CN115025019A - 一种含有牡丹提取物的护肤品及其制备方法 - Google Patents
一种含有牡丹提取物的护肤品及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种含有牡丹提取物的护肤品及其制备方法，属于护肤品技术领域。本发明提供的一种含有牡丹提取物的护肤品，其中包含了牡丹提取物、忍冬花提取物、川赤芍根提取物、升麻提取物、酵母发酵产物提取物、马齿苋提取物、二裂酵母发酵产物溶胞物等功效成分，尤其牡丹等植物提取物添加后显著提高了对DPPH自由基的清除率，增强了护肤品的抗氧化活性。因此，本发明提供了一种抗氧化活性强，具有延缓皮肤衰老作用的牡丹提取物护肤品。
Description
技术领域
本发明涉及护肤品技术领域，尤其涉及一种含有牡丹提取物的护肤品及其制备方法。
背景技术
牡丹花花色泽艳丽，玉笑珠香，风流潇洒，富丽堂皇，素有“花中之王”的美誉。牡丹籽是牡丹的种子。以牡丹籽为原料提取得到的牡丹提取物其有效成分是牡丹籽油，牡丹籽油具有极高的应用价值。牡丹籽油具有降低血脂、降低胆固醇，预防心脑血管疾病的作用。牡丹籽油中含有的亚麻酸可以有效降低血脂血压。同时牡丹籽油还具有抗氧化、延缓衰老的作用。牡丹籽油中除了含有高达80％的不饱和脂肪酸外，还含有齐墩果酸、山奈酚、反式白藜芦醇、顺式葡根素、豆甾醇、胡萝卜苷等多种化学成分和其他药理活性物质，如芪类和黄酮类。将其用于护肤品可以达到保湿、柔润、滋养、抗氧化、消除皱纹、紧致肌肤的效果，从而延缓肌肤衰老。
尽管牡丹提取物(牡丹籽油)在抗氧化、延缓肌肤衰老方面具有很好的效果，但是将多种植物提取物配伍使用，能够达到增效甚至协同增效的作用。例如，中国发明专利CN201810965442.8(公开日)提供了一种添加中药提取物的保健护肤品，该护肤品中含有由马齿苋提取物、黄连提取物、皂刺提取物和丹皮酚组成的天然有效成分，通过控制各组分的配比用量，使各组分在充分发挥各自的基础功效之外，能够协同增效，有效调节人体内分泌，从根本上起到祛斑美白的作用。但是，并非任意的植物提取物配伍使用均能达到增效的效果，如果配伍不当还可能导致降效。
发明内容
本发明的目的在于提供一种含有牡丹提取物的护肤品及其制备方法，提高现有护肤产品的抗氧化、抗衰老能力。
为了实现上述发明目的，本发明提供以下技术方案：
本发明提供了一种含有牡丹提取物的护肤品，由包括如下重量份的原料制备得到：海藻糖0.1～2份、烟酰胺0.5～5份、牡丹提取物0.02～1份、忍冬花提取物0.01～1份、川赤芍根提取物0.005～1份、升麻提取物0.045～1份、酵母发酵产物提取物0.1～3份、马齿苋提取物0.045～1份、二裂酵母发酵产物溶胞物0.15～0.8份、糖类同分异构体0.05～0.5份、柠檬酸0.1～0.8份、香精0.01～0.1份、丝氨酸0.05～1份、甘氨酸0.01～1份、精氨酸0.01～1份、天冬氨酸0.1～1份、缬氨酸0.04～0.5份、异亮氨酸0.01～0.8份、亮氨酸0.1～0.5份、丙氨酸0.01～0.1份、谷氨酸0.02～0.09份、脯氨酸0.01～0.08份、棕榈酰三肽-50.001～0.01份、乙酰基六肽-80.001～0.01份、PEG-40-氢化蓖麻油1～5份、1,2-己二醇0.5～0.8份、对羟基苯乙酮0.6～0.8份、异戊二醇1～5份、丙二醇1～5份、水解透明质酸钠0.01～0.1份、透明质酸钠0.01～0.1份、乙酰壳糖胺0.5～5份、乳酸钠0.00001～0.00003、辛甘醇0.1～0.5份、丁二醇2～4份、甘油2～4份、黄原胶0.01～0.1份、卡波姆0.02～0.5份、EDTA二钠0.01～0.05份、水100～200份。
