CN115040610A - Composition and preparation for reducing blood pressure and preparation method - Google Patents
Composition and preparation for reducing blood pressure and preparation method Download PDFInfo
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Abstract
The invention provides a composition for reducing blood pressure, a preparation and a preparation method thereof, wherein the composition for reducing blood pressure comprises the following raw materials in parts by weight: 2-10 parts of apocynum venetum, 2-10 parts of folium cortex eucommiae, 0.5-5 parts of rhizoma gastrodiae, 1-8 parts of radix puerariae, 1-5 parts of pseudo-ginseng and 0.5-3 parts of white tea. Wherein, the apocynum venetum and the eucommia ulmoides leaves are monarch drugs and can clear heat and calm the liver, nourish the liver and kidney and stably regulate the blood pressure. The rhizoma gastrodiae and the radix puerariae are ministerial drugs, and the rhizoma gastrodiae and the radix puerariae are used for dredging collaterals and assisting in balancing blood pressure. Notoginseng, bitter in flavor and warm in nature, can tonify deficiency, remove stasis, activate blood and alleviate pain, and is used as adjuvant drug. The white tea has the effects of reducing blood pressure and blood fat, improving the taste and harmonizing the medicines. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, clearing heat and calming the liver, tonifying the kidney and tonifying deficiency, has the function of reducing blood pressure and has an obvious effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for reducing blood pressure, a preparation and a preparation method.
Background
Hypertension is a hidden fierce of health of middle-aged and elderly people at present, the hypertension is arterial pressure rise, similar to hyperlipidemia, and continuous hypertension can cause heart disease and other cardiovascular and cerebrovascular complications.
At present, the treatment of hypertension is mainly western medicines, the patient's condition can be controlled only by insisting on taking the medicine for a long time, but the disease cannot be cured fundamentally, and certain side effects can be generated to the body even complications are caused after long-term taking. Based on the reasons, the traditional Chinese medicine has functions of preventing and assisting treatment of hypertension, compared with western medicines, the traditional Chinese medicine adopts nontoxic natural medicines, does not produce great side effect on human bodies, can be taken for a long time, and can still well maintain the stability of the blood pressure after patients stop taking the medicine. However, the traditional Chinese medicine has a non-obvious blood pressure reducing effect.
Disclosure of Invention
The invention aims to provide a composition for reducing blood pressure, a preparation and a preparation method thereof, and aims to solve the problem that the blood pressure reducing effect of the traditional Chinese medicine is not obvious.
In order to achieve the purpose, the invention adopts the following technical scheme:
the composition for reducing blood pressure comprises the following raw materials in parts by weight: 2-10 parts of apocynum venetum, 2-10 parts of folium cortex eucommiae, 0.5-5 parts of rhizoma gastrodiae, 1-8 parts of radix puerariae, 1-5 parts of pseudo-ginseng and 0.5-3 parts of white tea.
Optionally, the composition for reducing blood pressure comprises the following raw materials in parts by weight: 3-8 parts of apocynum venetum, 3-8 parts of eucommia ulmoides leaves, 1-3 parts of gastrodia elata, 1-5 parts of kudzuvine roots, 1-3 parts of pseudo-ginseng and 0.5-1.5 parts of white tea.
The invention also provides a preparation method of the composition for reducing blood pressure, which comprises the following steps:
weighing apocynum venetum, folium cortex eucommiae, rhizoma gastrodiae, radix puerariae and radix notoginseng according to the selected weight parts, mixing, performing reflux extraction by using water, concentrating and drying to obtain an aqueous extract;
sterilizing white tea by radiation, pulverizing, and sieving to obtain white tea powder;
weighing white tea powder according to the selected weight parts, and mixing the white tea powder with the water extract to obtain the composition for assisting in reducing blood pressure.
Optionally, water with the mass of 12-16 times of the extract is added during the reflux extraction, and the reflux extraction is carried out for 2-3 times, and each time lasts for 1-2 h.
Optionally, Co 60-gamma rays are adopted for radiation sterilization, and the radiation dose is 4.0-6.0 kGy.
The invention also provides a medicinal preparation for reducing blood pressure, which comprises the composition for reducing blood pressure or the composition for reducing blood pressure prepared by the preparation method.
