:

Early shoot borer (Chilo infuscatellus) incidence (%):

Fifty shoots per plot were selected randomly and presence of characteristic “dead heart” (damaged shoots) were recorded to calculate per cent shoot damage by early shoot borer at 45 and 60 (DAP) days after planting.

Early shoot borer (ESB) control calculated by below formula,

% Early shoot borer data used to check the synergism by applying Colby’s formula given above. Shoot count:

Count the number of shoots/tillers from 1 mrl (meter row length) from randomly selected 5 spot per plot at 75 DAP.

Table 3:

Treatment details for field bio efficacy against early shoot borer infesting sugarcane

Treatment composition from 1 to 6 are innovative ready-mix combinations. Treatment composition from Sr. No. 7 to 20 are prior arts. THO-Thiocyclam Hydrogen Oxalate, HA-Humic Acid

Table 4: Bio efficacy against sugarcane early shoot borer (ESB), Chilo infuscatellus and shoot count

All innovative ready mix combinations (sr.no.1 to 6) shows synergism in efficacy against early shoot borer control and also provides very good residual control (duration of control) compared to all prior art treatments (sr.no.7 to 20). The number of productive shoots are much higher in innovative ready mix combinations (sr.no.1 to 6) compared to all prior art treatments (sr.no.7 to 20). Conclusion:

1. Synergism was observed in innovative ready mix combinations (sr.no. 1 to 6)

2. The innovative ready mix combinations provides better control of ESB (early shoot borer).

3. The innovative ready mix combinations provides longer duration of control.

4. The innovative on farm mixture treatments produce higher number of productive shoots contributing to the cane yield.

5. Other visual observations are excellent plant growth and vigor, dark green color leaves, large leaf blades, increased girth of cane, profuse root system which are directly contributing to the cane yield. Farmers has to spend less on insect control.

EXAMPLE: 10

Experiment 3: Bio efficacy against insect pests infesting paddy crop

Crop & Variety : Paddy Location : Dhamtari, Chattishgarh

Plot size : 20 sq. mt. (5m x 4m)

Number of Treatments: 18

Application Time : 20 DATP (Days after transplanting)

Method of Application: Broadcasting in to soil. The required quantity of ready-mix granules and other prior art treatments was mixed with sand and manually broadcasted.

Observation Methods: same as given in Experiment 1.

Table 5: Treatment details for bio-efficacy against insect-pests infesting paddy crop

THO-Thiocyclam Hydrogen Oxalate, OSA-Ortho Silicic Acid

Table 6: Bio-efficacy against insect-pests infesting paddy crop

All innovative ready-mix formulations (sr.no.1 to 3) shows synergistic activities in terms of control of leaf folder, stem borer and brown plant hopper compared to all prior art treatments (sr.no. 4 to 11). The one-time granular application in paddy crop provides season long control of key pests of paddy crop and thereby reducing the number of pesticidal applications and also reducing the risk of frequent pesticidal exposure. The innovative ready-mix formulations also yielded higher number of productive tillers contributing directly to the rice grain yield as compared to all prior art treatments. Conclusion:

1. Very high level of synergism was observed in terms of key insect pest control of paddy crop i.e. leaf folder, stem borer and brown plant hopper.

2. Provides season long control of key insect pests of paddy crop.

3. Higher yield observed in the treatment of innovative ready-mix formulation 4. Other visual observations are excellent plant growth and vigor, dark green color leaves, large leaf blades, profuse root system.

EXAMPLE: 11

Experiment 4: Bio efficacy against insect pests infesting paddy crop Crop & Variety : Paddy

Location : Nabha, Punjab

Plot size : 25 sq. mt. (5m x 5m)

Number of Treatments: 24

Application Time : 16 DATP (Days after transplanting) Method of Application: Broadcasting into soil. The required quantity of ready-mix granules and other prior art treatments was mixed with sand and manually broad casted.

Agronomic Practices : Fertilizer, irrigation, inter culturing, earthing up and weeding done as per the crop requirement.