本发明还提供了一种所述的含有牡丹提取物的护肤品的制备方法，包括如下步骤：
(1)取异戊二醇、丙二醇、水解透明质酸钠、透明质酸钠、乙酰壳糖胺、乳酸钠、辛甘醇、丁二醇、甘油、黄原胶、卡波姆、EDTA二钠和水混合溶解，然后加入PEG-40氢化蓖麻油、1,2-己二醇和对羟基苯乙酮乳化；
(2)将乳化后的混合物与丝氨酸、甘氨酸、精氨酸、天冬氨酸、缬氨酸、异亮氨酸、亮氨酸、丙氨酸、谷氨酸、脯氨酸、棕榈酰三肽-5、乙酰基六肽-8混合；
(3)在步骤(2)冷却后的混合物中加入海藻糖、烟酰胺、牡丹提取物、忍冬花提取物、川赤芍根提取物、升麻提取物、酵母发酵产物提取物、马齿苋提取物、二裂酵母发酵产物溶胞物、糖类同分异构体，即制备得到含有牡丹提取物的护肤品。
优选的，所述溶解的温度为80～90℃，溶解时间为5～10min。
优选的，所述乳化采用剪切乳化，所述剪切乳化的转速为1300～2300rpm。
优选的，所述剪切乳化的温度为60～70℃，乳化的时间为20～30min。
优选的，步骤(3)中所述冷却后的混合物的温度为40～50℃。
本发明提供了一种含有牡丹提取物的护肤品，其中包含了牡丹提取物、忍冬花提取物、川赤芍根提取物、升麻提取物、酵母发酵产物提取物、马齿苋提取物、二裂酵母发酵产物溶胞物等功效成分，尤其牡丹等植物提取物添加后显著提高了对DPPH自由基的清除率，增强了护肤品的抗氧化活性。因此，本发明提供了一种抗氧化活性强，具有延缓皮肤衰老作用的牡丹提取物护肤品。
具体实施方式
下面结合实施例对本发明提供的技术方案进行详细的说明，但是不能把它们理解为对本发明保护范围的限定。
以下实施例中，海藻糖、烟酰胺、酵母发酵产物提取物、二裂酵母发酵产物溶胞物、糖类同分异构体、柠檬酸、香精购自上海全丽生物科技有限公司；牡丹提取物由牡丹油和提取物按照质量比1：100混合得到，其中牡丹油购自四川国康瑞璞牡丹产业研究有限公司，提取物购自上海全丽生物科技有限公司；忍冬花提取物、川赤芍根提取物、升麻提取物、马齿苋提取物、川芎提取物、红花提取物、厚朴提取物、党参提取物、麻提取物、金银花提取物购自陕西天之润生物科技有限公司；丝氨酸、甘氨酸、精氨酸、天冬氨酸、缬氨酸、异亮氨酸、亮氨酸、丙氨酸、谷氨酸、脯氨酸、棕榈酰三肽-5、乙酰基六肽-8、PEG-40-氢化蓖麻油、1,2-己二醇、对羟基苯乙酮、异戊二醇、丙二醇、水解透明质酸钠、透明质酸钠、乙酰壳糖胺、乳酸钠、辛甘醇、丁二醇、甘油、黄原胶、卡波姆、EDTA二钠购自上海全丽生物科技有限公司；水为纯净水。
实施例1
称取如下重量份的各原料：海藻糖1份、烟酰胺2份、牡丹提取物0.1份、忍冬花提取物0.2份、川赤芍根提取物0.02份、升麻提取物0.5份、酵母发酵产物提取物1.5份、马齿苋提取物0.1份、二裂酵母发酵产物溶胞物0.5份、糖类同分异构体0.05份、柠檬酸0.5份、香精0.05份、丝氨酸0.35份、甘氨酸0.05份、精氨酸0.1份、天冬氨酸0.3份、缬氨酸0.2份、异亮氨酸0.1份、亮氨酸0.3份、丙氨酸0.05份、谷氨酸0.06份、脯氨酸0.06份、棕榈酰三肽-50.004份、乙酰基六肽-80.008份、PEG-40-氢化蓖麻油0.4份、1,2-己二醇0.5份、对羟基苯乙酮0.8份、异戊二醇4份、丙二醇3份、水解透明质酸钠0.05份、透明质酸钠0.05份、乙酰壳糖胺2份、乳酸钠0.00002、辛甘醇0.3份、丁二醇3份、甘油4份、黄原胶0.06份、卡波姆0.2份、EDTA二钠0.03份、水150份。