Optionally, conventional auxiliary materials are added into the composition for reducing blood pressure, and a clinically acceptable solution, granules, tablets, powder, capsules and pills are prepared according to a conventional process.
The invention also provides a medicinal tea for reducing blood pressure, which comprises the composition for reducing blood pressure or the composition for reducing blood pressure prepared by the preparation method.
Compared with the prior art, the invention has the following beneficial effects:
1. the apocynum venetum composition for reducing blood pressure provided by the invention can calm liver yang, clear heat and promote urination; folium Eucommiae is effective in nourishing liver and kidney, and strengthening tendons and bones; the two are monarch drugs, and can clear heat and calm liver, nourish liver and kidney, and stably regulate blood pressure. Gastrodia elata has the effects of calming endogenous wind and relieving spasm, and dispelling wind and dredging collaterals; radix Puerariae has effects of invigorating yang, relieving diarrhea, dredging meridian passage; the rhizoma gastrodiae and the radix puerariae are ministerial drugs, and the rhizoma gastrodiae and the radix puerariae are used for dredging collaterals and assisting in balancing blood pressure. Notoginseng, bitter in flavor and warm in nature, can tonify deficiency, remove stasis, activate blood and alleviate pain, and is used as adjuvant drug. The white tea has the effects of reducing blood pressure and blood fat, improving the taste and harmonizing the medicines. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, clearing heat and calming the liver, tonifying the kidney and tonifying deficiency, has the function of reducing blood pressure and has an obvious effect.
2. The composition for reducing blood pressure provided by the invention can improve the compliance of patients to take by adding the flavoring agent and combining the characteristics of pure and fragrant taste and sweet mouthfeel of the white tea, and is beneficial to the acceptance of the patients.
3. According to the preparation method of the composition for reducing blood pressure, disclosed by the invention, the white tea is subjected to radiation sterilization and then is mixed with the apocynum venetum, the folium cortex eucommiae, the gastrodia elata, the radix puerariae and the panax notoginseng, so that adverse reactions and drug-induced diseases caused by taking the prepared composition can be avoided, and the composition prepared by the preparation method has a remarkable blood pressure reducing function.
4. According to the preparation method of the composition for reducing blood pressure, provided by the invention, the amount of water added, the extraction times and time are further limited when reflux extraction is carried out by using water, and the effect of reducing blood pressure of the prepared composition can be further improved by combining the type of rays and the radiation amount adopted by radiation sterilization.
5. The blood pressure reducing medicinal preparation provided by the invention can be prepared into corresponding preparations according to the actual requirements of different crowds.
6. The medicinal tea for reducing blood pressure provided by the invention not only can improve the drug loading amount and reduce the daily taking times (2 bags per day), but also can achieve the effect of assisting a patient to reduce blood pressure more safely through daily tea drinking.
Detailed Description
In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more apparent, the present invention is further described in detail below with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
This example provides a composition for lowering blood pressure, which is prepared by the following steps:
pretreatment of
Sterilizing white tea with Co60 radiation (radiation dose is 4kGy), pulverizing, and sieving with 80 mesh sieve to obtain white tea powder (20-80 mesh).
Preparation of aqueous extracts
Mixing 2kg of apocynum venetum, 2kg of folium cortex eucommiae, 0.5kg of rhizoma gastrodiae, 1kg of radix puerariae and 1kg of radix notoginseng, adding 12 times of water, carrying out reflux extraction for 3 times, extracting for 1 hour each time, filtering, combining filtrates, concentrating under reduced pressure at 4 ℃ and 0.09Mpa until the relative density is 1.05(60 ℃), and filtering through 300-mesh filter cloth to obtain a concentrated extract;
centrifuging the first concentrated extract at 4000rpm for 3min, removing supernatant, concentrating the residue at 40 deg.C and 0.09Mpa under reduced pressure to relative density of 1.20(60 deg.C), drying the second concentrated extract at 50 deg.C under reduced pressure, and pulverizing to obtain water extract.
Mixing
Mixing the above water extract with 0.5kg white tea powder at 8rpm of three-dimensional mixer for 30min to obtain the composition for lowering blood pressure.