Observation Methods: same as above Table 7: Treatment details for bio-efficacy against insect-pests infesting paddy crop

Treatment number 6 to 16 are prior art treatments.

THO-Thiocyclam Hydrogen Oxalate, Gr-Granule, OD-Oil Dispersion, WP-Wettable Powder, SC-Suspension Concentrate. Table 8: Bio-efficacy against insect-pests infesting paddy crop

All innovative ready-mix formulations (sr.no.1 to 5) shows synergistic activities in terms of control of leaf folder, stem borer and brown plant hopper compared to all prior art treatments (sr.no. 6 to 16).

EXAMPLE: 12

Experiment 5: Bio efficacy against insect pests infesting paddy crop

Crop & Variety : Paddy

Location : Dhamtari, Chattishgarh Plot size : 20 sq. mt. (5m x 4m)

Number of Treatments: 20

Application Time : 25 DATP (Days after transplanting)

Method of Application: Broadcasting into soil. The required quantity of ready-mix granules and other prior art treatments was mixed with sand and manually broad casted. Observation Methods: same as given in Experiment 1.

Table 9: Treatment details for bio-efficacy against insect-pests infesting paddy crop

Treatment composition from Sr. No. 1 to 4 are innovative ready-mix granular formulations to

10 are prior arts. Treatment composition from Sr. No. 5 to 17 are prior arts.

THO-Thiocyclam hydrogen oxalate, Cloth-Clothianidin, kg/h-Kilogram per hectare, GR- Granule, L-Liquid, SC- Suspension concentrate.

Table 10: Bio-efficacy against insect-pests infesting paddy crop

All innovative ready-mix formulations (sr.no.1 to 4) shows synergistic activities in terms of efficacy against leaf folder, stem borer and brown plant hopper compared to all prior art treatments (sr.no. 5 to 17).

EXAMPLE: 13

Experiment 6: Control of early shoot borer (ESB), Chilo infuscatellus infesting sugarcane crop

Crop & Variety : Sugarcane, Co-0118 Location : Dhanaula, Dist. Amroha, Uttar Pradesh Treatments : 30 Plot size : 25 sq.m Spacing : 90 cm row to row

Planting material : 3 budded setts, 4 setts per meter Time of Application : At the time of planting.

Observation Methods: same as in Experiment 2. Table 11: Treatment details for bio-efficacy against insect-pests infesting sugarcane crop

Cartap-Cartap hydrochloride, GR-Granule, OD-Oil Dispersion, SC-Suspension Concentrate,

SL-Soluble liquid, SP-Soluble Powder, WG-Wettable Granule.

Table 12: Bio-efficacy against insect-pests infesting sugarcane crop

All innovative ready-mix formulations (sr.no.1 to 6) shows synergistic activities in terms of efficacy against early shoot borer and provides longer duration of control and also produces higher number of productive shoot compared to all prior art treatments (sr.no. 7 to 20).

Visual observations on all bio-efficacy trials:

The innovative ready-mix combinations shows synergism in terms of bio-efficacy against key insect-pests of paddy and sugarcane crop. Many other visual observations like, excellent plant growth and vigor, bigger leaf blade and size, more number of leaves, tillers, shoots, branches, more number of secondary and tertiary roots and rootlets were observed. Increased overall biomass, more number of grains per panicle, increased panicle length.