将异戊二醇、丙二醇、水解透明质酸钠、透明质酸钠、乙酰壳糖胺、乳酸钠、辛甘醇、丁二醇、甘油、黄原胶、卡波姆、EDTA二钠和水混合加热至85℃溶解8min。然后加入PEG-40氢化蓖麻油、1,2-己二醇和对羟基苯乙酮进行剪切乳化，控制剪切乳化的转速为1800rpm，温度为65℃，时间为25min。在乳化后的混合物中加入丝氨酸、甘氨酸、精氨酸、天冬氨酸、缬氨酸、异亮氨酸、亮氨酸、丙氨酸、谷氨酸、脯氨酸、棕榈酰三肽-5、乙酰基六肽-8混合均匀，冷却至45℃后，加入海藻糖、烟酰胺、牡丹提取物、忍冬花提取物、川赤芍根提取物、升麻提取物、酵母发酵产物提取物、马齿苋提取物、二裂酵母发酵产物溶胞物、糖类同分异构体，混合均匀，继续冷却至20℃，即制备得到含有牡丹提取物的护肤品。
实施例2
称取如下重量份的各原料：海藻糖0.5份、烟酰胺1份、牡丹提取物0.3份、忍冬花提取物0.5份、川赤芍根提取物0.01份、升麻提取物0.1份、酵母发酵产物提取物0.8份、马齿苋提取物0.5份、二裂酵母发酵产物溶胞物0.8份、糖类同分异构体0.1份、柠檬酸0.8份、香精0.04份、丝氨酸0.5份、甘氨酸0.1份、精氨酸0.05份、天冬氨酸0.5份、缬氨酸0.1份、异亮氨酸0.2份、亮氨酸0.1份、丙氨酸0.01份、谷氨酸0.08份、脯氨酸0.03份、棕榈酰三肽-50.006份、乙酰基六肽-80.006份、PEG-40-氢化蓖麻油0.5份、1,2-己二醇0.6份、对羟基苯乙酮0.6份、异戊二醇3份、丙二醇4份、水解透明质酸钠0.04份、透明质酸钠0.06份、乙酰壳糖胺3份、乳酸钠0.00003、辛甘醇0.1份、丁二醇2份、甘油3份、黄原胶0.05份、卡波姆0.1份、EDTA二钠0.05份、水120份。
将异戊二醇、丙二醇、水解透明质酸钠、透明质酸钠、乙酰壳糖胺、乳酸钠、辛甘醇、丁二醇、甘油、黄原胶、卡波姆、EDTA二钠和水混合加热至80℃溶解10min。然后加入PEG-40氢化蓖麻油、1,2-己二醇和对羟基苯乙酮进行剪切乳化，控制剪切乳化的转速为2300rpm，温度为60℃，时间为20min。在乳化后的混合物中加入丝氨酸、甘氨酸、精氨酸、天冬氨酸、缬氨酸、异亮氨酸、亮氨酸、丙氨酸、谷氨酸、脯氨酸、棕榈酰三肽-5、乙酰基六肽-8混合均匀，冷却至50℃后，加入海藻糖、烟酰胺、牡丹提取物、忍冬花提取物、川赤芍根提取物、升麻提取物、酵母发酵产物提取物、马齿苋提取物、二裂酵母发酵产物溶胞物、糖类同分异构体，混合均匀，继续冷却至25℃，即制备得到含有牡丹提取物的护肤品。
实施例3