Example 2
This example provides a composition for lowering blood pressure, which is prepared by the following steps:
pretreatment of
Sterilizing white tea with Co60 radiation (radiation dose is 5kGy), pulverizing, sieving with 80 mesh sieve to obtain white tea powder (20-80 mesh);
preparation of aqueous extracts
Mixing 10kg of apocynum venetum, 10kg of folium cortex eucommiae, 5kg of rhizoma gastrodiae, 8kg of radix puerariae and 5kg of radix notoginseng, adding 14 times of water, carrying out reflux extraction for 2 times, extracting for 2 hours each time, filtering, combining filtrates, concentrating under reduced pressure at 60 ℃ and 0.05Mpa until the relative density is 1.10(60 ℃), and filtering through 300-mesh filter cloth to obtain a concentrated extract;
centrifuging the first concentrated extract at 4000rpm for 3min, removing supernatant, concentrating the residue at 60 deg.C under 0.05Mpa to relative density of 1.25(60 deg.C), drying the second concentrated extract at 55 deg.C under reduced pressure, and pulverizing to obtain water extract.
Mixing
Mixing the above water extract with 3kg white tea powder at three-dimensional mixer 8rpm for 30min to obtain the composition for lowering blood pressure.
Example 3
This example provides a composition for lowering blood pressure, which is prepared by the following steps:
pretreatment of
Sterilizing white tea with Co60 radiation (radiation dose is 6kGy), pulverizing, sieving with 80 mesh sieve to obtain white tea powder (20-80 mesh);
preparation of aqueous extracts
Mixing 6kg of apocynum venetum, 7kg of folium cortex eucommiae, 2kg of rhizoma gastrodiae, 2kg of radix puerariae and 2kg of radix notoginseng, adding 16 times of water, carrying out reflux extraction for 3 times, extracting for 1.5h each time, filtering, combining filtrates, concentrating under reduced pressure at 80 ℃ and 0.04Mpa until the relative density is 1.1(60 ℃), and filtering through 300-mesh filter cloth to obtain a concentrated extract;
centrifuging the first concentrated extract at 4000rpm for 3min, removing supernatant, concentrating under reduced pressure at 80 deg.C and 0.09Mpa to relative density of 1.25(60 deg.C), drying the second concentrated extract at 65 deg.C under reduced pressure, and pulverizing to obtain water extract.
Mixing
Mixing the above water extract with 1kg white tea powder at 8rpm for 30min to obtain the composition for lowering blood pressure.
Example 4
This example provides a composition for lowering blood pressure, which is prepared by the following steps:
pretreatment of
Sterilizing white tea with Co60 radiation (radiation dose is 5kGy), pulverizing, sieving with 80 mesh sieve, and discarding to obtain white tea powder (20-80 mesh);
preparation of aqueous extracts
Mixing 3kg of apocynum venetum, 3kg of folium cortex eucommiae, 1kg of rhizoma gastrodiae, 1kg of radix puerariae and 1kg of radix notoginseng, adding 14 times of water, carrying out reflux extraction for 2 times, extracting for 1 hour each time, filtering, combining filtrates, concentrating under reduced pressure at 50 ℃ and 0.05Mpa until the relative density is 1.1(60 ℃), and filtering through 300-mesh filter cloth to obtain a concentrated extract;
centrifuging the first concentrated extract at 4000rpm for 3min, removing supernatant, concentrating the residue at 50 deg.C and 0.05Mpa under reduced pressure to relative density of 1.25(60 deg.C), drying the second concentrated extract at 60 deg.C under reduced pressure, and pulverizing to obtain water extract.
Mixing
Mixing the above water extract with 1.0kg white tea powder at 8rpm for 30min to obtain the composition for lowering blood pressure.
Example 5
This example provides a composition for lowering blood pressure, which is prepared by the following steps:
pretreatment of
Sterilizing white tea with Co60 radiation (radiation dose is 5kGy), pulverizing, sieving with 80 mesh sieve to obtain white tea powder (20-80 mesh);
preparation of aqueous extracts
Mixing 8kg of apocynum venetum, 8kg of folium cortex eucommiae, 3kg of gastrodia elata, 5kg of radix puerariae and 3kg of pseudo-ginseng, adding 14 times of water, performing reflux extraction for 3 times, performing extraction for 2 hours each time, filtering, combining filtrates, performing reduced pressure concentration at 50 ℃ and 0.05Mpa until the relative density is 1.1(60 ℃), and passing through 300-mesh filter cloth to obtain a concentrated extract;
centrifuging the first concentrated extract at 4000rpm for 3min, removing supernatant, concentrating the residue at 50 deg.C and 0.05Mpa under reduced pressure to relative density of 1.25(60 deg.C), drying the second concentrated extract at 60 deg.C under reduced pressure, and pulverizing to obtain water extract.