Claims

CLAIMS We claim; 1) A synergistic agrochemical composition for soil application comprising: a. at least one insecticide selected from class of Nereistoxin in an amount of 0.1 to 40% by weight or mixture thereof; b. at least one insecticide selected from the class of phenylpyrazole, neonicotinoids, sulfoximines, butenolides, mesoionics, chordotonal organ modulators, diamides, metadiamide, isoxazolines and compounds with unknown class or unknown mode of action in an amount of 0.1 to 40% by weight or mixture thereof; c. at least one plant growth regulator selected from the class of auxin, cytokinin, ethylene modulators, gibberellins, growth inhibitors, growth retardants, growth stimulators, unclassified growth regulators, micronutrients or plant health additives in an amount of 0.1 to 20% by weight or mixture thereof; d. inactive formulation excipients. 2) The synergistic agrochemical composition as claimed in claim 1 wherein, the synergistic agrochemical composition comprising: a. at least one insecticide from class of Nereistoxin is selected from bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride or thiosultap sodium; or mixture thereof; b. at least one insecticide selected from the class of phenylpyrazole, neonicotinoids, sulfoximines, butenolides, mesoionics, chordotonal organ modulators, diamides, metadiamide, isoxazolines and compounds with unknown class or unknown mode of action; or mixture thereof; c. at least one plant growth regulator selected from the class of auxin, cytokinin, ethylene modulators, gibberellins, growth inhibitors, growth retardants, growth stimulators, unclassified growth regulators, micronutrients or plant health additives or mixture thereof. 3) The synergistic agrochemical composition as claimed in claim land claim 2 wherein the insecticide from the class of Neonicotinoids is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr and cycloxylidin; from the class of sulfoximines is a sulfoxaflor; from the class of butenolides is a flupyradifurone; from the class of mesoionics such as triflumezopyrim, and dichloromezotiaz; from the class of Chordotonal organs modulator is selected from flonicamid, pyridine azomethine like pymetrozine, pyrifluquinazon and pyropenes like afidopyropen; from the class of diamides is selected from chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, cyproflanilide, flubendiamide, tetraniliprole, tetrachlorantraniliprole and tyclopyrazoflor; from the class of metadiamide is a broflanilide; from the class of Isoxazolines is selected from Fluxametamide and Isocycloseram; from the class of compounds of unknown or uncertain mode of action is selected from azadirechtin, benzpyrimoxan, pyridalyl, oxazosulfyl, dimpropyridaz, nematicidal compounds such as cyclobutrifluram, fluazaindolizine and tioxazafen. 4) The synergistic insecticidal composition as claimed in claim 1 and claim 2 wherein, the plant growth regulator from the group of Auxins is selected from Indole acetic acid, Indole butyric acid, alpha- naphthyl acetic acid; from the group of Cytokinins is selected from kinetin, zeatin, 6-benzylaminopurine, dipheylurea, thidiazuron; from the group of Ethylene modulators is selected from aviglycine, prohexadione, prohexadione calcium, trinexapac, trinexapac-ethyl, aminoethoxyvinylglycine (AVG); from the group of Gibberellins is selected from gibberelline, gibberellic acid, GA3; from the group of Growth inhibitors is selected from abscisic acid, chlorpropham, flumetralin, jasmonic acid, maleic hydrazide, mepiquat, mepiquat chloride, mepiquat pentaborate; from the group of Growth retardants is selected from chlormequat, chlormequat chloride, paclobutrazol, uniconazole-P; from the group of Growth stimulators is selected from brassinolide, forchlorfenuron, triacontanol, silicic acid, Salicylic acid, Nitrophenolate (sodium para-nitrophenolate, ortho-nitrophenolate, sodium-5-nitroguaiacolate), nitrobenzene; from the group of Micronutrients is selected from Zinc (zinc sulphate heptahydrate ZnS047H20, zinc sulphate mono hydrate ZnS04.H20, chelated zinc as Zn-EDTA, zinc oxide, Zinc Lactate Gluconate, Zinc Polyflavonoid), Zinc in the form of Zinc protein lacto gluconate or zinc oxide or zinc sulphate or in nanoparticle form, Boron (borax-sodium tetraborate, boric acid (H3B03), di-sodium octa borate tetra hydrate (Na2B8013.4H20), di-sodium tetra borate penta hydrate, anhydrous borax, ), Manganese (manganese sulphate), Copper (copper sulphate), Iron (ferrous sulphate, chelated iron as Fe-EDTA), Molybdanum (ammonium molybdate), Magnesium (Magnesium sulphate) or Sulphur (elemental sulphur, boronated sulphur); from the group of plant health additives is selected from acids like humic acid, potassium humate, fulvic acid, potassium fulvic acid, humic substances, fatty acids/lipids, amino acid, carboxylic acid, protein hydrolysates; Extracts chitosan, chitin, seaweed extract (Ascophyllum nodosum), polyamines, peptides, polysaccharides, botanicals; Microbials (bacteria, fungus, alagae etc.), microalgae polysaccharides, octadeconoic acid, amylopectin, hydrogen 1-octadecenyl butanedioate, ascorbyl palmitate, lactic acid, cellulose acetate, fumaric acid, octanoic acid, myristic acid, oleic acid, carbonic acid, sorbic acid, citric acid, D-glucitol, L- ascorbic acid and mixture thereof. 