称取如下重量份的各原料：海藻糖1.5份、烟酰胺3份、牡丹提取物0.08份、忍冬花提取物0.05份、川赤芍根提取物0.1份、升麻提取物0.05份、酵母发酵产物提取物1份、马齿苋提取物0.3份、二裂酵母发酵产物溶胞物0.2份、糖类同分异构体0.15份、柠檬酸0.3份、香精0.08份、丝氨酸0.1份、甘氨酸0.15份、精氨酸0.08份、天冬氨酸0.7份、缬氨酸0.09份、异亮氨酸0.3份、亮氨酸0.5份、丙氨酸0.05份、谷氨酸0.05份、脯氨酸0.08份、棕榈酰三肽-50.002份、乙酰基六肽-80.005份、PEG-40-氢化蓖麻油0.3份、1,2-己二醇0.8份、对羟基苯乙酮0.7份、异戊二醇2份、丙二醇5份、水解透明质酸钠0.05份、透明质酸钠0.05份、乙酰壳糖胺1份、乳酸钠0.00001、辛甘醇0.2份、丁二醇4份、甘油2份、黄原胶0.01份、卡波姆0.4份、EDTA二钠0.02份、水150份。
将异戊二醇、丙二醇、水解透明质酸钠、透明质酸钠、乙酰壳糖胺、乳酸钠、辛甘醇、丁二醇、甘油、黄原胶、卡波姆、EDTA二钠和水混合加热至90℃溶解5min。然后加入PEG-40氢化蓖麻油、1,2-己二醇和对羟基苯乙酮进行剪切乳化，控制剪切乳化的转速为1500rpm，温度为70℃，时间为30min。在乳化后的混合物中加入丝氨酸、甘氨酸、精氨酸、天冬氨酸、缬氨酸、异亮氨酸、亮氨酸、丙氨酸、谷氨酸、脯氨酸、棕榈酰三肽-5、乙酰基六肽-8混合均匀，冷却至40℃后，加入海藻糖、烟酰胺、牡丹提取物、忍冬花提取物、川赤芍根提取物、升麻提取物、酵母发酵产物提取物、马齿苋提取物、二裂酵母发酵产物溶胞物、糖类同分异构体，混合均匀，继续冷却至20℃，即制备得到含有牡丹提取物的护肤品。
实验例1
测定实施例1～3制备的含有牡丹提取物的护肤品的抗氧化活性。
配置DPPH溶液：精密称取DPPH粉末0.0100g，置于250ml容量瓶中，加入95％乙醇溶解，并定容至250ml。
配置待测样品：分别取实施例1～3制备的样品用蒸馏水配成5％(v/v)的待测液。
取4.0ml DPPH溶液和1.0ml待测样液，混合均匀，避光放置30min，以95％的乙醇溶液为参比，测定517nm处的吸光度值。同时设置4.0ml 95％乙醇溶液和1.0ml待测样液组，用于消除背景影响。按照如下公式，计算DPPH自由基清除率。
DPPH自由基清除率％＝[1-(待测液吸光度-背景吸光度)]/参比吸光度×100％
表1不同样品DPPH自由基清除率
| 样品 | DPPH自由基清除率 |
| 实施例1 | 98.5％ |
| 实施例2 | 97.8％ |
| 实施例3 | 98.2％ |
因此，本发明提供的含有牡丹提取物的护肤品对DPPH自由基清除率较高，具有较强的抗氧化能力。
实验例2
为了筛选得到抗氧化活性强的护肤品，本发明前期将牡丹提取物与多种植物提取物配伍检测其DPPH自由基清除率。现将典型对比例总结如下：
预配方1：与实施例1相比没有使用忍冬花提取物、川赤芍根提取物、升麻提取物、马齿苋提取物。
预配方2：与实施例1相比没有使用川赤芍根提取物、升麻提取物、马齿苋提取物。
预配方3：与实施例1相比没有使用忍冬花提取物。
预配方4：与实施例1相比没有使用忍冬花提取物，代替与牡丹提取物配伍的是金银花提取物0.2份。
预配方5：与实施例1相比没有使用川赤芍根提取物、升麻提取物、马齿苋提取物，代替与牡丹提取物配伍的是金银花提取物0.05份、红花提取物0.5份、党参提取物0.3份。
预配方6：与实施例1相比没有使用忍冬花提取物、川赤芍根提取物、升麻提取物、马齿苋提取物，代替与牡丹提取物配伍的是川芎提取物0.2份、红花提取物0.05份、厚朴提取物0.3份、党参提取物1.5份和天麻提取物0.1份。
同时按照实验例1的方法检测各预配方的DPPH自由基清除率。
表2不同预配方样品DPPH自由基清除率