Mixing
Mixing the above water extract with 1.5kg white tea powder at 8rpm for 30min to obtain the composition for lowering blood pressure.
Comparative example 1
This comparative example is similar to example 1 except that the white tea has been omitted from this comparative example.
Comparative example 2
This comparative example is similar to example 1 except that the pseudo-ginseng was omitted from this comparative example.
Comparative example 3
This comparative example is similar to example 1 except that an equal amount of salvia was used instead of panax notoginseng.
Comparative example 4
The comparative example is similar to example 1, except that eucommia ulmoides is used instead of eucommia ulmoides leaves, and the amount of eucommia ulmoides in the comparative example is 2 kg.
Comparative example 5
This comparative example is similar to example 1, except that the amount of white tea powder is different only, and the amount of white tea powder used in this comparative example is 0.1 kg.
Comparative example 6
This comparative example is similar to example 1, except that the amount of notoginseng was varied, and the amount of notoginseng used in this comparative example was 0.5 kg.
Comparative example 7
This comparative example is similar to example 1, except that the amounts of the raw materials are different, and the amounts of the raw materials in this comparative example are as follows:
2kg of apocynum venetum, 6kg of folium cortex eucommiae, 10kg of rhizoma gastrodiae, 6kg of radix puerariae, 7kg of pseudo-ginseng and 1kg of white tea powder.
Experimental example 1
Blood pressure lowering test
1.1 Experimental samples
Appropriate amounts of the compositions prepared in examples 1 to 5 and comparative examples 1 to 7 were weighed and prepared into test solutions each having a concentration of 0.5g (as extracted) per 10mL using sterile water.
1.2 Experimental animals and groups
The method selects Beijing Weitonglihua experimental animal technology company [ license number: 180-220g male Spontaneous Hypertension Rats (SHR) bred by SCXK { Jing } 2021-0009 }130 were aged 10-12 weeks. The experiment was randomly divided into 13 groups of 10, each, examples 1-5, comparative examples 1-7 and model control. The normal animal group was selected from 10 healthy SD male rats (laboratory animal production license number SCXK { Zhe } 2021-.
1.3 dosage and administration mode
The test solutions of examples 1 to 5 and comparative examples 1 to 7, the model control group and the normal animal group were replaced with sterile water at a concentration of 0.5g/10mL by gavage administration of the test solutions of examples 1 to 5 and comparative examples 1 to 7, respectively. The preparation is administrated by intragastric administration once a day, the dose of each administration is 1.0mL/100g mouse weight, and the preparation is continuously administrated for four weeks.
1.4 instruments
RBP-1B type rat sphygmomanometer and animal balance
1.5 test methods
The blood pressure and the heart rate of the tested rat are measured for a plurality of times in one week before the test, so that the tested rat is suitable for the pressure measuring environment. And measuring the blood pressure and the heart rate of the animal in a waking state and a resting state according to the requirements of a pressure measuring instrument. The pressure and heart rate were measured 1 time and 1 time before the start of the experiment. Blood pressure and heart rate were measured once after four weeks of the test. After the test sample administration was stopped, observation was continued for 7 days, and blood pressure and heart rate were measured once. The pressure measuring method and time of the normal animal group are the same as above.
1.6 data processing
Blood pressure and heart rate are measured data, and data processing is carried out by SPSS software. Performing variance analysis by using variance analysis program, wherein the variance is uniform, calculating F value, and the F value is less than F 0.05 . And (4) conclusion: the difference between the average numbers of all groups is not significant; f value is more than or equal to F 0.05 P is less than or equal to 0.05, using a plurality of test groups and oneCounting by a pairwise comparison method of the mean number among the control groups; carrying out proper variable conversion on the data with abnormal variance or abnormal variance, and carrying out statistics by using the converted data after meeting the requirements of normal variance or abnormal variance: if the variable still does not reach the goal of being normal or uniform in variance after conversion, the statistics is carried out by using the rank sum test.
1.7 results
Table 1 experimental blood pressure test results (n-10,
)
note: denotes P <0.05 compared to model control group; denotes P <0.01 compared to model control.