5) The synergistic insecticidal composition as claimed in claim 1 wherein, inactive excipients comprises a. wetting agent in an amount of 2 to 4 % by weight b. dispersing agent in an amount of 1 to 5 % by weight c. colorant in an amount of 0.1 to 1.0 % by weight d. solvents in an amount of 2 to 5 % by weight e. carrier in an amount of 30 to 95 % by weight 6) The synergistic agrochemical composition as claimed in claim 1 wherein, the formulation for the said composition is selected from Powder for dry soil application (DS), Granule/ soil applied (GR), Controlled (Slow or Fast) release granules (CR), Jambo balls or bags (bags in water soluble pouch), Water soluble granule (SG), Water dispersible granule (WG or WDG), Soil Applied Granules (SAG). ) The synergistic insecticidal composition as claimed in claim land claim 6 wherein, the preferred composition and formulation thereof comprises: i. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Humic acid 0.8; ii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Fulvic acid 0.8%; iii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Amino acid 0.8%; iv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Chitosan 0.8%; v. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + ortho silicic acid 0.25% ; vi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Brassinolide 0.0025% ; vii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Salicylic acid 0.25%; viii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Triacontanol 0.125% ; ix. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Zinc 1% ; x. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Clothianidin 1.2% + Sulphur 20%; xi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Thiamethoxam 1.2% + Humic acid 0.8%; xii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Thiamethoxam 1.2% + Ortho silicic acid 0.25% ; xiii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Thiamethoxam 1.2% + Brassinolide 0.0025%; xiv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Thiamethoxam 1.2% + Zinc 1% ; xv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flupyrimin 1 % + Humic acid 1%; xvi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flupyrimin 1 % + Ortho silicic acid 0.25 1%; xvii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flupyrimin 1 % + Brassinolide 0.0025%; xviii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flupyrimin 1 % + Triacontanol 0.125% ; xix. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Triflumezopyrim 0.25 % + Humic acid 1.5% ; xx. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Triflumezopyrim 0.25 % + Ortho silicic acid 3.5%; xxi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Triflumezopyrim 0.25 % + Brassinolide 0.0025% xxii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Triflumezopyrim 0.25 % +Salicylic acid 0.25%; xxiii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 3% + Triflumezopyrim 0.25 % +Sulphur 20%; xxiv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Fipronil 0.6% + Ortho silicic acid 0.25; xxv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Fipronil 0.6% + Brassinolide 0.0025%; xxvi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Fipronil 0.6% + Salicylic acid 0.25%; xxvii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Fipronil 0.6% + Triacontanol 0.125%; xxviii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Cyantraniliprole 0.6% + Humic acid 1%; xxix. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Cyantraniliprole 0.5% + Fulvic acid 1.6% ; xxx. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Cyantraniliprole 0.5% + Chitosan 2%; xxxi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Cyantraniliprole 0.5% + Brassinolide 0.002%; xxxii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Cyantraniliprole 0.5% + Triacontanol 0.10% ; xxxiii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Cyantraniliprole 0.5% + Paclobutrazol 0.24%; xxxiv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Cyantraniliprole 0.5% + Zinc 2%; xxxv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Cyantraniliprole 0.5% + Sulphur 20%; xxxvi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2.5% + Chlorantraniliprole 0.5% + Humic acid 1%; xxxvii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Chlorantraniliprole 0.4% + Brassinolide 0.002% ; xxxviii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Chlorantraniliprole 0.4% + Triacontanol 0.10%; xxxix. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Chlorantraniliprole 0.4% + Zinc 2%; xl. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% +Chlorantraniliprole 0.4% + Sulphur 20% ; xli. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Tetraniliprole 0.6% + Humic acid 1%; xlii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Tetraniliprole 0.6% + Brassinolide 0.002%; xliii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Tetraniliprole 0.6% + Triacontanol 0.10%; xliv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Tetraniliprole 0.6% + Paclobutrazol 0.2%; xlv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Tetraniliprole 0.6% + Zinc 2%; xlvi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flubendiamide 0.6% + Humic acid 1%; xlvii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flubendiamide 0.5% + Brassinolide 0.002%; xlviii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flubendiamide 0.5% + Triacontanol 0.10%; xlix. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flubendiamide 0.5% + Paclobutrazol 0.24%;

1. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flubendiamide 0.5% + Zinc 2%; li. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2% + Flubendiamide 0.4% + Sulphur 20%; lii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2.5% + Cyclaniliprole 0.5% + Humic acid 1% liii. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2.5% + Cyclaniliprole 0.5% + Brassinolide 0.002% ; liv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2.5% + Cyclaniliprole 0.5% + Triacontanol 0.10%; lv. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2.5% + Cyclaniliprole 0.5% + Zinc 2%; lvi. Granule (GR) formulation of Thiocyclam hydrogen oxalate 2.5% + Cyhalodiamide 0.5% + Humic acid 1%; lvii. Granule (GR) formulation of Cartap Hydrochloride 2.4% + Cyantraniliprole 0.6% + Humic acid 1.6% ; lviii. Granule (GR) formulation of Cartap Hydrochloride 2.4% + Cyantraniliprole 0.6% + Brassinolide 0.003%; lix. Granule (GR) formulation of Cartap Hydrochloride 2.4% + Cyantraniliprole 0.6% + Zinc 2%; lx. Granule (GR) formulation of Cartap Hydrochloride 2.4% + Chlorantraniliprole 0.5% + Humic acid 1.6%; lxi. Granule (GR) formulation of Cartap Hydrochloride 2% + Tetraniliprole 0.6% + Fulvic acid 1.6%; lxii. Granule (GR) formulation of Cartap Hydrochloride 2% + Tetraniliprole 0.6% + Zinc 2%; lxiii. Granule (GR) formulation of Cartap Hydrochloride 2% + Cyclaniliprole 0.6% + Humic acid 1.6%; lxiv. Granule (GR) formulation of Cartap Hydrochloride 2.4% + Cyhalodiamide 0.5% + Humic acid 1.6% ; lxv. Granule (GR) formulation of Cartap Hydrochloride 2% + Flubendiamide 0.5% + Humic acid 1.6% ; lxvi. Granule (GR) formulation of Cartap Hydrochloride 2% + Flupyrimin 1% + Humic acid 2% ; lxvii. Granule (GR) formulation of Cartap Hydrochloride 2% + Flupyrimin 1% + Ortho silicic acid 0.25% ; lxviii. Granule (GR) formulation of Cartap Hydrochloride 2% + Flupyrimin 1% + Zinc

2%; lxix. Granule (GR) formulation of Cartap Hydrochloride 3% + Clothianidin 1.2 % + Humic acid 0.8% ; lxx. Granule (GR) formulation of Cartap Hydrochloride 3% + Clothianidin 1.2 % + Fulvic acid 0.8% ; lxxi. Granule (GR) formulation of Cartap Hydrochloride 3% + Clothianidin 1.2 % + Ortho silicic acid 0.25% ; lxxii. Granule (GR) formulation of Cartap Hydrochloride 3% + Clothianidin 1.2 % + Zinc 1%; lxxiii. Granule (GR) formulation of Cartap Hydrochloride 3% + Thiamethoxam 1.2 % + Humic acid 0.8%; lxxiv. Granule-Slow release (GR-SL) formulation of Thiocyclam Hydrogen Oxalate 2.0 %+ Cyantraniliprole 0.5%+ Triacontanol 0.1%.