| 样品 | DPPH自由基清除率 |
| 预配方1 | 57.5％ |
| 预配方2 | 72.5％ |
| 预配方3 | 61.8％ |
| 预配方4 | 62.9％ |
| 预配方5 | 80.6％ |
| 预配方6 | 79.8％ |
由此可见，不同的植物提取物配伍使用对DPPH自由基的清除率具有不同的效果，而本发明筛选得到的护肤品配方能够极显著的提高对DPPH自由基的清除率，具有更强的抗氧化活性。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。
Claims (6)
1.一种含有牡丹提取物的护肤品，其特征在于，由包括如下重量份的原料制备得到：海藻糖0.1～2份、烟酰胺0.5～5份、牡丹提取物0.02～1份、忍冬花提取物0.01～1份、川赤芍根提取物0.005～1份、升麻提取物0.045～1份、酵母发酵产物提取物0.1～3份、马齿苋提取物0.045～1份、二裂酵母发酵产物溶胞物0.15～0.8份、糖类同分异构体0.05～0.5份、柠檬酸0.1～0.8份、香精0.01～0.1份、丝氨酸0.05～1份、甘氨酸0.01～1份、精氨酸0.01～1份、天冬氨酸0.1～1份、缬氨酸0.04～0.5份、异亮氨酸0.01～0.8份、亮氨酸0.1～0.5份、丙氨酸0.01～0.1份、谷氨酸0.02～0.09份、脯氨酸0.01～0.08份、棕榈酰三肽-50.001～0.01份、乙酰基六肽-80.001～0.01份、PEG-40-氢化蓖麻油1～5份、1,2-己二醇0.5～0.8份、对羟基苯乙酮0.6～0.8份、异戊二醇1～5份、丙二醇1～5份、水解透明质酸钠0.01～0.1份、透明质酸钠0.01～0.1份、乙酰壳糖胺0.5～5份、乳酸钠0.00001～0.00003、辛甘醇0.1～0.5份、丁二醇2～4份、甘油2～4份、黄原胶0.01～0.1份、卡波姆0.02～0.5份、EDTA二钠0.01～0.05份、水100～200份。
2.一种权利要求1所述的含有牡丹提取物的护肤品的制备方法，其特征在于，包括如下步骤：
(1)取异戊二醇、丙二醇、水解透明质酸钠、透明质酸钠、乙酰壳糖胺、乳酸钠、辛甘醇、丁二醇、甘油、黄原胶、卡波姆、EDTA二钠和水混合溶解，然后加入PEG-40氢化蓖麻油、1,2-己二醇和对羟基苯乙酮乳化；
(2)将乳化后的混合物与丝氨酸、甘氨酸、精氨酸、天冬氨酸、缬氨酸、异亮氨酸、亮氨酸、丙氨酸、谷氨酸、脯氨酸、棕榈酰三肽-5、乙酰基六肽-8混合；
(3)在步骤(2)冷却后的混合物中加入海藻糖、烟酰胺、牡丹提取物、忍冬花提取物、川赤芍根提取物、升麻提取物、酵母发酵产物提取物、马齿苋提取物、二裂酵母发酵产物溶胞物、糖类同分异构体，即制备得到含有牡丹提取物的护肤品。
3.如权利要求2所述的制备方法，其特征在于，所述溶解的温度为80～90℃，溶解时间为5～10min。
4.如权利要求3所述的制备方法，其特征在于，所述乳化采用剪切乳化，所述剪切乳化的转速为1300～2300rpm。
5.如权利要求4所述的制备方法，其特征在于，所述剪切乳化的温度为60～70℃，乳化的时间为20～30min。
6.如权利要求2～5任一项所述的制备方法，其特征在于，步骤(3)中所述冷却后的混合物的温度为40～50℃。
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