Table 2 results of rat heart rate experiments (n 10,
)
as can be seen from the experimental data in the above table, examples 1-5 had no significant difference in heart rate compared to the model control group. The hypotensive compositions of examples 1-5 had good hypotensive efficacy (P <0.01) compared to the model control group, with statistical significance. The blood pressure-lowering compositions of comparative examples 1 to 6 had no blood pressure-lowering effect compared to the model control group, and comparative example 7 had a certain blood pressure-lowering effect compared to the model control group (P < 0.05), but the blood pressure-lowering effect was not significant compared to examples 1 to 5. The composition composed of the pseudo-ginseng, the apocynum venetum, the kudzuvine root, the gastrodia elata, the eucommia ulmoides leaves and the white tea in specific dosage provided by the invention has the effect of synergistically enhancing the blood pressure reduction, and when a part of components in the composition are lacked, replaced or the dosage of the components is not in the range defined by the invention, the synergistic effect can be influenced, so that the blood pressure reduction effect is obviously reduced.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (8)
1. The composition for reducing blood pressure is characterized by comprising the following raw materials in parts by weight: 2-10 parts of apocynum venetum, 2-10 parts of folium cortex eucommiae, 0.5-5 parts of rhizoma gastrodiae, 1-8 parts of radix puerariae, 1-5 parts of pseudo-ginseng and 0.5-3 parts of white tea.
2. The blood pressure lowering composition according to claim 1, comprising the following raw materials in parts by weight: 3-8 parts of apocynum venetum, 3-8 parts of eucommia ulmoides leaves, 1-3 parts of gastrodia elata, 1-5 parts of kudzuvine roots, 1-3 parts of pseudo-ginseng and 0.5-1.5 parts of white tea.
3. A method of preparing the hypotensive composition of claim 1 or 2, comprising the steps of:
weighing apocynum venetum, folium cortex eucommiae, rhizoma gastrodiae, radix puerariae and radix notoginseng according to the selected weight parts, mixing, and performing reflux extraction with water to obtain an aqueous extract;
sterilizing white tea by radiation, pulverizing, and sieving to obtain white tea powder;
weighing white tea powder according to the selected weight parts, and mixing the white tea powder with the water extract to obtain the composition for reducing the blood pressure.
4. The method for preparing the composition for lowering blood pressure according to claim 3, wherein water in an amount 12-16 times the mass of the extract is added during the reflux extraction, and the reflux extraction is performed for 2-3 times, each time for 1-2 hours.
5. The method for preparing the composition for lowering blood pressure according to claim 3 or 4, wherein Co 60-gamma ray is used for radiation sterilization, and the radiation dose is 4.0-6.0 kGy.
6. A pharmaceutical preparation for lowering blood pressure, comprising the composition for lowering blood pressure according to claim 1 or 2 or the composition for lowering blood pressure produced by the production method according to any one of claims 3 to 5.
7. The blood pressure lowering pharmaceutical preparation according to claim 6, wherein conventional adjuvants are added into the blood pressure lowering composition, and a clinically acceptable solution, granule, tablet, powder, capsule and pill are prepared according to a conventional process.
8. A medicinal tea for lowering blood pressure, comprising the composition for lowering blood pressure according to claim 1 or 2 or the composition for lowering blood pressure produced by the production method according to any one of claims 3 to 5.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116832116A (en) * | 2023-07-04 | 2023-10-03 | 河北御芝林生物科技有限公司 | Application of composition in preparation of product for improving or preventing heart injury caused by surgery |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658597A (en) * | 2009-09-16 | 2010-03-03 | 北京利美亚科技有限公司 | Health care step-down tea and preparation method thereof |
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2022
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| CN101658597A (en) * | 2009-09-16 | 2010-03-03 | 北京利美亚科技有限公司 | Health care step-down tea and preparation method thereof |
Non-Patent Citations (1)
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| 张民生: "现代养生学", 陕西科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116832116A (en) * | 2023-07-04 | 2023-10-03 | 河北御芝林生物科技有限公司 | Application of composition in preparation of product for improving or preventing heart injury caused by surgery |
| CN116832116B (en) * | 2023-07-04 | 2024-03-12 | 河北御芝林生物科技有限公司 | Application of composition in preparation of product for improving or preventing heart injury caused by surgery |
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