8) The synergistic agrochemical composition as claimed in claim 1 and claim 6 wherein, the Granule-Slow release (GR-SL) formulation comprises: a) at least one insecticide from class of Nereistoxin present in an amount of 0.1 to 40% by weight of the composition is selected from Thiocyclam hydrogen oxalate, Cartap Hydrochloride or mixture thereof; b) at least one insecticide present in an amount of 0.1 to 40% by weight of the composition is selected from Clothianidin, Thiamethoxam, Flupyrimin, Triflumezopyrim, Fipronil, Cyantraniliprole, Chlorantraniliprole, Tetraniliprole, Flubendiamide, Cyclaniliprole, Cyantraniliprole, Tetraniliprole, Cyclaniliprole or mixture thereof; c) at least one plant growth regulator present in an amount of 0.1 to 20% by weight is selected from Humic acid, Fulvic acid, Amino acid, Chitosan, ortho silicic acid, Brassinolide, Salicylic acid, Triacontanol, Zinc, Sulphur, Ortho silicic acid, Triacontanol or mixture thereof; d) Wetting agent in an amount of 2 to 4 % by weight; e) Slow release agent in an amount of 18 to 24 % by weight; f) Dispersing agent I in an amount of 0.1 to 4% by weight; g) Dispersing agent II in an amount of 0.1 to 4% by weight; h) Colourant in an amount of 0.1 to 1.0 % by weight; i) Solvent in an amount of 2 to 5 % by weight; j) Carrier in an amount of 30 to 95 % by weight.

9) The synergistic insecticidal composition as claimed in claim 1 wherein, the Granule (GR) formulation comprises: a) at least one insecticide from class of Nereistoxin present in an amount of 0.1 to 40% by weight of the composition is selected from Thiocyclam hydrogen oxalate, Cartap Hydrochloride or mixture thereof; b) at least one insecticide present in an amount of 0.1 to 40% by weight of the composition is selected from Clothianidin, Thiamethoxam, Flupyrimin, Triflumezopyrim, Fipronil, Cyantraniliprole, Chlorantraniliprole, Tetraniliprole, Flubendiamide, Cyclaniliprole, Cyantraniliprole, Tetraniliprole, Cyclaniliprole or mixture thereof; c) at least one plant growth regulator present in an amount of 0.1 to 20% by weight is selected from Humic acid, Fulvic acid, Amino acid, Chitosan, ortho silicic acid, Brassinolide, Salicylic acid, Triacontanol, Zinc, Sulphur, Ortho silicic acid, Triacontanol or mixture thereof; d) Wetting agent in an amount of 2 to 4 % by weight; e) Dispersing agent I in an amount of 0.1 to 4% by weight; f) Dispersing agent II in an amount of 0.1 to 4% by weight; g) Colourant in an amount of 0.1 to 1.0 % by weight; h) Solvent in an amount of 2 to 5 % by weight; i) Carrier in an amount of 30 to 95 % by weight.

10) The synergistic agrochemical composition as claimed in claim 1 and claim 5 wherein, wetting agent for granule (GR) formulation is seleted from Mono C2-6alkyl ether of a polyC2-4alkylene oxide block copolymer , condensation product of castor oil and polyC2- 4alkylene oxide, alkoxylated castor oil is available under the trade name Agnique CSO- 36, a mono- or di-ester of a C12-24fatty acid and polyC2-4alkylene oxide, carboxylates, sulphates, sulphonates, alcohol ethoxylates, alkyl phenol ethoxylates, fatty acid ethoxylates, sorbitan esters, ethoxylated fats or oils, amine ethoxylates, phosphate esters, ethylene oxide - propylene oxide copolymers, fluorocarbons, alkyd-polyethylene glycol resin, polyalkylene glycol ether, apolyalkoxylated nonyl phenyl, alkoxylated primary alcohol, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, hydroxylated stearic acid polyalkylene glycol polymer, and their corresponding salts, alkyd-polyethylene glycol resin, polyalkylene glycol ether, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, tristyrylphenol phosphate potassium salt, dodecysulfate sodium salt.

