CN115052874A - 一种作用于crbn蛋白的三并环类化合物的结晶及其制备方法 - Google Patents
一种作用于crbn蛋白的三并环类化合物的结晶及其制备方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
本申请公开了一种作用于CRBN蛋白的三并环化合物的结晶及其制备方法，具体涉及式(I)化合物的结晶及其制备方法，还包括所述结晶在制备治疗与CRBN蛋白相关疾病的药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010153435 | 2020-03-06 | ||
| CN2020101534355 | 2020-03-06 | ||
| PCT/CN2021/079340 WO2021175317A1 (zh) | 2020-03-06 | 2021-03-05 | 一种作用于crbn蛋白的三并环类化合物的结晶及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115052874A true CN115052874A (zh) | 2022-09-13 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180012797.5A Pending CN115052874A (zh) | 2020-03-06 | 2021-03-05 | 一种作用于crbn蛋白的三并环类化合物的结晶及其制备方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230123104A1 (zh) |
| EP (1) | EP4116300A4 (zh) |
| CN (1) | CN115052874A (zh) |
| AU (1) | AU2021229979A1 (zh) |
| CA (1) | CA3170620A1 (zh) |
| WO (1) | WO2021175317A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202409025A (zh) * | 2022-08-19 | 2024-03-01 | 大陸商正大天晴藥業集團股份有限公司 | 包含環己基的化合物、包含其的藥物組合物及其用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110372669A (zh) * | 2019-06-19 | 2019-10-25 | 浙江省医学科学院 | 一种基于crbn配体诱导egfr降解的化合物及其制备方法、药物组合物和应用 |
| CN110621664A (zh) * | 2017-05-12 | 2019-12-27 | 韩国化学研究院 | 新型哌啶-2,6-二酮衍生物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180228907A1 (en) * | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| MX2019009046A (es) * | 2017-01-31 | 2019-10-30 | Arvinas Operations Inc | Ligandos de cereblon y compuestos bifuncionales que comprenden el mismo. |
| WO2019060693A1 (en) * | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| JP2021521192A (ja) * | 2018-04-13 | 2021-08-26 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | セレブロンリガンドおよび同リガンドを含む二機能性化合物 |
| CA3111649A1 (en) * | 2018-09-07 | 2020-03-12 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Tricyclic compounds acting on crbn proteins |
-
2021
- 2021-03-05 CA CA3170620A patent/CA3170620A1/en active Pending
- 2021-03-05 CN CN202180012797.5A patent/CN115052874A/zh active Pending
- 2021-03-05 WO PCT/CN2021/079340 patent/WO2021175317A1/zh unknown
- 2021-03-05 US US17/909,708 patent/US20230123104A1/en active Pending
- 2021-03-05 AU AU2021229979A patent/AU2021229979A1/en active Pending
- 2021-03-05 EP EP21764296.6A patent/EP4116300A4/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110621664A (zh) * | 2017-05-12 | 2019-12-27 | 韩国化学研究院 | 新型哌啶-2,6-二酮衍生物及其用途 |
| CN110372669A (zh) * | 2019-06-19 | 2019-10-25 | 浙江省医学科学院 | 一种基于crbn配体诱导egfr降解的化合物及其制备方法、药物组合物和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4116300A1 (en) | 2023-01-11 |
| CA3170620A1 (en) | 2021-09-10 |
| EP4116300A4 (en) | 2024-03-27 |
| AU2021229979A1 (en) | 2022-10-27 |
| US20230123104A1 (en) | 2023-04-20 |
| WO2021175317A1 (zh) | 2021-09-10 |
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