11) The synergistic agrochemical composition as claimed in claim 1 and claim 5 wherein, dispersing agent for granule (GR) formulation is seleted from Copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly(oxypropylene) block polymer with poly(oxyethylene), ethoxylated tristyrene phenol is alpha-[2,4,6-tris[l-(phenyl)ethyl] phenyl] -omega-hydroxy poly(oxyethylene, poly(oxy- 1 ,2-ethanediyl)-alpha-C 10-15 alkyl- omega-hydroxy phosphate or sulphate and/or a C10-13alkylbenzenesulfonic acid, tristyrylphenols, nonylphenols, dinonylphenol and octylphenols, styrylphenol polyethoxyester phosphate, alkoxylated C14-20fatty amines.

12) The synergistic agrochemical composition as claimed in claim 1 and claim 5 wherein, colorant is seleted from Crystal violet, Thalocyano dye chlorinated, Aerosol green FFB dye, Rodamine, Azo compound.

13) The synergistic agrochemical composition as claimed in claim 1 and claim 5 wherein, solvent is seleted from fatty acid methyl ester, cyclohexane, xylene, mineral oil or kerosene, mixtures or substituted naphthalenes, mixtures of mono- and polyalkylated aromatics, dibutyl phthalate or dioctyl phthalate, ethylene glycol monomethyl or monoethyl ether, butyrolactone, octanol, castor oil, soybean oil, cottonseed oil, epoxidised coconut oil or soybean oil, aromatic hydrocarbons, dipropyleneglycol monomethylether, polypropylene glycol [M.W. 2000-4000], polyoxyethylene polyoxypropylene glycols, polyoxypropylene polyoxyethylene glycols, diethyleneglycol, polyethylene glycol [M.W. 200-4000 amu], methoxy polyethylene glycols 350, 550, 750, 2000, 5000; glycerol, methyl oleate, n-octanol, alkyl phosphates such as tri-n-butyl phosphate, propylene carbonate and isoparaffinic, tetrahydrofurfuryl alcohol, gamma-butyrolactone, N-methyl- 2-pyrrolidone, tetramethylurea, dimethylsulfoxide, N,N-dimethylacetamide , Diacetone alcohol, Polybutene, Propylene carbonate, Dipropylene glycol isomer mixture. 14) The synergistic agrochemical composition as claimed in claim 1 and claim 6 wherein, slow release (control release) agent for controlled relaease granule (CR) formulation is selected from Xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethylcellulose, Sodium Polyacrylate, modified starch, Parafin wax, Polyvinyl acetate, Montan wax and vinyl acetate, Polyethylene Glycol 6000, Cationic hydrosoluble polymer, C4 alkylated Polyvinyl pyrrolidone

15) The synergistic agrochemical composition as claimed in claim 1 and claim 5 wherein, carrier is seleted from diatomaceous earth, attapulgite or zeolites, dolomite, limestone, silica, fly ash, hydrated lime, wheat flour, wood flour, ground wheat straw, cellulose and soy flour, bentonite, kaolin, attapulgite, diatomaceous earth, calcium carbonate, talc, muscovite mica, fused sodium potassium, aluminum silicate , perlite, talc and muscovite mica, urea, sulfur-coated urea, isobutylidene diurea, ammonium nitrate, ammonium sulfate, ammonium phosphate, triple super phosphate, phosphoric acid, potassium sulfate, potassium nitrate, potassium metaphosphate, potassium chloride, dipotassium carbonate, potassium oxide and a combination of these, calcium, magnesium, sulfur, iron, manganese, copper, zinc; oxides, humic acid, Wood floor, Calcium silicate, Cellulose granules, Magnesium stearate.